Tyrphostin A1 (BioDeep_00000695588)
代谢物信息卡片
Tyrphostin A1
化学式: C11H8N2O (184.0637)
中文名称: 酪氨酸磷酸化抑制剂A1
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1=CC=C(C=C1)C=C(C#N)C#N
InChI: InChI=1S/C11H8N2O/c1-14-11-4-2-9(3-5-11)6-10(7-12)8-13/h2-6H,1H3
描述信息
D000970 - Antineoplastic Agents > D020032 - Tyrphostins
D004791 - Enzyme Inhibitors
同义名列表
2 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Chao Wang, Tianwei Hu, Xu Yan, Tingting Meng, Yutong Wang, Qingmei Wang, Xiaoyue Zhang, Ying Gu, Clara Sánchez-Rodríguez, Astrid Gadeyne, Jinxing Lin, Staffan Persson, Daniël Van Damme, Chuanyou Li, Sebastian Y Bednarek, Jianwei Pan. Differential Regulation of Clathrin and Its Adaptor Proteins during Membrane Recruitment for Endocytosis.
Plant physiology.
2016 05; 171(1):215-29. doi:
10.1104/pp.15.01716. [PMID: 26945051] - Anna Vittoria Carluccio, Stefania Zicca, Livia Stavolone. Hitching a ride on vesicles: cauliflower mosaic virus movement protein trafficking in the endomembrane system.
Plant physiology.
2014 Mar; 164(3):1261-70. doi:
10.1104/pp.113.234534. [PMID: 24477592] - John M Smith, Daniel J Salamango, Michelle E Leslie, Carina A Collins, Antje Heese. Sensitivity to Flg22 is modulated by ligand-induced degradation and de novo synthesis of the endogenous flagellin-receptor FLAGELLIN-SENSING2.
Plant physiology.
2014 Jan; 164(1):440-54. doi:
10.1104/pp.113.229179. [PMID: 24220680] - Maxime Agbeci, Romain Grangeon, Richard S Nelson, Huanquan Zheng, Jean-François Laliberté. Contribution of host intracellular transport machineries to intercellular movement of turnip mosaic virus.
PLoS pathogens.
2013; 9(10):e1003683. doi:
10.1371/journal.ppat.1003683. [PMID: 24098128] - Martina Beck, Ji Zhou, Christine Faulkner, Daniel MacLean, Silke Robatzek. Spatio-temporal cellular dynamics of the Arabidopsis flagellin receptor reveal activation status-dependent endosomal sorting.
The Plant cell.
2012 Oct; 24(10):4205-19. doi:
10.1105/tpc.112.100263. [PMID: 23085733] - Ya A Sheremet, A I Yemets, A Azmi, K Vissenberg, J P Verbelen, Ya B Blume. Effects of tyrosine kinase and phosphatase inhibitors on mitosis progression in synchronized tobacco BY-2 cells.
TSitologiia i genetika.
2012 Sep; 46(5):3-11. doi:
. [PMID: 23342643] - Doan-Trung Luu, Alexandre Martinière, Mathias Sorieul, John Runions, Christophe Maurel. Fluorescence recovery after photobleaching reveals high cycling dynamics of plasma membrane aquaporins in Arabidopsis roots under salt stress.
The Plant journal : for cell and molecular biology.
2012 Mar; 69(5):894-905. doi:
10.1111/j.1365-313x.2011.04841.x. [PMID: 22050464] - Masaru Fujimoto, Shin-ichi Arimura, Takashi Ueda, Hideki Takanashi, Yoshikazu Hayashi, Akihiko Nakano, Nobuhiro Tsutsumi. Arabidopsis dynamin-related proteins DRP2B and DRP1A participate together in clathrin-coated vesicle formation during endocytosis.
Proceedings of the National Academy of Sciences of the United States of America.
2010 Mar; 107(13):6094-9. doi:
10.1073/pnas.0913562107. [PMID: 20231465] - Sheung Kwan Lam, Yi Cai, Yu Chung Tse, Juan Wang, Angus Ho Yin Law, Peter Pimpl, Ho Yin Edwin Chan, Jun Xia, Liwen Jiang. BFA-induced compartments from the Golgi apparatus and trans-Golgi network/early endosome are distinct in plant cells.
The Plant journal : for cell and molecular biology.
2009 Dec; 60(5):865-81. doi:
10.1111/j.1365-313x.2009.04007.x. [PMID: 19709389] - Thanos Ghelis, Gérard Bolbach, Gilles Clodic, Yvette Habricot, Emile Miginiac, Bruno Sotta, Emmanuelle Jeannette. Protein tyrosine kinases and protein tyrosine phosphatases are involved in abscisic acid-dependent processes in Arabidopsis seeds and suspension cells.
