doxycycline hydrochloride (BioDeep_00000693808)
代谢物信息卡片
doxycycline hydrochloride
化学式: C22H25ClN2O8 (480.129936)
中文名称: 盐酸多西环素
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.Cl
InChI: /m0./s1
描述信息
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
C784 - Protein Synthesis Inhibitor > C1595 - Tetracycline Antibiotic
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
C254 - Anti-Infective Agent > C258 - Antibiotic
同义名列表
1 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:652992
- KEGGdrug: D07877
- PubChem: 54685920
- ChEMBL: CHEMBL1256723
- MeSH: Doxycycline
- CAS: 10592-13-9
- CAS: 100929-47-3
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Menglong Geng, Hui Gao, Baolin Wang, Kun Huang, Xiaoyan Wu, Chunmei Liang, Shuangqin Yan, Yan Han, Peng Ding, Wei Wang, Sheng Wang, Peng Zhu, Kaiyong Liu, Yunxia Cao, Fangbiao Tao. Urinary tetracycline antibiotics exposure during pregnancy and maternal thyroid hormone parameters: A repeated measures study.
The Science of the total environment.
2022 Sep; 838(Pt 2):156146. doi:
10.1016/j.scitotenv.2022.156146. [PMID: 35605876] - Jia-Xin He, Hou-Qun Yuan, Yu-Fei Zhong, Xiong-Xin Peng, Yi-Fan Xia, Si-Yi Liu, Qing Fan, Jun-Lan Yang, Ke Deng, Xiao-Ying Wang, Guang-Ming Bao. A luminescent Eu3+-functionalized MOF for sensitive and rapid detection of tetracycline antibiotics in swine wastewater and pig kidney.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2022 Sep; 277(?):121252. doi:
10.1016/j.saa.2022.121252. [PMID: 35447556] - Phuong Thi Thu Nguyen, Ha Viet Pham, Dung Hoang Van, Linh Van Pham, Hoi Thanh Nguyen, Hung Van Nguyen. Randomized controlled trial of the relative efficacy of high-dose intravenous ceftriaxone and oral cefixime combined with doxycycline for the treatment of Chlamydia trachomatis and Neisseria gonorrhoeae co-infection.
BMC infectious diseases.
2022 Jul; 22(1):607. doi:
10.1186/s12879-022-07595-w. [PMID: 35810277] - Wei Gao, Fuquan Fang, Tianna J Xia, Yan Zhang, Jiehao Sun, Qiaolin Wu, Weijian Wang. Doxycycline can reduce glycocalyx shedding by inhibiting matrix metalloproteinases in patients undergoing cardiopulmonary bypass: A randomized controlled trial.
Microvascular research.
2022 07; 142(?):104381. doi:
10.1016/j.mvr.2022.104381. [PMID: 35588887] - Breanna M Scorza, Kurayi G Mahachi, Arin D Cox, Angela J Toepp, Danielle Pessoa-Pereira, Phyllis Tyrrell, Jesse Buch, Jennifer A Foltz, Dean Lee, Christine A Petersen. Role of NK-Like CD8+ T Cells during Asymptomatic Borrelia burgdorferi Infection.
Infection and immunity.
2022 05; 90(5):e0055521. doi:
10.1128/iai.00555-21. [PMID: 35416707] - Satish Kumar Sharma, Pankaj Bhatt, Syed Mohammed Basheeruddin Asdaq, Mohammed Kanan Alshammari, Abeer Alanazi, Naif Saleh Alrasheedi, Bader Abdullah Alrashdi, Saad Saleh Alyami, Bshayer Hamdan Alhazmi, Perwaiz Alam, Prerna Sharma, Ritu Tomar, Mandeep K Arora, Mohd Imran. Combined therapy with ivermectin and doxycycline can effectively alleviate the cytokine storm of COVID-19 infection amid vaccination drive: A narrative review.
Journal of infection and public health.
2022 May; 15(5):566-572. doi:
10.1016/j.jiph.2022.03.014. [PMID: 35462191] - Preetha Shridas, Ailing Ji, Andrea C Trumbauer, Victoria P Noffsinger, Steve W Leung, Adam J Dugan, Sean E Thatcher, Lisa A Cassis, Frederick C de Beer, Nancy R Webb, Lisa R Tannock. Adipocyte-Derived Serum Amyloid A Promotes Angiotensin II-Induced Abdominal Aortic Aneurysms in Obese C57BL/6J Mice.
Arteriosclerosis, thrombosis, and vascular biology.
2022 05; 42(5):632-643. doi:
10.1161/atvbaha.121.317225. [PMID: 35344382] - Volodymyr Volodymyrovych Bezruk, Igor Dmytrovych Shkrobanets, Oleksii Serhiiovych Godovanets, Oleksandr Hryhorovych Buriak, Olga Ivanivna Pervozvanska, Ludmila Mykhailivna Honcharuk, Nina Ivanivna Voytkevich, Olena Victorivna Makarova, Oksana Ivanivna Yurkiv, Michael Ivanovych Sheremet, Mykhailo Mykhailovich Hresko, Mariya Ivanivna Velia, Svyatoslava Vasylivna Yurniuk, Maryna Dmytrivna Hresko, Tetiana Sergiivna Bulyk, Larysa Vasylyvna Rynzhuk. Management of antibacterial therapy of infectious and inflammatory diseases of the urinary tract in children and regional peculiarities during the COVID-19 pandemic.
Journal of medicine and life.
