2,4,6-trinitrobenzenesulfonic acid (BioDeep_00000699229)
代谢物信息卡片
2,4,6-trinitrobenzenesulfonic acid
化学式: C6H3N3O9S (292.9590028)
中文名称: 2 4 6-三硝基苯磺酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=C(C=C(C(=C1[N+](=O)[O-])S(=O)(=O)O)[N+](=O)[O-])[N+](=O)[O-]
InChI: InChI=1S/C6H3N3O9S/c10-7(11)3-1-4(8(12)13)6(19(16,17)18)5(2-3)9(14)15/h1-2H,(H,16,17,18)
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:53063
- PubChem: 11045
- ChEMBL: CHEMBL3586251
- MeSH: Trinitrobenzenesulfonic Acid
- CAS: 37006-19-2
- CAS: 2508-19-2
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Lian Wang, Xue Song, Yueqing Zhou, Yongsheng Xia, Zi Yang, Xiaohua Chen, Ruohan Shi, Zhijun Geng, Xiaofeng Zhang, Yueyue Wang, Jing Li, Jianguo Hu, Lugen Zuo. Sclareol protected against intestinal barrier dysfunction ameliorating Crohn's disease-like colitis via Nrf2/NF-B/MLCK signalling.
International immunopharmacology.
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International journal of biological macromolecules.
2024 Feb; 258(Pt 2):129043. doi:
10.1016/j.ijbiomac.2023.129043. [PMID: 38158054] - Dongsheng Wu, Yu Zhang, Bo Zou, Yi Lu, Hui Cao. Shaoyao decoction alleviates TNBS-induced ulcerative colitis by decreasing inflammation and balancing the homeostasis of Th17/Treg cells.
BMC complementary medicine and therapies.
2023 Nov; 23(1):424. doi:
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Journal of translational medicine.
2023 08; 21(1):554. doi:
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Molecules (Basel, Switzerland).
2023 Mar; 28(7):. doi:
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The Kaohsiung journal of medical sciences.
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Life sciences.
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Immunopharmacology and immunotoxicology.
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
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Nitric oxide : biology and chemistry.
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Journal of ethnopharmacology.
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Cells.
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
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International immunopharmacology.
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Iranian biomedical journal.
2020 09; 24(5):281-7. doi:
10.29252/ibj.24.5.276. [PMID: 32429633] - Sandra R Lourenssen, Michael G Blennerhassett. M2 Macrophages and Phenotypic Modulation of Intestinal Smooth Muscle Cells Characterize Inflammatory Stricture Formation in Rats.
The American journal of pathology.
2020 09; 190(9):1843-1858. doi:
10.1016/j.ajpath.2020.05.015. [PMID: 32479820] - Yuksel Altinel, Şenay Yalçın, Gulçin Ercan, Erkan Yavuz, Candaş Erçetin, Osman Bilgin Gülçiçek, Atilla Çelik, Güven Özkaya, Hafize Uzun. The efficacy of curcumin on PDGF expression and NF-kappa B pathway: TNBS-induced colitis.
Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES.
2020 Sep; 26(5):663-670. doi:
10.14744/tjtes.2019.45570. [PMID: 32946092] - Souad Mouzaoui, Sreeparna Banerjee, Bahia Djerdjouri. Low-dose curcumin reduced TNBS-associated mucin depleted foci in mice by scavenging superoxide anion and lipid peroxides, rebalancing matrix NO synthase and aconitase activities, and recoupling mitochondria.
Inflammopharmacology.
2020 Aug; 28(4):949-965. doi:
10.1007/s10787-019-00684-4. [PMID: 31960283] - Jian-Guo Gao, Mo-Sang Yu, Meng-Meng Zhang, Xue-Wei Gu, Yue Ren, Xin-Xin Zhou, Dong Chen, Tian-Lian Yan, You-Ming Li, Xi Jin. Adipose-derived mesenchymal stem cells alleviate TNBS-induced colitis in rats by influencing intestinal epithelial cell regeneration, Wnt signaling, and T cell immunity.
