Pinaverium (BioDeep_00000693022)
代谢物信息卡片
化学式: C26H41BrNO4+ (510.2218786000001)
中文名称: 匹维溴胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1(C2CCC(C1C2)CCOCC[N+]3(CCOCC3)CC4=CC(=C(C=C4Br)OC)OC)C
InChI: InChI=1S/C26H41BrNO4/c1-26(2)21-6-5-19(22(26)16-21)7-11-31-12-8-28(9-13-32-14-10-28)18-20-15-24(29-3)25(30-4)17-23(20)27/h15,17,19,21-22H,5-14,16,18H2,1-4H3/q+1
描述信息
A - Alimentary tract and metabolism > A03 - Drugs for functional gastrointestinal disorders > A03A - Drugs for functional gastrointestinal disorders
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010276 - Parasympatholytics
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
同义名列表
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:135811
- PubChem: 40704
- DrugBank: DB09090
- ChEMBL: CHEMBL1909324
- CAS: 59995-65-2
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Huaiyu Li, Yun Chen, Ziyi Hu, Ying Yi, Jing Ye, Yuliang Zhou, Zhiying Yu, Haiyi Tang. Comparison of acupuncture and pinaverium bromide in the treatment of irritable bowel syndrome: A protocol for systematic review and meta-analysis.
Medicine.
2021 Apr; 100(16):e25604. doi:
10.1097/md.0000000000025604
. [PMID: 33879727] - Lixia Pei, Hao Geng, Jing Guo, Guohui Yang, Lin Wang, Rongrong Shen, Shuyu Xia, Min Ding, Hua Feng, Jin Lu, Jing Li, Lian Liu, Yanye Shu, Xiangdong Fang, Xiaoliang Wu, Xiaoxiao Wang, Shengjie Weng, Lu Ju, Xiao Chen, Hong Shen, Jianhua Sun. Effect of Acupuncture in Patients With Irritable Bowel Syndrome: A Randomized Controlled Trial.
Mayo Clinic proceedings.
2020 08; 95(8):1671-1683. doi:
10.1016/j.mayocp.2020.01.042
. [PMID: 32499125] - Xu-Dong Tang, Sheng-Sheng Zhang, Xiao-Hua Hou, Zhen-Hua Li, Su-Ning Chen, Pei-Min Feng, Xiao-Nan Yang, Hui-Zhen Li, Jie-Qiong Wu, Pei-Jun Xia, Xiao-Jun Yang, Heng-Jun Zhou, Hai-Yan Wang, Yao-Wei Ai, Kang Li. Post-marketing Re-evaluation of Tongxiening Granules () in Treatment of Diarrhea-Predominant Irritable Bowel Syndrome: A Multi-center, Randomized, Double-Blind, Double-Dummy and Positive Control Trial.
Chinese journal of integrative medicine.
2019 Dec; 25(12):887-894. doi:
10.1007/s11655-019-3030-x
. [PMID: 31292845] - Heng Fan, Liang Zheng, Yaoliang Lai, Weimin Lu, Zhixiang Yan, Qi Xiao, Baiwen Li, Min Tang, Dawei Huang, Yuanyuan Wang, Zhen Li, Yuwei Mei, Zhengyan Jiang, Xingxing Liu, Qing Tang, Dongmei Zuo, Jingyi Ye, Yongqiang Yang, Huisuo Huang, Zongxiang Tang, Jun Xiao. Tongxie Formula Reduces Symptoms of Irritable Bowel Syndrome.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.
2017 Nov; 15(11):1724-1732. doi:
10.1016/j.cgh.2017.06.026
. [PMID: 28634136] - Liyang Xing, Liuxin Qu, Hong Chen, Song Gao. Clinical effect of traditional Chinese spinal orthopedic manipulation in treatment of Functional Abdominal Pain Syndrome.
Complementary therapies in medicine.
2017 Jun; 32(?):19-24. doi:
10.1016/j.ctim.2017.03.009
. [PMID: 28619300] - Omar Patiño-Rodríguez, Juan Ramón Zapata-Morales, Abraham Escobedo-Moratilla, Manuel Díaz de León-Cabrero, Irma Torres-Roque, José Pérez-Urizar. Determination of Pinaverium Bromide in Human Plasma by a Sensitive and Robust UPLC-MS-MS Method and Application to a Pharmacokinetic Study in Mexican Subjects.
Journal of chromatographic science.
2015 Sep; 53(8):1373-8. doi:
10.1093/chromsci/bmv027
. [PMID: 25862744] - Xiao-wei Wu, Yu Hou, Hong-zan Ji, Ming-ming Liang, Lian-e Xu, Fang-yu Wang. [Treating irritable bowel syndrome by wuling capsule combined pinaverium bromide: a clinical research].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2015 Apr; 35(4):415-8. doi:
"
. [PMID: 26043562] - Ming-xian Chen, Jun-xian Chen, Liang Xia, Rui Fu, Zheng Lu. [Treating irritable bowel syndrome with diarrhea patients by yigan fupi decoction: a randomized controlled trial].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2014 Jun; 34(6):656-60. doi:
"
. [PMID: 25046944] - Liyang Xing, Liuxin Qu, Hong Chen, Song Gao. A clinical observation of irritable bowel syndrome treated by traditional Chinese spinal orthopedic manipulation.
