cilofungin (BioDeep_00000699015)

   


代谢物信息卡片


cilofungin

化学式: C49H71N7O17 (1029.4906196)
中文名称: 西洛芬净
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCCCCCOC1=CC=C(C=C1)C(=O)NC2CC(C(NC(=O)C3C(C(CN3C(=O)C(NC(=O)C(NC(=O)C4CC(CN4C(=O)C(NC2=O)C(C)O)O)C(C(C5=CC=C(C=C5)O)O)O)C(C)O)C)O)O)O
InChI: InChI=1S/C49H71N7O17/c1-5-6-7-8-9-10-19-73-31-17-13-28(14-18-31)42(65)50-32-21-34(61)45(68)54-47(70)38-39(62)24(2)22-56(38)49(72)36(26(4)58)52-46(69)37(41(64)40(63)27-11-15-29(59)16-12-27)53-44(67)33-20-30(60)23-55(33)48(71)35(25(3)57)51-43(32)66/h11-18,24-26,30,32-41,45,57-64,68H,5-10,19-23H2,1-4H3,(H,50,65)(H,51,66)(H,52,69)(H,53,67)(H,54,70)

描述信息

D000890 - Anti-Infective Agents > D000935 - Antifungal Agents > D054714 - Echinocandins
C254 - Anti-Infective Agent > C514 - Antifungal Agent