World journal of gastroenterology.
2020 Jul; 26(26):3750-3766. doi:
10.3748/wjg.v26.i26.3750. [PMID: 32774055] - Jian Li, Lan Liu, Qiu Zhao, Min Chen. Role of Interleukin-17 in Pathogenesis of Intestinal Fibrosis in Mice.
Digestive diseases and sciences.
2020 07; 65(7):1971-1979. doi:
10.1007/s10620-019-05969-w. [PMID: 31808003] - Éva Boros, Bence Prontvai, Zoltán Kellermayer, Péter Balogh, Patrícia Sarlós, Áron Vincze, Csaba Varga, Zoltán Maróti, Balázs Bálint, István Nagy. Transcriptome Based Profiling of the Immune Cell Gene Signature in Rat Experimental Colitis and Human IBD Tissue Samples.
Biomolecules.
2020 06; 10(7):. doi:
10.3390/biom10070974. [PMID: 32610492] - Oyindamola O Abiodun, Aderemi S Sosanya, Norah Nwadike, Adedunke O Oshinloye. Beneficial effect of Bidens pilosa L. (Asteraceae) in a rat model of colitis.
Journal of basic and clinical physiology and pharmacology.
2020 Jun; 31(6):. doi:
10.1515/jbcpp-2019-0166. [PMID: 32598311] - Chi Zhou, Xian-Rui Wu, Hua-Shan Liu, Xuan-Hui Liu, Gui-Hua Liu, Xiao-Bin Zheng, Tuo Hu, Zhen-Xing Liang, Xiao-Wen He, Xiao-Jian Wu, Leona C Smith, Yuanyuan Zhang, Ping Lan. Immunomodulatory Effect of Urine-derived Stem Cells on Inflammatory Bowel Diseases via Downregulating Th1/Th17 Immune Responses in a PGE2-dependent Manner.
Journal of Crohn's & colitis.
2020 Jun; 14(5):654-668. doi:
10.1093/ecco-jcc/jjz200. [PMID: 31841595] - Lei Zhu, Lu-Zhou Xu, Song Zhao, Zhao-Feng Shen, Hong Shen, Li-Bin Zhan. Protective effect of baicalin on the regulation of Treg/Th17 balance, gut microbiota and short-chain fatty acids in rats with ulcerative colitis.
Applied microbiology and biotechnology.
2020 Jun; 104(12):5449-5460. doi:
10.1007/s00253-020-10527-w. [PMID: 32322944] - Nalan Gülşen Ünal, Ayşegül Kozak, Sibel Karakaya, Nevin Oruç, Burcu Barutçuoğlu, Çağdaş Aktan, Murat Sezak, Ahmet Ömer Özütemiz. Anti-Inflammatory Effect of Crude Momordica charantia L. Extract on 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Colitis Model in Rat and the Bioaccessibility of its Carotenoid Content.
Journal of medicinal food.
2020 Jun; 23(6):641-648. doi:
10.1089/jmf.2019.0124. [PMID: 31702423] - P C Konturek, K Konturek, T Brzozowski, D Wojcik, M Magierowski, A Targosz, G Krzysiek-Maczka, Z Sliwowski, M Strzalka, K Magierowska, U Szczyrk, S Kwiecien, A Ptak-Belowska, M Neurath, W Dieterich, S Wirtz, Y Zopf. Participation of the intestinal microbiota in the mechanism of beneficial effect of treatment with synbiotic Syngut on experimental colitis under stress conditions.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2020 Jun; 71(3):. doi:
10.26402/jpp.2020.3.03. [PMID: 32991312] - Karuppusamy Arunachalam, Amilcar Sabino Damazo, Antonio Macho, Joaquim Corsino da Silva Lima, Eduarda Pavan, Fabiana de Freitas Figueiredo, Darley Maria Oliveira, Valdir Cechinel-Filho, Theodoro Marcel Wagner, Domingos Tabajara de Oliveira Martins. Piper umbellatum L. (Piperaceae): Phytochemical profiles of the hydroethanolic leaf extract and intestinal anti-inflammatory mechanisms on 2,4,6 trinitrobenzene sulfonic acid induced ulcerative colitis in rats.
