ICG-001 (BioDeep_00000697932)
代谢物信息卡片
(6S,9aS)-N-benzyl-6-(4-hydroxybenzyl)-8-(naphthalen-1-ylmethyl)-4,7-dioxooctahydro-1H-pyrazino[1,2-a]pyrimidine-1-carboxamide
化学式: C33H32N4O4 (548.2423431999999)
中文名称: (6S,9aS)-六氢-6-[(4-羟基苯基)甲基]-8-(1-萘基甲基)-4,7-二氧代-N-(苯甲基)-2H-吡嗪并[1,2-a]嘧啶-1(6H)-甲酰胺, 2,3-二氢-1,4-苯并恶嗪
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CN(C2CN(C(=O)C(N2C1=O)CC3=CC=C(C=C3)O)CC4=CC=CC5=CC=CC=C54)C(=O)NCC6=CC=CC=C6
InChI: InChI=1S/C33H32N4O4/c38-27-15-13-23(14-16-27)19-29-32(40)35(21-26-11-6-10-25-9-4-5-12-28(25)26)22-30-36(18-17-31(39)37(29)30)33(41)34-20-24-7-2-1-3-8-24/h1-16,29-30,38H,17-22H2,(H,34,41)/t29-,30+/m0/s1
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:95032
- PubChem: 11238147
- ChEMBL: CHEMBL2312139
- CAS: 780757-88-2
- CAS: 847591-62-2
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Guihong Liang, Jinlong Zhao, Jianke Pan, Yuan Yang, Yaoxing Dou, Weiyi Yang, Lingfeng Zeng, Jun Liu. Network pharmacology identifies fisetin as a treatment for osteoporosis that activates the Wnt/β-catenin signaling pathway in BMSCs.
Journal of orthopaedic surgery and research.
2023 Apr; 18(1):312. doi:
10.1186/s13018-023-03761-1. [PMID: 37087476] - Kiminori Kimura, Tatsuya Kanto, Shinji Shimoda, Kenichi Harada, Masamichi Kimura, Koji Nishikawa, Jun Imamura, Eiichi Ogawa, Masanao Saio, Yoshihiro Ikura, Takuji Okusaka, Kazuaki Inoue, Tetsuya Ishikawa, Ichiro Ieiri, Junji Kishimoto, Koji Todaka, Terumi Kamisawa. Safety, tolerability, and anti-fibrotic efficacy of the CBP/β-catenin inhibitor PRI-724 in patients with hepatitis C and B virus-induced liver cirrhosis: An investigator-initiated, open-label, non-randomised, multicentre, phase 1/2a study.
EBioMedicine.
2022 Jun; 80(?):104069. doi:
10.1016/j.ebiom.2022.104069. [PMID: 35605429] - Thanachai Methatham, Shota Tomida, Natsuka Kimura, Yasushi Imai, Kenichi Aizawa. Inhibition of the canonical Wnt signaling pathway by a β-catenin/CBP inhibitor prevents heart failure by ameliorating cardiac hypertrophy and fibrosis.
Scientific reports.
2021 07; 11(1):14886. doi:
10.1038/s41598-021-94169-6. [PMID: 34290289] - Yahong Liu, Qijian Feng, Jinhua Miao, Qinyu Wu, Shan Zhou, Weiwei Shen, Yanqiu Feng, Fan Fan Hou, Youhua Liu, Lili Zhou. C-X-C motif chemokine receptor 4 aggravates renal fibrosis through activating JAK/STAT/GSK3β/β-catenin pathway.
Journal of cellular and molecular medicine.
2020 04; 24(7):3837-3855. doi:
10.1111/jcmm.14973. [PMID: 32119183] - Annika Fendler, Daniel Bauer, Jonas Busch, Klaus Jung, Annika Wulf-Goldenberg, Severine Kunz, Kun Song, Adam Myszczyszyn, Sefer Elezkurtaj, Bettina Erguen, Simone Jung, Wei Chen, Walter Birchmeier. Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients.
Nature communications.
2020 02; 11(1):929. doi:
10.1038/s41467-020-14700-7. [PMID: 32066735] - Padmashree Rao, Min Pang, Xi Qiao, Hong Yu, Hailong Wang, Ying Yang, Xiaojun Ren, Min Hu, Titi Chen, Qi Cao, Yiping Wang, Matloob Khushi, Geoff Zhang, Yuan Min Wang, Chow Heok P'ng, Brian Nankivell, Vincent W Lee, Stephen I Alexander, Guoping Zheng, David C Harris. Promotion of β-catenin/Foxo1 signaling ameliorates renal interstitial fibrosis.
Laboratory investigation; a journal of technical methods and pathology.
2019 11; 99(11):1689-1701. doi:
10.1038/s41374-019-0276-z. [PMID: 31243340] - Liangxiang Xiao, Bo Xu, Lili Zhou, Roderick J Tan, Dong Zhou, Haiyan Fu, Aiqing Li, Fan Fan Hou, Youhua Liu. Wnt/β-catenin regulates blood pressure and kidney injury in rats.
