sodium fumarate (BioDeep_00000695583)
代谢物信息卡片
disodium fumarate
化学式: C4H2Na2O4 (159.9748)
中文名称: 富马酸二钠
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(=CC(=O)[O-])C(=O)[O-].[Na+].[Na+]
InChI: /q
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Antika Boondaeng, Jureeporn Keabpimai, Chanaporn Trakunjae, Nanthavut Niyomvong. Fumaric acid production from fermented oil palm empty fruit bunches using fungal isolate K20: a comparison between free and immobilized cells.
PeerJ.
2024; 12(?):e17282. doi:
10.7717/peerj.17282. [PMID: 38666083] - Tantan Gao, Xudong Wang, Yanqiu Qin, Zhengguang Ren, Xiaoyan Zhao. Watermelon Root Exudates Enhance Root Colonization of Bacillus amyloliquefaciens TR2.
Current microbiology.
2023 Feb; 80(4):110. doi:
10.1007/s00284-023-03206-2. [PMID: 36802037] - Fei Sun, Xiang-Qin Wu, Yue Qi, Xing-Yu Chen, Yu-Hua Cao, Jian-Gang Wang, Shu-Mei Wang, Sheng-Wang Liang. [Application of partial least squares algorithm to explore bioactive components of crude and stir-baked hawthorn for invigorating spleen and promoting digestion].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2023 Feb; 48(4):958-965. doi:
10.19540/j.cnki.cjcmm.20220712.302. [PMID: 36872266] - Anjali Zaveri, Jacqueline Edwards, Simone Rochfort. Production of Primary Metabolites by Rhizopus stolonifer, Causal Agent of Almond Hull Rot Disease.
Molecules (Basel, Switzerland).
2022 Oct; 27(21):. doi:
10.3390/molecules27217199. [PMID: 36364023] - S V Popov, R G Guseynov, O N Skryabin, K V Sivak, V V Perepelitsa, A V Davydov, R S Barhitdinov, A S Katunin, M M Mirzabekov. [Evaluation of the results of sodium fumarate, furosemide, and mannitol on the initiation and outcome of renal warm ischemia in an experimental study].
Urologiia (Moscow, Russia : 1999).
2022 May; ?(2):18-26. doi:
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Drug and chemical toxicology.
2022 Apr; ?(?):1-12. doi:
10.1080/01480545.2022.2058011. [PMID: 35373681] - Fayiz M Reda, Ismail E Ismail, Adel I Attia, Ahmed M Fikry, Eman Khalifa, Mahmoud Alagawany. Use of fumaric acid as a feed additive in quail's nutrition: its effect on growth rate, carcass, nutrient digestibility, digestive enzymes, blood metabolites, and intestinal microbiota.
Poultry science.
2021 Dec; 100(12):101493. doi:
10.1016/j.psj.2021.101493. [PMID: 34715545] - Zilong Li, Qinhua Chen, Jin Wang, Xiaoyan Pan, Wen Lu. Research Progress and Application of Bioorthogonal Reactions in Biomolecular Analysis and Disease Diagnosis.
Topics in current chemistry (Cham).
2021 Sep; 379(6):39. doi:
10.1007/s41061-021-00352-8. [PMID: 34590223] - Niloufar Salehi, Gislaine Kuminek, Jozef Al-Gousous, David C Sperry, Dale E Greenwood, Nicholas M Waltz, Gordon L Amidon, Robert M Ziff, Gregory E Amidon. Improving Dissolution Behavior and Oral Absorption of Drugs with pH-Dependent Solubility Using pH Modifiers: A Physiologically Realistic Mass Transport Analysis.
Molecular pharmaceutics.
2021 09; 18(9):3326-3341. doi:
10.1021/acs.molpharmaceut.1c00262. [PMID: 34428047] - Sengnolotha Marak, Elena Shumilina, Nutan Kaushik, Eva Falch, Alexander Dikiy. Effect of Different Drying Methods on the Nutritional Value of Hibiscus sabdariffa Calyces as Revealed by NMR Metabolomics.
Molecules (Basel, Switzerland).
