Fiacitabine (BioDeep_00000695747)
代谢物信息卡片
化学式: C9H11FIN3O4 (370.97783280000004)
中文名称: 非西他滨
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=C(C(=NC(=O)N1C2C(C(C(O2)CO)O)F)N)I
InChI: InChI=1S/C9H11FIN3O4/c10-5-6(16)4(2-15)18-8(5)14-1-3(11)7(12)13-9(14)17/h1,4-6,8,15-16H,2H2,(H2,12,13,17)/t4-,5+,6-,8-/m1/s1
描述信息
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
C471 - Enzyme Inhibitor > C29575 - DNA Polymerase Inhibitor
C254 - Anti-Infective Agent > C281 - Antiviral Agent
D000970 - Antineoplastic Agents
同义名列表
1 个代谢物同义名
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Donald F Smee, Robert W Sidwell. Anti-cowpox virus activities of certain adenosine analogs, arabinofuranosyl nucleosides, and 2'-fluoro-arabinofuranosyl nucleosides.
Nucleosides, nucleotides & nucleic acids.
2004; 23(1-2):375-83. doi:
10.1081/ncn-120028334. [PMID: 15043161] - B E Korba, J L Gerin. Use of a standardized cell culture assay to assess activities of nucleoside analogs against hepatitis B virus replication.
Antiviral research.
1992 Jul; 19(1):55-70. doi:
10.1016/0166-3542(92)90056-b. [PMID: 1444322] - I Fourel, J Li, O Hantz, C Jacquet, J J Fox, C Trépo. Effects of 2'-fluorinated arabinosyl-pyrimidine nucleosides on duck hepatitis B virus DNA level in serum and liver of chronically infected ducks.
Journal of medical virology.
1992 Jun; 37(2):122-6. doi:
10.1002/jmv.1890370209. [PMID: 1629711] - I Fourel, O Hantz, K A Watanabe, C Jacquet, B Chomel, J J Fox, C Trepo. Inhibitory effects of 2'-fluorinated arabinosyl-pyrimidine nucleosides on woodchuck hepatitis virus replication in chronically infected woodchucks.
Antimicrobial agents and chemotherapy.
1990 Mar; 34(3):473-5. doi:
10.1128/aac.34.3.473. [PMID: 2334160] - B Leyland-Jones, H Donnelly, S Groshen, P Myskowski, A L Donner, M Fanucchi, J Fox. 2'-Fluoro-5-iodoarabinosylcytosine, a new potent antiviral agent: efficacy in immunosuppressed individuals with herpes zoster.
The Journal of infectious diseases.
1986 Sep; 154(3):430-6. doi:
10.1093/infdis/154.3.430. [PMID: 3525694] - D F Smee, N L Campbell, T R Matthews. Comparative anti-herpesvirus activities of 9-(1,3-dihydroxy-2-propoxymethyl)guanine, acyclovir, and two 2'-fluoropyrimidine nucleosides.
Antiviral research.
1985 Oct; 5(5):259-67. doi:
10.1016/0166-3542(85)90040-3. [PMID: 2998275] - A Feinberg, B Leyland-Jones, M P Fanucchi, C Hancock, J J Fox, K A Watanabe, P M Vidal, L Williams, C W Young, F S Philips. Biotransformation and elimination of [2-14C]-1-(2-deoxy-2'-fluoro-beta-D -arabinofuranosyl)-5-iodocytosine in immunosuppressed patients with herpesvirus infections.
Antimicrobial agents and chemotherapy.
1985 May; 27(5):733-8. doi:
10.1128/aac.27.5.733. [PMID: 2990323] - T C Chou, C Lopez, J M Colacino, A Feinberg, K A Watanabe, J J Fox, F S Philips. Metabolic competition studies of 2'-fluoro-5-iodo-1-beta-d-arabinofuranosylcytosine in vero cells and herpes simplex type 1-infected vero cells.
Molecular pharmacology.
1984 Nov; 26(3):587-93. doi:
NULL. [PMID: 6092904] - K A Schat, R F Schinazi, B W Calnek. Cell-specific antiviral activity of 1-(2-fluoro-2-deoxy-beta-D-arabinofuranosyl)-5-iodocytosine (FIAC) against Marek's disease herpesvirus and turkey herpesvirus.
Antiviral research.
1984 Oct; 4(5):259-70. doi:
10.1016/0166-3542(84)90031-7. [PMID: 6097179] - K A Watanabe, T L Su, U Reichman, N Greenberg, C Lopez, J J Fox. Nucleosides. 129. Synthesis of antiviral nucleosides: 5-alkenyl-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)uracils.
Journal of medicinal chemistry.
1984 Jan; 27(1):91-4. doi:
10.1021/jm00367a020. [PMID: 6317862] - J Reefschläger, G Herrmann, D Bärwolff, B Schwarz, D Cech, P Langen. Antiherpes activity of (E)-5-(2-bromovinyl)- and 5-vinyl-1-beta-D-arabinofuranosyluracil and some other 5-substituted uracil arabinosyl nucleosides in two different cell lines.
Antiviral research.
1983 Sep; 3(3):175-87. doi:
10.1016/0166-3542(83)90024-4. [PMID: 6316849] - F S Philips, A Feinberg, T C Chou, P M Vidal, T L Su, K A Watanabe, J J Fox. Distribution, metabolism, and excretion of 1-(2-fluoro-2-deoxy-beta-D- arabinofuranosyl)thymine and 1-(2-fluoro-2-deoxy-beta-D-arabinofuranosyl)-5- iodocytosine.
Cancer research.
1983 Aug; 43(8):3619-27. doi:
NULL. [PMID: 6305489] - K A Watanabe, T L Su, R S Klein, C K Chu, A Matsuda, M W Chun, C Lopez, J J Fox. Nucleosides. 123. Synthesis of antiviral nucleosides: 5-substituted 1-(2-deoxy-2-halogeno-beta-D-arabinofuranosyl)cytosines and -uracils. Some structure-activity relationships.
Journal of medicinal chemistry.
1983 Feb; 26(2):152-6. doi:
10.1021/jm00356a007. [PMID: 6298422] - H S Allaudeen, J Descamps, R K Sehgal, J J Fox. Selective inhibition of DNA replication in herpes simplex virus infected cells by 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine.
The Journal of biological chemistry.
1982 Oct; 257(20):11879-82. doi:
NULL. [PMID: 6288702] - T C Chou, A Feinberg, A J Grant, P Vidal, U Reichman, K A Watanabe, J J Fox, F S Philips. Pharmacological disposition and metabolic fate of 2'-fluoro-5-iodo-1-beta-D-arabinofuranosylcytosine in mice and rats.
Cancer research.
1981 Sep; 41(9 Pt 1):3336-42. doi:
NULL. [PMID: 7260900] - A Larsson, B Oberg. Selective inhibition of herpesvirus deoxyribonucleic acid synthesis by acycloguanosine, 2'-fluoro-5-iodo-aracytosine, and (E)-5-(2-bromovinyl)-2'-deoxyuridine.
Antimicrobial agents and chemotherapy.
1981 May; 19(5):927-9. doi:
10.1128/aac.19.5.927. [PMID: 6271053]