A-769662 (BioDeep_00000696460)
代谢物信息卡片
4-Hydroxy-3-(2-hydroxy-[1,1-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile
化学式: C20H12N2O3S (360.0568602000001)
中文名称: 4-羟基-3-(2-羟基-1,1-联苯-4-基)-6-氧代-6,7-二氢噻吩并[2,3-B]吡啶-5-甲腈
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C(=C1)C2=CC=C(C=C2)C3=CSC4=C3C(=C(C(=O)N4)C#N)O)O
InChI: InChI=1S/C20H12N2O3S/c21-9-14-18(24)17-15(10-26-20(17)22-19(14)25)12-7-5-11(6-8-12)13-3-1-2-4-16(13)23/h1-8,10,23H,(H2,22,24,25)
描述信息
A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM.
同义名列表
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:91429
- PubChem: 54708532
- ChEMBL: CHEMBL512504
- CAS: 844499-71-4
- medchemexpress: HY-50662
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yuxiang Hu, Jiaqi Bai, Yongqing Xia, Yan Lin, Li Ma, Xuemei Xu, Yanfeng Ding, Lin Chen. Increasing SnRK1 activity with the AMPK activator A-769662 accelerates seed germination in rice.
Plant physiology and biochemistry : PPB.
2022 Aug; 185(?):155-166. doi:
10.1016/j.plaphy.2022.06.005. [PMID: 35696890] - F Anthony Romero, Christopher T Jones, Yingzi Xu, Martijn Fenaux, Randall L Halcomb. The Race to Bash NASH: Emerging Targets and Drug Development in a Complex Liver Disease.
Journal of medicinal chemistry.
2020 05; 63(10):5031-5073. doi:
10.1021/acs.jmedchem.9b01701. [PMID: 31930920] - Wei Yang, Adam C Munhall, Steven W Johnson. Dopamine Evokes a Trace Amine Receptor-dependent Inward Current that is Regulated by AMP Kinase in Substantia Nigra Dopamine Neurons.
Neuroscience.
2020 02; 427(?):77-91. doi:
10.1016/j.neuroscience.2019.11.044. [PMID: 31883822] - J Huang, M-A Guesthier, S A Burgos. AMP-activated protein kinase controls lipid and lactose synthesis in bovine mammary epithelial cells.
Journal of dairy science.
2020 Jan; 103(1):340-351. doi:
10.3168/jds.2019-16343. [PMID: 31733862] - Luping Yang, Yijing Jiang, Lihong Shi, Dongling Zhong, Yuxi Li, Juan Li, Rongjiang Jin. AMPK: Potential Therapeutic Target for Alzheimer's Disease.
Current protein & peptide science.
2020; 21(1):66-77. doi:
10.2174/1389203720666190819142746. [PMID: 31424367] - Hesham Shamshoum, Kyle D Medak, Logan K Townsend, Kristen E Ashworth, Natasha D Bush, Margaret K Halm, Bruce E Kemp, David C Wright. AMPK β1 activation suppresses antipsychotic-induced hyperglycemia in mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2019 12; 33(12):14010-14021. doi:
10.1096/fj.201901820r. [PMID: 31581839] - Laura Kitzmiller, John R Ledford, Paul W Hake, Michael O'Connor, Giovanna Piraino, Basilia Zingarelli. Activation of AMP-Activated Protein Kinase by A769662 Ameliorates Sepsis-Induced Acute Lung Injury in Adult Mice.
Shock (Augusta, Ga.).
2019 11; 52(5):540-549. doi:
10.1097/shk.0000000000001303. [PMID: 30562237] - Denis A Babkov, Olga N Zhukowskaya, Alexander V Borisov, Valentina A Babkova, Elena V Sokolova, Anastasia A Brigadirova, Roman A Litvinov, Alexandra A Kolodina, Anatolii S Morkovnik, Vadim S Sochnev, Gennady S Borodkin, Alexander A Spasov. Towards multi-target antidiabetic agents: Discovery of biphenyl-benzimidazole conjugates as AMPK activators.
Bioorganic & medicinal chemistry letters.
2019 09; 29(17):2443-2447. doi:
10.1016/j.bmcl.2019.07.035. [PMID: 31358465] - Wilfred Lieberthal, Meiyi Tang, Mersema Abate, Mark Lusco, Jerrold S Levine. AMPK-mediated activation of Akt protects renal tubular cells from stress-induced apoptosis in vitro and ameliorates ischemic AKI in vivo.
American journal of physiology. Renal physiology.
2019 07; 317(7):F1-F11. doi:
10.1152/ajprenal.00553.2018. [PMID: 30995114] - Hannah E Steele, Yunxia Guo, Bai-Yan Li, Sungsoo Na. Mechanotransduction of mitochondrial AMPK and its distinct role in flow-induced breast cancer cell migration.
Biochemical and biophysical research communications.
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Kidney international.
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Current medicinal chemistry.
2019; 26(27):5207-5229. doi:
10.2174/0929867325666180406120051. [PMID: 29623826] - Nadia Boudaba, Allison Marion, Camille Huet, Rémi Pierre, Benoit Viollet, Marc Foretz. AMPK Re-Activation Suppresses Hepatic Steatosis but its Downregulation Does Not Promote Fatty Liver Development.