Complementary therapies in medicine.
2013 Dec; 21(6):613-7. doi:
10.1016/j.ctim.2013.09.005
. [PMID: 24280469] - Jin-Min Ren, Xi Zhao, Chuan-Ping Wang, Qian Sun, Li-Xin Yin, Zhi-Qing Zhang. A sensitive and specific liquid chromatography/tandem mass spectrometry method for determination of pinaverium bromide in human plasma: application to a pharmacokinetic study in healthy volunteers.
Biomedical chromatography : BMC.
2011 Dec; 25(12):1369-73. doi:
10.1002/bmc.1611
. [PMID: 21308709] - Wen-yan Gao, Chang-hong Wang, Yi-fan Lin. [Effect of jianpi tiaogan wenshen recipe in treating diarrhea-predominant irritable bowel syndrome].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2010 Jan; 30(1):13-7. doi:
"
. [PMID: 20353024] - Zhan-fan Liang, Ri-hui Chen, Yun-sheng Xu, Qing-xiang Chen, Mei-ling Dong. [Tiaohe Ganpi Hexin Decoction in treatment of irritable bowel syndrome with diarrhea: a randomized controlled trial].
Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine.
2009 Sep; 7(9):819-22. doi:
10.3736/jcim20090904
. [PMID: 19747435] - Alexander C Ford, Nicholas J Talley, Brennan M R Spiegel, Amy E Foxx-Orenstein, Lawrence Schiller, Eamonn M M Quigley, Paul Moayyedi. Effect of fibre, antispasmodics, and peppermint oil in the treatment of irritable bowel syndrome: systematic review and meta-analysis.
BMJ (Clinical research ed.).
2008 Nov; 337(?):a2313. doi:
10.1136/bmj.a2313
. [PMID: 19008265] - S Evangelista. Quaternary ammonium derivatives as spasmolytics for irritable bowel syndrome.
Current pharmaceutical design.
2004; 10(28):3561-8. doi:
10.2174/1381612043382972
. [PMID: 15579053] - Yun Shen, Gan Cai, Xu Sun. [Randomized controlled clinical study on effect of Chinese compound changjitai in treating diarrheic irritable bowel syndrome].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2003 Nov; 23(11):823-5. doi:
"
. [PMID: 14666762] - L Nagy, R E Morales, M Beinborn, P Vattay, S Szabo. Investigation of gastroprotective compounds at subcellular level in isolated gastric mucosal cells.
American journal of physiology. Gastrointestinal and liver physiology.
2000 Dec; 279(6):G1201-8. doi:
10.1152/ajpgi.2000.279.6.g1201
. [PMID: 11093942] - C L Lu, C Y Chen, F Y Chang, S S Chang, L J Kang, R H Lu, S D Lee. Effect of a calcium channel blocker and antispasmodic in diarrhoea-predominant irritable bowel syndrome.
Journal of gastroenterology and hepatology.
2000 Aug; 15(8):925-30. doi:
10.1046/j.1440-1746.2000.02230.x
. [PMID: 11022835] - M H Bobo, R Magous, M O Christen, J P Bali. Effect of pinaverium and other calcium channel blockers on contraction of isolated gastric antral smooth muscle cells caused by gastrointestinal hormones.
Life sciences.
1994; 54(25):1947-54. doi:
10.1016/0024-3205(94)90129-5
. [PMID: 8201843] - O Feron, M Wibo, M O Christen, T Godfraind. Interaction of pinaverium (a quaternary ammonium compound) with 1,4-dihydropyridine binding sites in rat ileum smooth muscle.
British journal of pharmacology.
1992 Feb; 105(2):480-4. doi:
10.1111/j.1476-5381.1992.tb14279.x
. [PMID: 1313732] - F Wuytack, G De Schutter, R Casteels. Action of pinaverium bromide on calmodulin-regulated functions.
European journal of pharmacology.
1985 Aug; 114(1):85-8. doi:
10.1016/0014-2999(85)90525-4
. [PMID: 2995077] - G A de Weerdt, R P Beke, H G Verdievel, F Barbier, J A Jonckheere, A P de Leenheer. Quantitative gas chromatographic mass spectrometric determination of pinaverium-bromide in human serum.
Biomedical mass spectrometry.
1983 Mar; 10(3):162-7. doi:
10.1002/bms.1200100310
. [PMID: 6850068] - O Weitzel, G Seidel, S Engelbert, M Berksoy, G Eberhardt, R Bode. Investigation of possible interaction between pinaverium bromide and digoxin.
Current medical research and opinion.
1983; 8(8):600-2. doi:
10.1185/03007998309109804
. [PMID: 6653138]