HA14-1 (BioDeep_00000693619)
代谢物信息卡片
化学式: C17H17BrN2O5 (408.0320772)
中文名称: HA14-1
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCOC(=O)C1=C(OC2=C(C1C(C#N)C(=O)OCC)C=C(C=C2)Br)N
InChI: InChI=1S/C17H17BrN2O5/c1-3-23-16(21)11(8-19)13-10-7-9(18)5-6-12(10)25-15(20)14(13)17(22)24-4-2/h5-7,11,13H,3-4,20H2,1-2H3
描述信息
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Kishu Ranjan, Anupama Sharma, Avadhesha Surolia, Chandramani Pathak. Regulation of HA14-1 mediated oxidative stress, toxic response, and autophagy by curcumin to enhance apoptotic activity in human embryonic kidney cells.
BioFactors (Oxford, England).
2014 Jan; 40(1):157-69. doi:
10.1002/biof.1098. [PMID: 23559532] - Hai-Dong Xu, Dan Wu, Jin-Hua Gu, Jian-Bin Ge, Jun-Chao Wu, Rong Han, Zhong-Qin Liang, Zheng-Hong Qin. The pro-survival role of autophagy depends on Bcl-2 under nutrition stress conditions.
PloS one.
2013; 8(5):e63232. doi:
10.1371/journal.pone.0063232. [PMID: 23658815] - Rui Zhao, Yonghua Xie, Ying Tan, Chunyan Tan, Yuyang Jiang. Binding of a bcl-2 family inhibitor to bovine serum albumin: fluorescence quenching and molecular docking study.
Protein and peptide letters.
2012 Sep; 19(9):949-54. doi:
10.2174/092986612802084401. [PMID: 22486616] - Heather M Wilkins, Kristin Marquardt, Lawrence H Lash, Daniel A Linseman. Bcl-2 is a novel interacting partner for the 2-oxoglutarate carrier and a key regulator of mitochondrial glutathione.
Free radical biology & medicine.
2012 Jan; 52(2):410-9. doi:
10.1016/j.freeradbiomed.2011.10.495. [PMID: 22115789] - S A Malik, I Orhon, E Morselli, A Criollo, S Shen, G Mariño, A BenYounes, P Bénit, P Rustin, M C Maiuri, G Kroemer. BH3 mimetics activate multiple pro-autophagic pathways.
Oncogene.
2011 Sep; 30(37):3918-29. doi:
10.1038/onc.2011.104. [PMID: 21460857] - M Weyland, F Manero, A Paillard, D Grée, G Viault, D Jarnet, P Menei, P Juin, I Chourpa, J-P Benoit, R Grée, E Garcion. Mitochondrial targeting by use of lipid nanocapsules loaded with SV30, an analogue of the small-molecule Bcl-2 inhibitor HA14-1.
Journal of controlled release : official journal of the Controlled Release Society.
2011 Apr; 151(1):74-82. doi:
10.1016/j.jconrel.2010.11.032. [PMID: 21138749] - David Kessel, Michael Price, John J Reiners. The Bcl-2 antagonist HA14-1 forms a fluorescent albumin complex that can be mistaken for several oxidized ROS probes.
Photochemistry and photobiology.
2008 Sep; 84(5):1272-6. doi:
10.1111/j.1751-1097.2008.00371.x. [PMID: 18513234] - Yaming Su, Xiaoping Zhang, Patrick J Sinko. Exploitation of drug-induced Bcl-2 overexpression for restoring normal apoptosis function: a promising new approach to the treatment of multidrug resistant cancer.
Cancer letters.
2007 Aug; 253(1):115-23. doi:
10.1016/j.canlet.2007.01.018. [PMID: 17349740]