N-Ethyl-2-pyrrolidone (BioDeep_00000691108)

   


代谢物信息卡片


1-Ethyl-2-pyrrolidinone

化学式: C6H11NO (113.0841)
中文名称: 1-乙基-2-吡咯烷酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCN1CCCC1=O
InChI: InChI=1S/C6H11NO/c1-2-7-5-3-4-6(7)8/h2-5H2,1H3

描述信息

同义名列表

3 个代谢物同义名

1-Ethyl-2-pyrrolidinone; N-Ethyl-2-pyrrolidone; 1-Ethyl-2-pyrrolidinone



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Maria I H Schmied-Tobies, Aline Murawski, Enrico Rucic, Gerda Schwedler, Daniel Bury, Monika Kasper-Sonnenberg, Stephan Koslitz, Holger M Koch, Thomas Brüning, Marike Kolossa-Gehring. Alkyl pyrrolidone solvents N-methyl-2-pyrrolidone (NMP) and N-ethyl-2-pyrrolidone (NEP) in urine of children and adolescents in Germany - human biomonitoring results of the German Environmental Survey 2014-2017 (GerESV). Environment international. 2021 01; 146(?):106221. doi: 10.1016/j.envint.2020.106221. [PMID: 33113467]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Dongchao Xie, Weidong Dai, Meiling Lu, Junfeng Tan, Yue Zhang, Mei Chen, Zhi Lin. Nontargeted metabolomics predicts the storage duration of white teas with 8-C N-ethyl-2-pyrrolidinone-substituted flavan-3-ols as marker compounds. Food research international (Ottawa, Ont.). 2019 11; 125(?):108635. doi: 10.1016/j.foodres.2019.108635. [PMID: 31554114]
  • Daniel Bury, Anne Marie Saillenfait, Fabrice Marquet, Heiko U Käfferlein, Thomas Brüning, Holger M Koch. Toxicokinetics of N-ethyl-2-pyrrolidone and its metabolites in blood, urine and amniotic fluid of rats after oral administration. Archives of toxicology. 2019 04; 93(4):921-929. doi: 10.1007/s00204-019-02404-x. [PMID: 30729276]
  • Nadin Ulrich, Daniel Bury, Holger M Koch, Maria Rüther, Till Weber, Heiko-Udo Käfferlein, Tobias Weiss, Thomas Brüning, Marike Kolossa-Gehring. Metabolites of the alkyl pyrrolidone solvents NMP and NEP in 24-h urine samples of the German Environmental Specimen Bank from 1991 to 2014. International archives of occupational and environmental health. 2018 Nov; 91(8):1073-1082. doi: 10.1007/s00420-018-1347-y. [PMID: 30167791]
  • A M Saillenfait, F Marquet, J P Sabaté, D Ndiaye, A M Lambert-Xolin. 4-Week repeated dose oral toxicity study of N-ethyl-2-pyrrolidone in Sprague Dawley rats. Regulatory toxicology and pharmacology : RTP. 2016 Nov; 81(?):275-283. doi: 10.1016/j.yrtph.2016.09.011. [PMID: 27634062]
  • NULL. [Not Available]. Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz. 2015 Sep; 58(9):1041-52. doi: 10.1007/s00103-015-2210-x. [PMID: 26275567]
  • Stephan Koslitz, Swetlana Meier, Birgit Karin Schindler, Tobias Weiss, Holger Martin Koch, Thomas Brüning, Heiko Udo Käfferlein. Biomonitoring of N-ethyl-2-pyrrolidone in automobile varnishers. Toxicology letters. 2014 Dec; 231(2):142-6. doi: 10.1016/j.toxlet.2014.10.016. [PMID: 25455446]
  • Birgit K Schindler, Stephan Koslitz, Swetlana Meier, Vladimir N Belov, Holger M Koch, Tobias Weiss, Thomas Brüning, Heiko U Käfferlein. Quantification of four major metabolites of embryotoxic N-methyl- and N-ethyl-2-pyrrolidone in human urine by cooled-injection gas chromatography and isotope dilution mass spectrometry. Analytical chemistry. 2012 Apr; 84(8):3787-94. doi: 10.1021/ac300439w. [PMID: 22449166]
  • Sheng-Hao Wang, Li-Na Yin, Ze-Hua Liang, Si-Jie Lu, Su Zeng. Stereoselective behavior of a novel biodegradable racemic ketoprofen injectable implant in rats. Chirality. 2007 Nov; 19(10):769-74. doi: 10.1002/chir.20453. [PMID: 17687761]
  • M K Samson, R L Stephens, S Rivkin, M Opipari, T Maloney, C W Groppe, R Fisher. Vinblastine, bleomycin, and cis-dichlorodiammineplatinum(II) in disseminated testicular cancer: preliminary report of a Southwest Oncology Group Study. Cancer treatment reports. 1979 Sep; 63(9-10):1663-7. doi: . [PMID: 91435]