UNII:73033I28Y6 (BioDeep_00000692562)

   


代谢物信息卡片


Mosapride citrate dihydrate

化学式: C27H37ClFN3O12 (649.2049684000001)
中文名称: 枸橼酸莫沙必利
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCOC1=CC(=C(C=C1C(=O)NCC2CN(CCO2)CC3=CC=C(C=C3)F)Cl)N.C(C(=O)O)C(CC(=O)O)(C(=O)O)O.O.O
InChI: 2*1H2

描述信息

D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017366 - Serotonin Receptor Agonists
D005765 - Gastrointestinal Agents

同义名列表

3 个代谢物同义名

Mosapride citrate dihydrate; UNII:73033I28Y6; Mosapride citrate hydrate



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Dongya Chen, Jingfang Xiong, Hui Feng, Yihui Liu, Jianjun Xu, Hong Xu. The influence of mosapride on gut microbiota of carbon tetrachloride-induced cirrhosis rats based on 16S rRNA gene sequencing. Advances in clinical and experimental medicine : official organ Wroclaw Medical University. 2022 Jun; 31(6):623-633. doi: 10.17219/acem/146320. [PMID: 35275452]
  • Karen Paola Camarillo Cárdenas, Jessica García González, Federico Alberto Argüelles Tello, Jorge Arturo Ocampo Ramírez, José Belisario Moreno Hernández, Murali Mohan Pendela. Relative bioavailability and pharmacokinetic comparison of a fixed-dose combination tablet of mosapride, pancreatin, and simethicone relative to single-component mosapride tablets in healthy Mexican subjects. Fundamental & clinical pharmacology. 2022 Apr; 36(2):427-435. doi: 10.1111/fcp.12739. [PMID: 34837418]
  • Zhenyun Dou, Zhou Xu, Qizheng Wang, Jiangshu Li, Chunlin Yu, Yequan Miao, Tailiang Ren, Haijun Wang. Mosapride Citrate Combined with Divine Qu Disinfectant Oral Liquid for Children Function Dyspepsia and the Influence of Serum Factors. Journal of healthcare engineering. 2022; 2022(?):3053277. doi: 10.1155/2022/3053277. [PMID: 35340223]
  • Min-Soo Kim, In-Hwan Baek. Pharmacokinetic analysis of mosapride following intravenous and oral administration in beagle dogs. Journal of veterinary pharmacology and therapeutics. 2020 Sep; 43(5):454-460. doi: 10.1111/jvp.12867. [PMID: 32304239]
  • Lin Xu, Jiaqi Zhang, Juanjuan Li, Lin Lv, Zedan Zhang, Fengyun Wang, Xudong Tang. Clinical study on post evaluation after listing of Qizhi Weitong granules: Study protocol clinical trial (SPIRIT compliant). Medicine. 2020 Apr; 99(16):e19758. doi: 10.1097/md.0000000000019758. [PMID: 32311977]
  • Kunjie Li, Xu Jiang, Zhili Xiong, Feng Qin, Longshan Zhao. The tissue distribution and excretion study of mosapride and its active des-p-fluorobenzyl and 4'-N-oxide metabolites in rats by ultra-high performance liquid chromatography-tandem mass spectrometry method. Xenobiotica; the fate of foreign compounds in biological systems. 2020 Feb; 50(2):115-124. doi: 10.1080/00498254.2019.1588410. [PMID: 30883253]
  • Hong Xu, Jingfang Xiong, Jianjun Xu, Shuiming Li, Yang Zhou, Dongya Chen, Xinjun Cai, Jian Ping, Min Deng, Jianyong Chen. Mosapride Stabilizes Intestinal Microbiota to Reduce Bacterial Translocation and Endotoxemia in CCl4-Induced Cirrhotic Rats. Digestive diseases and sciences. 2017 10; 62(10):2801-2811. doi: 10.1007/s10620-017-4704-x. [PMID: 28815345]
