Suc-Leu-Leu-Val-Tyr-AMC (BioDeep_00000687981)
代谢物信息卡片
Suc-Leu-Leu-Val-Tyr-AMC
化学式: C40H53N5O10 (763.3792238)
中文名称: SUC-LEU-LEU-VAL-酪氨酸-AMC
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)C(CC3=CC=C(C=C3)O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)CCC(=O)O
InChI: InChI=1S/C40H53N5O10/c1-21(2)16-29(42-33(47)14-15-34(48)49)38(52)43-30(17-22(3)4)39(53)45-36(23(5)6)40(54)44-31(19-25-8-11-27(46)12-9-25)37(51)41-26-10-13-28-24(7)18-35(50)55-32(28)20-26/h8-13,18,20-23,29-31,36,46H,14-17,19H2,1-7H3,(H,41,51)(H,42,47)(H,43,52)(H,44,54)(H,45,53)(H,48,49)/t29-,30-,31-,36-/m0/s1
描述信息
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D049408 - Luminescent Agents
D004396 - Coloring Agents > D005456 - Fluorescent Dyes
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Marzena Tylicka, Ewa Matuszczak, Maria Karpińska, Adam Hermanowicz, Wojciech Dębek, Halina Ostrowska. Proteasome and C-reactive protein inflammatory response in children undergoing shorter and longer lasting laparoscopic cholecystectomy.
Scandinavian journal of clinical and laboratory investigation.
2017 Dec; 77(8):610-616. doi:
10.1080/00365513.2017.1385839. [PMID: 29022764] - Daniela Correia da Silva, Paula B Andrade, Patrícia Valentão, David M Pereira. Neurotoxicity of the steroidal alkaloids tomatine and tomatidine is RIP1 kinase- and caspase-independent and involves the eIF2α branch of the endoplasmic reticulum.
The Journal of steroid biochemistry and molecular biology.
2017 07; 171(?):178-186. doi:
10.1016/j.jsbmb.2017.03.009. [PMID: 28300624] - Ewa Matuszczak, Marzena Tylicka, Wojciech Dębek, Adam Hermanowicz, Halina Ostrowska. The comparison of C-proteasome activity in the plasma of children after burn injury, mild head injury and blunt abdominal trauma.
Advances in medical sciences.
2015 Sep; 60(2):253-8. doi:
10.1016/j.advms.2015.04.005. [PMID: 26005993] - Yuejuan Zheng, Xin Jiang, Feng Gao, Junxiang Song, Jinxia Sun, Lixin Wang, Xiaoxia Sun, Zhenhui Lu, Huiyong Zhang. Identification of plant-derived natural products as potential inhibitors of the Mycobacterium tuberculosis proteasome.
BMC complementary and alternative medicine.
2014 Oct; 14(?):400. doi:
10.1186/1472-6882-14-400. [PMID: 25315519] - E Matuszczak, M Tylicka, W Dębek, A Hermanowicz, H Ostrowska. Correlation between circulating proteasome activity, total protein and c-reactive protein levels following burn in children.
Burns : journal of the International Society for Burn Injuries.
2014 Aug; 40(5):842-7. doi:
10.1016/j.burns.2013.11.004. [PMID: 24290960] - Marzena Tylicka, Ewa Matuszczak, Wojciech Dębek, Adam Hermanowicz, Halina Ostrowska. Circulating proteasome activity following mild head injury in children.
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery.
2014 Jul; 30(7):1191-6. doi:
10.1007/s00381-014-2409-4. [PMID: 24700339] - Prodyot K Chatterjee, Michael M Yeboah, Oonagh Dowling, Xiangying Xue, Saul R Powell, Yousef Al-Abed, Christine N Metz. Nicotinic acetylcholine receptor agonists attenuate septic acute kidney injury in mice by suppressing inflammation and proteasome activity.
PloS one.
2012; 7(5):e35361. doi:
10.1371/journal.pone.0035361. [PMID: 22586448] - Yi-Chen Lin, Han-Min Chen, I-Min Chou, An-Na Chen, Chia-Pei Chen, Guang-Huar Young, Chi-Tsai Lin, Chiung-Hsiang Cheng, Shih-Chung Chang, Rong-Huay Juang. Plastidial starch phosphorylase in sweet potato roots is proteolytically modified by protein-protein interaction with the 20S proteasome.
PloS one.
2012; 7(4):e35336. doi:
10.1371/journal.pone.0035336. [PMID: 22506077] - Dominika Hempel, Marek Z Wojtukiewicz, Leszek Kozłowski, Jacek Romatowski, Halina Ostrowska. Increased plasma proteasome chymotrypsin-like activity in patients with advanced solid tumors.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.
2011 Aug; 32(4):753-9. doi:
10.1007/s13277-011-0177-2. [PMID: 21611786] - Eun Jin Yang, Seon Hwy Kim, Sun Choel Yang, Sang Min Lee, Sun-Mi Choi. Melittin restores proteasome function in an animal model of ALS.
Journal of neuroinflammation.