Journal of ethnopharmacology.
2020 May; 254(?):112707. doi:
10.1016/j.jep.2020.112707. [PMID: 32112897] - Man Zhang, Heng Fan, Songwei Tan, Qing Tang, Xingxing Liu, Dongmei Zuo, Yi Liao, Zhen Nan, Chen Tan. The Chinese medicinal herb decoction QRZSLXF enhances anti-inflammatory effect in TNBS-induced colitis via balancing Th17/Tregs differentiation.
Journal of ethnopharmacology.
2020 Apr; 251(?):112549. doi:
10.1016/j.jep.2020.112549. [PMID: 31918016] - Luana H Maurer, Cinthia B B Cazarin, Andréia Quatrin, Natália M Minuzzi, Sabrina M Nichelle, Celina de A Lamas, Valéria H A Cagnon, Joseane Morari, Lício A Velloso, Mário R Maróstica Júnior, Tatiana Emanuelli. Grape peel powder attenuates the inflammatory and oxidative response of experimental colitis in rats by modulating the NF-κB pathway and activity of antioxidant enzymes.
Nutrition research (New York, N.Y.).
2020 04; 76(?):52-70. doi:
10.1016/j.nutres.2020.01.006. [PMID: 32155506] - Ana E V Quaglio, Vinicius M Cruz, Luiz D Almeida-Junior, Celso A R A Costa, Luiz C Di Stasi. Bidens pilosa (Black Jack) Standardized Extract Ameliorates Acute TNBS-induced Intestinal Inflammation in Rats.
Planta medica.
2020 Mar; 86(5):319-330. doi:
10.1055/a-1089-8342. [PMID: 32000263] - X-S Bai, G Bai, L-D Tang, Y Li, Y Huan, H Wang. MiR-195 alleviates ulcerative colitis in rats via MAPK signaling pathway.
European review for medical and pharmacological sciences.
2020 03; 24(5):2640-2646. doi:
10.26355/eurrev_202003_20533. [PMID: 32196614] - Ipek Süntar, Can Kerem Cevik, Ali Osman Çeribaşı, Alper Gökbulut. Healing effects of Cornus mas L. in experimentally induced ulcerative colitis in rats: From ethnobotany to pharmacology.
Journal of ethnopharmacology.
2020 Feb; 248(?):112322. doi:
10.1016/j.jep.2019.112322. [PMID: 31644942] - Xin Yan, Qing-Ge Lu, Li Zeng, Xiao-Hai Li, Yu Liu, Xue-Feng Du, Guo-Min Bai. Synergistic protection of astragalus polysaccharides and matrine against ulcerative colitis and associated lung injury in rats.
World journal of gastroenterology.
2020 Jan; 26(1):55-69. doi:
10.3748/wjg.v26.i1.55. [PMID: 31933514] - Marta Szandruk-Bender, Maria Rutkowska, Anna Merwid-Ląd, Benita Wiatrak, Adam Szeląg, Stanisław Dzimira, Beata Sobieszczańska, Małgorzata Krzystek-Korpacka, Alicja Z Kucharska, Agnieszka Matuszewska, Beata Nowak, Narcyz Piórecki, Anna Duda-Madej, Urszula Walczuk, Michał Turniak, Iwona Bednarz-Misa, Tomasz Sozański. Cornelian Cherry Iridoid-Polyphenolic Extract Improves Mucosal Epithelial Barrier Integrity in Rat Experimental Colitis and Exerts Antimicrobial and Antiadhesive Activities In Vitro.
Oxidative medicine and cellular longevity.