2021 Mar; 26(6):. doi:
10.3390/molecules26061675. [PMID: 33802805] - G A Nagana Gowda, Natalie N Hong, Daniel Raftery. Evaluation of Fumaric Acid and Maleic Acid as Internal Standards for NMR Analysis of Protein Precipitated Plasma, Serum, and Whole Blood.
Analytical chemistry.
2021 02; 93(6):3233-3240. doi:
10.1021/acs.analchem.0c04766. [PMID: 33538164] - Kerri M Smith, Ian D Wilson, Paul D Rainville. Sensitive and Reproducible Mass Spectrometry-Compatible RP-UHPLC Analysis of Tricarboxylic Acid Cycle and Related Metabolites in Biological Fluids: Application to Human Urine.
Analytical chemistry.
2021 01; 93(2):1009-1015. doi:
10.1021/acs.analchem.0c03863. [PMID: 33290053] - Wioletta Siemiradzka, Barbara Dolińska, Florian Ryszka. Preparation of Sterile Raw Material - Chicken Eggshells in the Process of their Transformation into Selected Calcium Salts.
Current pharmaceutical biotechnology.
2021; 22(2):299-304. doi:
10.2174/1389201021666200903120835. [PMID: 32881665] - Gurpreet Kaur, Thippeswamy Boreddy Shivanandappa, Manish Kumar, Ajay Singh Kushwah. Fumaric acid protect the cadmium-induced hepatotoxicity in rats: owing to its antioxidant, anti-inflammatory action and aid in recast the liver function.
Naunyn-Schmiedeberg's archives of pharmacology.
2020 10; 393(10):1911-1920. doi:
10.1007/s00210-020-01900-7. [PMID: 32440768] - Syed Ilias Basha, Somnath Ghosh, K Vinothkumar, B Ramesh, P Hema Praksh Kumari, K V Murali Mohan, E Sukumar. Fumaric acid incorporated Ag/agar-agar hybrid hydrogel: A multifunctional avenue to tackle wound healing.
Materials science & engineering. C, Materials for biological applications.
2020 Jun; 111(?):110743. doi:
10.1016/j.msec.2020.110743. [PMID: 32279739] - Gulsah Gundogdu, Onur Senol, Fatma Demirkaya Miloglu, Yavuzer Koza, Fuat Gundogdu, Ahmet Hacımüftüoğlu, A M Abd El-Aty. Serum metabolite profiling of ST-segment elevation myocardial infarction using liquid chromatography quadrupole time-of-flight mass spectrometry.
Biomedical chromatography : BMC.
2020 Feb; 34(2):e4738. doi:
10.1002/bmc.4738. [PMID: 31677392] - Masumeh Doosti, Mir Saeed Seyed Dorraji, Seyedeh Neda Mousavi, Mohammad Hossein Rasoulifard, Seyed Hojjat Hosseini. Enhancing quercetin bioavailability by super paramagnetic starch-based hydrogel grafted with fumaric acid: An in vitro and in vivo study.
Colloids and surfaces. B, Biointerfaces.
2019 Nov; 183(?):110487. doi:
10.1016/j.colsurfb.2019.110487. [PMID: 31518957] - Zong Xian Zhu, Dan Li Jiang, Bi Jun Li, Hui Qin, Zi Ning Meng, Hao Ran Lin, Jun Hong Xia. Differential Transcriptomic and Metabolomic Responses in the Liver of Nile Tilapia (Oreochromis niloticus) Exposed to Acute Ammonia.
Marine biotechnology (New York, N.Y.).
2019 Aug; 21(4):488-502. doi:
10.1007/s10126-019-09897-8. [PMID: 31076921] - Forouzan Heidari, Abbas Bahari, Ali Amarlou, Barat Ali Fakheri. Fumaric acids as a novel antagonist of TLR-4 pathway mitigates arsenic-exposed inflammation in human monocyte-derived dendritic cells.
Immunopharmacology and immunotoxicology.
2019 Aug; 41(4):513-520. doi:
10.1080/08923973.2019.1645166. [PMID: 31397191] - Jin-Seok Choi, Jong Chan Byeon, Jeong-Sook Park. Naftopidil-fumaric acid interaction in a solid dispersion system: Improving the dissolution rate and oral absorption of naftopidil in rats.
