brotizolam (BioDeep_00000692563)
代谢物信息卡片
brotizolam
化学式: C15H10BrClN4S (391.94980300000003)
中文名称: 溴替唑仑
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=NN=C2N1C3=C(C=C(S3)Br)C(=NC2)C4=CC=CC=C4Cl
InChI: InChI=1S/C15H10BrClN4S/c1-8-19-20-13-7-18-14(9-4-2-3-5-11(9)17)10-6-12(16)22-15(10)21(8)13/h2-6H,7H2,1H3
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
N - Nervous system > N05 - Psycholeptics > N05C - Hypnotics and sedatives > N05CD - Benzodiazepine derivatives
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C1012 - Benzodiazepine
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:31308
- KEGGdrug: D01744
- PubChem: 2451
- DrugBank: DB09017
- ChEMBL: CHEMBL32479
- CAS: 57801-81-7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jumpei Saito, Mariko Ishii, Yoriko Miura, Naho Yakuwa, Hiroyo Kawasaki, Tomo Suzuki, Akimasa Yamatani, Haruhiko Sago, Yoshiyuki Tachibana, Atsuko Murashima. Brotizolam During Pregnancy and Lactation: Brotizolam Levels in Maternal Serum, Cord Blood, Breast Milk, and Neonatal Serum.
Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine.
2021 07; 16(7):579-582. doi:
10.1089/bfm.2021.0013. [PMID: 33666494] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Ruth Verplaetse, Eva Cuypers, Jan Tytgat. The evaluation of the applicability of a high pH mobile phase in ultrahigh performance liquid chromatography tandem mass spectrometry analysis of benzodiazepines and benzodiazepine-like hypnotics in urine and blood.
Journal of chromatography. A.
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Human & experimental toxicology.
2011 Jul; 30(7):777-81. doi:
10.1177/0960327110379250. [PMID: 20670988] - Mitsuhiro Nakamura, Tomofumi Ohmori, Yoshinori Itoh, Masato Terashita, Kazuyuki Hirano. Simultaneous determination of benzodiazepines and their metabolites in human serum by liquid chromatography-tandem mass spectrometry using a high-resolution octadecyl silica column compatible with aqueous compounds.
Biomedical chromatography : BMC.
2009 Apr; 23(4):357-64. doi:
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Physiology & behavior.
2009 Feb; 96(2):307-14. doi:
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2007 Feb; 29(1):40-4. doi:
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Journal of anesthesia.
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2006 Jun; 28(3):299-302. doi:
10.1097/01.ftd.0000200010.33430.0e. [PMID: 16778710] - Emiko Kurisaki, Makiko Hayashida, Makoto Nihira, Youkichi Ohno, Hirobumi Mashiko, Takaaki Okano, Shin-ichi Niwa, Kouichi Hiraiwa. Diagnostic performance of Triage for benzodiazepines: urine analysis of the dose of therapeutic cases.
Journal of analytical toxicology.
2005 Sep; 29(6):539-43. doi:
NULL. [PMID: 16168176] - Takaki Tokairin, Takashi Fukasawa, Norio Yasui-Furukori, Toshiaki Aoshima, Akihito Suzuki, Yoshimasa Inoue, Tomonori Tateishi, Koichi Otani. Inhibition of the metabolism of brotizolam by erythromycin in humans: in vivo evidence for the involvement of CYP3A4 in brotizolam metabolism.
British journal of clinical pharmacology.
2005 Aug; 60(2):172-5. doi:
10.1111/j.1365-2125.2005.02380.x. [PMID: 16042670] - T Osanai, T Ohkubo, N Yasui, T Kondo, S Kaneko. Effect of itraconazole on the pharmacokinetics and pharmacodynamics of a single oral dose of brotizolam.
British journal of clinical pharmacology.
2004 Nov; 58(5):476-81. doi:
10.1111/j.1365-2125.2004.02208.x. [PMID: 15521894] - Carsten Kratzsch, Oliver Tenberken, Frank T Peters, Armin A Weber, Thomas Kraemer, Hans H Maurer. Screening, library-assisted identification and validated quantification of 23 benzodiazepines, flumazenil, zaleplone, zolpidem and zopiclone in plasma by liquid chromatography/mass spectrometry with atmospheric pressure chemical ionization.
Journal of mass spectrometry : JMS.
