Latamoxef Sodium (BioDeep_00000696429)

   


代谢物信息卡片


Moxalactam disodium

化学式: C20H18N6Na2O9S (564.0651338)
中文名称: 拉氧头孢 钠盐
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN1C(=NN=N1)SCC2=C(N3C(C(C3=O)(NC(=O)C(C4=CC=C(C=C4)O)C(=O)[O-])OC)OC2)C(=O)[O-].[Na+].[Na+]
InChI: /q

描述信息

D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic

同义名列表

2 个代谢物同义名

Moxalactam disodium; Latamoxef Sodium



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Hui Qi, Chen Kou, Yu-Jie Qi, Bo-Hao Tang, Yue-E Wu, Fei Jin, Xiao-Jing Luo, Yan-Hua Shen, Ya-Jie Guo, Xue Qi, Ya-Cui Wang, Qian Dong, Xing-Kai Chen, Hai-Yan Shi, Yi Zheng, Wei Zhao, A-Dong Shen. Population pharmacokinetics and dosing optimization of latamoxef in neonates and young infants. International journal of antimicrobial agents. 2019 Mar; 53(3):347-351. doi: 10.1016/j.ijantimicag.2018.11.017. [PMID: 30472290]
  • Qian Dong, Hai-Yan Shi, Chen Kou, Xin Huang, A-Dong Shen, Wei Zhao. A microscale HPLC-UV method for the determination of latamoxef in plasma: An adapted method for therapeutic drug monitoring in neonates. Biomedical chromatography : BMC. 2018 Aug; 32(8):e4243. doi: 10.1002/bmc.4243. [PMID: 29573350]
  • Aurijit Sarkar, Kelcey C Anderson, Glen E Kellogg. Computational analysis of structure-based interactions and ligand properties can predict efflux effects on antibiotics. European journal of medicinal chemistry. 2012 Jun; 52(?):98-110. doi: 10.1016/j.ejmech.2012.03.008. [PMID: 22483632]
  • Gönül Özel, Volkan Aslan, Gül Bahar Erdem, Mustafa Çağatay, Irfan Sencan, Ali Mert. [Comparison of oxacillin, cefoxitin, ceftizoxime, and moxalactam disk diffusion methods for detection of methicillin susceptibility in staphylococci]. Mikrobiyoloji bulteni. 2011 Apr; 45(2):258-65. doi: . [PMID: 21644068]
  • Markus Fridén, Helena Ljungqvist, Brian Middleton, Ulf Bredberg, Margareta Hammarlund-Udenaes. Improved measurement of drug exposure in the brain using drug-specific correction for residual blood. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2010 Jan; 30(1):150-61. doi: 10.1038/jcbfm.2009.200. [PMID: 19756019]
  • S Carroll, M Hargreaves, A Goonetilleke. Sourcing faecal pollution from onsite wastewater treatment systems in surface waters using antibiotic resistance analysis. Journal of applied microbiology. 2005; 99(3):471-82. doi: 10.1111/j.1365-2672.2005.02644.x. [PMID: 16108788]
  • Hai Ying Gu. Trace determination of shiomarin using a hanging copper/amalgam drop electrode. Journal of pharmaceutical and biomedical analysis. 2002 Jun; 29(1-2):341-6. doi: 10.1016/s0731-7085(02)00062-6. [PMID: 12062695]
  • T Yoshikawa, T Oguma, T Ichihashi, H Kinoshita, K Hirano, H Yamada. Epimerization of moxalactam by albumin and simulation of in vivo epimerization by a physiologically based pharmacokinetic model. Chirality. 1999; 11(4):309-15. doi: 10.1002/(sici)1520-636x(1999)11:4<309::aid-chir8>3.0.co;2-g. [PMID: 10224658]
  • Y Jung, K Chay, D Song, S Yang, M Lee, B Ahn. Protein carbonyl formation in blood plasma by cephalosporins. Archives of biochemistry and biophysics. 1997 Sep; 345(2):311-7. doi: 10.1006/abbi.1997.0268. [PMID: 9308904]
  • H Y Gu, D M Sun, A M Yu, H Y Chen. [Polarographic behavior of latamoxef sodium and its trace determination]. Yao xue xue bao = Acta pharmaceutica Sinica. 1997 May; 32(5):373-6. doi: NULL. [PMID: 11498875]
  • S Hashimoto, H Igimi, K Uchida, T Satoh, Y Benno, N Takeuchi. Effects of beta-lactam antibiotics on intestinal microflora and bile acid metabolism in rats. Lipids. 1996 Jun; 31(6):601-9. doi: 10.1007/bf02523830. [PMID: 8784740]