EBioMedicine.
2018 Feb; 28(?):194-209. doi:
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Andrology.
2017 Nov; 5(6):1131-1140. doi:
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Cell death & disease.
2017 03; 8(3):e2637. doi:
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Atherosclerosis.
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Molecular and cellular endocrinology.
2017 01; 440(?):57-68. doi:
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American journal of physiology. Renal physiology.
2016 10; 311(4):F731-F739. doi:
10.1152/ajprenal.00541.2015. [PMID: 27252492] - Maryam Rameshrad, Hamid Soraya, Nasrin Maleki-Dizaji, Haleh Vaez, Alireza Garjani. A-769662, a direct AMPK activator, attenuates lipopolysaccharide-induced acute heart and lung inflammation in rats.
Molecular medicine reports.
2016 Mar; 13(3):2843-9. doi:
10.3892/mmr.2016.4821. [PMID: 26820069] - Jung Hwan Hwang, Yong-Hoon Kim, Jung-Ran Noh, Dong-Hee Choi, Kyoung-Shim Kim, Chul-Ho Lee. Enhanced Production of Adenosine Triphosphate by Pharmacological Activation of Adenosine Monophosphate-Activated Protein Kinase Ameliorates Acetaminophen-Induced Liver Injury.
Molecules and cells.
2015 Oct; 38(10):843-50. doi:
10.14348/molcells.2015.0072. [PMID: 26434492] - A Hurtado de Llera, D Martin-Hidalgo, M C Gil, L J Garcia-Marin, M J Bragado. AMPK up-activation reduces motility and regulates other functions of boar spermatozoa.
Molecular human reproduction.
2015 Jan; 21(1):31-45. doi:
10.1093/molehr/gau091. [PMID: 25281642] - Eden Ross, Rehman Ata, Thanusi Thavarajah, Sergei Medvedev, Peter Bowden, John G Marshall, Costin N Antonescu. AMP-Activated Protein Kinase Regulates the Cell Surface Proteome and Integrin Membrane Traffic.
PloS one.
2015; 10(5):e0128013. doi:
10.1371/journal.pone.0128013. [PMID: 26010094] - Monica Guma, Yun Wang, Benoit Viollet, Ru Liu-Bryan. AMPK Activation by A-769662 Controls IL-6 Expression in Inflammatory Arthritis.
PloS one.
2015; 10(10):e0140452. doi:
10.1371/journal.pone.0140452. [PMID: 26474486] - Yanqi Dang, Shuang Ling, Ju Duan, Jing Ma, Rongzhen Ni, Jin-Wen Xu. Bavachalcone-induced manganese superoxide dismutase expression through the AMP-activated protein kinase pathway in human endothelial cells.
Pharmacology.
2015; 95(3-4):105-10. doi:
10.1159/000375452. [PMID: 25766656] - Marina Kemmerer, Florian Finkernagel, Marcela Frota Cavalcante, Dulcineia Saes Parra Abdalla, Rolf Müller, Bernhard Brüne, Dmitry Namgaladze. AMP-Activated Protein Kinase Interacts with the Peroxisome Proliferator-Activated Receptor Delta to Induce Genes Affecting Fatty Acid Oxidation in Human Macrophages.
PloS one.
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American journal of physiology. Heart and circulatory physiology.
2014 Oct; 307(8):H1120-33. doi:
10.1152/ajpheart.00210.2014. [PMID: 25128166] - Scott A Fraser, Matthew Davies, Marina Katerelos, Kurt Gleich, Suet-Wan Choy, Rohan Steel, Sandra Galic, Peter F Mount, Bruce E Kemp, David A Power. Activation of AMPK reduces the co-transporter activity of NKCC1.
Molecular membrane biology.
2014 Mar; 31(2-3):95-102. doi:
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Toxicology and applied pharmacology.
2013 Dec; 273(2):325-34. doi:
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Diabetologia.
2013 Jun; 56(6):1372-82. doi:
10.1007/s00125-013-2867-3. [PMID: 23460021] - Li-Fang Yu, Yuan-Yuan Li, Ming-Bo Su, Mei Zhang, Wei Zhang, Li-Na Zhang, Tao Pang, Run-Tao Zhang, Bing Liu, Jing-Ya Li, Jia Li, Fa-Jun Nan. Development of Novel Alkene Oxindole Derivatives As Orally Efficacious AMP-Activated Protein Kinase Activators.
ACS medicinal chemistry letters.
2013 May; 4(5):475-80. doi:
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The Journal of cell biology.
2012 Dec; 199(7):1117-30. doi:
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The Journal of biological chemistry.
2012 Jul; 287(28):23451-63. doi:
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Science (New York, N.Y.).
2012 May; 336(6083):918-22. doi:
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Biochemical and biophysical research communications.
2010 Jun; 396(3):656-61. doi:
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American journal of physiology. Cell physiology.
2009 Dec; 297(6):C1554-66. doi:
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Biological & pharmaceutical bulletin.
2009 Jun; 32(6):993-8. doi:
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