Materials science & engineering. C, Materials for biological applications.
2019 Feb; 95(?):264-274. doi:
10.1016/j.msec.2018.10.089. [PMID: 30573249] - Ruixia Lan, Inho Kim. Effects of organic acid and medium chain fatty acid blends on the performance of sows and their piglets.
Animal science journal = Nihon chikusan Gakkaiho.
2018 Dec; 89(12):1673-1679. doi:
10.1111/asj.13111. [PMID: 30270486] - Guangyuan Wang, Tingting Bai, Zhengang Miao, Weiguang Ning, Wenxing Liang. Simultaneous production of single cell oil and fumaric acid by a newly isolated yeast Aureobasidium pullulans var. aubasidani DH177.
Bioprocess and biosystems engineering.
2018 Nov; 41(11):1707-1716. doi:
10.1007/s00449-018-1994-0. [PMID: 30069713] - Juan P Zubimendi, Andrea Martinatto, Maria P Valacco, Silvia Moreno, Carlos S Andreo, María F Drincovich, Marcos A Tronconi. The complex allosteric and redox regulation of the fumarate hydratase and malate dehydratase reactions of Arabidopsis thaliana Fumarase 1 and 2 gives clues for understanding the massive accumulation of fumarate.
The FEBS journal.
2018 06; 285(12):2205-2224. doi:
10.1111/febs.14483. [PMID: 29688630] - Guanshi Zhang, Manjula Darshi, Kumar Sharma. The Warburg Effect in Diabetic Kidney Disease.
Seminars in nephrology.
2018 03; 38(2):111-120. doi:
10.1016/j.semnephrol.2018.01.002. [PMID: 29602394] - Shatrupa Ray, Sandhya Mishra, Kartikay Bisen, Surendra Singh, Birinchi Kumar Sarma, Harikesh Bahadur Singh. Modulation in phenolic root exudate profile of Abelmoschus esculentus expressing activation of defense pathway.
Microbiological research.
2018 Mar; 207(?):100-107. doi:
10.1016/j.micres.2017.11.011. [PMID: 29458844] - N Remling, S Riede, U Meyer, A Beineke, G Breves, G Flachowsky, S Dänicke. Influence of fumaric acid on ruminal parameters and organ weights of growing bulls fed with grass or maize silage.
Animal : an international journal of animal bioscience.
2017 Oct; 11(10):1754-1761. doi:
10.1017/s1751731117000696. [PMID: 28397627] - Jay Nath, Tom B Smith, Kamlesh Patel, Sam R Ebbs, Alex Hollis, Daniel A Tennant, Christian Ludwig, Andrew R Ready. Metabolic differences between cold stored and machine perfused porcine kidneys: A 1H NMR based study.
Cryobiology.
2017 02; 74(?):115-120. doi:
10.1016/j.cryobiol.2016.11.006. [PMID: 27919740] - Xin Li, Jin Zhou, Shuiping Ouyang, Jia Ouyang, Qiang Yong. Fumaric Acid Production from Alkali-Pretreated Corncob by Fed-Batch Simultaneous Saccharification and Fermentation Combined with Separated Hydrolysis and Fermentation at High Solids Loading.
Applied biochemistry and biotechnology.
2017 Feb; 181(2):573-583. doi:
10.1007/s12010-016-2232-3. [PMID: 27604834] - Yu Kyong Kim, Mun Ju Choi, Tae Young Oh, Kyung-Sang Yu, SeungHwan Lee. A comparative pharmacokinetic and tolerability analysis of the novel orotic acid salt form of tenofovir disoproxil and the fumaric acid salt form in healthy subjects.
Drug design, development and therapy.
2017; 11(?):3171-3177. doi:
10.2147/dddt.s149125. [PMID: 29158663] - Marcos Hernández Suárez, Daniel Molina Pérez, Elena M Rodríguez-Rodríguez, Carlos Díaz Romero, Francisco Espinosa Borreguero, Purificación Galindo-Villardón. The Compositional HJ-Biplot-A New Approach to Identifying the Links among Bioactive Compounds of Tomatoes.
