Glasdegib (BioDeep_00000685210)
代谢物信息卡片
化学式: C21H22N6O (374.1855002)
中文名称: 格拉德吉
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1CCC(CC1C2=NC3=CC=CC=C3N2)NC(=O)NC4=CC=C(C=C4)C#N
InChI: InChI=1S/C21H22N6O/c1-27-11-10-16(24-21(28)23-15-8-6-14(13-22)7-9-15)12-19(27)20-25-17-4-2-3-5-18(17)26-20/h2-9,16,19H,10-12H2,1H3,(H,25,26)(H2,23,24,28)/t16-,19-/m1/s1
描述信息
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01X - Other antineoplastic agents > L01XJ - Hedgehog pathway inhibitors
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C188731 - Hedgehog Pathway Inhibitor
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor
同义名列表
2 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:145428
- KEGGdrug: D10636
- PubChem: 25166913
- DrugBank: DB11978
- ChEMBL: CHEMBL2043437
- CAS: 1095173-27-5
- CAS: 1692868-09-9
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Joanna C Masters, Robert R LaBadie, Joanne Salageanu, Jerry Li, Naveed Shaik. Pharmacokinetics and Safety of Glasdegib in Participants With Moderate/Severe Hepatic Impairment: A Phase I, Single-Dose, Matched Case-Control Study.
Clinical pharmacology in drug development.
2021 07; 10(7):707-717. doi:
10.1002/cpdd.897. [PMID: 33356019] - Luke K Fostvedt, Naveed Shaik, Giovanni Martinelli, Andrew J Wagner, Ana Ruiz-Garcia. Exposure-response modeling of the effect of glasdegib on cardiac repolarization in patients with cancer.
Expert review of clinical pharmacology.
2021 Jul; 14(7):927-935. doi:
10.1080/17512433.2021.1925538. [PMID: 33993815] - Naveed Shaik, Robert R LaBadie, Brian Hee, Geoffrey Chan. Evaluation of the impact of renal impairment on the pharmacokinetics of glasdegib in otherwise healthy volunteers.
Cancer chemotherapy and pharmacology.
2021 02; 87(2):241-250. doi:
10.1007/s00280-020-04207-9. [PMID: 33388951] - Naveed Shaik, Brian Hee, Yali Liang, Robert Roland LaBadie. Absolute Oral Bioavailability of Glasdegib (PF-04449913), a Smoothened Inhibitor, in Randomized Healthy Volunteers.
Clinical pharmacology in drug development.
2019 10; 8(7):895-902. doi:
10.1002/cpdd.692. [PMID: 30977980] - Aaron T Gerds, Tetsuzo Tauchi, Ellen Ritchie, Michael Deininger, Catriona Jamieson, Ruben Mesa, Mark Heaney, Norio Komatsu, Hironobu Minami, Yun Su, Naveed Shaik, Xiaoxi Zhang, Christine DiRienzo, Mirjana Zeremski, Geoffrey Chan, Moshe Talpaz. Phase 1/2 trial of glasdegib in patients with primary or secondary myelofibrosis previously treated with ruxolitinib.
Leukemia research.
2019 04; 79(?):38-44. doi:
10.1016/j.leukres.2019.02.012. [PMID: 30849661] - Naveed Shaik, Brian Hee, Hua Wei, Robert R LaBadie. Evaluation of the effects of formulation, food, or a proton-pump inhibitor on the pharmacokinetics of glasdegib (PF-04449913) in healthy volunteers: a randomized phase I study.
Cancer chemotherapy and pharmacology.
2019 03; 83(3):463-472. doi:
10.1007/s00280-018-3748-8. [PMID: 30536154] - M Naveed Shaik, Brian Hee, Hua Wei, Robert R LaBadie. Evaluation of the effect of rifampin on the pharmacokinetics of the Smoothened inhibitor glasdegib in healthy volunteers.
British journal of clinical pharmacology.
2018 06; 84(6):1346-1353. doi:
10.1111/bcp.13568. [PMID: 29488303] - Justine L Lam, Alfin Vaz, Brian Hee, Yali Liang, Xin Yang, M Naveed Shaik. Metabolism, excretion and pharmacokinetics of [14C]glasdegib (PF-04449913) in healthy volunteers following oral administration.
Xenobiotica; the fate of foreign compounds in biological systems.
2017 Dec; 47(12):1064-1076. doi:
10.1080/00498254.2016.1261307. [PMID: 27866461] - Nagdeep Giri, Lisa H Lam, Robert R LaBadie, Joseph F Krzyzaniak, Hong Jiang, Brian Hee, Yali Liang, M Naveed Shaik. Evaluation of the effect of new formulation, food, or a proton pump inhibitor on the relative bioavailability of the smoothened inhibitor glasdegib (PF-04449913) in healthy volunteers.
Cancer chemotherapy and pharmacology.
2017 Dec; 80(6):1249-1260. doi:
10.1007/s00280-017-3472-9. [PMID: 29086063] - M Naveed Shaik, Robert R LaBadie, Dan Rudin, Wendy J Levin. Evaluation of the effect of food and ketoconazole on the pharmacokinetics of the smoothened inhibitor PF-04449913 in healthy volunteers.
Cancer chemotherapy and pharmacology.
2014 Aug; 74(2):411-8. doi:
10.1007/s00280-014-2502-0. [PMID: 24944041]