L 701324 (BioDeep_00000693605)

   


代谢物信息卡片


7-chloro-4-hydroxy-3-(3-phenoxyphenyl)quinolin-2(1H)-one

化学式: C21H14ClNO3 (363.06621640000003)
中文名称: L-701324
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C(C=C1)OC2=CC=CC(=C2)C3=C(C4=C(C=C(C=C4)Cl)NC3=O)O
InChI: InChI=1S/C21H14ClNO3/c22-14-9-10-17-18(12-14)23-21(25)19(20(17)24)13-5-4-8-16(11-13)26-15-6-2-1-3-7-15/h1-12H,(H2,23,24,25)

描述信息

D018377 - Neurotransmitter Agents > D018683 - Excitatory Amino Acid Agents > D018691 - Excitatory Amino Acid Antagonists
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
L-701324 is a potent, orally active NMDA receptor antagonist that antagonizes the activity of the NMDA receptor by blocking its glycine B binding site. L-701324 binds with high affinity to rat brain membranes (IC50=2 nM). L-701324 has antidepressant activity[1][2][3].

同义名列表

2 个代谢物同义名

7-chloro-4-hydroxy-3-(3-phenoxyphenyl)quinolin-2(1H)-one; L 701324



数据库引用编号

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代谢反应

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文献列表

  • Akiko Matsuura, Yuko Fujita, Masaomi Iyo, Kenji Hashimoto. Effects of sodium benzoate on pre-pulse inhibition deficits and hyperlocomotion in mice after administration of phencyclidine. Acta neuropsychiatrica. 2015 Jun; 27(3):159-67. doi: 10.1017/neu.2015.1. [PMID: 25648314]
  • Lauren Debrouse, Benita Hurd, Carly Kiselycznyk, Aaron Plitt, Alyssa Todaro, Masayoshi Mishina, Seth G N Grant, Marguerite Camp, Ozge Gunduz-Cinar, Andrew Holmes. Probing the modulation of acute ethanol intoxication by pharmacological manipulation of the NMDAR glycine co-agonist site. Alcoholism, clinical and experimental research. 2013 Feb; 37(2):223-33. doi: 10.1111/j.1530-0277.2012.01922.x. [PMID: 22934986]
  • Kenneth W Perry, Julie F Falcone, Matthew J Fell, John W Ryder, Hong Yu, Patrick L Love, Jason Katner, Kimberly D Gordon, Mark R Wade, Teresa Man, George G Nomikos, Lee A Phebus, Annick J Cauvin, Kirk W Johnson, Carrie K Jones, Beth J Hoffmann, George E Sandusky, Magnus W Walter, Warren J Porter, Lijuan Yang, Kalpana M Merchant, Harlan E Shannon, Kjell A Svensson. Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs. cortical brain areas. Neuropharmacology. 2008 Oct; 55(5):743-54. doi: 10.1016/j.neuropharm.2008.06.016. [PMID: 18602930]
  • M Rowley, J J Kulagowski, A P Watt, D Rathbone, G I Stevenson, R W Carling, R Baker, G R Marshall, J A Kemp, A C Foster, S Grimwood, R Hargreaves, C Hurley, K L Saywell, M D Tricklebank, P D Leeson. Effect of plasma protein binding on in vivo activity and brain penetration of glycine/NMDA receptor antagonists. Journal of medicinal chemistry. 1997 Dec; 40(25):4053-68. doi: 10.1021/jm970417o. [PMID: 9406596]