  • Rasha Mohamed El Nashar, Nour T Abdel Ghani, Nesrine A El Gohary, A Barhoum, Adel Madbouly. Molecularly imprinted polymers based biomimetic sensors for mosapride citrate detection in biological fluids. Materials science & engineering. C, Materials for biological applications. 2017 Jul; 76(?):123-129. doi: 10.1016/j.msec.2017.03.087. [PMID: 28482490]
  • Chengying Wang, Hong Sun, Shaojie Wang, Zhonggui He, Longshan Zhao, Zhili Xiong, Feng Qin. Development and validation of a chiral liquid chromatography method for the determination of MP 3950 enantiomers, a high selective 5-HT4 receptor agonist, in rat plasma and its application to stereoselective pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Oct; 1033-1034(?):49-54. doi: 10.1016/j.jchromb.2016.08.012. [PMID: 27521532]
  • Xin Chang, Shuai Wang, Yong-Rui Bao, Tian-Jiao Li, Xiao-Meng Yu, Xian-Sheng Meng. Multicomponent, multitarget integrated adjustment - Metabolomics study of Qizhiweitong particles curing gastrointestinal motility disorders in mice induced by atropine. Journal of ethnopharmacology. 2016 Aug; 189(?):14-21. doi: 10.1016/j.jep.2016.05.024. [PMID: 27180317]
  • J-W Chae, J-A Hwang, I-H Baek, S Pradhan, B Song, H-M Back, M Yun, C Pai, J S Bang, H-Y Yun, W Kang, K-I Kwon. Determination of influence of food intake after a single oral dose of mosapride in beagle dogs using nonlinear mixed effect modeling. Journal of veterinary pharmacology and therapeutics. 2015 Dec; 38(6):590-5. doi: 10.1111/jvp.12228. [PMID: 25955782]
  • Katsunori Nonogaki, Takao Kaji. Mosapride, a selective serotonin 5-HT4 receptor agonist, and alogliptin, a selective dipeptidyl peptidase-4 inhibitor, exert synergic effects on plasma active GLP-1 levels and glucose tolerance in mice. Diabetes research and clinical practice. 2015 Dec; 110(3):e18-21. doi: 10.1016/j.diabres.2015.10.011. [PMID: 26497774]
  • Chao-xian Zhang, Li-ke Guo. Dalitong granule combined with electroacupuncture in the treatment of functional dyspepsia: A randomized controlled trial. Chinese journal of integrative medicine. 2015 Oct; 21(10):743-50. doi: 10.1007/s11655-015-2175-5. [PMID: 26129900]
  • J-W Chae, B-J Song, I-H Baek, H-Y Yun, J Y Ma, K-I Kwon. Effects of food intake on pharmacokinetics of mosapride in beagle dogs. Journal of veterinary pharmacology and therapeutics. 2015 Oct; 38(5):497-9. doi: 10.1111/jvp.12200. [PMID: 25622855]
  • Longshan Zhao, Xiaohong Sun, Zhili Xiong, Shaojie Wang. Simultaneous determination of mosapride and its active des-p-fluorobenzyl and 4'-N-oxide metabolites in rat plasma using UPLC-MS/MS: an application for a pharmacokinetic study. Talanta. 2015 May; 137(?):130-5. doi: 10.1016/j.talanta.2015.01.021. [PMID: 25770615]
  • Daisuke Maruoka, Makoto Arai, Takeshi Tanaka, Kenichiro Okimoto, Arata Oyamada, Shoko Minemura, Masaru Tsuboi, Tomoaki Matsumura, Tomoo Nakagawa, Tatsuo Kanda, Tatsuro Katsuno, Fumio Imazeki, Osamu Yokosuka. Mosapride citrate increases postprandial glucagon-like peptide-1, insulin, and gene expression of sweet taste receptors. Digestive diseases and sciences. 2015 Feb; 60(2):345-53. doi: 10.1007/s10620-014-3271-7. [PMID: 25008428]