International journal of molecular sciences.
2016 Nov; 17(11):. doi:
10.3390/ijms17111828. [PMID: 27827839] - M M Montiel-Rozas, E Madejón, P Madejón. Effect of heavy metals and organic matter on root exudates (low molecular weight organic acids) of herbaceous species: An assessment in sand and soil conditions under different levels of contamination.
Environmental pollution (Barking, Essex : 1987).
2016 Sep; 216(?):273-281. doi:
10.1016/j.envpol.2016.05.080. [PMID: 27267743] - Marco Sciacovelli, Emanuel Gonçalves, Timothy Isaac Johnson, Vincent Roberto Zecchini, Ana Sofia Henriques da Costa, Edoardo Gaude, Alizee Vercauteren Drubbel, Sebastian Julian Theobald, Sandra Riekje Abbo, Maxine Gia Binh Tran, Vinothini Rajeeve, Simone Cardaci, Sarah Foster, Haiyang Yun, Pedro Cutillas, Anne Warren, Vincent Gnanapragasam, Eyal Gottlieb, Kristian Franze, Brian Huntly, Eamonn Richard Maher, Patrick Henry Maxwell, Julio Saez-Rodriguez, Christian Frezza. Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition.
Nature.
2016 08; 537(7621):544-547. doi:
10.1038/nature19353. [PMID: 27580029] - Yao Shi, Susanna Tse, Brian Rago, Udeni Yapa, Fumin Li, Douglas M Fast. Quantification of fumarate and investigation of endogenous and exogenous fumarate stability in rat plasma by LC-MS/MS.
Bioanalysis.
2016 Apr; 8(7):661-75. doi:
10.4155/bio-2015-0026. [PMID: 26978279] - Dong Wuk Kim, Young Hun Kim, Abid Mehmood Yousaf, Dong Shik Kim, Taek Kwan Kwon, Jung Hee Park, Yong Il Kim, Jae-Hyun Park, Sung Giu Jin, Kyung Soo Kim, Kwan Hyung Cho, Dong Xun Li, Jong Oh Kim, Chul Soon Yong, Jong Soo Woo, Han-Gon Choi. Novel montelukast sodium-loaded stable oral suspension bioequivalent to the commercial granules in rats.
Archives of pharmacal research.
2016 Apr; 39(4):539-546. doi:
10.1007/s12272-015-0664-x. [PMID: 26983932] - Vanessa Vieira, Lillian Barros, Anabela Martins, Isabel C F R Ferreira. Nutritional and Biochemical Profiling of Leucopaxillus candidus (Bres.) Singer Wild Mushroom.
Molecules (Basel, Switzerland).
2016 Jan; 21(1):99. doi:
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PloS one.
2016; 11(1):e0148280. doi:
10.1371/journal.pone.0148280. [PMID: 26824236] - Da-Hao Huang, Kun Wang, Chihwei P Chiu, Tzu-Ming Pan, Tsung-Yu Tsai. Effects of chemical and low-temperature treatments and adaption on the responses of virulence factor genes and outer membrane proteins in Escherichia coli O157:H7.
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi.
2015 Dec; 48(6):604-12. doi:
10.1016/j.jmii.2014.03.007. [PMID: 24856424] - Liangsheng Xu, Meichun Xiang, David White, Weidong Chen. pH dependency of sclerotial development and pathogenicity revealed by using genetically defined oxalate-minus mutants of Sclerotinia sclerotiorum.
Environmental microbiology.
2015 Aug; 17(8):2896-909. doi:
10.1111/1462-2920.12818. [PMID: 25720941] - N Remling, S Riede, P Lebzien, U Meyer, M Höltershinken, S Kersten, G Breves, G Flachowsky, S Dänicke. Effects of fumaric acid on rumen fermentation, milk composition and metabolic parameters in lactating cows.
Journal of animal physiology and animal nutrition.
2014 Oct; 98(5):968-81. doi:
10.1111/jpn.12152. [PMID: 24313964] - Nan-Sun Kim, Hwa-Young Yu, Nguyen-Duc Chung, Tae-Ho Kwon, Moon-Sik Yang. High-level production of recombinant trypsin in transgenic rice cell culture through utilization of an alternative carbon source and recycling system.