同义名列表

2 个代谢物同义名

cilofungin; CID 456395



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • D J Frost, K Brandt, J Capobianco, R Goldman. Characterization of (1,3)-beta-glucan synthase in Candida albicans: microsomal assay from the yeast or mycelial morphological forms and a permeabilized whole-cell assay. Microbiology (Reading, England). 1994 Sep; 140 ( Pt 9)(?):2239-46. doi: 10.1099/13500872-140-9-2239. [PMID: 7952175]
  • L Angiolella, N Simonetti, A Cassone. The lipopeptide antimycotic, cilofungin modulates the incorporation of glucan-associated proteins into the cell wall of Candida albicans. The Journal of antimicrobial chemotherapy. 1994 Jun; 33(6):1137-46. doi: 10.1093/jac/33.6.1137. [PMID: 7928807]
  • Y T Ko, R D Ludescher, D J Frost, B P Wasserman. Use of cilofungin as direct fluorescent probe for monitoring antifungal drug-membrane interaction. Antimicrobial agents and chemotherapy. 1994 Jun; 38(6):1378-85. doi: 10.1128/aac.38.6.1378. [PMID: 8092841]
  • N Khardori, H Nguyen, L C Stephens, L Kalvakuntla, B Rosenbaum, G P Bodey. Comparative efficacies of cilofungin (Ly121019) and amphotericin B against disseminated Candida albicans infection in normal and granulocytopenic mice. Antimicrobial agents and chemotherapy. 1993 Apr; 37(4):729-36. doi: 10.1128/aac.37.4.729. [PMID: 8494367]
  • I W Fong, R M Bannatyne, P C Cheng. The comparative efficacy of cilofungin, fluconazole and amphotericin B in disseminated Candida tropicalis infection in neutropenic mice. Clinical and investigative medicine. Medecine clinique et experimentale. 1992 Oct; 15(5):434-9. doi: NULL. [PMID: 1458716]
  • K Bartizal, G Abruzzo, C Trainor, D Krupa, K Nollstadt, D Schmatz, R Schwartz, M Hammond, J Balkovec, F Vanmiddlesworth. In vitro antifungal activities and in vivo efficacies of 1,3-beta-D-glucan synthesis inhibitors L-671,329, L-646,991, tetrahydroechinocandin B, and L-687,781, a papulacandin. Antimicrobial agents and chemotherapy. 1992 Aug; 36(8):1648-57. doi: 10.1128/aac.36.8.1648. [PMID: 1416847]
  • T J Walsh, J W Lee, J Bacher, P Kelly, P A Pizzo. Continuous intravenous infusion and simultaneous pharmacokinetic monitoring in ambulatory rabbits with a programmable micropump and dual subcutaneous Silastic central venous catheters. Laboratory animal science. 1992 Jun; 42(3):286-92. doi: NULL. [PMID: 1320161]
  • R M Bannatyne, P C Cheng, I W Fong. Comparison of the efficacy of cilofungin, fluconazole and amphotericin B in the treatment of systemic Candida albicans infection in the neutropenic mouse. Infection. 1992 May; 20(3):168-70. doi: 10.1007/bf01704614. [PMID: 1644494]
  • J G Sundelof, R Hajdu, W J Cleare, J Onishi, H Kropp. Pharmacokinetics of L-671,329 in rhesus monkeys and DBA/2 mice. Antimicrobial agents and chemotherapy. 1992 Mar; 36(3):607-10. doi: 10.1128/aac.36.3.607. [PMID: 1622170]
  • M S Rouse, B M Tallan, J M Steckelberg, N K Henry, W R Wilson. Efficacy of cilofungin therapy administered by continuous intravenous infusion for experimental disseminated candidiasis in rabbits. Antimicrobial agents and chemotherapy. 1992 Jan; 36(1):56-8. doi: 10.1128/aac.36.1.56. [PMID: 1590700]
  • M D Richardson, L A Smyth, G S Shankland. Stimulation of human neutrophil phagocytosis of Candida albicans by a beta-glucan synthase inhibitor, cilofungin. FEMS microbiology immunology. 1991 Oct; 3(5):299-303. doi: 10.1111/j.1574-6968.1991.tb04226.x. [PMID: 1797051]
  • A M Sugar, L Z Goldani, M Picard. Treatment of murine invasive candidiasis with amphotericin B and cilofungin: evidence for enhanced activity with combination therapy. Antimicrobial agents and chemotherapy. 1991 Oct; 35(10):2128-30. doi: 10.1128/aac.35.10.2128. [PMID: 1759836]
  • T J Walsh, J W Lee, P Kelly, J Bacher, J Lecciones, V Thomas, C Lyman, D Coleman, R Gordee, P A Pizzo. Antifungal effects of the nonlinear pharmacokinetics of cilofungin, a 1,3-beta-glucan synthetase inhibitor, during continuous and intermittent intravenous infusions in treatment of experimental disseminated candidiasis. Antimicrobial agents and chemotherapy. 1991 Jul; 35(7):1321-8. doi: 10.1128/aac.35.7.1321. [PMID: 1929288]
  • D W Denning, D A Stevens. Efficacy of cilofungin alone and in combination with amphotericin B in a murine model of disseminated aspergillosis. Antimicrobial agents and chemotherapy. 1991 Jul; 35(7):1329-33. doi: 10.1128/aac.35.7.1329. [PMID: 1929289]
  • J W Lee, P Kelly, J Lecciones, D Coleman, R Gordee, P A Pizzo, T J Walsh. Cilofungin (LY121019) shows nonlinear plasma pharmacokinetics and tissue penetration in rabbits. Antimicrobial agents and chemotherapy. 1990 Nov; 34(11):2240-5. doi: 10.1128/aac.34.11.2240. [PMID: 2073114]
  • K R Smith, K M Lank, C G Cobbs, G A Cloud, W E Dismukes. Comparison of cilofungin and amphotericin B for therapy of murine candidiasis. Antimicrobial agents and chemotherapy. 1990 Aug; 34(8):1619-21. doi: 10.1128/aac.34.8.1619. [PMID: 2221875]
  • C J Morrison, D A Stevens. Comparative effects of cilofungin and amphotericin B on experimental murine candidiasis. Antimicrobial agents and chemotherapy. 1990 May; 34(5):746-50. doi: 10.1128/aac.34.5.746. [PMID: 2193617]
  • T Meshulam, S M Levitz, R D Diamond, A M Sugar. Effect of cilofungin (LY121019), a fungal cell wall synthesis inhibitor, on interactions of Candida albicans with human neutrophils. The Journal of antimicrobial chemotherapy. 1989 Nov; 24(5):741-5. doi: 10.1093/jac/24.5.741. [PMID: 2689424]
  • J R Perfect, M M Hobbs, K A Wright, D T Durack. Treatment of experimental disseminated candidiasis with cilofungin. Antimicrobial agents and chemotherapy. 1989 Oct; 33(10):1811-2. doi: 10.1128/aac.33.10.1811. [PMID: 2589848]
  • F C Odds. Activity of cilofungin (LY121019) against Candida species in vitro. The Journal of antimicrobial chemotherapy. 1988 Dec; 22(6):891-7. doi: 10.1093/jac/22.6.891. [PMID: 3243737]
  • V Strippoli, F D D'Auria, N Simonetti. A study of the antifungal activity of LY121019, a new echinocandin derivative. Chemioterapia : international journal of the Mediterranean Society of Chemotherapy. 1988 Feb; 7(1):33-7. doi: NULL. [PMID: 3288366]
  • R S Gordee, D J Zeckner, L F Ellis, A L Thakkar, L C Howard. In vitro and in vivo anti-Candida activity and toxicology of LY121019. The Journal of antibiotics. 1984 Sep; 37(9):1054-65. doi: 10.7164/antibiotics.37.1054. [PMID: 6389460]