Fidarestat (BioDeep_00000689939)
代谢物信息卡片
Fidarestat
化学式: C12H10FN3O4 (279.0655312)
中文名称: 非达司他
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C(OC2=C(C13C(=O)NC(=O)N3)C=C(C=C2)F)C(=O)N
InChI: InChI=1S/C12H10FN3O4/c13-5-1-2-7-6(3-5)12(4-8(20-7)9(14)17)10(18)15-11(19)16-12/h1-3,8H,4H2,(H2,14,17)(H2,15,16,18,19)/t8-,12-/m0/s1
数据库引用编号
6 个数据库交叉引用编号
- KEGGdrug: D86149
- KEGGdrug: D01842
- PubChem: 160024
- DrugBank: DB02021
- ChEMBL: CHEMBL84446
- CAS: 136087-85-9
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Roshan M Borkar, Shankar Gajji, Soheb A Mohammed, Mithul Srivastava, Velma Ganga Reddy, Aishwarya Jala, Shailendra Asthana, Ahmed Kamal, Sanjay K Banerjee, Srinivas Ragampeta. Identification and characterization of in vitro and in vivo fidarestat metabolites: Toxicity and efficacy evaluation of metabolites.
Journal of mass spectrometry : JMS.
2021 Feb; 56(2):e4694. doi:
10.1002/jms.4694. [PMID: 33410180] - Himangshu Sonowal, Pabitra B Pal, Jian-Jun Wen, Sanjay Awasthi, Kota V Ramana, Satish K Srivastava. Aldose reductase inhibitor increases doxorubicin-sensitivity of colon cancer cells and decreases cardiotoxicity.
Scientific reports.
2017 06; 7(1):3182. doi:
10.1038/s41598-017-03284-w. [PMID: 28600556] - Kirtikar Shukla, Pabitra Bikash Pal, Himangshu Sonowal, Satish K Srivastava, Kota V Ramana. Aldose Reductase Inhibitor Protects against Hyperglycemic Stress by Activating Nrf2-Dependent Antioxidant Proteins.
Journal of diabetes research.
2017; 2017(?):6785852. doi:
10.1155/2017/6785852. [PMID: 28740855] - Roshan M Borkar, Murali Mohan Bhandi, Ajay P Dubey, Prajwal P Nandekar, Abhay T Sangamwar, Sanjay K Banerjee, R Srinivas. Plasma protein binding, pharmacokinetics, tissue distribution and CYP450 biotransformation studies of fidarestat by ultra high performance liquid chromatography-high resolution mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2015 Jan; 102(?):386-99. doi:
10.1016/j.jpba.2014.10.008. [PMID: 25459938] - Saumya Pandey. Aldose Reductase Inhibitor Fidarestat as a Promising Drug Targeting Autophagy in Colorectal Carcinoma: a Pilot Study.
Asian Pacific journal of cancer prevention : APJCP.
2015; 16(12):4981-5. doi:
10.7314/apjcp.2015.16.12.4981. [PMID: 26163626] - Veeresham Ciddi, Dilip Dodda. Therapeutic potential of resveratrol in diabetic complications: In vitro and in vivo studies.
Pharmacological reports : PR.
2014 Oct; 66(5):799-803. doi:
10.1016/j.pharep.2014.04.006. [PMID: 25149983] - Umesh C S Yadav, K V Ramana, Satish K Srivastava. Aldose reductase regulates acrolein-induced cytotoxicity in human small airway epithelial cells.
Free radical biology & medicine.
2013 Dec; 65(?):15-25. doi:
10.1016/j.freeradbiomed.2013.06.008. [PMID: 23770200] - Umesh C S Yadav, Amarjit S Naura, Leopoldo Aguilera-Aguirre, Istvan Boldogh, Hamid A Boulares, William J Calhoun, Kota V Ramana, Satish K Srivastava. Aldose reductase inhibition prevents allergic airway remodeling through PI3K/AKT/GSK3β pathway in mice.
PloS one.
2013; 8(2):e57442. doi:
10.1371/journal.pone.0057442. [PMID: 23460857] - Kazunori Takahashi, Hiroki Mizukami, Kosuke Kamata, Wataru Inaba, Noriaki Kato, Chihiro Hibi, Soroku Yagihashi. Amelioration of acute kidney injury in lipopolysaccharide-induced systemic inflammatory response syndrome by an aldose reductase inhibitor, fidarestat.
PloS one.
2012; 7(1):e30134. doi:
10.1371/journal.pone.0030134. [PMID: 22253906] - Umesh C S Yadav, Leopoldo Aguilera-Aguirre, Istvan Boldogh, Kota V Ramana, Satish K Srivastava. Aldose reductase deficiency in mice protects from ragweed pollen extract (RWE)-induced allergic asthma.
Respiratory research.