2011 Jun; 8(?):69. doi:
10.1186/1742-2094-8-69. [PMID: 21682930] - Asaf A Qureshi, Julia C Reis, Christopher J Papasian, David C Morrison, Nilofer Qureshi. Tocotrienols inhibit lipopolysaccharide-induced pro-inflammatory cytokines in macrophages of female mice.
Lipids in health and disease.
2010 Dec; 9(?):143. doi:
10.1186/1476-511x-9-143. [PMID: 21162750] - Tsui-Ling Chang, Hsiou-Yu Ding, Kang-Ning Teng, Yi-Chen Fang. 5,6,3',4'-Tetrahydroxy-7-methoxyflavone as a novel potential proteasome inhibitor.
Planta medica.
2010 Jul; 76(10):987-94. doi:
10.1055/s-0029-1240899. [PMID: 20195959] - Hwan-Ching Tai, Henrike Besche, Alfred L Goldberg, Erin M Schuman. Characterization of the Brain 26S Proteasome and its Interacting Proteins.
Frontiers in molecular neuroscience.
2010; 3(?):. doi:
10.3389/fnmol.2010.00012. [PMID: 20717473] - Lotta Gustafsson, Sonja Aits, Patrik Onnerfjord, Maria Trulsson, Petter Storm, Catharina Svanborg. Changes in proteasome structure and function caused by HAMLET in tumor cells.
PloS one.
2009; 4(4):e5229. doi:
10.1371/journal.pone.0005229. [PMID: 19365565] - Sarah Chapelsky, Sarah Batty, Mia Frost, Jeremy Mogridge. Inhibition of anthrax lethal toxin-induced cytolysis of RAW264.7 cells by celastrol.
PloS one.
2008 Jan; 3(1):e1421. doi:
10.1371/journal.pone.0001421. [PMID: 18183301] - Kavita Prasad, Bozena Winnik, Mona J Thiruchelvam, Brian Buckley, Oleg Mirochnitchenko, Eric K Richfield. Prolonged toxicokinetics and toxicodynamics of paraquat in mouse brain.
Environmental health perspectives.
2007 Oct; 115(10):1448-53. doi:
10.1289/ehp.9932. [PMID: 17938734] - Miguel Díaz-Hernández, Adriana G Valera, María A Morán, Pilar Gómez-Ramos, Beatriz Alvarez-Castelao, José G Castaño, Félix Hernández, José J Lucas. Inhibition of 26S proteasome activity by huntingtin filaments but not inclusion bodies isolated from mouse and human brain.
Journal of neurochemistry.
2006 Sep; 98(5):1585-96. doi:
10.1111/j.1471-4159.2006.03968.x. [PMID: 16787406] - Patricio Morales, Eduardo Pizarro, Milene Kong, Marcos Jara. Extracellular localization of proteasomes in human sperm.
Molecular reproduction and development.
2004 May; 68(1):115-24. doi:
10.1002/mrd.20052. [PMID: 15039955] - Patricio Morales, Milene Kong, Eduardo Pizarro, Consuelo Pasten. Participation of the sperm proteasome in human fertilization.
Human reproduction (Oxford, England).
2003 May; 18(5):1010-7. doi:
10.1093/humrep/deg111. [PMID: 12721178] - Halina Ostrowska, Justyna Kornelia Ostrowska, Krzysztof Worowski, Piotr Radziwon. Human platelet 20S proteasome: inhibition of its chymotrypsin-like activity and identification of the proteasome activator PA28. A preliminary report.
Platelets.
2003 May; 14(3):151-7. doi:
10.1080/0953710031000092802. [PMID: 12850839] - Hitoshi Sawada, Youko Takahashi, Junko Fujino, Sandra Y Flores, Hideyoshi Yokosawa. Localization and roles in fertilization of sperm proteasomes in the ascidian Halocynthia roretzi.
Molecular reproduction and development.
2002 Jun; 62(2):271-6. doi:
10.1002/mrd.10089. [PMID: 11984838] - T Goasduff, A I Cederbaum. CYP2E1 degradation by in vitro reconstituted systems: role of the molecular chaperone hsp90.
Archives of biochemistry and biophysics.
2000 Jul; 379(2):321-30. doi:
10.1006/abbi.2000.1870. [PMID: 10898951] - N Watanabe, S Yamada. Activation of 20S proteasomes from spinach leaves by fatty acids.
Plant & cell physiology.
1996 Mar; 37(2):147-51. doi:
10.1093/oxfordjournals.pcp.a028925. [PMID: 8665092] - M Arao, T Yamaguchi, T Sugimoto, M Fukase, K Chihara. Characterization of a chymotrypsin-like hydrolytic activity in the opossum kidney cell.
Biochemistry and cell biology = Biochimie et biologie cellulaire.
1994 Mar; 72(3-4):157-62. doi:
10.1139/o94-023. [PMID: 7818850] - K Inaba, M Morisawa. Chymotrypsin-like protease activity associated with demembranated sperm of chum salmon.
Biology of the cell.
1992; 76(3):329-33. doi:
10.1016/0248-4900(92)90435-4. [PMID: 1305478]