2022 May; 15(5):617-619. doi:
10.25122/jml-2021-0293. [PMID: 35815078] - Manas Kumar Panigrahi, Hemanta Kumar Nayak, Subash Chandra Samal. A recent surge of doxycycline-induced pill esophagitis during the corona virus disease 2019 (COVID-19) pandemic.
Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology.
2022 04; 41(2):206-207. doi:
10.1007/s12664-021-01224-1. [PMID: 34994946] - Lu Ding, Yatian Cao, Huihui Li, Fuxiang Wang, Dong-Yu Guo, Weiting Yang, Qinhe Pan. A ratiometric fluorescence-scattering sensor for rapid, sensitive and selective detection of doxycycline in animal foodstuffs.
Food chemistry.
2022 Mar; 373(Pt B):131669. doi:
10.1016/j.foodchem.2021.131669. [PMID: 34863605] - Eugenia Sancho, Fabio Granados-Chinchilla, Elías Barquero-Calvo. Determination of streptomycin and doxycycline using LC/MS towards an effective treatment against an experimental Brucella abortus infection in mice.
Journal of microbiological methods.
2022 03; 194(?):106436. doi:
10.1016/j.mimet.2022.106436. [PMID: 35219705] - Haralampos Milionis, Konstantinos Kostikas. Is it prime time to consider a clinical trial of doxycycline for the management of COVID-19?.
Postgraduate medical journal.
2022 03; 98(e2):e107. doi:
10.1136/postgradmedj-2020-139358. [PMID: 35232857] - Yucong Fan, Weihua Yu, Yunwen Liao, Xiaohui Jiang, Zhonghua Wang, Zhengjun Cheng. Ratiometric detection of doxycycline in pharmaceutical based on dual ligands-enhanced copper nanoclusters.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2022 Feb; 267(Pt 1):120509. doi:
10.1016/j.saa.2021.120509. [PMID: 34688060] - Scott Marston, Gudrun Mirick Mueller, Arick Sabin, Glen T Hansen, Bruce Lindgren, Conrado Aparicio, Alexandra R Armstrong, Ole H Larsen, Andrew Schmidt, Richard Kyle, Ramon Gustilo, Dean Tsukayama, Joan Bechtold, Mats Bue. Systemic versus free antibiotic delivery in preventing acute exogenous implant related infection in a rat model.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society.
2022 02; 40(2):429-438. doi:
10.1002/jor.25052. [PMID: 33913540] - Karla E Merz, Jinhee Hwang, Chunxue Zhou, Rajakrishnan Veluthakal, Erika M McCown, Angelica Hamilton, Eunjin Oh, Wenting Dai, Patrick T Fueger, Lei Jiang, Janice M Huss, Debbie C Thurmond. Enrichment of the exocytosis protein STX4 in skeletal muscle remediates peripheral insulin resistance and alters mitochondrial dynamics via Drp1.
Nature communications.
2022 01; 13(1):424. doi:
10.1038/s41467-022-28061-w. [PMID: 35058456] - Kai-Ni Shen, Wei-Jun Fu, Yu Wu, Yu-Jun Dong, Zhong-Xia Huang, Yong-Qiang Wei, Chun-Rui Li, Chun-Yan Sun, Ye Chen, Hui-Lei Miao, Yue-Lun Zhang, Xin-Xin Cao, Dao-Bin Zhou, Jian Li. Doxycycline Combined With Bortezomib-Cyclophosphamide-Dexamethasone Chemotherapy for Newly Diagnosed Cardiac Light-Chain Amyloidosis: A Multicenter Randomized Controlled Trial.
Circulation.
2022 01; 145(1):8-17. doi:
10.1161/circulationaha.121.055953. [PMID: 34503349] - Selamawit Girma, Wondwossen Amogne. Investigating latent syphilis in HIV treatment-experienced Ethiopians and response to therapy.
PloS one.
2022; 17(7):e0270878. doi:
10.1371/journal.pone.0270878. [PMID: 35819944] - Elisabete Ferreira, Zaida L Almeida, Pedro F Cruz, Marta Silva E Sousa, Paula Veríssimo, Rui M M Brito. Searching for the Best Transthyretin Aggregation Protocol to Study Amyloid Fibril Disruption.
International journal of molecular sciences.
2021 Dec; 23(1):. doi:
10.3390/ijms23010391. [PMID: 35008816] - Linda My Huynh, Benjamin T Bonebrake, Dominick J DiMaio, Michael J Baine, Benjamin A Teply. Development of bullous pemphigoid following radiation therapy combined with nivolumab for renal cell carcinoma: A case report of abscopal toxicities.
Medicine.
2021 Dec; 100(49):e28199. doi:
10.1097/md.0000000000028199. [PMID: 34889301] - Jon Brandon Mullholand, Nathanial Tolman, Anna De Obaldia, Eileen Hennrikus. Central nervous system involvement of anaplasmosis.
BMJ case reports.
2021 Dec; 14(12):. doi:
10.1136/bcr-2021-243665. [PMID: 34880034] - Dolly Patel, Adeel Ahmad, Parth Maheshwari, Benjamin Bird, Adam Albert. Bacillus pumilus-Borne Food Poisoning in an Immunosuppressed Host.
The American journal of medicine.
2021 12; 134(12):e573-e574. doi:
10.1016/j.amjmed.2021.06.025. [PMID: 34297978] - Jeong Min Cho, Jeonghyun Chang, Dong-Min Kim, Yee Gyung Kwak, Chong Rae Cho, Je Eun Song. Human granulocytic anaplasmosis combined with rhabdomyolysis: a case report.