2020; 2020(?):7697851. doi:
10.1155/2020/7697851. [PMID: 33299531] - Xiaocang Cao, Liyun Duan, Huixing Hou, Yue Liu, Shang Chen, Shuaiqiang Zhang, Yuanyuan Liu, Chen Wang, Xin Qi, Na Liu, Zhibo Han, Dekui Zhang, Zhong-Chao Han, Zhikun Guo, Qiang Zhao, Zongjin Li. IGF-1C hydrogel improves the therapeutic effects of MSCs on colitis in mice through PGE2-mediated M2 macrophage polarization.
Theranostics.
2020; 10(17):7697-7709. doi:
10.7150/thno.45434. [PMID: 32685014] - Haider Rasheed Alrafas, Philip B Busbee, Mitzi Nagarkatti, Prakash S Nagarkatti. Resveratrol Downregulates miR-31 to Promote T Regulatory Cells during Prevention of TNBS-Induced Colitis.
Molecular nutrition & food research.
2020 01; 64(1):e1900633. doi:
10.1002/mnfr.201900633. [PMID: 31730734] - Jing Ma, Jianhui Li, Meirui Qian, Nan He, Ying Cao, Yaping Liu, Kaichun Wu, Shuixiang He. The comprehensive pathophysiological changes in a novel rat model of postinflammatory visceral hypersensitivity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2019 12; 33(12):13560-13571. doi:
10.1096/fj.201901489r. [PMID: 31570003] - Juliana Kelly da Silva-Maia, Ângela Giovana Batista, Cinthia Baú Betim Cazarin, Edilene Siqueira Soares, Stanislau Bogusz Junior, Raquel Franco Leal, Maria Alice da Cruz-Höfling, Mário Roberto Maróstica Junior. Aqueous Extract of Brazilian Berry (Myrciaria jaboticaba) Peel Improves Inflammatory Parameters and Modulates Lactobacillus and Bifidobacterium in Rats with Induced-Colitis.
Nutrients.
2019 Nov; 11(11):. doi:
10.3390/nu11112776. [PMID: 31731626] - N Konthapakdee, L Grundy, T O'Donnell, S Garcia-Caraballo, S M Brierley, D Grundy, D M Daly. Serotonin exerts a direct modulatory role on bladder afferent firing in mice.
The Journal of physiology.
2019 11; 597(21):5247-5264. doi:
10.1113/jp278751. [PMID: 31520534] - Marcos F F Calabresi, Alexandre Tanimoto, André G Próspero, Fabio P F Mello, Guilherme Soares, Luiz C Di Stasi, José R A Miranda. Changes in colonic contractility in response to inflammatory bowel disease: Long-term assessment in a model of TNBS-induced inflammation in rats.
Life sciences.
2019 Nov; 236(?):116833. doi:
10.1016/j.lfs.2019.116833. [PMID: 31491456] - Xue Li, Xinzhi Wei, Yue Sun, Jie Du, Xin Li, Zhe Xun, Yan Chun Li. High-fat diet promotes experimental colitis by inducing oxidative stress in the colon.
American journal of physiology. Gastrointestinal and liver physiology.
2019 10; 317(4):G453-G462. doi:
10.1152/ajpgi.00103.2019. [PMID: 31411504] - Elif Yorulmaz, Hatice Yorulmaz, Emel Sağlam Gökmen, Serdar Altınay, Suat Hayri Küçük, Oğuzhan Zengi, Duygu Sultan Çelik, Dede Şit. Therapeutic effectiveness of rectally administered fish oil and mesalazine in trinitrobenzenesulfonic acid-induced colitis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Oct; 118(?):109247. doi:
10.1016/j.biopha.2019.109247. [PMID: 31351432] - Luana Haselein Maurer, Cinthia Baú Betim Cazarin, Andréia Quatrin, Natália Machado Minuzzi, Eduarda Lasch Costa, Joseane Morari, Lício Augusto Velloso, Raquel Franco Leal, Eliseu Rodrigues, Vivian Caetano Bochi, Mário Roberto Maróstica Júnior, Tatiana Emanuelli. Grape peel powder promotes intestinal barrier homeostasis in acute TNBS-colitis: A major role for dietary fiber and fiber-bound polyphenols.
