Acifran (BioDeep_00000693612)

   


代谢物信息卡片


Acifran

化学式: C12H10O4 (218.057906)
中文名称: 阿西弗兰
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1(C(=O)C=C(O1)C(=O)O)C2=CC=CC=C2
InChI: InChI=1S/C12H10O4/c1-12(8-5-3-2-4-6-8)10(13)7-9(16-12)11(14)15/h2-7H,1H3,(H,14,15)

描述信息

C78276 - Agent Affecting Digestive System or Metabolism > C29703 - Antilipidemic Agent > C98151 - Niacin-based Antilipidemic Agent

同义名列表

1 个代谢物同义名

Acifran



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Dominique Maciejewski-Lenoir, Jeremy G Richman, Yaron Hakak, Ibragim Gaidarov, Dominic P Behan, Daniel T Connolly. Langerhans cells release prostaglandin D2 in response to nicotinic acid. The Journal of investigative dermatology. 2006 Dec; 126(12):2637-46. doi: 10.1038/sj.jid.5700586. [PMID: 17008871]
  • Keyvan Mahboubi, Terri Witman-Jones, Jean E Adamus, Jack T Letsinger, Darren Whitehouse, Allan R Moorman, Diane Sawicki, Nils Bergenhem, Stuart A Ross. Triglyceride modulation by acifran analogs: activity towards the niacin high and low affinity G protein-coupled receptors HM74A and HM74. Biochemical and biophysical research communications. 2006 Feb; 340(2):482-90. doi: 10.1016/j.bbrc.2005.12.022. [PMID: 16389067]
  • Andrew K P Taggart, Jukka Kero, Xiaodong Gan, Tian-Quan Cai, Kang Cheng, Marc Ippolito, Ning Ren, Rebecca Kaplan, Kenneth Wu, Tsuei-Ju Wu, Lan Jin, Chen Liaw, Ruoping Chen, Jeremy Richman, Daniel Connolly, Stefan Offermanns, Samuel D Wright, M Gerard Waters. (D)-beta-Hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G. The Journal of biological chemistry. 2005 Jul; 280(29):26649-52. doi: 10.1074/jbc.c500213200. [PMID: 15929991]
  • Nicholas B Pike, Alan Wise. Identification of a nicotinic acid receptor: is this the molecular target for the oldest lipid-lowering drug?. Current opinion in investigational drugs (London, England : 2000). 2004 Mar; 5(3):271-5. doi: ". [PMID: 15083592]
  • R A Cercós-del-Pozo, F Pérez-Giménez, J Gálvez-Alvarez, M T Salabert-Salvador, F J Garcia-March, G M Antón-Fos. Correlation of pharmacological properties of a group of hypolipaemic drugs by molecular topology. The Journal of pharmacy and pharmacology. 1996 Mar; 48(3):240-4. doi: 10.1111/j.2042-7158.1996.tb05909.x. [PMID: 8737046]
  • M N Cayen, E S Ferdinandi, D R Hicks, R Gonzalez, L Cosyns, J Dubuc, M Kraml, K D Edwards. Pharmacokinetics and disposition of the lipid-lowering drug acifran in normal subjects and in patients with renal failure. Clinical pharmacology and therapeutics. 1990 Jan; 47(1):50-6. doi: 10.1038/clpt.1990.7. [PMID: 2295219]
  • J C LaRosa, V T Miller, K D Edwards, M R DeBovis, D B Stoy. Acifran: a double-blind, randomized, placebo-controlled efficacy study in type IIa hyperlipoproteinemic patients. Artery. 1987; 14(6):338-50. doi: NULL. [PMID: 3314798]
  • M N Cayen, R Gonzalez, E S Ferdinandi, E Greselin, D R Hicks, M Kraml, D Dvornik. The metabolic disposition of acifran, a new antihyperlipidemic agent, in rats and dogs. Xenobiotica; the fate of foreign compounds in biological systems. 1986 Mar; 16(3):251-63. doi: 10.3109/00498258609043528. [PMID: 3705621]
  • D B Hunninghake, K D Edwards, G S Sopko, R L Tosiello. Controlled trial of acifran in type II hyperlipoproteinemia. Clinical pharmacology and therapeutics. 1985 Sep; 38(3):313-7. doi: 10.1038/clpt.1985.177. [PMID: 4028627]
  • R Gonzalez, D Thibeault. A liquid chromatographic method for the determination of AY-25,712, a lipid-lowering agent, in serum. Clinical biochemistry. 1983 Aug; 16(4):244-8. doi: 10.1016/s0009-9120(83)90112-1. [PMID: 6616810]
  • M A Kallai-Sanfacon, M N Cayen, J Dubuc, E Greselin, D Dvornik. Effect of AY-25,712 and other lipid-lowering agents on liver catalase and liver carnitine acetyltransferase in rats. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1983 Jul; 173(3):367-71. doi: 10.3181/00379727-173-41658. [PMID: 6867010]
  • M N Cayen, M A Kallai-Sanfacon, J Dubuc, E Greselin, D Dvornik. Effect of AY-25,712 on fatty acid metabolism in rats. Atherosclerosis. 1982 Dec; 45(3):281-90. doi: 10.1016/0021-9150(82)90229-5. [PMID: 7159499]
  • M N Cayen, M A Kallai-Sanfacon, J Dubuc, E Greselin, D Dvornik. Evaluation of the lipid-lowering activity of AY-25,712 in rats. Atherosclerosis. 1982 Dec; 45(3):267-79. doi: 10.1016/0021-9150(82)90228-3. [PMID: 6818976]