n-acetyl-s-benzyl-l-cysteine (BioDeep_00000694381)

   


代谢物信息卡片


n-acetyl-s-benzyl-l-cysteine

化学式: C12H15NO3S (253.07726)
中文名称: N-乙酰基-S-苄基-L-半胱氨酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)NC(CSCC1=CC=CC=C1)C(=O)O
InChI: InChI=1S/C12H15NO3S/c1-9(14)13-11(12(15)16)8-17-7-10-5-3-2-4-6-10/h2-6,11H,7-8H2,1H3,(H,13,14)(H,15,16)/t11-/m0/s1

描述信息

The S-benzyl derivative of N-acetyl-L-cysteine.

同义名列表

1 个代谢物同义名

n-acetyl-s-benzyl-l-cysteine



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Hengyou Zhang, Yinghua Huang. Genome-wide identification and characterization of greenbug-inducible NAC transcription factors in sorghum. Molecular biology reports. 2024 Jan; 51(1):207. doi: 10.1007/s11033-023-09158-x. [PMID: 38270755]
  • Huan He, Qiuyue Li, Liang Fang, Wen Yang, Feican Xu, Yan Yan, Renjun Mao. Comprehensive analysis of NAC transcription factors in Scutellaria baicalensis and their response to exogenous ABA and GA3. International journal of biological macromolecules. 2023 Jul; 244(?):125290. doi: 10.1016/j.ijbiomac.2023.125290. [PMID: 37302633]
  • Soon Su Shin, Eun Hye Yang, Hyo Choon Lee, Seong Ho Moon, Jae-Hong Ryoo. Association of metabolites of benzene and toluene with lipid profiles in Korean adults: Korean National Environmental Health Survey (2015-2017). BMC public health. 2022 10; 22(1):1917. doi: 10.1186/s12889-022-14319-x. [PMID: 36242012]
  • Honesty Tohon, Mathieu Valcke, Rocio Aranda-Rodriguez, Andy Nong, Sami Haddad. Estimation of toluene exposure in air from BMA (S-benzylmercapturic acid) urinary measures using a reverse dosimetry approach based on physiologically pharmacokinetic modeling. Regulatory toxicology and pharmacology : RTP. 2021 Mar; 120(?):104860. doi: 10.1016/j.yrtph.2020.104860. [PMID: 33406392]
  • Cecilie Rosting, Raymond Olsen. Biomonitoring of the benzene metabolite s-phenylmercapturic acid and the toluene metabolite s-benzylmercapturic acid in urine from firefighters. Toxicology letters. 2020 Sep; 329(?):20-25. doi: 10.1016/j.toxlet.2020.04.018. [PMID: 32380125]
  • Liang Li, Hui Wang, Yongjiu Jin, Yazhou Shuang, Laisheng Li. Preparation of a new benzylureido-β-cyclodextrin-based column and its application for the determination of phenylmercapturic acid and benzylmercapturic acid enantiomers in human urine by LC/MS/MS. Analytical and bioanalytical chemistry. 2019 Aug; 411(21):5465-5479. doi: 10.1007/s00216-019-01920-0. [PMID: 31177331]
  • Jie Li, Xinjie Zhang, Zhini He, Qing Sun, Fei Qin, Zhenlie Huang, Xiao Zhang, Xin Sun, Linhua Liu, Liping Chen, Chen Gao, Shan Wang, Fangping Wang, Daochuan Li, Xiaowen Zeng, Qifei Deng, Qing Wang, Bo Zhang, Huanwen Tang, Wen Chen, Yongmei Xiao. MGMT hypomethylation is associated with DNA damage in workers exposed to low-dose benzene. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 2017 Jul; 22(5):470-475. doi: 10.1080/1354750x.2016.1274335. [PMID: 28001451]
  • Frédéric Cosnier, Céline Brochard, Manuella Burgart, Benoît Cossec. Mercapturic acids derived from toluene in rat urine samples: identification and measurement by gas chromatography-tandem mass spectrometry. Analytical and bioanalytical chemistry. 2012 Oct; 404(6-7):1907-17. doi: 10.1007/s00216-012-6262-6. [PMID: 22829455]
  • Clayton B'Hymer, Edward Krieg, Kenneth L Cheever, Christine A Toennis, John C Clark, James S Kesner, Roger Gibson, Mary Ann Butler. Evaluation and comparison of urinary metabolic biomarkers of exposure for the jet fuel JP-8. Journal of toxicology and environmental health. Part A. 2012; 75(11):661-72. doi: 10.1080/15287394.2012.688483. [PMID: 22712851]