2004 Aug; 39(8):856-72. doi:
10.1002/jms.599. [PMID: 15329838] - Yachiyo Tabuchi, Yoshihiro Takamitsu. [Perioperative management for nephrectomy using combined spinal-epidural anesthesia with sedation in a patient with cerebral palsy under maintenance hemodialysis].
Masui. The Japanese journal of anesthesiology.
2002 Nov; 51(11):1268-71. doi:
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European journal of drug metabolism and pharmacokinetics.
1990 Oct; 15(4):287-93. doi:
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Arzneimittel-Forschung.
1990 Mar; 40(3):239-43. doi:
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Biulleten' eksperimental'noi biologii i meditsiny.
1989 Aug; 108(8):137-9. doi:
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Zeitschrift fur Rechtsmedizin. Journal of legal medicine.
1987; 98(4):221-8. doi:
10.1007/bf00201226. [PMID: 2889301] - K Ueno, H Kitagawa, H Kitagawa, H Kohei, T Furukawa, K Kushiku. Effects of brotizolam on smooth muscle and other organs.
Arzneimittel-Forschung.
1986 Mar; 36(3A):560-7. doi:
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Arzneimittel-Forschung.
1986 Mar; 36(3A):597-600. doi:
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Arzneimittel-Forschung.
1986 Mar; 36(3A):568-74. doi:
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Arzneimittel-Forschung.
1986 Mar; 36(3A):540-51. doi:
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Arzneimittel-Forschung.
1986 Mar; 36(3A):575-8. doi:
NULL. [PMID: 3718580] - P Danneberg, K Böke-Kuhn, W D Bechtel, E Lehr. Pharmacological action of some known and possible metabolites of brotizolam.
Arzneimittel-Forschung.
1986 Mar; 36(3A):587-91. doi:
NULL. [PMID: 3013212] - W D Bechtel, J Mierau, K Brandt, H J Förster, K H Pook. Metabolic fate of [14C]-brotizolam in the rat, dog, monkey and man.
Arzneimittel-Forschung.
1986 Mar; 36(3A):578-86. doi:
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Arzneimittel-Forschung.
1986 Mar; 36(3A):592-6. doi:
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British journal of clinical pharmacology.
1986 Feb; 21(2):197-204. doi:
10.1111/j.1365-2125.1986.tb05175.x. [PMID: 3954936] - W D Bechtel, E Goetzke. Elimination of brotizolam in elderly patients after multiple doses.
European journal of clinical pharmacology.
1986; 31(2):243-5. doi:
10.1007/bf00606668. [PMID: 3803423] - W D Bechtel, K H Weber. Brotizolam radioimmunoassay: development, evaluation, and application to human plasma samples.
Journal of pharmaceutical sciences.
1985 Dec; 74(12):1265-9. doi:
10.1002/jps.2600741205. [PMID: 4087192] - Y Itohda, S Niiya, K Tuzaki, H Hara, T Fujie, S Haseba, Y Gotoh. [Effects of brotizolam (WE 941) as a premedicant on plasma noradrenaline (NA) concentration].
Masui. The Japanese journal of anesthesiology.
1984 Feb; 33(2):168-72. doi:
NULL. [PMID: 6371289] - R Jochemsen, P A Van Rijn, T G Hazelzet, D D Breimer. Assay of midazolam and brotizolam in plasma by a gas chromatographic and a radioreceptor technique.
Pharmaceutisch weekblad. Scientific edition.
1983 Dec; 5(6):308-12. doi:
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British journal of clinical pharmacology.
1983; 16 Suppl 2(?):291S-297S. doi:
10.1111/j.1365-2125.1983.tb02303.x. [PMID: 6140948] - R Jochemsen, J G Wesselman, J Hermans, C J van Boxtel, D D Breimer. Pharmacokinetics of brotizolam in healthy subjects following intravenous and oral administration.
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1983; 16 Suppl 2(?):285S-290S. doi:
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British journal of clinical pharmacology.
1983; 16 Suppl 2(?):309S-313S. doi:
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Sleep.
1983; 6(1):72-6. doi:
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British journal of clinical pharmacology.
1983; 16 Suppl 2(?):385S-389S. doi:
10.1111/j.1365-2125.1983.tb02314.x. [PMID: 6362697] - C Hewett, H Kreuzer, H Köllmer, A Niggeschulze, H Stötzer. The toxicology of brotizolam.
British journal of clinical pharmacology.
1983; 16 Suppl 2(?):267S-274S. doi:
10.1111/j.1365-2125.1983.tb02299.x. [PMID: 6686462]