Met-Enkephalin-Arg-Phe (BioDeep_00000692789)
代谢物信息卡片
化学式: C42H56N10O9S (876.3952246000001)
中文名称: TYR-GLY-GLY-PHE-MET-ARG-PHE
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CSCCC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)CNC(=O)CNC(=O)C(CC3=CC=C(C=C3)O)N
InChI: InChI=1S/C42H56N10O9S/c1-62-20-18-32(39(58)50-31(13-8-19-46-42(44)45)38(57)52-34(41(60)61)23-27-11-6-3-7-12-27)51-40(59)33(22-26-9-4-2-5-10-26)49-36(55)25-47-35(54)24-48-37(56)30(43)21-28-14-16-29(53)17-15-28/h2-7,9-12,14-17,30-34,53H,8,13,18-25,43H2,1H3,(H,47,54)(H,48,56)(H,49,55)(H,50,58)(H,51,59)(H,52,57)(H,60,61)(H4,44,45,46)
描述信息
D018377 - Neurotransmitter Agents > D018847 - Opioid Peptides
D018377 - Neurotransmitter Agents > D004745 - Enkephalins
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- L Granholm, E Roman, I Nylander. Single housing during early adolescence causes time-, area- and peptide-specific alterations in endogenous opioids of rat brain.
British journal of pharmacology.
2015 Jan; 172(2):606-14. doi:
10.1111/bph.12753. [PMID: 24821004] - Z Benyhe, G Toth, M Wollemann, A Borsodi, Z Helyes, C Rougeot, S Benyhe. Effects of synthetic analogues of human opiorphin on rat brain opioid receptors.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2014 Aug; 65(4):525-30. doi:
. [PMID: 25179084] - V M Pickel, E T Shobin, D A Lane, K Mackie. Cannabinoid-1 receptors in the mouse ventral pallidum are targeted to axonal profiles expressing functionally opposed opioid peptides and contacting N-acylphosphatidylethanolamine-hydrolyzing phospholipase D terminals.
Neuroscience.
2012 Dec; 227(?):10-21. doi:
10.1016/j.neuroscience.2012.07.050. [PMID: 22863674] - Krisztina Csabafi, Miklós Jászberényi, Zsolt Bagosi, Géza Tóth, Mária Wollemann, Gyula Telegdy. The action of a synthetic derivative of Met5-enkephalin-Arg6-Phe7 on behavioral and endocrine responses.
Peptides.
2011 Aug; 32(8):1656-60. doi:
10.1016/j.peptides.2011.05.029. [PMID: 21722680] - Vladana Vukojević, Yu Ming, Claudio D'Addario, Mats Hansen, Ulo Langel, Rüdiger Schulz, Björn Johansson, Rudolf Rigler, Lars Terenius. Mu-opioid receptor activation in live cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2008 Oct; 22(10):3537-48. doi:
10.1096/fj.08-108894. [PMID: 18587007] - Maarit Marmendal, Erika Roman, C J Peter Eriksson, Ingrid Nylander, Claudia Fahlke. Maternal separation alters maternal care, but has minor effects on behavior and brain opioid peptides in adult offspring.
Developmental psychobiology.
2004 Nov; 45(3):140-52. doi:
10.1002/dev.20027. [PMID: 15505796] - E Bujdosó, M Jászberényi, J Farkas, G Tóth, M Wollemann, G Telegdy. Behavioral and neuroendocrine actions of the Met-enkephalin-related peptide MERF.
Hormones and behavior.
2003 Feb; 43(2):302-11. doi:
10.1016/s0018-506x(03)00004-7. [PMID: 12694640] - G Simonetta, I R Young, I C McMillen. Plasma catecholamine and met-enkephalin-Arg6-Phe7 responses to hypoxaemia after adrenalectomy in the fetal sheep.
Journal of the autonomic nervous system.
1996 Sep; 60(3):108-14. doi:
10.1016/0165-1838(96)00026-4. [PMID: 8912260] - Z Mateo, L Napier, J F Gaugl, B A Barron, J L Caffrey. Hemorrhage alters plasma and cardiac enkephalins and catecholamines in anesthetized dogs.
The American journal of physiology.
1995 Dec; 269(6 Pt 2):H2082-9. doi:
10.1152/ajpheart.1995.269.6.h2082. [PMID: 8594920] - G Simonetta, I R Young, C L Coulter, N J Hey, I C McMillen. Fetal adrenalectomy does not affect circulating enkephalins in the sheep fetus during late gestation.
Neuroendocrinology.
1993 Mar; 57(3):408-15. doi:
10.1159/000126386. [PMID: 8321412] - C L Coulter, A S Giraud, S B Hooper, L Parker, I C McMillen. Fetal asphyxia stimulates an increase in fetal plasma catecholamines and [Met]-enkephalin-arg6-phe7 in the late-gestation sheep fetus.
Journal of developmental physiology.
1990 Nov; 14(5):267-72. doi:
NULL. [PMID: 2129244] - A S Giraud, L Parker, C Reichman, M Familari, A I Smith, J Funder. Generation of Met-enkephalin Arg6Phe7 immunoreactivity by proteolytic cleavage of mammalian plasma precursors by pepsin.
Endocrinology.
1989 Apr; 124(4):1711-6. doi:
10.1210/endo-124-4-1711. [PMID: 2538308] - S Kobayashi, T Ohashi, T Uchida, K Nakao, H Imura, N Yanaihara, A A Verhofstad. Co-storage of adrenaline and noradrenaline with Met-enkephalin-Arg6-Gly7-Leu8 and Met-enkephalin-Arg6-Phe7 in chromaffin cells of hamster adrenal medulla.
Archivum histologicum Japonicum = Nihon soshikigaku kiroku.
1984 Aug; 47(3):319-36. doi:
10.1679/aohc.47.319. [PMID: 6388526] - J Chou, J Tang, E Costa. Met5-enkephalin-arg6-phe7 content of human and rabbit plasma.
Life sciences.
1983 May; 32(22):2589-95. doi:
10.1016/0024-3205(83)90243-6. [PMID: 6343745] - M Benuck, M J Berg, N Marks. Rat brain and kidney metalloendopeptidase: enkephalin heptapeptide conversion to form a cardioactive neuropeptide, Phe-Met-Arg-Phe-amide.
Biochemical and biophysical research communications.
1982 Aug; 107(3):1123-9. doi:
10.1016/0006-291x(82)90638-6. [PMID: 6753836] - M Benuck, M J Berg, N Marks. Met-enkephalin-Arg6-Phe7 metabolism: conversion to Met-enkephalin by brain and kidney dipeptidyl carboxypeptidases.
Biochemical and biophysical research communications.
1981 Mar; 99(2):630-6. doi:
10.1016/0006-291x(81)91791-5. [PMID: 7016119]