  • Hirofumi Okubo, Yusuke Nakatsu, Hideyuki Sakoda, Akifumi Kushiyama, Midori Fujishiro, Toshiaki Fukushima, Yasuka Matsunaga, Haruya Ohno, Masayasu Yoneda, Hideaki Kamata, Takanori Shinjo, Misaki Iwashita, Fusanori Nishimura, Tomoichiro Asano. Mosapride citrate improves nonalcoholic steatohepatitis with increased fecal lactic acid bacteria and plasma glucagon-like peptide-1 level in a rodent model. American journal of physiology. Gastrointestinal and liver physiology. 2015 Jan; 308(2):G151-8. doi: 10.1152/ajpgi.00198.2014. [PMID: 25428903]
  • Xiaohong Sun, Longshan Zhao, Lili Niu, Feng Qin, Xiumei Lu, Zhili Xiong, Famei Li. Structure identification and elucidation of mosapride metabolites in human urine, feces and plasma by ultra performance liquid chromatography-tandem mass spectrometry method. Xenobiotica; the fate of foreign compounds in biological systems. 2014 Aug; 44(8):734-42. doi: 10.3109/00498254.2014.880201. [PMID: 24417754]
  • Kazutaka Aoki, Hiroshi Kamiyama, Kiyomi Masuda, Yu Togashi, Yasuo Terauchi. Mosapride citrate, a 5-HT₄ receptor agonist, increased the plasma active and total glucagon-like peptide-1 levels in non-diabetic men. Endocrine journal. 2013; 60(4):493-9. doi: . [PMID: 23257734]
  • Liping Wang, Huajun Fan, Kunhong Wu, Xiaosheng Peng, Zitao Jiang, Linquan Zang. [Chiral separation of benzamide antipsychotics and determination of their enantiomers by high performance liquid chromatography]. Se pu = Chinese journal of chromatography. 2012 Dec; 30(12):1265-70. doi: 10.3724/sp.j.1123.2012.07035. [PMID: 23593884]
  • Shin-Hee Kim, Yoo-Sin Park, Jung Mogg Kim, Hae-Jeong Park, Min-Ho Lee, Hoon-Ki Park, Young-Jae Kim, Sam Hyun Cho, Leslie M Shaw, Juâ Seop Kang. Pharmacokinetic and bioavailability studies of 5 mg mosapride tablets in healthy Korean volunteers. International journal of clinical pharmacology and therapeutics. 2012 Jul; 50(7):524-31. doi: 10.5414/cp201506. [PMID: 22541755]
  • Quan Hu, Jiake Chai, Sen Hu, Guoyong Zhou, Zhiyong Sheng. Oral hypertonic electrolyte-glucose/mosapride complex solution for resuscitation of burn shock in dogs. Journal of burn care & research : official publication of the American Burn Association. 2012 Mar; 33(2):e63-9. doi: 10.1097/bcr.0b013e31823dc6f4. [PMID: 22138812]
  • O Ia Skliarov, O I Detsyk. [The changes of the activity of NO-synthases and oxidative processes under conditions of 5-HT receptors activation in the stomach and large intestine in streptozocin-induced diabetes mellitus]. Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994). 2012; 58(5):22-7. doi: 10.15407/fz58.05.022. [PMID: 23233943]
  • M Kanazawa, S Watanabe, C Tana, H Komuro, M Aoki, S Fukudo. Effect of 5-HT4 receptor agonist mosapride citrate on rectosigmoid sensorimotor function in patients with irritable bowel syndrome. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 2011 Aug; 23(8):754-e332. doi: 10.1111/j.1365-2982.2011.01732.x. [PMID: 21615623]