Enzyme and microbial technology.
2014 Sep; 63(?):21-7. doi:
10.1016/j.enzmictec.2014.04.010. [PMID: 25039055] - Karthigayan Shanmugasundaram, Bijaya Nayak, Eun-Hee Shim, Carolina B Livi, Karen Block, Sunil Sudarshan. The oncometabolite fumarate promotes pseudohypoxia through noncanonical activation of NF-κB signaling.
The Journal of biological chemistry.
2014 Aug; 289(35):24691-9. doi:
10.1074/jbc.m114.568162. [PMID: 25028521] - A Haghikia, R Linker, R Gold. [Fumaric acid as therapeutic agent for multiple sclerosis].
Der Nervenarzt.
2014 Jun; 85(6):720-6. doi:
10.1007/s00115-014-4005-y. [PMID: 24668400] - Shuai Gu, Qing Xu, He Huang, Shuang Li. Alternative respiration and fumaric acid production of Rhizopus oryzae.
Applied microbiology and biotechnology.
2014 Jun; 98(11):5145-52. doi:
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Food chemistry.
2014 Apr; 148(?):415-9. doi:
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2014 Jan; 49(1):89-94. doi:
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Molecular pharmaceutics.
2013 Dec; 10(12):4687-97. doi:
10.1021/mp400516b. [PMID: 24168322] - Yingjiao Wang, Tyler Robison, Heather Wiatrowski. The impact of ionic mercury on antioxidant defenses in two mercury-sensitive anaerobic bacteria.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine.
2013 Dec; 26(6):1023-31. doi:
10.1007/s10534-013-9679-2. [PMID: 24150569] - Nicola Ternette, Ming Yang, Mahima Laroyia, Mitsuhiro Kitagawa, Linda O'Flaherty, Kathryn Wolhulter, Kaori Igarashi, Kaori Saito, Keiko Kato, Roman Fischer, Alexandre Berquand, Benedikt M Kessler, Terry Lappin, Norma Frizzell, Tomoyoshi Soga, Julie Adam, Patrick J Pollard. Inhibition of mitochondrial aconitase by succination in fumarate hydratase deficiency.
Cell reports.
2013 Mar; 3(3):689-700. doi:
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Terapevticheskii arkhiv.
2013; 85(12):75-8. doi:
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Plant science : an international journal of experimental plant biology.
2013 Jan; 198(?):1-6. doi:
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Chemosphere.
2013 Jan; 90(4):1449-54. doi:
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Biological trace element research.
2012 Dec; 150(1-3):509-12. doi:
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Prikladnaia biokhimiia i mikrobiologiia.
2012 Nov; 48(6):631-9. doi:
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Journal of food science.
2012 Oct; 77(10):C1064-70. doi:
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Research in veterinary science.
2012 Aug; 93(1):46-7. doi:
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Applied and environmental microbiology.
2012 Feb; 78(3):705-16. doi:
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Terapevticheskii arkhiv.
2012; 84(10):62-4. doi:
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TheScientificWorldJournal.
2012; 2012(?):564367. doi:
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Journal of pharmaceutical and biomedical analysis.
2011 Dec; 56(4):758-62. doi:
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Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
2011 Dec; 34(12):1882-3. doi:
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Human mutation.
2011 Sep; 32(9):1046-52. doi:
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Plant signaling & behavior.
2011 Sep; 6(9):1305-11. doi:
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Nature.
2011 Aug; 477(7363):225-8. doi:
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The British journal of dermatology.
2011 Mar; 164(3):648-51. doi:
10.1111/j.1365-2133.2010.10171.x. [PMID: 21143462] - Alexandre Jousset, Laurène Rochat, Arnaud Lanoue, Michael Bonkowski, Christoph Keel, Stefan Scheu. Plants respond to pathogen infection by enhancing the antifungal gene expression of root-associated bacteria.
Molecular plant-microbe interactions : MPMI.
2011 Mar; 24(3):352-8. doi:
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