Salcaprozate sodium (BioDeep_00000689316)
代谢物信息卡片
Salcaprozate sodium
化学式: C15H20NNaO4 (301.12899600000003)
中文名称: 8-(2-羟基苯甲酰胺基)辛酸钠
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C(=C1)C(=O)NCCCCCCCC(=O)[O-])O.[Na+]
InChI: /q
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
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Plant Reactome(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Tine A Baekdal, Morten Donsmark, Marie-Louise Hartoft-Nielsen, Flemming L Søndergaard, Alyson Connor. Relationship Between Oral Semaglutide Tablet Erosion and Pharmacokinetics: A Pharmacoscintigraphic Study.
Clinical pharmacology in drug development.
2021 05; 10(5):453-462. doi:
10.1002/cpdd.938. [PMID: 33750044] - Caroline Twarog, Kai Liu, Peter J O'Brien, Kenneth A Dawson, Elias Fattal, Brigitte Illel, David J Brayden. A head-to-head Caco-2 assay comparison of the mechanisms of action of the intestinal permeation enhancers: SNAC and sodium caprate (C10).
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2020 Jul; 152(?):95-107. doi:
10.1016/j.ejpb.2020.04.023. [PMID: 32387703] - Ying Li, Chunyan Zhu. Development and In Vitro and In Vivo Evaluation of Microspheres Containing Sodium N-[8-(2-hydroxybenzoyl)amino]caprylate for the Oral Delivery of Berberine Hydrochloride.
Molecules (Basel, Switzerland).
2020 Apr; 25(8):. doi:
10.3390/molecules25081957. [PMID: 32340157] - Tine A Bækdal, Jeanett Borregaard, Cilie W Hansen, Mette Thomsen, Thomas W Anderson. Effect of Oral Semaglutide on the Pharmacokinetics of Lisinopril, Warfarin, Digoxin, and Metformin in Healthy Subjects.
Clinical pharmacokinetics.
2019 09; 58(9):1193-1203. doi:
10.1007/s40262-019-00756-2. [PMID: 30945118] - Ying Li, Dandan Yang, Chunyan Zhu. Impact of Sodium N-[8-(2-Hydroxybenzoyl)amino]-caprylate on Intestinal Permeability for Notoginsenoside R1 and Salvianolic Acids in Caco-2 Cells Transport and Rat Pharmacokinetics.
Molecules (Basel, Switzerland).
2018 Nov; 23(11):. doi:
10.3390/molecules23112990. [PMID: 30453465] - B Bittner, C McIntyre, H Tian, K Tang, N Shah, W Phuapradit, H Ahmed, H Chokshi, M Infeld, N Fotaki, H Ma, A Portron, P Jordan, J Schmidt. Phase I clinical study to select a novel oral formulation for ibandronate containing the excipient sodium N-[8-(2-hydroxybenzoyl) amino] caprylate (SNAC).
Die Pharmazie.
2012 Mar; 67(3):233-41. doi:
NULL. [PMID: 22530305] - M Cristina Castelli, Diane F Wong, Kristen Friedman, M Gary I Riley. Pharmacokinetics of oral cyanocobalamin formulated with sodium N-[8-(2-hydroxybenzoyl)amino]caprylate (SNAC): an open-label, randomized, single-dose, parallel-group study in healthy male subjects.
Clinical therapeutics.
2011 Jul; 33(7):934-45. doi:
10.1016/j.clinthera.2011.05.088. [PMID: 21722960] - R E Steinert, B Poller, M C Castelli, K Friedman, A R Huber, J Drewe, C Beglinger. Orally administered glucagon-like peptide-1 affects glucose homeostasis following an oral glucose tolerance test in healthy male subjects.
Clinical pharmacology and therapeutics.
2009 Dec; 86(6):644-50. doi:
10.1038/clpt.2009.159. [PMID: 19727071] - M Gary I Riley, M Cristina Castelli, Ellen Angela Paehler. Subchronic oral toxicity of salcaprozate sodium (SNAC) in Sprague-Dawley and Wistar rats.
International journal of toxicology.
2009 Jul; 28(4):278-93. doi:
10.1177/1091581809337737. [PMID: 19636071] - Shaker A Mousa, Fuming Zhang, Ahmad Aljada, Seema Chaturvedi, Majde Takieddin, Haifeng Zhang, Lianli Chi, M Cristina Castelli, Kristen Friedman, Michael M Goldberg, Robert J Linhardt. Pharmacokinetics and pharmacodynamics of oral heparin solid dosage form in healthy human subjects.
Journal of clinical pharmacology.
2007 Dec; 47(12):1508-20. doi:
10.1177/0091270007307242. [PMID: 18048572] - M Kidron, S Dinh, Y Menachem, R Abbas, B Variano, M Goldberg, E Arbit, H Bar-On. A novel per-oral insulin formulation: proof of concept study in non-diabetic subjects.
Diabetic medicine : a journal of the British Diabetic Association.
2004 Apr; 21(4):354-7. doi:
10.1111/j.1464-5491.2004.01160.x. [PMID: 15049938] - Dmitry Malkov, Huai-Zhen Wang, Steven Dinh, Isabel Gomez-Orellana. Pathway of oral absorption of heparin with sodium N-[8-(2-hydroxybenzoyl)amino] caprylate.
Pharmaceutical research.
2002 Aug; 19(8):1180-4. doi:
10.1023/a:1019802310702. [PMID: 12240944] - G F Pineo, R D Hull, V J Marder. Orally active heparin and low-molecular-weight heparin.
Current opinion in pulmonary medicine.
2001 Sep; 7(5):344-8. doi:
10.1097/00063198-200109000-00016. [PMID: 11584187]