siramesine (BioDeep_00000690827)

   


代谢物信息卡片


siramesine

化学式: C30H31FN2O (454.24202879999996)
中文名称: 西拉美新
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CN(CCC12C3=CC=CC=C3CO2)CCCCC4=CN(C5=CC=CC=C54)C6=CC=C(C=C6)F
InChI: InChI=1S/C30H31FN2O/c31-25-12-14-26(15-13-25)33-21-23(27-9-2-4-11-29(27)33)7-5-6-18-32-19-16-30(17-20-32)28-10-3-1-8-24(28)22-34-30/h1-4,8-15,21H,5-7,16-20,22H2

描述信息

C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent

同义名列表

1 个代谢物同义名

siramesine



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Inger Ødum Nielsen, Knut Kristoffer Bundgaard Clemmensen, Ditte Louise Fogde, Tiina Naumanen Dietrich, Jano Dicroce Giacobini, Mesut Bilgin, Marja Jäättelä, Kenji Maeda. Cationic amphiphilic drugs induce accumulation of cytolytic lysoglycerophospholipids in the lysosomes of cancer cells and block their recycling into common membrane glycerophospholipids. Molecular biology of the cell. 2024 Mar; 35(3):ar25. doi: 10.1091/mbc.e23-06-0263. [PMID: 38117591]
  • Rolf J Craven, Hilaree N Frazier, Olivier Thibault. Dependence of glucose transport on autophagy and GAPDH activity. Brain research. 2022 02; 1776(?):147747. doi: 10.1016/j.brainres.2021.147747. [PMID: 34864044]
  • Gloria E Villalpando-Rodriguez, Anna R Blankstein, Carmen Konzelman, Spencer B Gibson. Lysosomal Destabilizing Drug Siramesine and the Dual Tyrosine Kinase Inhibitor Lapatinib Induce a Synergistic Ferroptosis through Reduced Heme Oxygenase-1 (HO-1) Levels. Oxidative medicine and cellular longevity. 2019; 2019(?):9561281. doi: 10.1155/2019/9561281. [PMID: 31636810]
  • R F Dielschneider, H Eisenstat, S Mi, J M Curtis, W Xiao, J B Johnston, S B Gibson. Lysosomotropic agents selectively target chronic lymphocytic leukemia cells due to altered sphingolipid metabolism. Leukemia. 2016 06; 30(6):1290-300. doi: 10.1038/leu.2016.4. [PMID: 26859075]
  • Mikko J Parry, Juha-Matti I Alakoskela, Himanshu Khandelia, Subramanian Arun Kumar, Marja Jäättelä, Ajay K Mahalka, Paavo K J Kinnunen. High-affinity small molecule-phospholipid complex formation: binding of siramesine to phosphatidic acid. Journal of the American Chemical Society. 2008 Oct; 130(39):12953-60. doi: 10.1021/ja800516w. [PMID: 18767848]
  • Samer J Nuwayhid, Linda L Werling. Sigma2 (sigma2) receptors as a target for cocaine action in the rat striatum. European journal of pharmacology. 2006 Mar; 535(1-3):98-103. doi: 10.1016/j.ejphar.2005.12.077. [PMID: 16480713]
  • Anders Bach Nielsen, Anders Buur, Claus Larsen. Bioreversible quaternary N-acyloxymethyl derivatives of the poorly soluble tertiary amine Lu 28-179--synthesis, pharmaceutical chemical characterization and bioavailability studies in dogs. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2005 Dec; 26(5):421-8. doi: 10.1016/j.ejps.2005.07.009. [PMID: 16150581]
  • Marie Stampe Ostenfeld, Nicole Fehrenbacher, Maria Høyer-Hansen, Christian Thomsen, Thomas Farkas, Marja Jäättelä. Effective tumor cell death by sigma-2 receptor ligand siramesine involves lysosomal leakage and oxidative stress. Cancer research. 2005 Oct; 65(19):8975-83. doi: 10.1158/0008-5472.can-05-0269. [PMID: 16204071]
  • Janne Ørskov Christensen, Kirsten Schultz, Birgitte Mollgaard, Henning Gjelstrup Kristensen, Anette Mullertz. Solubilisation of poorly water-soluble drugs during in vitro lipolysis of medium- and long-chain triacylglycerols. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2004 Nov; 23(3):287-96. doi: 10.1016/j.ejps.2004.08.003. [PMID: 15489130]
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