CA 074 TFA (BioDeep_00000687962)
代谢物信息卡片
化学式: C18H29N3O6 (383.20562540000003)
中文名称: CA-074
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCNC(=O)C1C(O1)C(=O)NC(C(C)CC)C(=O)N2CCCC2C(=O)O
InChI: InChI=1S/C18H29N3O6/c1-4-8-19-15(22)13-14(27-13)16(23)20-12(10(3)5-2)17(24)21-9-6-7-11(21)18(25)26/h10-14H,4-9H2,1-3H3,(H,19,22)(H,20,23)(H,25,26)
描述信息
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D015853 - Cysteine Proteinase Inhibitors
D002491 - Central Nervous System Agents > D018696 - Neuroprotective Agents
D020011 - Protective Agents
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Panpan Feng, Wei Zhu, Nan Chen, Peizhi Li, Kun He, Jianping Gong. [Cathepsin B in hepatic Kupffer cells regulates activation of TLR4-independent inflammatory pathways in mice with lipopolysaccharide-induced sepsis].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2018 Dec; 38(12):1465-1471. doi:
10.12122/j.issn.1673-4254.2018.12.11. [PMID: 30613015] - Christopher B Toomey, David M Cauvi, John C Hamel, Andrea E Ramirez, K Michael Pollard. Cathepsin B regulates the appearance and severity of mercury-induced inflammation and autoimmunity.
Toxicological sciences : an official journal of the Society of Toxicology.
2014 Dec; 142(2):339-49. doi:
10.1093/toxsci/kfu189. [PMID: 25237059] - Chong Da Tan, Carey Hobbs, Mansoureh Sameni, Bonnie F Sloane, M Jackson Stutts, Robert Tarran. Cathepsin B contributes to Na+ hyperabsorption in cystic fibrosis airway epithelial cultures.
The Journal of physiology.
2014 Dec; 592(23):5251-68. doi:
10.1113/jphysiol.2013.267286. [PMID: 25260629] - Bing-Zhu Yan, Li-Yan Chen, Lan Kang, Xiao-Ren Wang, Man-Ru Bi, Wei Wang, Bao-Shan Yang. Hepatoprotective effects of cathepsin B inhibitor on acute hepatic failure induced by lipopolysaccharide/D-galactosamine in mice.
Hepatobiliary & pancreatic diseases international : HBPD INT.
2013 Feb; 12(1):80-6. doi:
10.1016/s1499-3872(13)60010-7. [PMID: 23392803] - Igor Stern, Norbert Schaschke, Luis Moroder, Dusan Turk. Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft.
The Biochemical journal.
2004 Jul; 381(Pt 2):511-7. doi:
10.1042/bj20040237. [PMID: 15084146] - T Ohshita, Y Hiroi. Degradation of serum albumin by rat liver and kidney lysosomes.
Journal of nutritional science and vitaminology.
1998 Oct; 44(5):641-53. doi:
10.3177/jnsv.44.641. [PMID: 9919484] - T Ohshita, T Nikawa, T Towatari, N Katunuma. Effects of selective inhibition of cathepsin B and general inhibition of cysteine proteinases on lysosomal proteolysis in rat liver in vivo and in vitro.
European journal of biochemistry.
1992 Oct; 209(1):223-31. doi:
10.1111/j.1432-1033.1992.tb17280.x. [PMID: 1382984]