  • W J Christ, O Asano, A L Robidoux, M Perez, Y Wang, G R Dubuc, W E Gavin, L D Hawkins, P D McGuinness, M A Mullarkey. E5531, a pure endotoxin antagonist of high potency. Science (New York, N.Y.). 1995 Apr; 268(5207):80-3. doi: 10.1126/science.7701344. [PMID: 7701344]
  • F Itoh, K Sato, T Harauchi, M Hirata, Y Mizushima. [Modification of vancomycin nephrotoxicity by other antibiotics in rats]. The Japanese journal of antibiotics. 1995 Mar; 48(3):380-8. doi: . [PMID: 7752451]
  • M Itoh, N Katoh, Y Ono, S Ohshima, K Miyake. Sequential changes in the prostatic fluid level of latamoxef in patients with acute bacterial prostatitis. Urologia internationalis. 1995; 55(2):101-4. doi: 10.1159/000282760. [PMID: 8533190]
  • M Yamamoto, M Jimbo, M Ide, N Tanaka, Y Umebara, S Hagiwara. Penetration of intravenous antibiotics into brain abscesses. Neurosurgery. 1993 Jul; 33(1):44-9. doi: 10.1227/00006123-199307000-00007. [PMID: 8102792]
  • K Tsukada, H Katoh, M Shiojima, S Takenoshita, Y Nagamachi. Mortality rate and bacteremia, endotoxin, and endothelin-1 levels in antibiotic therapy for E. coli septic peritonitis. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 1993 Feb; 101(2):97-100. doi: 10.1111/j.1699-0463.1993.tb00087.x. [PMID: 8489768]
  • T Hirano, T Manabe, K Imanishi, T Tobe. Protective effect of a cephalosporin, Shiomarin, plus a new potent protease inhibitor, E3123, on rat taurocholate-induced pancreatitis. Journal of gastroenterology and hepatology. 1993 Jan; 8(1):52-9. doi: 10.1111/j.1440-1746.1993.tb01175.x. [PMID: 8439663]
  • M Kuroyama, K Kumano, F Tomonaga, T Sakai, S Mashimo. [Protein binding of various cephems in healthy subjects and patients with chronic renal failure]. Nihon Jinzo Gakkai shi. 1991 Aug; 33(8):769-77. doi: . [PMID: 1770637]
  • W Nagata, M Narisada, M Yoshioka, T Yoshida, H Onoue. [Studies on oxacephems, an artificial type of beta-lactam antibiotics]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 1991 Feb; 111(2):77-102. doi: 10.1248/yakushi1947.111.2_77. [PMID: 2056448]
  • Y Suzuki, S Itoh, M Katoh, M Morita, Y Fukushi, S Toyota, S Katoh, K Oikawa, S Orikasa, K Majima. [Clinical study concerning of latamoxef concentration in the obstructed urinary tract]. Hinyokika kiyo. Acta urologica Japonica. 1990 Aug; 36(8):897-902. doi: NULL. [PMID: 2173381]
  • R Kojima, M Ito, Y Suzuki. Studies on the nephrotoxicity of aminoglycoside antibiotics and protection from these effects (6): A mechanism for the suppressive action of latamoxef on intrarenal tobramycin level. Japanese journal of pharmacology. 1990 May; 53(1):111-20. doi: 10.1254/jjp.53.111. [PMID: 2352376]
  • N Hashimoto, T Ichihashi, K Hirano, H Yamada. Epimerization kinetics of moxalactam in frozen urine and plasma samples. Pharmaceutical research. 1990 Apr; 7(4):364-9. doi: 10.1023/a:1015815321570. [PMID: 2362909]
  • J Z Montgomerie, D S Gilmore, H N Canawati, J W Morrow. Ceftazidime in treatment of urinary tract infection in patients with spinal cord injury: comparison with moxalactam. Urology. 1990 Jan; 35(1):93-5. doi: 10.1016/0090-4295(90)80024-h. [PMID: 2404368]
  • R Kojima, M Ito, Y Suzuki. Studies on the nephrotoxicity of aminoglycoside antibiotics and protection from these effects (7): Effect of latamoxef on binding of tobramycin to brush border membranes isolated from rat kidney cortex. Japanese journal of pharmacology. 1989 Dec; 51(4):465-73. doi: 10.1254/jjp.51.465. [PMID: 2615039]
  • H Schäfer, K Naber, D Adam. [Hemostasis disturbance caused by cephalosporins with an N-methylthiotetrazole side chain. A randomized pilot study]. Arzneimittel-Forschung. 1989 Sep; 39(9):1156-62. doi: . [PMID: 2590268]
