lecimibide (BioDeep_00000685213)
代谢物信息卡片
化学式: C34H40F2N4OS (590.2891)
中文名称: 来西贝特
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCCN(CCCCCSC1=NC(=C(N1)C2=CC=CC=C2)C3=CC=CC=C3)C(=O)NC4=C(C=C(C=C4)F)F
InChI: InChI=1S/C34H40F2N4OS/c1-2-3-4-5-13-22-40(34(41)37-30-21-20-28(35)25-29(30)36)23-14-8-15-24-42-33-38-31(26-16-9-6-10-17-26)32(39-33)27-18-11-7-12-19-27/h6-7,9-12,16-21,25H,2-5,8,13-15,22-24H2,1H3,(H,37,41)(H,38,39)
描述信息
C78276 - Agent Affecting Digestive System or Metabolism > C29703 - Antilipidemic Agent
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Kimiyuki Shibuya, Katsumi Kawamine, Toru Miura, Chiyoka Ozaki, Toshiyuki Edano, Ken Mizuno, Yasunobu Yoshinaka, Yoshihiko Tsunenari. Design, synthesis and pharmacology of aortic-selective acyl-CoA: Cholesterol O-acyltransferase (ACAT/SOAT) inhibitors.
Bioorganic & medicinal chemistry.
2018 08; 26(14):4001-4013. doi:
10.1016/j.bmc.2018.06.024. [PMID: 29945757] - M Hernandez, J Montenegro, M Steiner, D Kim, C Sparrow, P A Detmers, S D Wright, Y S Chao. Intestinal absorption of cholesterol is mediated by a saturable, inhibitable transporter.
Biochimica et biophysica acta.
2000 Jul; 1486(2-3):232-42. doi:
10.1016/s1388-1981(00)00067-6. [PMID: 10903474] - J R Burnett, L J Wilcox, D E Telford, S J Kleinstiver, P H Barrett, M W Huff. Inhibition of cholesterol esterification by DuP 128 decreases hepatic apolipoprotein B secretion in vivo: effect of dietary fat and cholesterol.
Biochimica et biophysica acta.
1998 Jul; 1393(1):63-79. doi:
10.1016/s0005-2760(98)00059-9. [PMID: 9714740] - R A Harte, S J Yeaman, B Jackson, K E Suckling. Effect of membrane environment on inhibition of acyl-CoA:cholesterol acyltransferase by a range of synthetic inhibitors.
Biochimica et biophysica acta.
1995 Oct; 1258(3):241-50. doi:
10.1016/0005-2760(95)00113-q. [PMID: 7548193] - C M Lai, B Brogdon, C Y Quon, H J Pieniaszek. Determination of DuP 128, an ACAT inhibitor and its sulphoxide and sulphone metabolites in human plasma by liquid chromatography.
Journal of pharmaceutical and biomedical analysis.
1994 Sep; 12(9):1163-72. doi:
10.1016/0731-7085(94)e0041-x. [PMID: 7803568] - M W Huff, D E Telford, P H Barrett, J T Billheimer, P J Gillies. Inhibition of hepatic ACAT decreases ApoB secretion in miniature pigs fed a cholesterol-free diet.
Arteriosclerosis and thrombosis : a journal of vascular biology.
1994 Sep; 14(9):1498-508. doi:
10.1161/01.atv.14.9.1498. [PMID: 8068612] - J W Hainer, J G Terry, J M Connell, H Zyruk, R M Jenkins, D L Shand, P J Gillies, K J Livak, T L Hunt, J R Crouse. Effect of the acyl-CoA:cholesterol acyltransferase inhibitor DuP 128 on cholesterol absorption and serum cholesterol in humans.
Clinical pharmacology and therapeutics.
1994 Jul; 56(1):65-74. doi:
10.1038/clpt.1994.102. [PMID: 8033496] - D R Sliskovic, B R Krause, J A Picard, M Anderson, R F Bousley, K L Hamelehle, R Homan, T N Julian, Z A Rashidbaigi, R L Stanfield. Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 6. The first water-soluble ACAT inhibitor with lipid-regulating activity.
Journal of medicinal chemistry.
1994 Mar; 37(5):560-2. doi:
10.1021/jm00031a002. [PMID: 8126693]
