Sodium aurothiomalate (BioDeep_00000691496)
代谢物信息卡片
Sodium aurothiomalate
化学式: C4H3AuNa2O4S (389.9213058)
中文名称: 硫代苹果酸金钠
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(C(C(=O)[O-])[S-])C(=O)[O-].[Na+].[Na+].[Au+]
InChI: /q
描述信息
M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01C - Specific antirheumatic agents > M01CB - Gold preparations
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C61074 - Serine/Threonine Kinase Inhibitor
D018501 - Antirheumatic Agents
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:35864
- PubChem: 22318
- DrugBank: DB09276
- MeSH: Gold Sodium Thiomalate
- CAS: 12244-57-4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Mehdi Amirhosseini, Hammoudi Alkaissi, Per A Hultman, Said Havarinasab. Autoantibodies in outbred Swiss Webster mice following exposure to gold and mercury.
Toxicology and applied pharmacology.
2021 02; 412(?):115379. doi:
10.1016/j.taap.2020.115379. [PMID: 33358697] - Aaron S Mansfield, Alan P Fields, Aminah Jatoi, Yingwei Qi, Alex A Adjei, Charles Erlichman, Julian R Molina. Phase I dose escalation study of the PKCι inhibitor aurothiomalate for advanced non-small-cell lung cancer, ovarian cancer, and pancreatic cancer.
Anti-cancer drugs.
2013 Nov; 24(10):1079-83. doi:
10.1097/cad.0000000000000009. [PMID: 23962904] - Mohammad S Iqbal, Syed G Taqi, Muhammad Arif, Muhammad Wasim, Muhammad Sher. In vitro distribution of gold in serum proteins after incubation of sodium aurothiomalate and auranofin with human blood and its pharmacological significance.
Biological trace element research.
2009 Sep; 130(3):204-9. doi:
10.1007/s12011-009-8330-0. [PMID: 19194667] - Roderick P Regala, E Aubrey Thompson, Alan P Fields. Atypical protein kinase C iota expression and aurothiomalate sensitivity in human lung cancer cells.
Cancer research.
2008 Jul; 68(14):5888-95. doi:
10.1158/0008-5472.can-08-0438. [PMID: 18632643] - Paul L Wood, M Amin Khan, Joseph R Moskal. Mechanism of action of the disease-modifying anti-arthritic thiol agents D-penicillamine and sodium aurothiomalate: restoration of cellular free thiols and sequestration of reactive aldehydes.
European journal of pharmacology.
2008 Feb; 580(1-2):48-54. doi:
10.1016/j.ejphar.2007.10.066. [PMID: 18022616] - Alfredo de la Escosura-Muñiz, María Begoña González-García, Agustín Costa-García. Determination of human serum albumin using aurothiomalate as electroactive label.
Analytical and bioanalytical chemistry.
2006 Feb; 384(3):742-50. doi:
10.1007/s00216-005-0213-4. [PMID: 16372180] - Shoji Sugii. [Adverse effects of DMARDs in treatment of rheumatoid arthritis].
Nihon rinsho. Japanese journal of clinical medicine.
2005 Jan; 63 Suppl 1(?):566-72. doi:
NULL. [PMID: 15799419] - Aida Chircorian, Amy M Barrios. Inhibition of lysosomal cysteine proteases by chrysotherapeutic compounds: a possible mechanism for the antiarthritic activity of Au(I).
Bioorganic & medicinal chemistry letters.
2004 Oct; 14(20):5113-6. doi:
10.1016/j.bmcl.2004.07.073. [PMID: 15380210] - Sofia Ernestam, Jon Lampa, Siv Rogberg, Johan Rönnelid, Lars Klareskog, Ingiäld Hafström. Evidence for immunostimulatory effects of intramuscular gold in patients with rheumatoid arthritis: correlation with skin reactions.
The Journal of rheumatology.
2003 Aug; 30(8):1748-55. doi:
NULL. [PMID: 12913930] - T K Kvien, H K Zeidler, P Hannonen, F A Wollheim, O Førre, I Hafström, J P Kaltwasser, M Leirisalo-Repo, B Manger, L Laasonen, H Prestele, P Kurki. Long term efficacy and safety of cyclosporin versus parenteral gold in early rheumatoid arthritis: a three year study of radiographic progression, renal function, and arterial hypertension.
Annals of the rheumatic diseases.
2002 Jun; 61(6):511-6. doi:
10.1136/ard.61.6.511. [PMID: 12006323] - Ake Svensson, Halvor Möller, Bert Björkner, Magnus Bruze, Ido Leden, Jan Theander, Kjell Ohlsson, Carina Linder. Rheumatoid arthritis, gold therapy, contact allergy and blood cytokines.
BMC dermatology.
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Rheumatology (Oxford, England).
2000 Nov; 39(11):1255-62. doi:
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Cancer biotherapy & radiopharmaceuticals.