BMC infectious diseases.
2021 Nov; 21(1):1184. doi:
10.1186/s12879-021-06869-z. [PMID: 34823480] - Juliana Montenegro Parente, Marcela Maria Blascke de Mello, Pedro Henrique Leite da Silva, Ana Carolina Mieko Omoto, Laena Pernomian, Isadora Sousa de Oliveira, Zabed Mahmud, Rubens Fazan, Eliane Candiani Arantes, Richard Schulz, Michele Mazzaron de Castro. MMP inhibition attenuates hypertensive eccentric cardiac hypertrophy and dysfunction by preserving troponin I and dystrophin.
Biochemical pharmacology.
2021 11; 193(?):114744. doi:
10.1016/j.bcp.2021.114744. [PMID: 34453903] - Jesús A Mosquera-Sulbaran, Adriana Pedreañez, Yenddy Carrero, Diana Callejas. C-reactive protein as an effector molecule in Covid-19 pathogenesis.
Reviews in medical virology.
2021 11; 31(6):e2221. doi:
10.1002/rmv.2221. [PMID: 34773448] - Irene Sartini, Beata Łebkowska-Wieruszewska, Andrzej Lisowski, Amnart Poapolathep, Andrejs Sitovs, Mario Giorgi. Doxycycline pharmacokinetics in geese.
Journal of veterinary pharmacology and therapeutics.
2021 Nov; 44(6):975-981. doi:
10.1111/jvp.13002. [PMID: 34318509] - Gwendolyn E Wood, Nicole L Jensen, Sabina Astete, Jørgen S Jensen, George E Kenny, Christine M Khosropour, Catherine W Gillespie, Lisa E Manhart, Patricia A Totten. Azithromycin and Doxycycline Resistance Profiles of U.S. Mycoplasma genitalium Strains and Their Association with Treatment Outcomes.
Journal of clinical microbiology.
2021 10; 59(11):e0081921. doi:
10.1128/jcm.00819-21. [PMID: 34406799] - Apu Chowdhury, Muhammad Sajid, Nabila Jahan, Temitope Isaac Adelusi, Pulak Maitra, Guolian Yin, Xudong Wu, Yuan Gao, Sicen Wang. A secondary approach with conventional medicines and supplements to recuperate current COVID-19 status.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Oct; 142(?):111956. doi:
10.1016/j.biopha.2021.111956. [PMID: 34332377] - Ejaz Shah, Calvin Abro, Fawwad Zaidi, Ruchika Goel. Doxycycline-induced acquired haemophilia A.
BMJ case reports.
2021 Oct; 14(10):. doi:
10.1136/bcr-2021-244748. [PMID: 34598965] - Bo Wang, Jinsong Ao, Xiaoyan Li, Weimin Yu, Dan Yu, Chengjun Qiu. Doxycycline sensitizes renal cell carcinoma to chemotherapy by preferentially inhibiting mitochondrial translation.
The Journal of international medical research.
2021 Oct; 49(10):3000605211044368. doi:
10.1177/03000605211044368. [PMID: 34644207] - George P Allen, Kristina M Deao, Stephanie A Hill, Sandra M Schipelliti, Thomas Tran. In vitro evaluation of antimicrobial resistance selection in Neisseria gonorrhoeae.
International journal of antimicrobial agents.
2021 Oct; 58(4):106417. doi:
10.1016/j.ijantimicag.2021.106417. [PMID: 34391903] - Javid Hosseini, Mohammadreza Pourani, Reihaneh Mehregan, Mohammad-Mehdi Forouzanfar, Reza M Robati. Frequency of COVID-19 in acne patients treated with oral doxycycline: A retrospective cross-sectional comparative study.
Journal of cosmetic dermatology.
2021 Oct; 20(10):3062-3063. doi:
10.1111/jocd.14403. [PMID: 34416093] - Rodrigo R R Duarte, Dennis C Copertino, Luis P Iñiguez, Jez L Marston, Yaron Bram, Yuling Han, Robert E Schwartz, Shuibing Chen, Douglas F Nixon, Timothy R Powell. Identifying FDA-approved drugs with multimodal properties against COVID-19 using a data-driven approach and a lung organoid model of SARS-CoV-2 entry.
Molecular medicine (Cambridge, Mass.).
2021 09; 27(1):105. doi:
10.1186/s10020-021-00356-6. [PMID: 34503440] - Luisa Diomede, Sara Baroni, Ada De Luigi, Arianna Piotti, Jacopo Lucchetti, Claudia Fracasso, Luca Russo, Valerio Bonaldo, Nicolò Panini, Federica Filippini, Fabio Fiordaliso, Alessandro Corbelli, Marten Beeg, Massimo Pizzato, Francesca Caccuri, Marco Gobbi, Emiliano Biasini, Arnaldo Caruso, Mario Salmona. Doxycycline Inhibition of a Pseudotyped Virus Transduction Does Not Translate to Inhibition of SARS-CoV-2 Infectivity.
Viruses.
2021 09; 13(9):. doi:
10.3390/v13091745. [PMID: 34578326] - Ronan J J Chapuis, Joe S Smith, Fabienne D Uehlinger, Melissa Meachem, Ron Johnson, Patricia M Dowling. Pharmacokinetics and pharmacodynamics of doxycycline in a Streptococcusequi subsp. zooepidemicus infection model in horses.
