PF-543 (BioDeep_00000687556)
代谢物信息卡片
Sphingosine Kinase 1 Inhibitor II
化学式: C27H31NO4S (465.19736860000006)
中文名称: PF-543
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=CC(=CC(=C1)OCC2=CC=C(C=C2)CN3CCCC3CO)CS(=O)(=O)C4=CC=CC=C4
InChI: InChI=1S/C27H31NO4S/c1-21-14-24(20-33(30,31)27-7-3-2-4-8-27)16-26(15-21)32-19-23-11-9-22(10-12-23)17-28-13-5-6-25(28)18-29/h2-4,7-12,14-16,25,29H,5-6,13,17-20H2,1H3/t25-/m1/s1
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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INOH(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tiandi Ding, Ying Zhi, Weilin Xie, Qingqiang Yao, Bo Liu. Rational design of SphK inhibitors using crystal structures aided by computer.
European journal of medicinal chemistry.
2021 Mar; 213(?):113164. doi:
10.1016/j.ejmech.2021.113164. [PMID: 33454547] - Hai-Jiao Chen, Hao-Ran Yang, Ying Zhi, Qing-Qiang Yao, Bo Liu. Evaluation of pyrrolidine-based analog of jaspine B as potential SphK1 inhibitors against rheumatoid arthritis.
Bioorganic & medicinal chemistry letters.
2021 02; 34(?):127754. doi:
10.1016/j.bmcl.2020.127754. [PMID: 33347967] - Longjun Li, Haitao Wang, Jun Zhang, Yeqin Sha, Fengjiao Wu, Shuang Wen, Lianping He, Liang Sheng, Qiang You, Meiqing Shi, Lixin Liu, Hong Zhou. SPHK1 deficiency protects mice from acetaminophen-induced ER stress and mitochondrial permeability transition.
Cell death and differentiation.
2020 06; 27(6):1924-1937. doi:
10.1038/s41418-019-0471-x. [PMID: 31827236] - Su Bin Kim, Taeho Lee, Hong Seop Moon, Sung Hwan Ki, Yoon Sin Oh, Joo-Youn Lee, Sang-Bum Kim, Jeong-Eun Park, Yongseok Kwon, Sanghee Kim, Dong Jae Baek, Eun-Young Park. Verification of the Necessity of the Tolyl Group of PF-543 for Sphingosine Kinase 1 Inhibitory Activity.
Molecules (Basel, Switzerland).
2020 May; 25(11):. doi:
10.3390/molecules25112484. [PMID: 32471162] - Athanasios Papakyriakou, Francesca Cencetti, Elisa Puliti, Laura Morelli, Jacopo Tricomi, Paola Bruni, Federica Compostella, Barbara Richichi. Glycans Meet Sphingolipids: Structure-Based Design of Glycan Containing Analogues of a Sphingosine Kinase Inhibitor.
ACS medicinal chemistry letters.
2020 May; 11(5):913-920. doi:
10.1021/acsmedchemlett.9b00665. [PMID: 32435405] - David R Adams, Salha Tawati, Giacomo Berretta, Paula Lopez Rivas, Jessica Baiget, Zhong Jiang, Aisha Alsfouk, Simon P Mackay, Nigel J Pyne, Susan Pyne. Topographical Mapping of Isoform-Selectivity Determinants for J-Channel-Binding Inhibitors of Sphingosine Kinases 1 and 2.
Journal of medicinal chemistry.
2019 04; 62(7):3658-3676. doi:
10.1021/acs.jmedchem.9b00162. [PMID: 30889352] - Yugesh Kharel, Sayeh Agah, Tao Huang, Anna J Mendelson, Oluwafunmilayo T Eletu, Peter Barkey-Bircann, James Gesualdi, Jeffrey S Smith, Webster L Santos, Kevin R Lynch. Saccharomyces cerevisiae as a platform for assessing sphingolipid lipid kinase inhibitors.
PloS one.
2018; 13(4):e0192179. doi:
10.1371/journal.pone.0192179. [PMID: 29672528] - Chunyang Du, Yunzhuo Ren, Fang Yao, Jialiang Duan, Hui'er Zhao, Yunxia Du, Xia Xiao, Huijun Duan, Yonghong Shi. Sphingosine kinase 1 protects renal tubular epithelial cells from renal fibrosis via induction of autophagy.