2011 Nov; 12(?):145. doi:
10.1186/1465-9921-12-145. [PMID: 22054012] - Ravinder Tammali, Ashish Saxena, Satish K Srivastava, Kota V Ramana. Aldose reductase inhibition prevents hypoxia-induced increase in hypoxia-inducible factor-1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) by regulating 26 S proteasome-mediated protein degradation in human colon cancer cells.
The Journal of biological chemistry.
2011 Jul; 286(27):24089-100. doi:
10.1074/jbc.m111.219733. [PMID: 21576240] - Joong Kyung Sung, Jang Hyun Koh, Mi Young Lee, Bo Hwan Kim, Soo Min Nam, Jae Hyun Kim, Jin Hee Yoo, So Hee Kim, Sun Won Hong, Eun Young Lee, Ran Choi, Choon Hee Chung. Aldose reductase inhibitor ameliorates renal vascular endothelial growth factor expression in streptozotocin-induced diabetic rats.
Yonsei medical journal.
2010 May; 51(3):385-91. doi:
10.3349/ymj.2010.51.3.385. [PMID: 20376891] - Soroku Yagihashi, Hiroki Mizukami, Saori Ogasawara, Shin-Ichiro Yamagishi, Hitoshi Nukada, Noriaki Kato, Chihiro Hibi, Sookja Chung, Stephen Chung. The role of the polyol pathway in acute kidney injury caused by hindlimb ischaemia in mice.
The Journal of pathology.
2010 Apr; 220(5):530-41. doi:
10.1002/path.2671. [PMID: 20112370] - Irina G Obrosova, Olga Ilnytska, Valeriy V Lyzogubov, Ivan A Pavlov, Nazar Mashtalir, Jerry L Nadler, Viktor R Drel. High-fat diet induced neuropathy of pre-diabetes and obesity: effects of 'healthy' diet and aldose reductase inhibition.
Diabetes.
2007 Oct; 56(10):2598-608. doi:
10.2337/db06-1176. [PMID: 17626889] - Tomoichiro Asano, Yasushi Saito, Masanobu Kawakami, Nobuhiro Yamada, Hisakuni Sekino, Setsuo Hasegawa. Erythrocytic sorbitol contents in diabetic patients correlate with blood aldose reductase protein contents and plasma glucose levels, and are normalized by the potent aldose reductase inhibitor fidarestat (SNK-860).
Journal of diabetes and its complications.
2004 Nov; 18(6):336-42. doi:
10.1016/j.diacomp.2004.04.003. [PMID: 15531183] - M A Yorek, L J Coppey, J S Gellett, E P Davidson, D D Lund. Effect of fidarestat and alpha-lipoic acid on diabetes-induced epineurial arteriole vascular dysfunction.
Experimental diabesity research.
2004 Apr; 5(2):123-35. doi:
10.1080/15438600490277824. [PMID: 15203883] - Irina G Obrosova, Alexander G Minchenko, Rukmini Vasupuram, Lauren White, Omorodola I Abatan, Arno K Kumagai, Robert N Frank, Martin J Stevens. Aldose reductase inhibitor fidarestat prevents retinal oxidative stress and vascular endothelial growth factor overexpression in streptozotocin-diabetic rats.
Diabetes.
2003 Mar; 52(3):864-71. doi:
10.2337/diabetes.52.3.864. [PMID: 12606532] - Ioannis Nicolaou, Vassilis J Demopoulos. Substituted pyrrol-1-ylacetic acids that combine aldose reductase enzyme inhibitory activity and ability to prevent the nonenzymatic irreversible modification of proteins from monosaccharides.
Journal of medicinal chemistry.
2003 Jan; 46(3):417-26. doi:
10.1021/jm0209477. [PMID: 12540241] - Tomoichiro Asano, Yasushi Saito, Masanobu Kawakami, Nobuhiro Yamada. Fidarestat (SNK-860), a potent aldose reductase inhibitor, normalizes the elevated sorbitol accumulation in erythrocytes of diabetic patients.
Journal of diabetes and its complications.
2002 Mar; 16(2):133-8. doi:
10.1016/s1056-8727(01)00175-1. [PMID: 12039395] - H Sobajima, T Aoki, H Sassa, T Suzuki, K Taniko, M Makino, K Mizuno, T Suzuki. Pharmacological properties of fidarestat, a potent aldose reductase inhibitor, clarified by using sorbitol in human and rat erythrocytes.
Pharmacology.
2001 May; 62(4):193-9. doi:
10.1159/000056094. [PMID: 11359994] - K Mizuno, T Suzuki, T Tanaka, K Taniko, T Suzuki. Inhibitory effects of fidarestat on aldose reductase and aldehyde reductase activity evaluated by a new method using HPLC with post-column spectrophotometric detection.
Biological & pharmaceutical bulletin.
2000 Feb; 23(2):244-8. doi:
10.1248/bpb.23.244. [PMID: 10706394]