Azd-4547 (BioDeep_00000687112)
代谢物信息卡片
化学式: C26H33N5O3 (463.2583268000001)
中文名称: AZD4547
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1CN(CC(N1)C)C2=CC=C(C=C2)C(=O)NC3=NNC(=C3)CCC4=CC(=CC(=C4)OC)OC
InChI: InChI=1S/C26H33N5O3/c1-17-15-31(16-18(2)27-17)22-9-6-20(7-10-22)26(32)28-25-13-21(29-30-25)8-5-19-11-23(33-3)14-24(12-19)34-4/h6-7,9-14,17-18,27H,5,8,15-16H2,1-4H3,(H2,28,29,30,32)/t17-,18+
描述信息
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C164035 - FGFR-targeting Agent
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C1967 - Tyrosine Kinase Inhibitor
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor > C155727 - FGFR Inhibitor
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Hiroyuki Suzuki, Hideki Iwamoto, Toshimitsu Tanaka, Takahiko Sakaue, Yasuko Imamura, Atsutaka Masuda, Toru Nakamura, Hironori Koga, Yujin Hoshida, Takumi Kawaguchi. Fibroblast growth factor inhibition by molecular-targeted agents mitigates immunosuppressive tissue microenvironment in hepatocellular carcinoma.
Hepatology international.
2024 Apr; 18(2):610-622. doi:
10.1007/s12072-023-10603-z. [PMID: 37864726] - Jinho Lee, Kyung Don Ju, Hyo Jin Kim, Bodokhsuren Tsogbadrakh, Hyunjin Ryu, Eunjeong Kang, Minjung Kang, Jaeseok Yang, Hee Gyung Kang, Curie Ahn, Kook-Hwan Oh. Soluble α-klotho anchors TRPV5 to the distal tubular cell membrane independent of FGFR1 by binding TRPV5 and galectin-1 simultaneously.
American journal of physiology. Renal physiology.
2021 04; 320(4):F559-F568. doi:
10.1152/ajprenal.00044.2021. [PMID: 33615893] - Shyang-Rong Shih, Shu-Lang Liao, Chih-Wei Shih, Yi-Hsuan Wei, Ting-Xuan Lu, Chien-Hsiang Chou, Er-Yen Yen, Yi-Cheng Chang, Chia-Chi Lin, Yu-Chiao Chi, Wei-Shiung Yang, Feng-Chiao Tsai. Fibroblast Growth Factor Receptor Inhibitors Reduce Adipogenesis of Orbital Fibroblasts and Enhance Myofibroblastic Differentiation in Graves' Orbitopathy.
Ocular immunology and inflammation.
2021 Jan; 29(1):193-202. doi:
10.1080/09273948.2019.1672196. [PMID: 31657648] - Magdalena Rausch, Andrea Weiss, Joanna Achkhanian, Andrei Rotari, Patrycja Nowak-Sliwinska. Identification of low-dose multidrug combinations for sunitinib-naive and pre-treated renal cell carcinoma.
British journal of cancer.
2020 08; 123(4):556-567. doi:
10.1038/s41416-020-0890-y. [PMID: 32439932] - Xuemei Chen, Xuejiao Zhang, Jiajun Xu, Yiqing Zhao, Jiachun Bao, Zhanxiong Zheng, Jibo Han. AZD4547 Attenuates Lipopolysaccharide-Induced Acute Kidney Injury by Inhibiting Inflammation: The Role of FGFR1 in Renal Tubular Epithelial Cells.
Drug design, development and therapy.
2020; 14(?):833-844. doi:
10.2147/dddt.s224343. [PMID: 32161443] - Liping Shan, Wei Liu, Yunhong Zhan. Sulfated polysaccharide of Sepiella maindroni ink targets Akt and overcomes resistance to the FGFR inhibitor AZD4547 in bladder cancer.
Aging.
2019 09; 11(18):7780-7795. doi:
10.18632/aging.102286. [PMID: 31545294] - Hideo Saka, Chiyoe Kitagawa, Yoshihito Kogure, Yasuo Takahashi, Koshi Fujikawa, Tamotsu Sagawa, Satoru Iwasa, Naoki Takahashi, Taro Fukao, Catherine Tchinou, Dónal Landers, Yasuhide Yamada. Safety, tolerability and pharmacokinetics of the fibroblast growth factor receptor inhibitor AZD4547 in Japanese patients with advanced solid tumours: a Phase I study.
Investigational new drugs.
2017 08; 35(4):451-462. doi:
10.1007/s10637-016-0416-x. [PMID: 28070720] - Oona Delpuech, Claire Rooney, Lorraine Mooney, Dawn Baker, Robert Shaw, Michael Dymond, Dennis Wang, Pei Zhang, Sarah Cross, Margaret Veldman-Jones, Joanne Wilson, Barry R Davies, Jonathan R Dry, Elaine Kilgour, Paul D Smith. Identification of Pharmacodynamic Transcript Biomarkers in Response to FGFR Inhibition by AZD4547.
Molecular cancer therapeutics.
2016 11; 15(11):2802-2813. doi:
10.1158/1535-7163.mct-16-0297. [PMID: 27550940] - Alejo Rodriguez-Vida, Matilde Saggese, Simon Hughes, Sarah Rudman, Simon Chowdhury, Neil R Smith, Peter Lawrence, Claire Rooney, Brian Dougherty, Donal Landers, Elaine Kilgour, Hendrik-Tobias Arkenau. Complexity of FGFR signalling in metastatic urothelial cancer.
Journal of hematology & oncology.
2015 Oct; 8(?):119. doi:
10.1186/s13045-015-0221-6. [PMID: 26497743] - Andrea Weiss, Robert H Berndsen, Xianting Ding, Chih-Ming Ho, Paul J Dyson, Hubert van den Bergh, Arjan W Griffioen, Patrycja Nowak-Sliwinska. A streamlined search technology for identification of synergistic drug combinations.
Scientific reports.
2015 Sep; 5(?):14508. doi:
10.1038/srep14508. [PMID: 26416286] - Paul R Gavine, Lorraine Mooney, Elaine Kilgour, Andrew P Thomas, Katherine Al-Kadhimi, Sarah Beck, Claire Rooney, Tanya Coleman, Dawn Baker, Martine J Mellor, A Nigel Brooks, Teresa Klinowska. AZD4547: an orally bioavailable, potent, and selective inhibitor of the fibroblast growth factor receptor tyrosine kinase family.
Cancer research.
2012 Apr; 72(8):2045-56. doi:
10.1158/0008-5472.can-11-3034. [PMID: 22369928]