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  • K Uchida, T Matsubara, K Hirauchi. Studies on oxacephem antibiotics: comparison of the effects of 1-oxa and 1-thia cephalosporins on blood coagulation activities and vitamin K metabolism in rats. Japanese journal of pharmacology. 1989 Jul; 50(3):283-8. doi: 10.1254/jjp.50.283. [PMID: 2761130]
  • P Chastagner, O Hartmann, C Tancrede, C Kalifa, C Patte, F Flamant, J Lemerle. Role of parenteral antibiotherapy in gastrointestinal tract flora suppression. A study in children treated with high-dose chemotherapy and autologous bone marrow transplantation. Bone marrow transplantation. 1989 Jul; 4(4):393-8. doi: NULL. [PMID: 2673459]
  • L S Welage, L G Hejmanowski, J H Wilton, C Walawander, D Rigan, J S Williams, J J Schentag. Comparison of N-methylthiotetrazole dispositions in healthy volunteers following single intravenous doses of moxalactam, cefoperazone, and cefotetan. Antimicrobial agents and chemotherapy. 1989 Jun; 33(6):857-61. doi: 10.1128/aac.33.6.857. [PMID: 2764537]
  • S Soback. Pharmacokinetics of single-dose administration of moxalactam in unweaned calves. American journal of veterinary research. 1989 Apr; 50(4):498-501. doi: NULL. [PMID: 2653122]
  • M Mizunaga, Y Ishikawa, K Ohashi, Y C Park, T Akiyama, T Kurita. [A case of ureteral and vesical malacoplakia]. Hinyokika kiyo. Acta urologica Japonica. 1989 Mar; 35(3):501-4. doi: NULL. [PMID: 2567569]
  • T Chimura, T Hirayama, T Ogawa, Y Shiina. [Effects of prophylactically used latamoxef with tobramycin against postoperative infections on therapeutic drug monitoring and renal function in the field of obstetrics and gynecology]. The Japanese journal of antibiotics. 1989 Jan; 42(1):189-92. doi: . [PMID: 2709617]
  • T Kitaura, S Tsukiai, S Arai, K Miyake, M Kimura, H Fukuchi. Ocular pharmacokinetics of latamoxef and cefaclor in humans. Penetration into aqueous humor. Journal of pharmacobio-dynamics. 1989 Jan; 12(1):60-6. doi: 10.1248/bpb1978.12.60. [PMID: 2724050]
  • T Kitaura, S Tsukiai, S Arai, K Miyake, M Kimura, H Fukuchi. Ocular pharmacokinetics of latamoxef and cefaclor in rabbits. Penetration into aqueous humor. Journal of pharmacobio-dynamics. 1988 Oct; 11(10):694-9. doi: 10.1248/bpb1978.11.694. [PMID: 3221302]
  • M Matsuura, S Satoh, F Kobayashi, T Matsubara, K Uchida. Vitamin K reversible hypoprothrombinemia in rats. II. Efficacy of vitamin K on latamoxef-induced coagulopathy in rats. Japanese journal of pharmacology. 1988 Aug; 47(4):357-65. doi: 10.1254/jjp.47.357. [PMID: 3184567]
  • L C Knodel, B R Goldspiel, R S Gibbs. Prospective cost analysis of moxalactam versus clindamycin plus gentamicin for endomyometritis after cesarean section. Antimicrobial agents and chemotherapy. 1988 Jun; 32(6):853-7. doi: 10.1128/aac.32.6.853. [PMID: 3415207]
  • Y Nishitani, T Aoki, T Yoshida, W Nagata. cis-Halovinylthioacetamido side chain, a new effective structural element for 7 beta-substitution in cephem and oxacephem antibiotics. I. 7 beta-cis-Chlorovinylthioacetamino-7 alpha-methoxy-1-oxacephems. The Journal of antibiotics. 1988 Mar; 41(3):316-31. doi: 10.7164/antibiotics.41.316. [PMID: 3366690]
  • J J Lefrère, M Leclercq, M Guillaumont, D Gozin, J Lerable. [Development of plasma levels of decarboxyprothrombin and vitamin K during treatment with moxalactam]. La Revue de medecine interne. 1988 Mar; 9(2):223-5. doi: 10.1016/s0248-8663(88)80127-9. [PMID: 3420334]
  • G D Morse, M A Apicella, J J Walshe. Absorption of intraperitoneal antibiotics. Drug intelligence & clinical pharmacy. 1988 Jan; 22(1):58-61. doi: 10.1177/106002808802200114. [PMID: 3349922]
  • H Goi, T Watanabe, T Hara, T Ishii, Y Kazuno, S Inouye. [Antibacterial activity of cefminox in human urine]. The Japanese journal of antibiotics. 1988 Jan; 41(1):25-36. doi: NULL. [PMID: 3367512]
