Hexamidine (BioDeep_00000697281)

   


代谢物信息卡片


4-[6-(4-carbamimidoylphenoxy)hexoxy]benzenecarboximidamide

化学式: C20H26N4O2 (354.2056)
中文名称: 己脒定
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=CC=C1C(=N)N)OCCCCCCOC2=CC=C(C=C2)C(=N)N
InChI: InChI=1S/C20H26N4O2/c21-19(22)15-5-9-17(10-6-15)25-13-3-1-2-4-14-26-18-11-7-16(8-12-18)20(23)24/h5-12H,1-4,13-14H2,(H3,21,22)(H3,23,24)

描述信息

D - Dermatologicals > D08 - Antiseptics and disinfectants > D08A - Antiseptics and disinfectants > D08AC - Biguanides and amidines
S - Sensory organs > S03 - Ophthalmological and otological preparations > S03A - Antiinfectives > S03AA - Antiinfectives
R - Respiratory system > R01 - Nasal preparations > R01A - Decongestants and other nasal preparations for topical use
R - Respiratory system > R02 - Throat preparations > R02A - Throat preparations > R02AA - Antiseptics
S - Sensory organs > S01 - Ophthalmologicals > S01A - Antiinfectives
C254 - Anti-Infective Agent > C258 - Antibiotic
D000890 - Anti-Infective Agents

同义名列表

2 个代谢物同义名

4-[6-(4-carbamimidoylphenoxy)hexoxy]benzenecarboximidamide; Hexamidine



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Wei-Yao Zhang, Wen-Chao Lu, Hao Jiang, Zheng-Bing Lv, Yi-Qian Xie, Fu-Lin Lian, Zhong-Jie Liang, Yu-Xi Jiang, Da-Jin Wang, Cheng Luo, Jia Jin, Fei Ye. Discovery of alkyl bis(oxy)dibenzimidamide derivatives as novel protein arginine methyltransferase 1 (PRMT1) inhibitors. Chemical biology & drug design. 2017 Dec; 90(6):1260-1270. doi: 10.1111/cbdd.13047. [PMID: 28636189]
  • N Parisi, P J Matts, R Lever, J Hadgraft, M E Lane. Hexamidine salts - applications in skin health and personal care products. International journal of cosmetic science. 2017 Aug; 39(4):361-365. doi: 10.1111/ics.12392. [PMID: 28129440]
  • S Salvatico, C Feuillolay, Y Mas, F Verrière, C Roques. Bactericidal activity of 3 cutaneous/mucosal antiseptic solutions in the presence of interfering substances: Improvement of the NF EN 13727 European Standard?. Medecine et maladies infectieuses. 2015 Mar; 45(3):89-94. doi: 10.1016/j.medmal.2015.01.006. [PMID: 25779009]
  • R Osborne, T Hakozaki, T Laughlin, D R Finlay. Application of genomics to breakthroughs in the cosmetic treatment of skin ageing and discoloration. The British journal of dermatology. 2012 Jun; 166 Suppl 2(?):16-9. doi: 10.1111/j.1365-2133.2012.10960.x. [PMID: 22670614]
  • Ha Eun Lee, Joo Yeon Ko, Young Hoon Kim, Seo Rye Yoo, Sang Ho Moon, Nack In Kim, Chun Wook Park, Jeong Hwan Kim, Hyun Ju Koh, Won Seok Park, Young Suck Ro. A double-blind randomized controlled comparison of APDDR-0901, a novel cosmeceutical formulation, and 0.1\% adapalene gel in the treatment of mild-to-moderate acne vulgaris. European journal of dermatology : EJD. 2011 Nov; 21(6):959-65. doi: 10.1684/ejd.2011.1546. [PMID: 21982956]
  • NULL. Final report on the safety assessment of Hexamidine and Hexamidine Diisethionate. International journal of toxicology. 2007; 26 Suppl 3(?):79-88. doi: 10.1080/10915810701663168. [PMID: 18273451]
  • D Perrine, J P Chenu, P Georges, J C Lancelot, C Saturnino, M Robba. Amoebicidal efficiencies of various diamidines against two strains of Acanthamoeba polyphaga. Antimicrobial agents and chemotherapy. 1995 Feb; 39(2):339-42. doi: 10.1128/aac.39.2.339. [PMID: 7726493]
  • S A Gromov, V A Gusel', S K Khorshev, D P Smirnov. [Therapeutic and pharmacological monitoring of individual monotherapy of epilepsy with hexamidine]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952). 1991; 91(6):34-8. doi: NULL. [PMID: 1664581]
  • P Maris. [The in vitro activity of veterinary antiseptics]. Annales de recherches veterinaires. Annals of veterinary research. 1990; 21(1):49-55. doi: NULL. [PMID: 2111651]
  • S A Gromov, T N Fedotenkova, E M Stabrovskiĭ. [Hexamidine content of the blood plasma and cerebrospinal fluid in patients with epilepsy]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952). 1988; 88(6):66-9. doi: NULL. [PMID: 3188751]
  • A I Boldarov, M Ia Maĭzelis, M Ia Vaĭntrub, A L Zabludovskiĭ, L E Gvirtsman. [Radioimmunologic study of the plasma concentrations of folic acid and various antiepileptic preparations during the treatment of epileptic patients]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952). 1983; 83(6):845-8. doi: NULL. [PMID: 6880514]