  • Guang-Xian Cai, Bai-Yan Liu, Jian Yi, Xue-Mei Chen, Fu-Ling Liu. Simotang enhances gastrointestinal motility, motilin and cholecystokinin expression in chronically stressed mice. World journal of gastroenterology. 2011 Mar; 17(12):1594-9. doi: 10.3748/wjg.v17.i12.1594. [PMID: 21472126]
  • Jun Huang, Yuan Tian, Zun-Jian Zhang, Jinheng Li, Xiaomei Cao. Pharmacokinetics and bioequivalence study of two mosapride citrate formulations after single-dose administration in healthy Chinese male volunteers. Arzneimittel-Forschung. 2011; 61(3):167-72. doi: 10.1055/s-0031-1296184. [PMID: 21528641]
  • Seiji Futagami, Katsuhiko Iwakiri, Tomotaka Shindo, Tetsuro Kawagoe, Akane Horie, Mayumi Shimpuku, Yuriko Tanaka, Noriyuki Kawami, Katya Gudis, Choitsu Sakamoto. The prokinetic effect of mosapride citrate combined with omeprazole therapy improves clinical symptoms and gastric emptying in PPI-resistant NERD patients with delayed gastric emptying. Journal of gastroenterology. 2010 Apr; 45(4):413-21. doi: 10.1007/s00535-009-0173-0. [PMID: 19997942]
  • Ching-Ling Cheng, Ya-Win Chang, Chen-Hsi Chou. HPLC-fluorescence assay for measuring mosapride in small volumes of rat plasma. Biomedical chromatography : BMC. 2010 Mar; 24(3):281-8. doi: 10.1002/bmc.1285. [PMID: 19653243]
  • J S Nam, J Y Nam, J S Yoo, M Cho, J S Park, C W Ahn, B S Cha, E J Lee, S K Lim, K R Kim, H C Lee. The effect of mosapride (5HT-4 receptor agonist) on insulin sensitivity and GLUT4 translocation. Diabetes research and clinical practice. 2010 Mar; 87(3):329-34. doi: 10.1016/j.diabres.2009.12.021. [PMID: 20060191]
  • Xiaohong Sun, Lili Niu, Xiaoqin Li, Xiumei Lu, Famei Li. Characterization of metabolic profile of mosapride citrate in rat and identification of two new metabolites: Mosapride N-oxide and morpholine ring-opened mosapride by UPLC-ESI-MS/MS. Journal of pharmaceutical and biomedical analysis. 2009 Aug; 50(1):27-34. doi: 10.1016/j.jpba.2009.03.011. [PMID: 19362796]
  • Guo-ying Zhou, Guo-sheng Zhou, Jin Jian-hong. [Clinical observation on transcutaneous electrical acupoint stimulation for treatment of functional dyspepsia]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. 2009 Jun; 29(6):436-40. doi: NULL. [PMID: 19563187]
  • J A M Smith, D T Beattie, D Marquess, J P Shaw, R G Vickery, P P A Humphrey. The in vitro pharmacological profile of TD-5108, a selective 5-HT(4) receptor agonist with high intrinsic activity. Naunyn-Schmiedeberg's archives of pharmacology. 2008 Jul; 378(1):125-37. doi: 10.1007/s00210-008-0282-y. [PMID: 18415081]
  • Katsuhito Arai, Yoshiaki Takeuchi, Hideki Watanabe, Atsushi Tsukurimichi, Naoki Uchida, Michio Imawari. Prokinetics influence the pharmacokinetics of rabeprazole. Digestion. 2008; 78(2-3):67-71. doi: 10.1159/000165351. [PMID: 18948689]
  • Yoichi Aoki, Hideki Hakamata, Yu Igarashi, Kazunari Uchida, Hisato Kobayashi, Norio Hirayama, Akira Kotani, Fumiyo Kusu. Liquid chromatography-tandem mass spectrometric method for determination of mosapride citrate in equine tissues. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2007 Oct; 858(1-2):135-42. doi: 10.1016/j.jchromb.2007.08.017. [PMID: 17851144]