Plant physiology.
2008 Nov; 148(3):1668-80. doi:
10.1104/pp.108.124594. [PMID: 18768909] - Alla Yemets, Yarina Sheremet, Kris Vissenberg, Jürgen Van Orden, Jean-Pierre Verbelen, Yaroslav B Blume. Effects of tyrosine kinase and phosphatase inhibitors on microtubules in Arabidopsis root cells.
Cell biology international.
2008 Jun; 32(6):630-7. doi:
10.1016/j.cellbi.2008.01.013. [PMID: 18343165] - Nathalie Leborgne-Castel, Jeannine Lherminier, Christophe Der, Jérôme Fromentin, Valérie Houot, Françoise Simon-Plas. The plant defense elicitor cryptogein stimulates clathrin-mediated endocytosis correlated with reactive oxygen species production in bright yellow-2 tobacco cells.
Plant physiology.
2008 Mar; 146(3):1255-66. doi:
10.1104/pp.107.111716. [PMID: 18184734] - Rebecca S Lipson, Steven G Clarke. S-adenosylmethionine-dependent protein methylation in mammalian cytosol via tyrphostin modification by catechol-O-methyltransferase.
The Journal of biological chemistry.
2007 Oct; 282(42):31094-102. doi:
10.1074/jbc.m705456200. [PMID: 17724020] - B R Hoover, C V Everett, A Sorkin, N R Zahniser. Rapid regulation of dopamine transporters by tyrosine kinases in rat neuronal preparations.
Journal of neurochemistry.
2007 Jun; 101(5):1258-71. doi:
10.1111/j.1471-4159.2007.04522.x. [PMID: 17419806] - Elena Ortiz-Zapater, Esther Soriano-Ortega, María Jesús Marcote, Dolores Ortiz-Masiá, Fernando Aniento. Trafficking of the human transferrin receptor in plant cells: effects of tyrphostin A23 and brefeldin A.
The Plant journal : for cell and molecular biology.
2006 Dec; 48(5):757-70. doi:
10.1111/j.1365-313x.2006.02909.x. [PMID: 17059402] - David R Taylor, Nicole T Watt, W Sumudhu S Perera, Nigel M Hooper. Assigning functions to distinct regions of the N-terminus of the prion protein that are involved in its copper-stimulated, clathrin-dependent endocytosis.
Journal of cell science.
2005 Nov; 118(Pt 21):5141-53. doi:
10.1242/jcs.02627. [PMID: 16254249] - Mariano Severgnini, Satoe Takahashi, Powen Tu, George Perides, Robert J Homer, Jhung W Jhung, Deepa Bhavsar, Brent H Cochran, Amy R Simon. Inhibition of the Src and Jak kinases protects against lipopolysaccharide-induced acute lung injury.
American journal of respiratory and critical care medicine.
2005 Apr; 171(8):858-67. doi:
10.1164/rccm.200407-981oc. [PMID: 15665321] - Xiuxu Chen, Sean T Zuckerman, Weiyuan John Kao. Intracellular protein phosphorylation in adherent U937 monocytes mediated by various culture conditions and fibronectin-derived surface ligands.
Biomaterials.
2005 Mar; 26(8):873-82. doi:
10.1016/j.biomaterials.2004.04.002. [PMID: 15353198] - Max Salomonsson, William J Arendshorst. Effect of tyrosine kinase blockade on norepinephrine-induced cytosolic calcium response in rat afferent arterioles.
American journal of physiology. Renal physiology.
2004 May; 286(5):F866-74. doi:
10.1152/ajprenal.00213.2003. [PMID: 15075182] - N Niisato, Y Marunaka. Forskolin activation of apical Cl- channel and Na+/K+/2Cl- cotransporter via a PTK-dependent pathway in renal epithelium.
Biochemical and biophysical research communications.
2001 Jul; 285(4):880-4. doi:
10.1006/bbrc.2001.5251. [PMID: 11467832] - C Fetscher, H Chen, R F Schäfers, G Wambach, G Heusch, M C Michel. Modulation of noradrenaline-induced microvascular constriction by protein kinase inhibitors.
Naunyn-Schmiedeberg's archives of pharmacology.
2001 Jan; 363(1):57-65. doi:
10.1007/s002100000338. [PMID: 11191837] - J Ibrahim, A D Hughes, P S Sever. Action of angiotensin II on DNA synthesis by human saphenous vein in organ culture.