Journal of veterinary pharmacology and therapeutics.
2021 Sep; 44(5):766-775. doi:
10.1111/jvp.12982. [PMID: 34057219] - Christopher C Butler, Ly-Mee Yu, Jienchi Dorward, Oghenekome Gbinigie, Gail Hayward, Benjamin R Saville, Oliver Van Hecke, Nicholas Berry, Michelle A Detry, Christina Saunders, Mark Fitzgerald, Victoria Harris, Ratko Djukanovic, Stephan Gadola, John Kirkpatrick, Simon de Lusignan, Emma Ogburn, Philip H Evans, Nicholas P B Thomas, Mahendra G Patel, F D Richard Hobbs. Doxycycline for community treatment of suspected COVID-19 in people at high risk of adverse outcomes in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial.
The Lancet. Respiratory medicine.
2021 09; 9(9):1010-1020. doi:
10.1016/s2213-2600(21)00310-6. [PMID: 34329624] - Iñaki Robles-Vera, Néstor de la Visitación, Marta Toral, Manuel Sánchez, Miguel Romero, Manuel Gómez-Guzmán, Félix Vargas, Juan Duarte, Rosario Jiménez. Changes in Gut Microbiota Induced by Doxycycline Influence in Vascular Function and Development of Hypertension in DOCA-Salt Rats.
Nutrients.
2021 Aug; 13(9):. doi:
10.3390/nu13092971. [PMID: 34578849] - Yasaman Shamshirgaran, Anna Jonebring, Anna Svensson, Isabelle Leefa, Mohammad Bohlooly-Y, Mike Firth, Kevin J Woollard, Alexis Hofherr, Ian M Rogers, Ryan Hicks. Rapid target validation in a Cas9-inducible hiPSC derived kidney model.
Scientific reports.
2021 08; 11(1):16532. doi:
10.1038/s41598-021-95986-5. [PMID: 34400685] - Lu Ding, Yanyu Zhao, Huihui Li, Qiujuan Zhang, Weiting Yang, Bo Fu, Qinhe Pan. A highly selective ratiometric fluorescent probe for doxycycline based on the sensitization effect of bovine serum albumin.
Journal of hazardous materials.
2021 08; 416(?):125759. doi:
10.1016/j.jhazmat.2021.125759. [PMID: 33831705] - Qing Hao Miow, Andres F Vallejo, Yu Wang, Jia Mei Hong, Chen Bai, Felicia Sw Teo, Alvin Dy Wang, Hong Rong Loh, Tuan Zea Tan, Ying Ding, Hoi Wah She, Suay Hong Gan, Nicholas I Paton, Josephine Lum, Alicia Tay, Cynthia Be Chee, Paul A Tambyah, Marta E Polak, Yee Tang Wang, Amit Singhal, Paul T Elkington, Jon S Friedland, Catherine Wm Ong. Doxycycline host-directed therapy in human pulmonary tuberculosis.
The Journal of clinical investigation.
2021 08; 131(15):. doi:
10.1172/jci141895. [PMID: 34128838] - Timo Sorsa, Vaibhav Sahni, Nurcan Buduneli, Shipra Gupta, Ismo T Räisänen, Lorne M Golub, Hsi-Ming Lee, Tommi Pätilä, Nagihan Bostanci, Jukka Meurman, Pirjo Pärnänen, Solomon O Nwhator, Mohita Singla, Krishan Gauba. Active matrix metalloproteinase-8 (aMMP-8) point-of-care test (POCT) in the COVID-19 pandemic.
Expert review of proteomics.
2021 08; 18(8):707-717. doi:
10.1080/14789450.2021.1976151. [PMID: 34468272] - Paula A Soeiro, Mayara A Romanelli, Marcelo O Cesar, Pâmella D Nogueira-Souza, Marcos Monteiro-Machado, Simone S C Oliveira, André L S Santos, Paulo A Melo, Lucienne S Lara. Doxycycline treatment reestablishes renal function of Wistar rats in experimental envenomation with Bothrops jararacussu venom.
Toxicon : official journal of the International Society on Toxinology.
2021 Aug; 199(?):20-30. doi:
10.1016/j.toxicon.2021.05.008. [PMID: 34058237] - Lekshmi Narendrakumar, Iype Joseph, Sabu Thomas. Potential effectiveness and adverse implications of repurposing doxycycline in COVID-19 treatment.
Expert review of anti-infective therapy.
2021 08; 19(8):1001-1008. doi:
10.1080/14787210.2021.1865803. [PMID: 33322952] - Marouf Alhalabi, Mohammed Waleed Alassi, Kamal Alaa Eddin, Khaled Cheha. Efficacy of two-week therapy with doxycycline-based quadruple regimen versus levofloxacin concomitant regimen for helicobacter pylori infection: a prospective single-center randomized controlled trial.
BMC infectious diseases.
2021 Jul; 21(1):642. doi:
10.1186/s12879-021-06356-5. [PMID: 34218802] - Tom Y Zhao, Neelesh A Patankar. Tetracycline as an inhibitor to the SARS-CoV-2.
Journal of cellular biochemistry.
2021 07; 122(7):752-759. doi:
10.1002/jcb.29909. [PMID: 33619758] - Nicolò Girometti, Muhammad H Junejo, Diarmuid Nugent, Alan McOwan, Gary Whitlock. Clinical and serological outcomes in patients treated with oral doxycycline for early neurosyphilis.
The Journal of antimicrobial chemotherapy.