  • Feng Qin, Ling-Yun Chen, Yuan-Yuan Ma, Dong Wang, Juan Liu, Xiu-Mei Lu, Fa-Mei Li. [Determination of mosapride in human plasma by high performance liquid chromatography tandem mass spectrometry]. Yao xue xue bao = Acta pharmaceutica Sinica. 2007 Aug; 42(8):882-5. doi: NULL. [PMID: 17944240]
  • Ramakrishna V S Nirogi, Vishwottam N Kandikere, Manoj Shukla, Koteshwara Mudigonda, Santosh Maurya, Prashanth Komarneni. Quantification of pseudoephedrine in human plasma by LC-MS/MS using mosapride as internal standard. Biomedical chromatography : BMC. 2007 Mar; 21(3):241-8. doi: 10.1002/bmc.745. [PMID: 17230461]
  • Ramakrishna V S Nirogi, Vishwottam N Kandikere, Manoj Shukla, Koteshwara Mudigonda, Santosh Maurya, Prashanth Komarneni. Quantification of fexofenadine in human plasma by liquid chromatography coupled to electrospray tandem mass spectrometry using mosapride as internal standard. Biomedical chromatography : BMC. 2007 Feb; 21(2):209-16. doi: 10.1002/bmc.740. [PMID: 17221908]
  • Takeo Odaka, Takuto Suzuki, Ayaka Seza, Taketo Yamaguchi, Hiromitsu Saisho. [Serotonin 5- HT4 receptor agonist (mosapride citrate)]. Nihon rinsho. Japanese journal of clinical medicine. 2006 Aug; 64(8):1491-4. doi: NULL. [PMID: 16898619]
  • Akihiro Asakawa, Naohiko Ueno, Miwako Katagi, Yuka Ijuin, Yoshinori Morita, Shigeto Mizuno, Toshio Inui, Ruka Sakamaki, Naotaka Shinfuku, Msaharu Uemoto. Mosapride improves food intake, while not worsening glycemic control and obesity, in ob/ob obese mice with decreased gastric emptying. Journal of diabetes and its complications. 2006 Jan; 20(1):56-8. doi: 10.1016/j.jdiacomp.2005.04.001. [PMID: 16389169]
  • N V S Ramakrishna, K N Vishwottam, S Manoj, M Koteshwara, J Chidambara, D P Varma. Validation and application of a high-performance liquid chromatography--tandem mass spectrometry assay for mosapride in human plasma. Biomedical chromatography : BMC. 2005 Sep; 19(7):539-48. doi: 10.1002/bmc.477. [PMID: 15654725]
  • Shinichi Futei, Yoshinori Sugino, Sachio Kuribayashi, Yutaka Imai, Fumiaki Ueno, Toshifumi Hibi, Toru Mitsushima. [New preparation method for barium enema: efficacy and administration of oral intestinal lavage solution with gastrointestinal prokinetic agent]. Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica. 2004 Jan; 64(1):22-30. doi: NULL. [PMID: 14994507]
  • Takao Katoh, Hirokazu Saitoh, Norihiko Ohno, Masao Tateno, Tsuyoshi Nakamura, Isao Dendo, Shinichi Kobayashi, Koichi Nagasawa. Drug interaction between mosapride and erythromycin without electrocardiographic changes. Japanese heart journal. 2003 Mar; 44(2):225-34. doi: 10.1536/jhj.44.225. [PMID: 12718484]
  • N Ueno, A Inui, A Asakawa, F Takao, Y Komatsu, K Kotani, R Nishimura, M Kasuga. Mosapride, a 5HT-4 receptor agonist, improves insulin sensitivity and glycaemic control in patients with Type II diabetes mellitus. Diabetologia. 2002 Jun; 45(6):792-7. doi: 10.1007/s00125-002-0835-4. [PMID: 12107722]