1999 Oct; 14(5):403-6. doi:
10.1089/cbr.1999.14.403. [PMID: 10850325] - G Pistritto, O Franzese, G Pozzoli, C Mancuso, G Tringali, P Preziosi, P Navarra. Bacterial lipopolysaccharide increases prostaglandin production by rat astrocytes via inducible cyclo-oxygenase: evidence for the involvement of nuclear factor kappaB.
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1999 Sep; 263(2):570-4. doi:
10.1006/bbrc.1999.1413. [PMID: 10491333] - A L Herrick, R Hodgkiss, P Reed, C Weinkove, M I Jayson, B Houston. No significant effects of sodium aurothiomalate on haem metabolism and mixed function oxygenase activity in patients with rheumatoid arthritis.
Clinical and experimental rheumatology.
1999 Jul; 17(4):461-2. doi:
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European journal of pharmacology.
1999 Jun; 374(3):477-87. doi:
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1999 Apr; 40(4):200-4. doi:
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Clinical rheumatology.
1999; 18(2):106-13. doi:
10.1007/s100670050066. [PMID: 10357114] - J D Jessop, M M O'Sullivan, P A Lewis, L A Williams, J P Camilleri, M J Plant, E C Coles. A long-term five-year randomized controlled trial of hydroxychloroquine, sodium aurothiomalate, auranofin and penicillamine in the treatment of patients with rheumatoid arthritis.
British journal of rheumatology.
1998 Sep; 37(9):992-1002. doi:
10.1093/rheumatology/37.9.992. [PMID: 9783766] - H Möller, K Ohlsson, C Linder, B Björkner, M Bruze. Cytokines and acute phase reactants during flare-up of contact allergy to gold.
American journal of contact dermatitis : official journal of the American Contact Dermatitis Society.
1998 Mar; 9(1):15-22. doi:
NULL. [PMID: 9471982] - P P Sfikakis, M A Dimopoulos, V L Souliotis, D Charalambopoulos, M Mavrikakis, P Panayiotidis. Effects of 2-chlorodeoxyadenosine and gold sodium thiomalate on human bcl-2 gene expression.
Immunopharmacology and immunotoxicology.
1998 Feb; 20(1):63-77. doi:
10.3109/08923979809034809. [PMID: 9543700] - F Shabani, J McNeil, L Tippett. The oxidative inactivation of tissue inhibitor of metalloproteinase-1 (TIMP-1) by hypochlorous acid (HOCI) is suppressed by anti-rheumatic drugs.
Free radical research.
1998 Feb; 28(2):115-23. doi:
10.3109/10715769809065797. [PMID: 9645388] - T Vlak, B Stambuk. [Comparative study of the effects of auranofin and aurothiomalate on laboratory and clinical indicators in patients with rheumatoid arthritis].
Reumatizam.
1998; 46(1):7-19. doi:
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International journal of clinical pharmacology research.
1998; 18(1):31-7. doi:
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Clinica chimica acta; international journal of clinical chemistry.
1997 Dec; 268(1-2):85-99. doi:
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Annals of the rheumatic diseases.
1997 Jun; 56(6):374-7. doi:
10.1136/ard.56.6.374. [PMID: 9227167] - J Nishio, R Koike, H Iizuka, T Nanki, N Mizushima, H Kohsaka, T Kubota, N Miyasaka. [A refractory case of adult-onset Still's disease].
Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology.
1997 Jun; 20(3):191-8. doi:
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British journal of rheumatology.
1997 Jan; 36(1):54-8. doi:
10.1093/rheumatology/36.1.54. [PMID: 9117175] - K Ujiie, T Shiigai. [Gold nephropathy].
Ryoikibetsu shokogun shirizu.
1997; ?(16 Pt 1):529-30. doi:
NULL. [PMID: 9277807] - P A Merkel, M A Dooley, D V Dawson, D S Pisetsky, R P Polisson. Interleukin-2 receptor levels in sera of patients with rheumatoid arthritis treated with sulfasalazine, parenteral gold, or placebo.
The Journal of rheumatology.
1996 Nov; 23(11):1856-61. doi:
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Endocrinology.
1996 Nov; 137(11):4864-70. doi:
10.1210/endo.137.11.8895358. [PMID: 8895358] - M Koda, S Yoshino, H Nakamura, G Asano. [Effects of disease modifying antirheumatic drugs (DMARDs) and DEX on IL-1 beta and IL-6 production by IL-1 beta stimulated synovial culture cells].
Nihon Ika Daigaku zasshi.
1996 Oct; 63(5):419-23. doi:
10.1272/jnms1923.63.419. [PMID: 8937133] - N Snowden, D M Dietch, L S Teh, R C Hilton, M R Haeney. Antibody deficiency associated with gold treatment: natural history and management in 22 patients.
