dihydroouabain (BioDeep_00000687883)

   


代谢物信息卡片


Sdccgsbi-0050343.P002

化学式: C29H46O12 (586.2989)
中文名称: 二氢哇巴因
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1C(C(C(C(O1)OC2CC(C3(C4C(CCC3(C2)O)C5(CCC(C5(CC4O)C)C6CC(=O)OC6)O)CO)O)O)O)O
InChI: InChI=1S/C29H46O12/c1-13-22(34)23(35)24(36)25(40-13)41-15-8-19(32)28(12-30)21-17(3-5-27(28,37)9-15)29(38)6-4-16(14-7-20(33)39-11-14)26(29,2)10-18(21)31/h13-19,21-25,30-32,34-38H,3-12H2,1-2H3/t13-,14?,15-,16+,17+,18+,19+,21+,22-,23+,24+,25-,26+,27-,28+,29-/m0/s1

描述信息

D020011 - Protective Agents > D002316 - Cardiotonic Agents > D002301 - Cardiac Glycosides
D020011 - Protective Agents > D002316 - Cardiotonic Agents > D013328 - Strophanthins

同义名列表

2 个代谢物同义名

dihydroouabain; Sdccgsbi-0050343.P002



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Kaja Karaś, Anna Sałkowska, Aurelia Walczak-Drzewiecka, Katarzyna Ryba, Jarosław Dastych, Rafał A Bachorz, Marcin Ratajewski. The cardenolides strophanthidin, digoxigenin and dihydroouabain act as activators of the human RORγ/RORγT receptors. Toxicology letters. 2018 Oct; 295(?):314-324. doi: 10.1016/j.toxlet.2018.07.002. [PMID: 29981919]
  • Mohammad Al-Ghoul, Roland Valdes. Mammalian cardenolides in cancer prevention and therapeutics. Therapeutic drug monitoring. 2008 Apr; 30(2):234-8. doi: 10.1097/ftd.0b013e31816b90ff. [PMID: 18367987]
  • M Adnan el-Masri, Barbara J Clark, Hassan M Qazzaz, Roland Valdes. Human adrenal cells in culture produce both ouabain-like and dihydroouabain-like factors. Clinical chemistry. 2002 Oct; 48(10):1720-30. doi: 10.1093/clinchem/48.10.1720. [PMID: 12324489]
  • P Manunta, B P Hamilton, J M Hamlyn. Structure-activity relationships for the hypertensinogenic activity of ouabain: role of the sugar and lactone ring. Hypertension (Dallas, Tex. : 1979). 2001 Feb; 37(2 Pt 2):472-7. doi: 10.1161/01.hyp.37.2.472. [PMID: 11230321]
  • H M Qazzaz, M A El-Masri, N J Stolowich, R Valdes. Two biologically active isomers of dihydroouabain isolated from a commercial preparation. Biochimica et biophysica acta. 1999 Nov; 1472(3):486-97. doi: 10.1016/s0304-4165(99)00153-1. [PMID: 10564763]
  • V V Senatorov, B Hu. Differential Na(+)-K(+)-ATPase activity in rat lemniscal and non-lemniscal auditory thalami. The Journal of physiology. 1997 Jul; 502 ( Pt 2)(?):387-95. doi: 10.1111/j.1469-7793.1997.387bk.x. [PMID: 9263918]
  • C Schumacher, H Becker, R Conrads, U Schotten, S Pott, M Kellinghaus, M Sigmund, F Schöndube, C Preusse, H D Schulte. Hypertrophic cardiomyopathy: a desensitized cardiac beta-adrenergic system in the presence of normal plasma catecholamine concentrations. Naunyn-Schmiedeberg's archives of pharmacology. 1995 Apr; 351(4):398-407. doi: 10.1007/bf00169081. [PMID: 7630430]
  • G Feige, T Leutert, A De Pover. Na,K-ATPase isozymes in rat tissues: differential sensitivities to sodium, vanadate and dihydroouabain. Progress in clinical and biological research. 1988; 268B(?):377-84. doi: NULL. [PMID: 2851817]
  • M Fagoo, P Braquet, J P Robin, A Esanu, T Godfraind. Evidence that mammalian lignans show endogenous digitalis-like activities. Biochemical and biophysical research communications. 1986 Feb; 134(3):1064-70. doi: 10.1016/0006-291x(86)90359-1. [PMID: 3004480]