  • R Kojima, M Ito, Y Suzuki. Studies on the nephrotoxicity of aminoglycoside antibiotics and protection from these effects. (5). Interaction of tobramycin with latamoxef in vitro. Journal of pharmacobio-dynamics. 1988 Jan; 11(1):9-17. doi: 10.1248/bpb1978.11.9. [PMID: 3385606]
  • T Matsubara, S Otsubo, A Ogawa, K Kawamoto, J Okamoto, K Sugeno, Y Tochino, T Yoshida, E Hirai. Effects of beta-lactam antibiotics and N-methyltetrazolethiol on the alcohol-metabolizing system in rats. Japanese journal of pharmacology. 1987 Nov; 45(3):303-15. doi: 10.1254/jjp.45.303. [PMID: 2893854]
  • G Petrikkos, M Androulakis, P Goumas, H Giamarellou. A comparative study of cefoxitin, cefotaxime, moxalactam and aztreonam kinetics in saliva. Chemioterapia : international journal of the Mediterranean Society of Chemotherapy. 1987 Oct; 6(5):355-8. doi: . [PMID: 3427696]
  • E J Bow, T J Louie. Changes in endogenous microflora among febrile granulocytopenic patients receiving empiric antibiotic therapy: implications for fungal superinfection. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. 1987 Sep; 137(5):397-403. doi: NULL. [PMID: 3304600]
  • A G Haslberger, U Ganzinger, H Reiter, H Schiel, A Millendorfer. Alterations of pharmacokinetic properties of gentamicin, penicillin G and two cephalosporins in septicaemic rabbits. The Journal of antimicrobial chemotherapy. 1987 Aug; 20(2):273-82. doi: 10.1093/jac/20.2.273. [PMID: 3667483]
  • J M Kellum, R J Duma, S L Gorbach, H J Sugerman, B W Haynes, A Gervin, H H Newsome. Single-dose antibiotic prophylaxis for biliary surgery. Cefazolin vs moxalactam. Archives of surgery (Chicago, Ill. : 1960). 1987 Aug; 122(8):918-22. doi: 10.1001/archsurg.1987.01400200068012. [PMID: 3115228]
  • K Mizojiri, R Norikura, A Takashima, H Tanaka, T Yoshimori, K Inazawa, T Yukawa, H Okabe, K Sugeno. Disposition of moxalactam and N-methyltetrazolethiol in rats and monkeys. Antimicrobial agents and chemotherapy. 1987 Aug; 31(8):1169-76. doi: 10.1128/aac.31.8.1169. [PMID: 3631941]
  • S Asari, M Horikawa, H Tsukamoto, K Kouda, C Hayashi, K Miyai. [Susceptibility of clinical isolates to aztreonam]. The Japanese journal of antibiotics. 1987 Jul; 40(7):1317-31. doi: . [PMID: 3479624]
  • H Nakahata, Y Hirai, Y Kumasaka, T Miyazawa, T Nakamura, K Imamura, I Makino, K Takebe, H Kudo. [Free methyltetrazolethiol concentrations in men subjected to intravenous administration of cephems with methyltetrazolethiol]. The Japanese journal of antibiotics. 1987 Jul; 40(7):1294-8. doi: NULL. [PMID: 3479623]
  • T Chimura, S Sato, T Suzuki, K Ito, Y Sumiyoshi, H Kanasugi, M Nakakuki, Y Abe, M Banzai. [Prophylactic effects of a combined use of a cephem antibiotic, latamoxef, and tobramycin on postoperative infection in obstetrics and gynecology]. The Japanese journal of antibiotics. 1987 Jul; 40(7):1253-8. doi: . [PMID: 3682180]
  • K Shindo, N Oikawa, S Chida, T Tsuburaya, M Sato. [Pharmacokinetic and clinical studies on latamoxef in the field of obstetrics and gynecology]. The Japanese journal of antibiotics. 1987 Jul; 40(7):1243-52. doi: NULL. [PMID: 3682179]
  • J Godard, M E Reverdy, P Mahul, D Perrot, G Fond, J Motin. [Erythromycin and latamoxef in the initial treatment of diffuse peritonitis with visceral failure]. Pathologie-biologie. 1987 Jun; 35(5 Pt 2):861-4. doi: . [PMID: 3309830]
  • R R Salem, A McIndoe, J A Matkin, A C Lidou, A Clarke, C B Wood. The hematologic effects of latamoxef sodium when used as a prophylaxis during surgical treatment. Surgery, gynecology & obstetrics. 1987 Jun; 164(6):525-9. doi: . [PMID: 3296254]