Hypertension (Dallas, Tex. : 1979).
2000 Nov; 36(5):917-21. doi:
10.1161/01.hyp.36.5.917. [PMID: 11082167] - N Niisato, W Van Driessche, M Liu, Y Marunaka. Involvement of protein tyrosine kinase in osmoregulation of Na(+) transport and membrane capacitance in renal A6 cells.
The Journal of membrane biology.
2000 May; 175(1):63-77. doi:
10.1007/s002320001055. [PMID: 10811968] - D Haynes-Johnson, M T Lai, C Campen, S Palmer. Diverse effects of tyrosine kinase inhibitors on follicle-stimulating hormone-stimulated estradiol and progesterone production from rat granulosa cells in serum-containing medium and serum-free medium containing epidermal growth factor.
Biology of reproduction.
1999 Jul; 61(1):147-53. doi:
10.1095/biolreprod61.1.147. [PMID: 10377043] - M G Atta, S C Dahl, H M Kwon, J S Handler. Tyrosine kinase inhibitors and immunosuppressants perturb the myo-inositol but not the betaine cotransporter in isotonic and hypertonic MDCK cells.
Kidney international.
1999 Mar; 55(3):956-62. doi:
10.1046/j.1523-1755.1999.055003956.x. [PMID: 10027932] - C M Crump, J L Williams, D J Stephens, G Banting. Inhibition of the interaction between tyrosine-based motifs and the medium chain subunit of the AP-2 adaptor complex by specific tyrphostins.
The Journal of biological chemistry.
1998 Oct; 273(43):28073-7. doi:
10.1074/jbc.273.43.28073. [PMID: 9774424] - U Rümenapp, M Schmidt, S Olesch, S Ott, C V Eichel-Streiber, K H Jakobs. Tyrosine-phosphorylation-dependent and rho-protein-mediated control of cellular phosphatidylinositol 4,5-bisphosphate levels.
The Biochemical journal.
1998 Sep; 334 ( Pt 3)(?):625-31. doi:
10.1042/bj3340625. [PMID: 9729471] - K Nakatani, N Nakahata, Y Hamada, S Tsurufuji, Y Ohizumi. Medium change amplifies mitogen-activated protein kinase-mediated prostaglandin E2 synthesis in Swiss 3T3 fibroblasts.
European journal of pharmacology.
1998 Aug; 356(1):91-100. doi:
10.1016/s0014-2999(98)00523-8. [PMID: 9761428] - N J Laping, B A Olson, R E DeWolf, C R Albrightson, T Fredrickson, C King, M Chirivella, F N Ziyadeh, P Nambi. Activation of glomerular mesangial cells by hepatocyte growth factor through tyrosine kinase and protein kinase C.
Biochemical pharmacology.
1998 Jan; 55(2):227-34. doi:
10.1016/s0006-2952(97)00461-9. [PMID: 9448746] - D Fishman, L Galitzki, E Priel, S Segal. Epidermal growth factor regulates protein kinase A activity in murine fibrosarcoma cells: differences between metastatic and nonmetastatic tumor cell variants.
Cancer research.
1997 Dec; 57(23):5410-5. doi:
NULL. [PMID: 9393768] - J Keller, M Schmidt, B Hussein, U Rümenapp, K H Jakobs. Muscarinic receptor-stimulated cytosol-membrane translocation of RhoA.
FEBS letters.
1997 Feb; 403(3):299-302. doi:
10.1016/s0014-5793(97)00067-7. [PMID: 9091321] - J Gillespie, J F Dye, M Schachter, P J Guillou. Inhibition of pancreatic cancer cell growth in vitro by the tyrphostin group of tyrosine kinase inhibitors.
British journal of cancer.
1993 Dec; 68(6):1122-6. doi:
10.1038/bjc.1993.491. [PMID: 8260363] - R M Lyall, A Zilberstein, A Gazit, C Gilon, A Levitzki, J Schlessinger. Tyrphostins inhibit epidermal growth factor (EGF)-receptor tyrosine kinase activity in living cells and EGF-stimulated cell proliferation.
The Journal of biological chemistry.
1989 Aug; 264(24):14503-9. doi:
10.1016/s0021-9258(18)71707-9. [PMID: 2788167] - A W Mondorf. [Evidence of urinary tubular proteins in inflammatory and toxic kidney damage].
Wiener medizinische Wochenschrift. Supplement.
1975; 27(?):20-3. doi:
NULL. [PMID: 5816]