2021 06; 76(7):1916-1919. doi:
10.1093/jac/dkab100. [PMID: 33783506] - Hubert J Sijben, Wieke M van Oostveen, Peter B R Hartog, Laura Stucchi, Andrea Rossignoli, Giovanna Maresca, Lia Scarabottolo, Adriaan P IJzerman, Laura H Heitman. Label-free high-throughput screening assay for the identification of norepinephrine transporter (NET/SLC6A2) inhibitors.
Scientific reports.
2021 06; 11(1):12290. doi:
10.1038/s41598-021-91700-7. [PMID: 34112854] - Yasemin Cag, Haluk Vahaboglu. A novel approach to managing COVID-19 patients: results of lopinavir plus doxycycline cohort-authors' reply.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.
2021 06; 40(6):1351-1352. doi:
10.1007/s10096-020-04099-w. [PMID: 33439342] - Keiji Kuroda, Satoru Takamizawa, Hiroshi Motoyama, Ryo Tsutsumi, Rie Sugiyama, Koji Nakagawa, Rikikazu Sugiyama, Yasushi Kuribayashi. Analysis of the therapeutic effects of hysteroscopic polypectomy with and without doxycycline treatment on chronic endometritis with endometrial polyps.
American journal of reproductive immunology (New York, N.Y. : 1989).
2021 06; 85(6):e13392. doi:
10.1111/aji.13392. [PMID: 33501741] - Subhrojyoti Bhowmick, Amit Dang, B N Vallish, Sumit Dang. Safety and Efficacy of Ivermectin and Doxycycline Monotherapy and in Combination in the Treatment of COVID-19: A Scoping Review.
Drug safety.
2021 06; 44(6):635-644. doi:
10.1007/s40264-021-01066-y. [PMID: 33864232] - Reaz Mahmud, Md Mujibur Rahman, Iftikher Alam, Kazi Gias Uddin Ahmed, A K M Humayon Kabir, S K Jakaria Been Sayeed, Mohammad Aftab Rassel, Farhana Binte Monayem, Md Shahidul Islam, Mohammad Monirul Islam, Anindita Das Barshan, Mohammad Mahfuzul Hoque, Md Uzzal Mallik, Mohammad Abdullah Yusuf, Mohammad Zaid Hossain. Ivermectin in combination with doxycycline for treating COVID-19 symptoms: a randomized trial.
The Journal of international medical research.
2021 May; 49(5):3000605211013550. doi:
10.1177/03000605211013550. [PMID: 33983065] - Dan-Dan Zhang, Xin-Peng Duan, Yu Xiao, Peng Wu, Zhong-Xiuzi Gao, Wen-Hui Wang, Dao-Hong Lin. Deletion of renal Nedd4-2 abolishes the effect of high sodium intake (HS) on Kir4.1, ENaC, and NCC and causes hypokalemia during high HS.
American journal of physiology. Renal physiology.
2021 05; 320(5):F883-F896. doi:
10.1152/ajprenal.00555.2020. [PMID: 33818128] - Sayonee Das, Sidhartha Chattopadhyay, Kausik Munsi, Sagar Basu. Scrub typhus with cerebral venous sinus thrombosis: a rare presentation.
BMJ case reports.
2021 Apr; 14(4):. doi:
10.1136/bcr-2020-241401. [PMID: 33910803] - Elisa Kortela, Mari J Kanerva, Juha Puustinen, Saija Hurme, Laura Airas, Anneli Lauhio, Ulla Hohenthal, Päivi Jalava-Karvinen, Tuomas Nieminen, Taru Finnilä, Tony Häggblom, Annukka Pietikäinen, Mari Koivisto, Johanna Vilhonen, Minna Marttila-Vaara, Jukka Hytönen, Jarmo Oksi. Oral Doxycycline Compared to Intravenous Ceftriaxone in the Treatment of Lyme Neuroborreliosis: A Multicenter, Equivalence, Randomized, Open-label Trial.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2021 04; 72(8):1323-1331. doi:
10.1093/cid/ciaa217. [PMID: 32133487] - Parthasarathi Bhattacharyya, Brajesh Singh, Surita Sarkar, Soumen Kumar Das, Bodhisattwa Chakraborty, Dipanjan Saha, Kumar Chakraborty, Indranil Saha, Koel Chaudhury. Impact of long-term doxycycline on lung function & exacerbations: A real-world open, prospective pilot observation on chronic obstructive pulmonary disease.
The Indian journal of medical research.
2021 Apr; 153(4):465-474. doi:
10.4103/ijmr.ijmr_1254_18. [PMID: 34380793] - Andrea Dean, Rathi Asaithambi, Hannah C Neubauer. Murine Typhus in 5 Children Hospitalized for Multisystem Inflammatory Syndrome in Children.
Hospital pediatrics.
2021 Apr; 11(4):e61-e65. doi:
10.1542/hpeds.2020-005652. [PMID: 33431429] - Hayder M Al-Kuraishy, Ali I Al-Gareeb, Naeem Qusty, Natália Cruz-Martins, Gaber El-Saber Batiha. Sequential doxycycline and colchicine combination therapy in Covid-19: The salutary effects.
Pulmonary pharmacology & therapeutics.
2021 04; 67(?):102008. doi:
10.1016/j.pupt.2021.102008. [PMID: 33727066] - Masashi Ohe, Ken Furuya, Houman Goudarzi. Multidrug treatment for COVID-19.
