Pinometostat (BioDeep_00000699601)
代谢物信息卡片
化学式: C30H42N8O3 (562.338)
中文名称: 匹诺司他
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)N(CC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)O)C4CC(C4)CCC5=NC6=C(N5)C=C(C=C6)C(C)(C)C
InChI: InChI=1S/C30H42N8O3/c1-16(2)37(13-22-25(39)26(40)29(41-22)38-15-34-24-27(31)32-14-33-28(24)38)19-10-17(11-19)6-9-23-35-20-8-7-18(30(3,4)5)12-21(20)36-23/h7-8,12,14-17,19,22,25-26,29,39-40H,6,9-11,13H2,1-5H3,(H,35,36)(H2,31,32,33)/t17?,19?,22-,25-,26-,29-/m1/s1
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:124919
- PubChem: 57345410
- DrugBank: DB12920
- ChEMBL: CHEMBL4079133
- ChEMBL: CHEMBL3087499
- ChEMBL: CHEMBL3414626
- CAS: 1380288-87-8
- CAS: 1380288-88-9
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Eytan M Stein, Guillermo Garcia-Manero, David A Rizzieri, Raoul Tibes, Jesus G Berdeja, Michael R Savona, Mojca Jongen-Lavrenic, Jessica K Altman, Blythe Thomson, Stephen J Blakemore, Scott R Daigle, Nigel J Waters, A Benjamin Suttle, Alicia Clawson, Roy Pollock, Andrei Krivtsov, Scott A Armstrong, Jorge DiMartino, Eric Hedrick, Bob Löwenberg, Martin S Tallman. The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia.
Blood.
2018 06; 131(24):2661-2669. doi:
10.1182/blood-2017-12-818948. [PMID: 29724899] - Sherri A Smith, Sandra Gagnon, Nigel J Waters. Mechanistic investigations into the species differences in pinometostat clearance: impact of binding to alpha-1-acid glycoprotein and permeability-limited hepatic uptake.
Xenobiotica; the fate of foreign compounds in biological systems.
2017 Mar; 47(3):185-193. doi:
10.3109/00498254.2016.1173265. [PMID: 27160567] - Nigel J Waters, Sherri A Smith, Edward J Olhava, Kenneth W Duncan, Richard D Burton, James O'Neill, Marie-Eve Rodrigue, Roy M Pollock, Mikel P Moyer, Richard Chesworth. Metabolism and disposition of the DOT1L inhibitor, pinometostat (EPZ-5676), in rat, dog and human.
Cancer chemotherapy and pharmacology.
2016 Jan; 77(1):43-62. doi:
10.1007/s00280-015-2929-y. [PMID: 26645404] - Aravind Basavapathruni, Edward J Olhava, Scott R Daigle, Carly A Therkelsen, Lei Jin, P Ann Boriack-Sjodin, Christina J Allain, Christine R Klaus, Alejandra Raimondi, Margaret Porter Scott, Angelos Dovletoglou, Victoria M Richon, Roy M Pollock, Robert A Copeland, Mikel P Moyer, Richard Chesworth, Paul G Pearson, Nigel J Waters. Nonclinical pharmacokinetics and metabolism of EPZ-5676, a novel DOT1L histone methyltransferase inhibitor.
Biopharmaceutics & drug disposition.
2014 May; 35(4):237-52. doi:
10.1002/bdd.1889. [PMID: 24415392] - Justin L Anglin, Yongcheng Song. A medicinal chemistry perspective for targeting histone H3 lysine-79 methyltransferase DOT1L.
Journal of medicinal chemistry.
2013 Nov; 56(22):8972-83. doi:
10.1021/jm4007752. [PMID: 23879463]