  • C B'Hymer. Validation of an HPLC-MS-MS method for the determination of urinary S-benzylmercapturic acid and S-phenylmercapturic acid. Journal of chromatographic science. 2011 Aug; 49(7):547-53. doi: 10.1093/chrsci/49.7.547. [PMID: 21801486]
  • Piero Lovreglio, Anna Barbieri, Mariella Carrieri, Laura Sabatini, Maria Enrica Fracasso, Denise Doria, Ignazio Drago, Antonella Basso, Maria Nicolà D'Errico, Giovanni Battista Bartolucci, Francesco Saverio Violante, Leonardo Soleo. Validity of new biomarkers of internal dose for use in the biological monitoring of occupational and environmental exposure to low concentrations of benzene and toluene. International archives of occupational and environmental health. 2010 Mar; 83(3):341-56. doi: 10.1007/s00420-009-0469-7. [PMID: 19830448]
  • Osamu Inoue, Toshio Kawai, Hirohiko Ukai, Yuki Maejima, Yoshinari Fukui, Fumiko Ohashi, Satoru Okamoto, Shiro Takada, Haruhiko Sakurai, Masayuki Ikeda. Limited validity of o-cresol and benzylmercapturic acid in urine as biomarkers of occupational exposure to toluene at low levels. Industrial health. 2008 Aug; 46(4):318-25. doi: 10.2486/indhealth.46.318. [PMID: 18716379]
  • Masayuki Ikeda, Hirohiko Ukai, Toshio Kawai, Osamu Inoue, Yuki Maejima, Yoshinari Fukui, Fumiko Ohashi, Satoru Okamoto, Shiro Takada, Haruhiko Sakurai. Changes in correlation coefficients of exposure markers as a function of intensity of occupational exposure to toluene. Toxicology letters. 2008 Jul; 179(3):148-54. doi: 10.1016/j.toxlet.2008.05.003. [PMID: 18583070]
  • Delphine Waniusiow, Pierre Campo, Benoît Cossec, Frédéric Cosnier, Stephane Grossman, Luc Ferrari. Toluene-induced hearing loss in acivicin-treated rats. Neurotoxicology and teratology. 2008 May; 30(3):154-60. doi: 10.1016/j.ntt.2008.02.006. [PMID: 18420380]
  • T Schettgen, A Musiol, A Alt, T Kraus. Fast determination of urinary S-phenylmercapturic acid (S-PMA) and S-benzylmercapturic acid (S-BMA) by column-switching liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2008 Mar; 863(2):283-92. doi: 10.1016/j.jchromb.2008.01.024. [PMID: 18258494]
  • Laura Sabatini, Anna Barbieri, Paolo Indiveri, Stefano Mattioli, Francesco Saverio Violante. Validation of an HPLC-MS/MS method for the simultaneous determination of phenylmercapturic acid, benzylmercapturic acid and o-methylbenzyl mercapturic acid in urine as biomarkers of exposure to benzene, toluene and xylenes. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2008 Feb; 863(1):115-22. doi: 10.1016/j.jchromb.2008.01.022. [PMID: 18255357]
  • Pierre Campo, Delphine Waniusiow, Benoît Cossec, Robert Lataye, Benoît Rieger, Frédéric Cosnier, Manuella Burgart. Toluene-induced hearing loss in phenobarbital treated rats. Neurotoxicology and teratology. 2008 Jan; 30(1):46-54. doi: 10.1016/j.ntt.2007.10.001. [PMID: 18160254]
  • Hirohiko Ukai, Toshio Kawai, Osamu Inoue, Yuki Maejima, Yoshinari Fukui, Fumiko Ohashi, Satoru Okamoto, Shiro Takada, Haruhiko Sakurai, Masayuki Ikeda. Comparative evaluation of biomarkers of occupational exposure to toluene. International archives of occupational and environmental health. 2007 Oct; 81(1):81-93. doi: 10.1007/s00420-007-0193-0. [PMID: 17653568]
  • A Barbieri, L Sabatini, P Indiveri, F S Violante. [Biological monitoring of exposure to benzene, toluene and xylenes in urban traffic wardens by LC-MS analysis]. Giornale italiano di medicina del lavoro ed ergonomia. 2007 Jul; 29(3 Suppl):536-8. doi: NULL. [PMID: 18409818]
  • Jui-Shu Chou, Yi-Chang Lin, Yee-Chung Ma, Jenn-Feng Sheen, Tung-Sheng Shih. Measurement of benzylmercapturic acid in human urine by liquid chromatography-electrospray ionization-tandem quadrupole mass spectrometry. Journal of analytical toxicology. 2006 Jun; 30(5):306-12. doi: 10.1093/jat/30.5.306. [PMID: 16839466]