Drug discoveries & therapeutics.
2021 Mar; 15(1):39-41. doi:
10.5582/ddt.2021.01005. [PMID: 33612572] - Martina Montinari, Laura Atzori, Sefora Valdevit, Franco Rongioletti. Erythema annulare centrifugum with anosmia and ageusia in a SARS-CoV-2 exposed patient successfully treated with doxycycline.
International journal of dermatology.
2021 Mar; 60(3):384-386. doi:
10.1111/ijd.15356. [PMID: 33368328] - Marta Jerez-Peña, Borja Salvador-Culla, María F de la Paz, Rafael I Barraquer. Bilateral Boston keratoprosthesis type 1 in a case of severe Mooren's ulcer.
European journal of ophthalmology.
2021 Mar; 31(2):NP33-NP38. doi:
10.1177/1120672120909768. [PMID: 32141311] - Ziling Zeng, Chunjuan Wang, Cuicui Liu, Baojie Wang, Xin Meng, Yan Chen, Shougang Guo. Follow-up of a Rickettsia felis encephalitis: Some new insights into clinical and imaging features.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2021 Mar; 104(?):300-302. doi:
10.1016/j.ijid.2020.12.090. [PMID: 33444751] - Banu Cakir. A novel approach to managing COVID-19 patients; results of lopinavir plus doxycycline cohort.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.
2021 03; 40(3):663-664. doi:
10.1007/s10096-020-04112-2. [PMID: 33415491] - Evan S Morrison, Shenbagam Dewar. Case Report: Limitations of Virtual Care in Older Adults with Functional and Cognitive Impairment.
American family physician.
2021 02; 103(4):201. doi:
NULL. [PMID: 33587583] - Yasemin Cag, Sacit Icten, Burcu Isik-Goren, Naciye Betul Baysal, Begum Bektas, Ece Selvi, Pinar Ergen, Ozlem Aydin, Ayse Canan Ucisik, Fatma Yilmaz-Karadag, Hulya Caskurlu, Tulin Akarsu-Ayazoglu, Hasan Kocoglu, Sinan Uzman, Muge Nural-Pamukcu, Ferhat Arslan, Gurhan Bas, Mahmut Tayyar Kalcioglu, Haluk Vahaboglu. A novel approach to managing COVID-19 patients; results of lopinavir plus doxycycline cohort.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.
2021 Feb; 40(2):407-411. doi:
10.1007/s10096-020-04016-1. [PMID: 32856202] - Giulia Barlozzari, Federico Romiti, Maurizio Zini, Adele Magliano, Claudio De Liberato, Franco Corrias, Guglielmo Capponi, Luisa Galli, Manuela Scarpulla, Carlotta Montagnani. Scalp eschar and neck lymphadenopathy by Rickettsia slovaca after Dermacentor marginatus tick bite case report: multidisciplinary approach to a tick-borne disease.
BMC infectious diseases.
2021 Jan; 21(1):103. doi:
10.1186/s12879-021-05807-3. [PMID: 33482743] - Sujata Devi, Sudipta Mohakud, Nilanjan Kar, Divya Muthuvel. Deep vein thrombosis with pulmonary thromboembolism in a case of severe COVID-19 pneumonia.
BMJ case reports.
2021 Jan; 14(1):. doi:
10.1136/bcr-2020-240932. [PMID: 33452066] - Alexandre Elias Malek, Bruno P Granwehr. Doxycycline as an Alternative to Azithromycin in Elderly Patients.
International journal of antimicrobial agents.
2021 Jan; 57(1):106168. doi:
10.1016/j.ijantimicag.2020.106168. [PMID: 33408018] - Zorana Milanović, Drina Janković, Sanja Vranješ-Đurić, Magdalena Radović, Željko Prijović, Gordana Zavišić, Marko Perić, Dalibor Stanković, Marija Mirković. 177Lu-doxycycline as potential radiopharmaceutical: electrochemical characterization, radiolabeling, and biodistribution in tumor-bearing mice.
International journal of radiation biology.
2021; 97(12):1687-1695. doi:
10.1080/09553002.2021.1976864. [PMID: 34473599] - Yu Wang, Ying Wen. An AIDS Patient with Recurrent Multiple Skin Crusted Ulcerations.
AIDS research and human retroviruses.
2021 01; 37(1):1-3. doi:
10.1089/aid.2020.0212. [PMID: 32981329] - Evangelia M Stavroulaki, Jan S Suchodolski, Rachel Pilla, Geoffrey T Fosgate, Chi-Hsuan Sung, Jonathan A Lidbury, Jörg M Steiner, Panagiotis G Xenoulis. Short- and long-term effects of amoxicillin/clavulanic acid or doxycycline on the gastrointestinal microbiome of growing cats.
PloS one.
2021; 16(12):e0253031. doi:
10.1371/journal.pone.0253031. [PMID: 34910719] - Michael Moser, Sarah Schmid, Katherine Sawicka, Tamalina Banerjee, Erick McNair, Jolanta Sawicka, Iwona Bil-Lula, Grzegorz Sawicki. Pre-arrest doxycycline protects donation after circulatory death kidneys.
Scientific reports.
2020 12; 10(1):22272. doi:
10.1038/s41598-020-79440-6. [PMID: 33335249] - Jarrod P Hulme-Jones, David L Gordon, Jeffrey A Barbara, Jordan Y Li. Mycoplasma hominis bursitis in a simultaneous pancreas-kidney transplant recipient: case report and literature review.