  • S Murakami, S Shiraishi, S Miyauchi, Y Miki. False-positive Thormählen test induced by latamoxef sodium. The Journal of dermatology. 1987 Jun; 14(3):237-40. doi: 10.1111/j.1346-8138.1987.tb03567.x. [PMID: 3312342]
  • E G Rhodes, R I Harris, R S Welch, D J Perry, R M Brown, B J Boughton. Empirical treatment of febrile, neutropenic patients with tobramycin and latamoxef. The Journal of hospital infection. 1987 May; 9(3):278-84. doi: 10.1016/0195-6701(87)90125-3. [PMID: 2886533]
  • U Ganzinger, F Schatz, H Haberl, A Haslberger, H Schiel, G Hitzenberger. Comparative pharmacokinetic analysis of latamoxef and CPW 86-363, a novel carboxy-pyrazol-cephalosporin and formation of N-methyl-thiotetrazole. International journal of clinical pharmacology, therapy, and toxicology. 1987 Mar; 25(3):152-6. doi: NULL. [PMID: 3557743]
  • Y Nakata, M Mizunaga, M Morikawa, H Osanai, M Fujisawa, F Inada, S Yachiku. [Study of levels of latamoxef in prostatic tissue and bladder mucosal tissue]. Hinyokika kiyo. Acta urologica Japonica. 1987 Feb; 33(2):289-93. doi: NULL. [PMID: 2438917]
  • P Van der Auwera, Y Van Laethem, N Defresne, M Husson, J Klastersky. Comparative serum bactericidal activity against test anaerobes in volunteers receiving imipenem, clindamycin, latamoxef and metronidazole. The Journal of antimicrobial chemotherapy. 1987 Feb; 19(2):205-10. doi: 10.1093/jac/19.2.205. [PMID: 3471750]
  • A Gabryelewicz, J Prokopowicz, N Wołosowicz, A Czajkowski, M Dabrowska. Changes in some hemostatic parameters in patients with infections treated with ceftazidime and latamoxef. Folia haematologica (Leipzig, Germany : 1928). 1987; 114(3):398-407. doi: . [PMID: 2444514]
  • J Prokopowicz, M Dabrowska, J Wysocka, N Wołosowicz, A Gabryelewicz. Does ceftazidime or latamoxef affect the phagocytic capabilities of human granulocytes?. Folia haematologica (Leipzig, Germany : 1928). 1987; 114(3):390-7. doi: . [PMID: 2444513]
  • K Uchida, M Nakamura, M Konishi, T Ishigami, T Komeno. Effect of latamoxef on platelet function and prothrombin time in partially nephrectomized rats. Japanese journal of pharmacology. 1987 Jan; 43(1):9-16. doi: 10.1254/jjp.43.9. [PMID: 3573419]
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  • J R Sharman, A Howarth. Modified method for the determination of moxalactam in plasma by high-performance liquid chromatography. Journal of chromatography. 1986 Sep; 381(2):447-52. doi: 10.1016/s0378-4347(00)83613-0. [PMID: 3760101]
  • J L Axelrod, R M Klein, R L Bergen, M Z Sheikh. Human vitreous levels of cefamandole and moxalactam. American journal of ophthalmology. 1986 Jun; 101(6):684-7. doi: 10.1016/0002-9394(86)90769-5. [PMID: 3717251]
  • M G Bergeron, P Simard. Influence of three modes of administration on the penetration of latamoxef into interstitial fluid and fibrin clots and its in-vivo activity against Haemophilus influenzae. The Journal of antimicrobial chemotherapy. 1986 Jun; 17(6):775-84. doi: 10.1093/jac/17.6.775. [PMID: 3488309]
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  • D Charles, B Larsen. Pharmacokinetics of cefotaxime, moxalactam, and cefoperazone in the early puerperium. Antimicrobial agents and chemotherapy. 1986 May; 29(5):873-6. doi: 10.1128/aac.29.5.873. [PMID: 3729345]
  • Y Matsuura, M Tamura, H Yamashina, M Higo, T Fujii, M Yamamoto, H Shimamoto, H Yamada, T Oguma, K Shimamura. [The prophylactic effects of latamoxef against the postoperative infections to open heart surgery. Studies on the penetration of latamoxef into the pericardial fluid and the auricle of heart]. The Japanese journal of antibiotics. 1986 May; 39(5):1241-9. doi: NULL. [PMID: 3761554]
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