CA-074 methyl ester (BioDeep_00000688002)
代谢物信息卡片
Methyl N-({(2s,3s)-3-[(Propylamino)carbonyl]oxiran-2-Yl}carbonyl)-L-Isoleucyl-L-Prolinate
化学式: C19H31N3O6 (397.2212746)
中文名称: CA-074甲酯
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCNC(=O)C1C(O1)C(=O)NC(C(C)CC)C(=O)N2CCCC2C(=O)OC
InChI: InChI=1S/C19H31N3O6/c1-5-9-20-16(23)14-15(28-14)17(24)21-13(11(3)6-2)18(25)22-10-7-8-12(22)19(26)27-4/h11-15H,5-10H2,1-4H3,(H,20,23)(H,21,24)/t11-,12-,13-,14-,15-/m0/s1
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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Plant Reactome(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kosuke Dodo, Erika Kuboki, Tadashi Shimizu, Ryu Imamura, Megumi Magarisawa, Masahiro Takahashi, Takuto Tokuhiro, Satoshi Yotsumoto, Kenichi Asano, Shuhei Nakao, Naoki Terayama, Takashi Suda, Masato Tanaka, Mikiko Sodeoka. Development of a Water-Soluble Indolylmaleimide Derivative IM-93 Showing Dual Inhibition of Ferroptosis and NETosis.
ACS medicinal chemistry letters.
2019 Sep; 10(9):1272-1278. doi:
10.1021/acsmedchemlett.9b00142. [PMID: 31531196] - Huan Wang, Yi-Xuan Yin, Dong-Mei Gong, Ling-Juan Hong, Gang Wu, Quan Jiang, Cheng-Kun Wang, Pablo Blinder, Sen Long, Feng Han, Ying-Mei Lu. Cathepsin B inhibition ameliorates leukocyte-endothelial adhesion in the BTBR mouse model of autism.
CNS neuroscience & therapeutics.
2019 04; 25(4):476-485. doi:
10.1111/cns.13074. [PMID: 30328295] - Yong Tang, Guojun Cao, Xiaobo Min, Tao Wang, Shiran Sun, Xiaolong Du, Weikang Zhang. Cathepsin B inhibition ameliorates the non-alcoholic steatohepatitis through suppressing caspase-1 activation.
Journal of physiology and biochemistry.
2018 Nov; 74(4):503-510. doi:
10.1007/s13105-018-0644-y. [PMID: 30019185] - Tianming Qiu, Pei Pei, Xiaofeng Yao, Liping Jiang, Sen Wei, Zhidong Wang, Jie Bai, Guang Yang, Ni Gao, Lei Yang, Shuangyue Qi, Rushan Yan, Xiaofang Liu, Xiance Sun. Taurine attenuates arsenic-induced pyroptosis and nonalcoholic steatohepatitis by inhibiting the autophagic-inflammasomal pathway.
Cell death & disease.
2018 09; 9(10):946. doi:
10.1038/s41419-018-1004-0. [PMID: 30237538] - Lei Wang, Yang Chen, Xiang Li, Youzhi Zhang, Erich Gulbins, Yang Zhang. Enhancement of endothelial permeability by free fatty acid through lysosomal cathepsin B-mediated Nlrp3 inflammasome activation.
Oncotarget.
2016 Nov; 7(45):73229-73241. doi:
10.18632/oncotarget.12302. [PMID: 27689324] - Christopher Fox, Pasquale Cocchiaro, Fiona Oakley, Rachel Howarth, Krystena Callaghan, Jack Leslie, Saimir Luli, Katrina M Wood, Federica Genovese, Neil S Sheerin, Anna Moles. Inhibition of lysosomal protease cathepsin D reduces renal fibrosis in murine chronic kidney disease.
Scientific reports.
2016 Feb; 6(?):20101. doi:
10.1038/srep20101. [PMID: 26831567] - Shina Wei, Youhua Huang, Xiaohong Huang, Jia Cai, Yang Yan, Chuanyu Guo, Qiwei Qin. Characterization of cathepsin B gene from orange-spotted grouper, Epinephelus coioides involved in SGIV infection.
Fish & shellfish immunology.
2014 Jan; 36(1):194-205. doi:
10.1016/j.fsi.2013.11.006. [PMID: 24239598] - Soon-Duck Ha, Sangwook Park, Clayton James Hattlmann, Stephen Dominic Barr, Sung Ouk Kim. Inhibition or deficiency of cathepsin B leads defects in HIV-1 Gag pseudoparticle release in macrophages and HEK293T cells.
Antiviral research.
2012 Jan; 93(1):175-84. doi:
10.1016/j.antiviral.2011.11.009. [PMID: 22138708] - Katri Niemi, Laura Teirilä, Jani Lappalainen, Kristiina Rajamäki, Marc H Baumann, Katariina Öörni, Henrik Wolff, Petri T Kovanen, Sampsa Matikainen, Kari K Eklund. Serum amyloid A activates the NLRP3 inflammasome via P2X7 receptor and a cathepsin B-sensitive pathway.
Journal of immunology (Baltimore, Md. : 1950).
2011 Jun; 186(11):6119-28. doi:
10.4049/jimmunol.1002843. [PMID: 21508263] - Angela J Eykelbosh, Glen Van Der Kraak. A role for the lysosomal protease cathepsin B in zebrafish follicular apoptosis.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.
2010 Jun; 156(2):218-23. doi:
10.1016/j.cbpa.2010.02.005. [PMID: 20170740] - Soon-Duck Ha, Andrew Martins, Khashayarsha Khazaie, Jiahuai Han, Bosco M C Chan, Sung Ouk Kim. Cathepsin B is involved in the trafficking of TNF-alpha-containing vesicles to the plasma membrane in macrophages.
Journal of immunology (Baltimore, Md. : 1950).
2008 Jul; 181(1):690-7. doi:
10.4049/jimmunol.181.1.690. [PMID: 18566436] - Roberta Castino, Deborah Pace, Marina Démoz, Marco Gargiulo, Chiara Ariatta, Elisabetta Raiteri, Ciro Isidoro. Lysosomal proteases as potential targets for the induction of apoptotic cell death in human neuroblastomas.
International journal of cancer.
2002 Feb; 97(6):775-9. doi:
10.1002/ijc.10139. [PMID: 11857353] - M Ahram, M Sameni, R G Qiu, B Linebaugh, D Kirn, B F Sloane. Rac1-induced endocytosis is associated with intracellular proteolysis during migration through a three-dimensional matrix.
Experimental cell research.
2000 Nov; 260(2):292-303. doi:
10.1006/excr.2000.5031. [PMID: 11035924] - M Sameni, K Moin, B F Sloane. Imaging proteolysis by living human breast cancer cells.
Neoplasia (New York, N.Y.).
2000 Nov; 2(6):496-504. doi:
10.1038/sj.neo.7900116. [PMID: 11228542]