Transplant infectious disease : an official journal of the Transplantation Society.
2020 Dec; 22(6):e13392. doi:
10.1111/tid.13392. [PMID: 32603519] - Richard J Bagshaw, Alexandra G A Stewart, Simon Smith, Angus W Carter, Josh Hanson. The Characteristics and Clinical Course of Patients with Scrub Typhus and Queensland Tick Typhus Infection Requiring Intensive Care Unit Admission: A 23-year Case Series from Queensland, Tropical Australia.
The American journal of tropical medicine and hygiene.
2020 12; 103(6):2472-2477. doi:
10.4269/ajtmh.20-0780. [PMID: 32959771] - Jørgen Skov Jensen, Christina Nørgaard, Nicole Scangarella-Oman, Magnus Unemo. In vitro activity of the first-in-class triazaacenaphthylene gepotidacin alone and in combination with doxycycline against drug-resistant and -susceptible Mycoplasma genitalium.
Emerging microbes & infections.
2020 Dec; 9(1):1388-1392. doi:
10.1080/22221751.2020.1775498. [PMID: 32552547] - Ibrahim Ozan Tekeli, Erdinc Turk, Duygu Durna Corum, Orhan Corum, Fatma Ceren Kirgiz, Kamil Uney. Pharmacokinetics, bioavailability and tissue residues of doxycycline in Japanese quails (Coturnix coturnix japonica) after oral administration.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.
2020 Dec; 37(12):2082-2092. doi:
10.1080/19440049.2020.1825827. [PMID: 33066710] - Hemesh Mahesh Patel. Murine typhus mistaken for COVID-19 in a young man.
BMJ case reports.
2020 Nov; 13(11):. doi:
10.1136/bcr-2020-239471. [PMID: 33148588] - Kerry A Morrone, Kaitlin Strumph, Mark J Liszewski, Jenai Jackson, Michael L Rinke, Ellen J Silver, Caterina Minniti, Jennifer Davila, William B Mitchell, Deepa Manwani. Acute chest syndrome in the setting of SARS-COV-2 infections-A case series at an urban medical center in the Bronx.
Pediatric blood & cancer.
2020 11; 67(11):e28579. doi:
10.1002/pbc.28579. [PMID: 32893954] - Győző Szolnoky. Further aspects of doxycycline therapy in COVID-19.
Dermatologic therapy.
2020 11; 33(6):e13810. doi:
10.1111/dth.13810. [PMID: 32533795] - Edoardo Francini, Salvatora T Miano, Anna I Fiaschi, Guido Francini. Doxycycline or minocycline may be a viable treatment option against SARS-CoV-2.
Medical hypotheses.
2020 11; 144(?):110054. doi:
10.1016/j.mehy.2020.110054. [PMID: 32758890] - Chinar Osman, Liam S Carroll, Christina Petridou, Mark Walker, Louis W Merton, Haider Katifi. Mononeuritis multiplex secondary to Lyme neuroborreliosis.
Ticks and tick-borne diseases.
2020 11; 11(6):101545. doi:
10.1016/j.ttbdis.2020.101545. [PMID: 32993951] - Ömer Faruk Elmas, Abdullah Demirbaş, Ümit Türsen, Mustafa Atasoy, Torello Lotti. Pemphigus and COVID-19: Critical overview of management with a focus on treatment choice.
Dermatologic therapy.
2020 11; 33(6):e14265. doi:
10.1111/dth.14265. [PMID: 32882079] - Mathieu Gendrot, Julien Andreani, Priscilla Jardot, Sébastien Hutter, Océane Delandre, Manon Boxberger, Joel Mosnier, Marion Le Bideau, Isabelle Duflot, Isabelle Fonta, Clara Rolland, Hervé Bogreau, Bernard La Scola, Bruno Pradines. In Vitro Antiviral Activity of Doxycycline against SARS-CoV-2.
Molecules (Basel, Switzerland).
2020 Oct; 25(21):. doi:
10.3390/molecules25215064. [PMID: 33142770] - Noelia Cambeiro-Pérez, Xiana González-Gómez, Ledicia Rey-Salgueiro, Jesús Simal-Gándara, Elena Martínez-Carballo. Rapid liquid chromatographic method for the control of doxycycline and tiamulin residues and their metabolites in vivo assays with pigs: Treatment and depletion.
Journal of pharmaceutical and biomedical analysis.
2020 Oct; 190(?):113428. doi:
10.1016/j.jpba.2020.113428. [PMID: 32739650] - Pravallika Chadalavada, C Roberto Simons-Linares, Prabhleen Chahal. Drug-induced acute pancreatitis: Prevalence, Causative agents, and Outcomes.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].
2020 Oct; 20(7):1281-1286. doi:
10.1016/j.pan.2020.07.401. [PMID: 32878711] - Waleed Hassan, Manish Talwar, Vasanthi Balaraman, Miklos Z Molnar. Ehrlichiosis infection mimicking thrombotic microangiopathy syndrome early after kidney transplantation.
Transplant infectious disease : an official journal of the Transplantation Society.
2020 Oct; 22(5):e13305. doi:
10.1111/tid.13305. [PMID: 32358827] - Cheryl Sachdeva, Anju Wadhwa, Anita Kumari, Firasat Hussain, Preeti Jha, Naveen K Kaushik. In silico Potential of Approved Antimalarial Drugs for Repurposing Against COVID-19.
Omics : a journal of integrative biology.