Food research international (Ottawa, Ont.).
2019 09; 123(?):425-439. doi:
10.1016/j.foodres.2019.04.068. [PMID: 31284994] - Ying Cai, Wen Liu, Yixuan Lin, Shaobao Zhang, Baorong Zou, Dan Xiao, Lei Lin, Yuping Zhong, Haihui Zheng, Qiongfeng Liao, Zhiyong Xie. Compound polysaccharides ameliorate experimental colitis by modulating gut microbiota composition and function.
Journal of gastroenterology and hepatology.
2019 Sep; 34(9):1554-1562. doi:
10.1111/jgh.14583. [PMID: 30589960] - Weiwei Qin, Lujun Li, Ting Wang, He Huang, Youhe Gao. Urine Proteome Changes in a TNBS-Induced Colitis Rat Model.
Proteomics. Clinical applications.
2019 09; 13(5):e1800100. doi:
10.1002/prca.201800100. [PMID: 31095872] - Chun-Hui Bao, Chun-Ye Wang, Guo-Na Li, Yi-Lu Yan, Di Wang, Xiao-Ming Jin, Lu-Yi Wu, Hui-Rong Liu, Xiao-Mei Wang, Zheng Shi, Huan-Gan Wu. Effect of mild moxibustion on intestinal microbiota and NLRP6 inflammasome signaling in rats with post-inflammatory irritable bowel syndrome.
World journal of gastroenterology.
2019 Aug; 25(32):4696-4714. doi:
10.3748/wjg.v25.i32.4696. [PMID: 31528095] - Wei He, Mengyang Liu, Yongmin Li, Haiyang Yu, Dan Wang, Qian Chen, Yue Chen, Yi Zhang, Tao Wang. Flavonoids from Citrus aurantium ameliorate TNBS-induced ulcerative colitis through protecting colonic mucus layer integrity.
European journal of pharmacology.
2019 Aug; 857(?):172456. doi:
10.1016/j.ejphar.2019.172456. [PMID: 31220438] - Hai-Mei Zhao, Yi Liu, Xiao-Ying Huang, Xue-Ke Liu, Fang Chen, Xiao-Yun Zhang, Fu-Chun Liu, Xiu-Yun Lu, Yao Wang, Duan-Yong Liu. Pharmacological mechanism of Sishen Wan® attenuated experimental chronic colitis by inhibiting wnt/β-catenin pathway.
Journal of ethnopharmacology.
2019 Aug; 240(?):111936. doi:
10.1016/j.jep.2019.111936. [PMID: 31078692] - Jia Liu, Ling Yu, Nuolan Mo, Hai Lan, Yan Zhang, Xin Liu, Qing Wu. Supercritical Fluid Extract of Angelica sinensis and Zingiber officinale Roscoe Ameliorates TNBS-Induced Colitis in Rats.
International journal of molecular sciences.
2019 Aug; 20(15):. doi:
10.3390/ijms20153816. [PMID: 31387229] - Hyo-Min Jang, Keon-Tae Park, Hyun-Deok Noh, So-Hyeon Lee, Dong-Hyun Kim. Kakkalide and irisolidone alleviate 2,4,6-trinitrobenzenesulfonic acid-induced colitis in mice by inhibiting lipopolysaccharide binding to toll-like receptor-4 and proteobacteria population.
International immunopharmacology.