  • N Ueda, R Yoshimura, K Shinkai, T Terao, J Nakamura. Characteristics of fluvoxamine-induced nausea. Psychiatry research. 2001 Nov; 104(3):259-64. doi: 10.1016/s0165-1781(01)00320-1. [PMID: 11728615]
  • H Itoh, T Nagano, M Takeyama. Effects of mosapride citrate on human plasma levels of motilin, gastrin, somatostatin, and secretin. Biological & pharmaceutical bulletin. 2001 Sep; 24(9):1072-5. doi: 10.1248/bpb.24.1072. [PMID: 11558572]
  • Y Kii, K Nakatsuji, I Nose, M Yabuuchi, Y Mizuki, T Ito. Effects of 5-HT(4) receptor agonists, cisapride and mosapride citrate on electrocardiogram in anaesthetized rats and guinea-pigs and conscious cats. Pharmacology & toxicology. 2001 Aug; 89(2):96-103. doi: 10.1034/j.1600-0773.2001.d01-142.x. [PMID: 11555327]
  • T Mushiroda, R Douya, E Takahara, O Nagata. The involvement of flavin-containing monooxygenase but not CYP3A4 in metabolism of itopride hydrochloride, a gastroprokinetic agent: comparison with cisapride and mosapride citrate. Drug metabolism and disposition: the biological fate of chemicals. 2000 Oct; 28(10):1231-7. doi: . [PMID: 10997945]
  • I Yokoyama, Y Mizuki, T Yamaguchi, T Fujii. Simultaneous enantiomeric determination of a gastroprokinetic agent mosapride citrate and its metabolite in plasma using alpha 1-acid glycoprotein HPLC column. Journal of pharmaceutical and biomedical analysis. 1997 Jun; 15(9-10):1527-35. doi: 10.1016/s0731-7085(96)02006-7. [PMID: 9226586]
  • S Matsumoto, M Tagawa, H Amejima, M Nakao, A Kagemoto, T Fujii, H Miyazaki, Y Sekine. Absorption, distribution and excretion of [carbonyl-14C]mosapride citrate after a single oral administration in rats, dogs and monkeys. Arzneimittel-Forschung. 1993 Oct; 43(10):1084-94. doi: NULL. [PMID: 8267675]
  • S Matsumoto, K Yoshida, A Itogawa, M Tagawa, T Fujii, H Miyazaki, Y Sekine. Metabolism of [carbonyl-14C]mosapride citrate after a single oral administration in rats, dogs and monkeys. Arzneimittel-Forschung. 1993 Oct; 43(10):1095-102. doi: NULL. [PMID: 8267676]
  • S Matsumoto, M Tagawa, T Hatoyama, T Fujii, H Miyazaki, Y Sekine. Absorption, distribution, metabolism and excretion of [carbonyl-14C]mosapride citrate after repeated oral administration in rats. Arzneimittel-Forschung. 1993 Oct; 43(10):1103-8. doi: NULL. [PMID: 8267677]
  • M Sakashita, Y Mizuki, T Hashizume, T Yamaguchi, H Miyazaki, Y Sekine. Pharmacokinetics of the gastrokinetic agent mosapride citrate after intravenous and oral administrations in rats. Arzneimittel-Forschung. 1993 Aug; 43(8):859-63. doi: NULL. [PMID: 8216443]
  • M Sakashita, T Yamaguchi, H Miyazaki, Y Sekine, T Nomiyama, S Tanaka, T Miwa, S Harasawa. Pharmacokinetics of the gastrokinetic agent mosapride citrate after single and multiple oral administrations in healthy subjects. Arzneimittel-Forschung. 1993 Aug; 43(8):867-72. doi: NULL. [PMID: 8216445]
  • M Sakashita, Y Mizuki, T Yamaguchi, H Miyazaki, Y Sekine. Pharmacokinetics of the gastrokinetic agent mosapride citrate after intravenous and oral administrations in dogs and monkeys. Arzneimittel-Forschung. 1993 Aug; 43(8):864-6. doi: NULL. [PMID: 8216444]