The international journal of biochemistry & cell biology.
2017 09; 90(?):17-28. doi:
10.1016/j.biocel.2017.07.011. [PMID: 28733250] - Mark E Schnute, Matthew D McReynolds, Jeffrey Carroll, Jill Chrencik, Maureen K Highkin, Kaliapan Iyanar, Gina Jerome, John W Rains, Matthew Saabye, Jeffrey A Scholten, Matthew Yates, Marek M Nagiec. Discovery of a Potent and Selective Sphingosine Kinase 1 Inhibitor through the Molecular Combination of Chemotype-Distinct Screening Hits.
Journal of medicinal chemistry.
2017 03; 60(6):2562-2572. doi:
10.1021/acs.jmedchem.7b00070. [PMID: 28231433] - Neil MacRitchie, Giora Volpert, Mohammed Al Washih, David G Watson, Anthony H Futerman, Simon Kennedy, Susan Pyne, Nigel J Pyne. Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodelling in a hypoxic model of pulmonary arterial hypertension.
Cellular signalling.
2016 08; 28(8):946-55. doi:
10.1016/j.cellsig.2016.03.014. [PMID: 27063355] - Molly D Congdon, Yugesh Kharel, Anne M Brown, Stephanie N Lewis, David R Bevan, Kevin R Lynch, Webster L Santos. Structure-Activity Relationship Studies and Molecular Modeling of Naphthalene-Based Sphingosine Kinase 2 Inhibitors.
ACS medicinal chemistry letters.
2016 Mar; 7(3):229-34. doi:
10.1021/acsmedchemlett.5b00304. [PMID: 26985306] - Dominik Vogt, Julia Weber, Katja Ihlefeld, Astrid Brüggerhoff, Ewgenij Proschak, Holger Stark. Design, synthesis and evaluation of 2-aminothiazole derivatives as sphingosine kinase inhibitors.
Bioorganic & medicinal chemistry.
2014 Oct; 22(19):5354-67. doi:
10.1016/j.bmc.2014.07.044. [PMID: 25150091] - Francesca Cingolani, Mireia Casasampere, Pol Sanllehí, Josefina Casas, Jordi Bujons, Gemma Fabrias. Inhibition of dihydroceramide desaturase activity by the sphingosine kinase inhibitor SKI II.
Journal of lipid research.
2014 Aug; 55(8):1711-20. doi:
10.1194/jlr.m049759. [PMID: 24875537] - Yujin Zhang, Vladimir Berka, Anren Song, Kaiqi Sun, Wei Wang, Weiru Zhang, Chen Ning, Chonghua Li, Qibo Zhang, Mikhail Bogdanov, Danny C Alexander, Michael V Milburn, Mostafa H Ahmed, Han Lin, Modupe Idowu, Jun Zhang, Gregory J Kato, Osheiza Y Abdulmalik, Wenzheng Zhang, William Dowhan, Rodney E Kellems, Pumin Zhang, Jianping Jin, Martin Safo, Ah-Lim Tsai, Harinder S Juneja, Yang Xia. Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression.
The Journal of clinical investigation.
2014 Jun; 124(6):2750-61. doi:
10.1172/jci74604. [PMID: 24837436] - Mark E Schnute, Matthew D McReynolds, Tom Kasten, Matthew Yates, Gina Jerome, John W Rains, Troii Hall, Jill Chrencik, Michelle Kraus, Ciaran N Cronin, Matthew Saabye, Maureen K Highkin, Richard Broadus, Shinji Ogawa, Kristin Cukyne, Laura E Zawadzke, Vincent Peterkin, Kaliapan Iyanar, Jeffrey A Scholten, Jay Wendling, Hideji Fujiwara, Olga Nemirovskiy, Arthur J Wittwer, Marek M Nagiec. Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1.
The Biochemical journal.
2012 May; 444(1):79-88. doi:
10.1042/bj20111929. [PMID: 22397330] - Kevin R Lynch. Building a better sphingosine kinase-1 inhibitor.
The Biochemical journal.
2012 May; 444(1):e1-2. doi:
10.1042/bj20120567. [PMID: 22533672]