  • Ulrike Elisabeth Rolle-Kampczyk, Martina Rehwagen, Ulrich Franck, Holger Weiss, Peter Krumbiegel, Olf Herbarth. Bio-effect monitoring using a [(15)N]methacetin test as diagnostic tool to monitor remediation effects in an industrially polluted region. Toxicology letters. 2006 Apr; 162(2-3):234-8. doi: 10.1016/j.toxlet.2005.09.017. [PMID: 16242870]
  • O Inoue, E Kanno, K Kasai, H Ukai, S Okamoto, M Ikeda. Benzylmercapturic acid is superior to hippuric acid and o-cresol as a urinary marker of occupational exposure to toluene. Toxicology letters. 2004 Mar; 147(2):177-86. doi: 10.1016/j.toxlet.2003.11.003. [PMID: 14757321]
  • Anna Barbieri, Laura Sabatini, Antonio Accorsi, Aldo Roda, Francesco Saverio Violante. Simultaneous determination of t,t-muconic, S-phenylmercapturic and S-benzylmercapturic acids in urine by a rapid and sensitive liquid chromatography/electrospray tandem mass spectrometry method. Rapid communications in mass spectrometry : RCM. 2004; 18(17):1983-8. doi: 10.1002/rcm.1580. [PMID: 15329865]
  • Hiroshi Moriwaki, Ayumi Watanabe, Ryuichi Arakawa, Yuji Tsujimoto, Mitsuru Shimizu, Tsutomu Noda, Munehiro Warashina, Masanobu Tanaka. Simultaneous determination of metabolites of trimethylbenzenes, dimethylbenzylmercapturicacid and dimethylhippuric acid, in human urine by solid-phase extraction followed by liquid chromatography tandem mass spectrometry. Journal of mass spectrometry : JMS. 2002 Nov; 37(11):1152-7. doi: 10.1002/jms.378. [PMID: 12447892]
  • Ulrike E Rolle-Kampczyk, Martina Rehwagen, Ulrike Diez, Matthias Richter, Olf Herbarth, Michael Borte. Passive smoking, excretion of metabolites, and health effects: results of the Leipzig's Allergy Risk Study (LARS). Archives of environmental health. 2002 Jul; 57(4):326-31. doi: 10.1080/00039890209601416. [PMID: 12530599]
  • Osamu Inoue, Etsuko Kanno, Toshiharu Yusa, Masaei Kakizaki, Hirohiko Ukai, Satoru Okamoto, Kae Higashikawa, Masayuki Ikeda. Urinary benzylmercapturic acid as a marker of occupational exposure to toluene. International archives of occupational and environmental health. 2002 Jun; 75(5):341-7. doi: 10.1007/s00420-002-0322-8. [PMID: 11981673]
  • Setsunori Takahashi, Takashi Uezono, Atsushi Akane, Kojiro Kimura. Simple method of methylation for gas chromatographic analysis of S-benzyl-N-acetylcysteine, a metabolite of toluene, in human urine. Journal of analytical toxicology. 2002 May; 26(4):189-92. doi: 10.1093/jat/26.4.189. [PMID: 12054357]
  • K Sano, Y Ikegami, T Uesugi. Initial intraorgan formation of mercapturic acid. Biological & pharmaceutical bulletin. 2001 Nov; 24(11):1324-8. doi: 10.1248/bpb.24.1324. [PMID: 11725973]
  • M Buratti, G Brambilla, S Fustinoni, O Pellegrino, S Pulviremti, A Colombi. Determination of monobromobimane derivatives of phenylmercapturic and benzylmercapturic acids in urine by high-performance liquid chromatography and fluorimetry. Journal of chromatography. B, Biomedical sciences and applications. 2001 Feb; 751(2):305-13. doi: 10.1016/s0378-4347(00)00491-6. [PMID: 11236086]
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  • M Imbriani, S Ghittori, A Cavalleri. [Significance of urinary concentrations of S-benzyl-N-acetylcysteine (S-BMA) in subjects exposed to toluene]. Giornale italiano di medicina del lavoro ed ergonomia. 1999 Oct; 21(4):329-33. doi: . [PMID: 10771747]
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  • S Takahashi, M Kagawa, K Shiwaku, K Matsubara. Determination of S-benzyl-N-acetyl-L-cysteine by gas chromatography/mass spectrometry as a new marker of toluene exposure. Journal of analytical toxicology. 1994 Mar; 18(2):78-80. doi: 10.1093/jat/18.2.78. [PMID: 8207937]
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