2019 Aug; 73(?):246-253. doi:
10.1016/j.intimp.2019.05.008. [PMID: 31112869] - Yuki Toyokawa, Tomohisa Takagi, Kazuhiko Uchiyama, Katsura Mizushima, Ken Inoue, Chihiro Ushiroda, Saori Kashiwagi, Takahiro Nakano, Yuma Hotta, Makoto Tanaka, Osamu Dohi, Tetsuya Okayama, Naohisa Yoshida, Kazuhiro Katada, Kazuhiro Kamada, Takeshi Ishikawa, Osamu Handa, Hideyuki Konishi, Yuji Naito, Yoshito Itoh. Ginsenoside Rb1 promotes intestinal epithelial wound healing through extracellular signal-regulated kinase and Rho signaling.
Journal of gastroenterology and hepatology.
2019 Jul; 34(7):1193-1200. doi:
10.1111/jgh.14532. [PMID: 30394577] - Xiaoyang Sheng, Xueqing Sun, Feng Li, Junli Wang, Jingqiu Ma. Linear growth failure induced by systemic inflammation inhibiting IGF-1/IGFBP axis in rats with asymptomatic colitis.
BMC gastroenterology.
2019 Jun; 19(1):96. doi:
10.1186/s12876-019-1023-z. [PMID: 31221091] - Benoît Foligné, Coline Plé, Marie Titécat, Arnaud Dendooven, Aurélien Pagny, Catherine Daniel, Elisabeth Singer, Muriel Pottier, Benjamin Bertin, Christel Neut, Dominique Deplanque, Laurent Dubuquoy, Pierre Desreumaux, Monique Capron, Annie Standaert. Contribution of the Gut Microbiota in P28GST-Mediated Anti-Inflammatory Effects: Experimental and Clinical Insights.
Cells.
2019 06; 8(6):. doi:
10.3390/cells8060577. [PMID: 31212833] - Guangyu Wu, Xiaoman Liu, Pei Zhou, Zhijun Xu, Mohammad Hegazy, Xin Huang, Yudong Huang. The construction of thiol-functionalized DNAsomes with small molecules response and protein release.
Materials science & engineering. C, Materials for biological applications.
2019 Jun; 99(?):1153-1163. doi:
10.1016/j.msec.2019.02.069. [PMID: 30889649] - Corinne E Metzger, S Anand Narayanan, David C Zawieja, Susan A Bloomfield. A moderately elevated soy protein diet mitigates inflammatory changes in gut and in bone turnover during chronic TNBS-induced inflammatory bowel disease.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.
2019 Jun; 44(6):595-605. doi:
10.1139/apnm-2018-0514. [PMID: 30352170] - Jan Bilski, Agnieszka Mazur-Bialy, Dagmara Wojcik, Marcin Magierowski, Marcin Surmiak, Slawomir Kwiecien, Katarzyna Magierowska, Magdalena Hubalewska-Mazgaj, Zbigniew Sliwowski, Tomasz Brzozowski. Effect of Forced Physical Activity on the Severity of Experimental Colitis in Normal Weight and Obese Mice. Involvement of Oxidative Stress and Proinflammatory Biomarkers.
Nutrients.
2019 May; 11(5):. doi:
10.3390/nu11051127. [PMID: 31117199] - Jing Zhou, Lu-Yi Wu, Liu Chen, Ya-Jing Guo, Yi Sun, Tao Li, Ji-Meng Zhao, Chun-Hui Bao, Huan-Gan Wu, Yin Shi. Herbs-partitioned moxibustion alleviates aberrant intestinal epithelial cell apoptosis by upregulating A20 expression in a mouse model of Crohn's disease.
World journal of gastroenterology.
2019 May; 25(17):2071-2085. doi:
10.3748/wjg.v25.i17.2071. [PMID: 31114134] - Maria Luisa Castejón, Maria Ángeles Rosillo, Isabel Villegas, Marina Sánchez-Hidalgo, Lila Hadidi, Farid Zaidi, Catalina Alarcón-de-la-Lastra. Quercus ilex Extract Ameliorates Acute TNBS-Induced Colitis in Rats.
Planta medica.
2019 May; 85(8):670-677. doi:
10.1055/a-0889-6132. [PMID: 31018218]