ozolinone (BioDeep_00000694187)

   


代谢物信息卡片


ozolinone

化学式: C11H16N2O3S (256.0881586)
中文名称: 奥唑林酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN1C(=CC(=O)O)SC(C1=O)N2CCCCC2
InChI: InChI=1S/C11H16N2O3S/c1-12-8(7-9(14)15)17-11(10(12)16)13-5-3-2-4-6-13/h7,11H,2-6H2,1H3,(H,14,15)/b8-7-

描述信息

C78275 - Agent Affecting Blood or Body Fluid > C448 - Diuretic > C49184 - Loop Diuretic
D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents
D045283 - Natriuretic Agents > D004232 - Diuretics

同义名列表

1 个代谢物同义名

ozolinone



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • M Barthelmebs, D Stephan, J P Krieger, M Grima, J L Imbs. Stereoselective renal effects of the loop diuretic ozolinone in the anesthetized dog. Naunyn-Schmiedeberg's archives of pharmacology. 1995 Jun; 351(6):660-71. doi: 10.1007/bf00170167. [PMID: 7675125]
  • J E Benabe, J Pedraza-Chaverri, M Martínez-Maldonado. Mechanisms of ozolinone-induced renin release and diuresis. American journal of hypertension. 1993 Aug; 6(8):701-7. doi: 10.1093/ajh/6.8.701. [PMID: 8217033]
  • L P Rybak, C Whitworth, V Scott. Comparative acute ototoxicity of loop diuretic compounds. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. 1991; 248(6):353-7. doi: 10.1007/bf00169028. [PMID: 1930985]
  • M Shalmi, J S Petersen, S Christensen. Stereospecificity of the effects of ozolinone on renal hemodynamics and on segmental tubular sodium reabsorption in conscious rats. European journal of pharmacology. 1990 May; 180(1):69-76. doi: 10.1016/0014-2999(90)90593-u. [PMID: 2365004]
  • H Knauf, M Missmahl, J Schölmerich, W Gerok, E Mutschler. Altered kinetics of etozolin and its active metabolite ozolinone in hepatitis and hepatic cirrhosis with ascites. Arzneimittel-Forschung. 1987 Dec; 37(12):1385-8. doi: NULL. [PMID: 3449068]
  • O Eriksson, P J Wistrand. Chloride transport inhibition by various types of loop diuretics in fish opercular epithelium. Acta physiologica Scandinavica. 1986 Jan; 126(1):93-101. doi: 10.1111/j.1748-1716.1986.tb07791.x. [PMID: 3953305]
  • K H Göttl, A Roesch, R Klinke. Quantitative evaluation of ototoxic side effects of furosemide, piretanide, bumetanide, azosemide and ozolinone in the cat--a new approach to the problem of ototoxicity. Naunyn-Schmiedeberg's archives of pharmacology. 1985 Nov; 331(2-3):275-82. doi: 10.1007/bf00634249. [PMID: 4088324]
  • J L Imbs, M Schmidt, E M Giesen, J Schwartz. Effect of captopril on intrarenal blood flow. The American journal of medicine. 1984 May; 76(5B):53-7. doi: 10.1016/0002-9343(84)90884-2. [PMID: 6375362]
  • J Greven, K Glaser, B Kölling, O Heidenreich. Attenuation by d-ozolinone of l-ozolinone-induced diuresis in rats. European journal of pharmacology. 1984 Mar; 98(3-4):331-6. doi: 10.1016/0014-2999(84)90281-4. [PMID: 6723778]
  • H Knauf, R Liebig, P Schollmeyer, J Rosenthal, E U Kölle, E Mutschler. Pharmacodynamics and kinetics of etozolin/ozolinone in hypertensive patients with normal and impaired kidney function. European journal of clinical pharmacology. 1984; 26(6):687-93. doi: 10.1007/bf00541926. [PMID: 6386484]
  • J Greven. Studies on the renal receptors of loop diuretics. Clinical and experimental hypertension. Part A, Theory and practice. 1983; 5(2):193-208. doi: 10.3109/10641968309048821. [PMID: 6831745]
  • H Nau, R Steldinger, E Ivan. Placental transfer of etozolin and ozolinone during the first half of gestation in man. European journal of clinical pharmacology. 1982; 23(3):253-60. doi: 10.1007/bf00547564. [PMID: 7173295]
  • C Liddiard, H Nau. Determination of etozolin and ozolinone in human plasma and tissues by reversed-phase high-performance liquid chromatography. Journal of chromatography. 1981 Oct; 225(2):504-8. doi: 10.1016/s0378-4347(00)80304-7. [PMID: 7298786]
  • R Kinne, E Kinne-Saffran, B Koenig, E Bayerdoerffer, J Eveloff. Control mechanisms in active chloride transport. Scandinavian audiology. Supplementum. 1981; 14 Suppl(?):17-24. doi: NULL. [PMID: 6276964]
  • J Greven, W Defrain, K Glaser, K Meywald, O Heidenreich. Studies with the optically active isomers of the new diuretic drug ozolinone. I. Differences in stereoselectivity of the renal target structures of ozolinone. Pflugers Archiv : European journal of physiology. 1980 Mar; 384(1):57-60. doi: 10.1007/bf00589514. [PMID: 7189866]
  • J Greven, M Beckers, W Defrain, K Meywald, O Heidenreich. Studies with the optically active isomers of the new diuretic drug ozolinone. II. Inhibition by d-ozolinone of furosemide-induced diuresis. Pflugers Archiv : European journal of physiology. 1980 Mar; 384(1):61-4. doi: 10.1007/bf00589515. [PMID: 7189867]
  • H Hengy, K O Vollmer, V Gladigau, E U Kölle. Assay of etozolin and its main metabolite, ozolinone, in plasma by high performance liquid chromatography. Arzneimittel-Forschung. 1980; 30(10):1788-90. doi: NULL. [PMID: 7192115]
  • J Greven, O Heidenreich. Effects of ozolinone, a diuretic active metabolite of etozoline, on renal function. I. Clearance studies in dogs. Naunyn-Schmiedeberg's archives of pharmacology. 1978 Oct; 304(3):283-7. doi: 10.1007/bf00507970. [PMID: 714186]