Annals of the rheumatic diseases.
1996 Sep; 55(9):616-21. doi:
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The Journal of rheumatology.
1996 Feb; 23(2):241-4. doi:
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Journal of biochemical toxicology.
1996; 11(4):175-81. doi:
10.1002/(sici)1522-7146(1996)11:4<175::aid-jbt2>3.0.co;2-h. [PMID: 9062847] - T Ogura, M Takaoka, T Yamauchi, T Oishi, Y Mimura, M Hashimoto, N Asano, M Yamamura, F Otsuka, H Makino, Z Ota, K Takahashi. Changes in urinary enzyme activity and histochemical findings in experimental tubular injury induced by gold sodium thiomalate.
Journal of medicine.
1996; 27(1-2):41-55. doi:
NULL. [PMID: 8863177] - J Christodoulou, P J Sadler, A Tucker. 1H NMR of albumin in human blood plasma: drug binding and redox reactions at Cys34.
FEBS letters.
1995 Nov; 376(1-2):1-5. doi:
10.1016/0014-5793(95)01231-2. [PMID: 8521951] - S Suzuki, M Okubo, S Kaise, M Ohara, R Kasukawa. Gold sodium thiomalate selectivity inhibits interleukin-5-mediated eosinophil survival.
The Journal of allergy and clinical immunology.
1995 Aug; 96(2):251-6. doi:
10.1016/s0091-6749(95)70015-3. [PMID: 7636062] - K Maeda, K Komuta, K Hasegawa, M Ohtsuki, H Morishita, T Igarashi. [A case of interstitial pneumonia in polymyositis difficult to distinguish from gold pneumonitis].
Nihon Kyobu Shikkan Gakkai zasshi.
1995 Jul; 33(7):745-9. doi:
NULL. [PMID: 7564001] - T Saito, S Nishi, R Karasawa, H In, H Hayashi, M Ueno, S Ogino, N Sugiyama, S Suzuki, Y Maruyama. An ultrastructural study of glomerular basement membrane in rheumatoid arthritis patients with urinary abnormalities.
Clinical nephrology.
1995 Jun; 43(6):360-7. doi:
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Thyroid : official journal of the American Thyroid Association.
1995 Apr; 5(2):113-6. doi:
10.1089/thy.1995.5.113. [PMID: 7647570] - Y Takahashi, T Funakoshi, H Shimada, S Kojima. The utility of chelating agents as antidotes for nephrotoxicity of gold sodium thiomalate in adjuvant-arthritic rats.
Toxicology.
1995 Mar; 97(1-3):151-7. doi:
10.1016/0300-483x(94)02944-p. [PMID: 7716781] - C McDonald, P Mortimer, G McAllister, P E Gardiner, J Reglinski, W E Smith. A comparative study of the interaction of Myocrisin with albumin and gamma-globulin.
Journal of pharmaceutical and biomedical analysis.
1995 Feb; 13(2):99-102. doi:
10.1016/0731-7085(94)00118-l. [PMID: 7539297] - J Lewandowicz, B Dabkowska, D Nowak. Influence of gold salts treatment on the serum concentration of IL-1 and IL-2 in patients with rheumatoid arthritis.
Archivum immunologiae et therapiae experimentalis.
1995; 43(3-4):195-8. doi:
NULL. [PMID: 8744695] - M Shingu, Y Fujikawa, T Wada, S Nonaka, M Nobunaga. Increased IL-1 receptor antagonist (IL-1ra) production and decreased IL-1 beta/IL-1ra ratio in mononuclear cells from rheumatoid arthritis patients.
British journal of rheumatology.
1995 Jan; 34(1):24-30. doi:
10.1093/rheumatology/34.1.24. [PMID: 7881833] - T Tonn, C Goebel, M Wilhelm, E Gleichmann. Gold kinetics under long-term treatment with gold(I) disodium thiomalate: a comparison in three different mouse strains.
British journal of rheumatology.
1994 Aug; 33(8):724-30. doi:
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Revista clinica espanola.
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Neuroscience letters.
1994 Jun; 174(2):185-7. doi:
10.1016/0304-3940(94)90017-5. [PMID: 7526289] - K Hashimoto, C E Whitehurst, P E Lipsky. Synergistic inhibition of T cell proliferation by gold sodium thiomalate and auranofin.
The Journal of rheumatology.
1994 Jun; 21(6):1020-6. doi:
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Toxicology.
1994 May; 90(1-2):39-51. doi:
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Rheumatology international.
1994; 14(1):1-7. doi:
10.1007/bf00302664. [PMID: 7939134] - R A Brown, J More, O S Ejim. Preparation of a gelatin-binding conjugate containing gold thiomalate.
Arzneimittel-Forschung.
1993 Jun; 43(6):682-5. doi:
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1993 Apr; 33(2):131-41. doi:
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Annals of the rheumatic diseases.
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