2020 10; 24(10):568-580. doi:
10.1089/omi.2020.0071. [PMID: 32757981] - Deep Bhowmik, Rajat Nandi, Rahul Jagadeesan, Niranjan Kumar, Amresh Prakash, Diwakar Kumar. Identification of potential inhibitors against SARS-CoV-2 by targeting proteins responsible for envelope formation and virion assembly using docking based virtual screening, and pharmacokinetics approaches.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases.
2020 10; 84(?):104451. doi:
10.1016/j.meegid.2020.104451. [PMID: 32640381] - Paweł Brzewski, Maria Kwiecińska, Joanna Sułowicz, Katarzyna Podolec, Aleksander Obtułowicz, Grzegorz Dyduch, Anna Wojas-Pelc. Bacillary Angiomatosis in Renal Transplant Recipient: A Case Report.
Transplantation proceedings.
2020 Oct; 52(8):2524-2526. doi:
10.1016/j.transproceed.2020.02.092. [PMID: 32334794] - A A Khryanin, V G Sturov. [Evaluation of the influence of systemic enzyme therapy on immune reactions in genitourinary chlamydia infection].
Urologiia (Moscow, Russia : 1999).
2020 Sep; ?(4):36-44. doi:
10.18565/urology.2020.4.36-44. [PMID: 32897012] - Mayssa Abdel Hady, Ossama M Sayed, Mohamed A Akl. Brain uptake and accumulation of new levofloxacin-doxycycline combination through the use of solid lipid nanoparticles: Formulation; Optimization and in-vivo evaluation.
Colloids and surfaces. B, Biointerfaces.
2020 Sep; 193(?):111076. doi:
10.1016/j.colsurfb.2020.111076. [PMID: 32408259] - Molly D Savadelis, Amanda E Coleman, Gregg S Rapoport, Ajay Sharma, Kaori Sakamoto, Deborah A Keys, Cameon M Ohmes, Joe A Hostetler, Michael T Dzimianski, Andrew R Moorhead. Clinical assessment of heartworm-infected Beagles treated with a combination of imidacloprid/moxidectin and doxycycline, or untreated.
Journal of veterinary internal medicine.
2020 Sep; 34(5):1734-1745. doi:
10.1111/jvim.15853. [PMID: 32691900] - Binta Sultan, Paul Benn, Gabriel Schembri, Hemanti Patel, Nataliya Brima, Sarah Alexander, Catherine A Ison. Test of cure study: a feasibility study to estimate the time to test of cure (TOC) for Neisseria gonorrhoeae and Chlamydia trachomatis infections.
Sexually transmitted infections.
2020 09; 96(6):402-407. doi:
10.1136/sextrans-2019-054302. [PMID: 32447324] - Stephan Grabbe, Stefan Beissert, Alexander Enk. Systemic immunosuppression in times of COVID-19: Do we need to rethink our standards?.
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG.
2020 08; 18(8):810-813. doi:
10.1111/ddg.14194. [PMID: 32743938] - Ewelina Patyra, Krzysztof Kwiatek, Carolina Nebot, Rosa Elvira Gavilán. Quantification of Veterinary Antibiotics in Pig and Poultry Feces and Liquid Manure as a Non-Invasive Method to Monitor Antibiotic Usage in Livestock by Liquid Chromatography Mass-Spectrometry.
Molecules (Basel, Switzerland).
2020 Jul; 25(14):. doi:
10.3390/molecules25143265. [PMID: 32709030] - Yuval Ramot, Shlomo Nedvetzki, Sefi Rosenfeld, Serge D Rousselle, Abraham Nyska, Noam Emanuel. D-PLEX100 in an Abdominal Surgery Incision Model in Miniature Swine: Safety Study.
Toxicologic pathology.
2020 07; 48(5):677-685. doi:
10.1177/0192623320928902. [PMID: 32525456] - Bernardo Guevara, Asha Gupta Cogdill. Helicobacter pylori: A Review of Current Diagnostic and Management Strategies.
Digestive diseases and sciences.
2020 07; 65(7):1917-1931. doi:
10.1007/s10620-020-06193-7. [PMID: 32170476] - Claudio Conforti, Roberta Giuffrida, Iris Zalaudek, Nicola Di Meo. Doxycycline, a widely used antibiotic in dermatology with a possible anti-inflammatory action against IL-6 in COVID-19 outbreak.
Dermatologic therapy.
2020 Jul; 33(4):e13437. doi:
10.1111/dth.13437. [PMID: 32314492] - Ahmed Farouk, Samar Salman. Dapsone and doxycycline could be potential treatment modalities for COVID-19.
Medical hypotheses.
2020 07; 140(?):109768. doi:
10.1016/j.mehy.2020.109768. [PMID: 32339778] - Anasuya Patel, Hemant Khande, Hariharan Periasamy, Santosh Mokale. Immunomodulatory Effect of Doxycycline Ameliorates Systemic and Pulmonary Inflammation in a Murine Polymicrobial Sepsis Model.
Inflammation.
2020 Jun; 43(3):1035-1043. doi:
10.1007/s10753-020-01188-y. [PMID: 31955291] - Joseph M Blondeau, Shantelle D Fitch. In vitro killing of canine strains of Staphylococcus pseudintermedius and Escherichia coli by cefazolin, cefovecin, doxycycline and pradofloxacin over a range of bacterial densities.
Veterinary dermatology.
2020 Jun; 31(3):187-e39. doi:
10.1111/vde.12835. [PMID: 31825131]