Biochimica et biophysica acta. Molecular basis of disease.
2019 06; 1865(6):1313-1322. doi:
10.1016/j.bbadis.2019.01.027. [PMID: 30710617] - Yue Zhao, Chunhong Wang, Cong Wang, Xue Hong, Jinhua Miao, Yulin Liao, Lili Zhou, Youhua Liu. An essential role for Wnt/β-catenin signaling in mediating hypertensive heart disease.
Scientific reports.
2018 06; 8(1):8996. doi:
10.1038/s41598-018-27064-2. [PMID: 29895976] - Andrew Sulaiman, Sarah McGarry, Li Li, Deyong Jia, Sarah Ooi, Christina Addison, Jim Dimitroulakos, Angel Arnaout, Carolyn Nessim, Zemin Yao, Guang Ji, Haiyan Song, Suresh Gadde, Xuguang Li, Lisheng Wang. Dual inhibition of Wnt and Yes-associated protein signaling retards the growth of triple-negative breast cancer in both mesenchymal and epithelial states.
Molecular oncology.
2018 04; 12(4):423-440. doi:
10.1002/1878-0261.12167. [PMID: 29316250] - Dong Zhou, Haiyan Fu, Liangxiang Xiao, Hongyan Mo, Hui Zhuo, Xiaojun Tian, Lin Lin, Jianhua Xing, Youhua Liu. Fibroblast-Specific β-Catenin Signaling Dictates the Outcome of AKI.
Journal of the American Society of Nephrology : JASN.
2018 04; 29(4):1257-1271. doi:
10.1681/asn.2017080903. [PMID: 29343518] - Xi Qiao, Padmashree Rao, Yun Zhang, Lixin Liu, Min Pang, Hailong Wang, Min Hu, Xinrui Tian, Jianlin Zhang, Ye Zhao, Xin Maggie Wang, Chengshi Wang, Hong Yu, Fei Guo, Qi Cao, Yiping Wang, Yuan Min Wang, Geoff Yu Zhang, Vincent W Lee, Stephen I Alexander, Guoping Zheng, David C H Harris. Redirecting TGF-β Signaling through the β-Catenin/Foxo Complex Prevents Kidney Fibrosis.
Journal of the American Society of Nephrology : JASN.
2018 02; 29(2):557-570. doi:
10.1681/asn.2016121362. [PMID: 29180394] - Yan He, Xiaoming Yuan, Hao Zuo, Ying Sun, Aiwen Feng. Berberine Exerts a Protective Effect on Gut-Vascular Barrier via the Modulation of the Wnt/Beta-Catenin Signaling Pathway During Sepsis.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2018; 49(4):1342-1351. doi:
10.1159/000493412. [PMID: 30205381] - Eva Gravesen, Anders Nordholm, Maria Mace, Marya Morevati, Estrid Høgdall, Carsten Nielsen, Andreas Kjær, Klaus Olgaard, Ewa Lewin. Effect of inhibition of CBP-coactivated β-catenin-mediated Wnt signalling in uremic rats with vascular calcifications.
PloS one.
2018; 13(8):e0201936. doi:
10.1371/journal.pone.0201936. [PMID: 30075015] - Lin Chen, Dan-Qian Chen, Ming Wang, Dan Liu, Hua Chen, Fang Dou, Nosratola D Vaziri, Ying-Yong Zhao. Role of RAS/Wnt/β-catenin axis activation in the pathogenesis of podocyte injury and tubulo-interstitial nephropathy.
Chemico-biological interactions.
2017 Aug; 273(?):56-72. doi:
10.1016/j.cbi.2017.05.025. [PMID: 28578904] - Tim Koopmans, Stijn Crutzen, Mark H Menzen, Andrew J Halayko, Tillie-Louise Hackett, Darryl A Knight, Reinoud Gosens. Selective targeting of CREB-binding protein/β-catenin inhibits growth of and extracellular matrix remodelling by airway smooth muscle.
British journal of pharmacology.
2016 12; 173(23):3327-3341. doi:
10.1111/bph.13620. [PMID: 27629364] - Lili Zhou, Yingjian Li, Sha Hao, Dong Zhou, Roderick J Tan, Jing Nie, Fan Fan Hou, Michael Kahn, Youhua Liu. Multiple genes of the renin-angiotensin system are novel targets of Wnt/β-catenin signaling.
Journal of the American Society of Nephrology : JASN.
2015 Jan; 26(1):107-20. doi:
10.1681/asn.2014010085. [PMID: 25012166] - Sha Hao, Weichun He, Yingjian Li, Hong Ding, Yayi Hou, Jing Nie, Fan Fan Hou, Michael Kahn, Youhua Liu. Targeted inhibition of β-catenin/CBP signaling ameliorates renal interstitial fibrosis.
Journal of the American Society of Nephrology : JASN.
2011 Sep; 22(9):1642-53. doi:
10.1681/asn.2010101079. [PMID: 21816937]