Delanzomib (BioDeep_00000685111)
代谢物信息卡片
化学式: C21H28BN3O5 (413.21219080000003)
中文名称: Delanzomib
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: B(C(CC(C)C)NC(=O)C(C(C)O)NC(=O)C1=CC=CC(=N1)C2=CC=CC=C2)(O)O
InChI: InChI=1S/C21H28BN3O5/c1-13(2)12-18(22(29)30)24-21(28)19(14(3)26)25-20(27)17-11-7-10-16(23-17)15-8-5-4-6-9-15/h4-11,13-14,18-19,26,29-30H,12H2,1-3H3,(H,24,28)(H,25,27)/t14-,18+,19+/m1/s1
描述信息
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D061988 - Proteasome Inhibitors
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C2160 - Proteasome Inhibitor
C471 - Enzyme Inhibitor
同义名列表
2 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:141530
- KEGGdrug: D10110
- PubChem: 24800541
- DrugBank: DB11956
- ChEMBL: CHEMBL270515
- CAS: 847499-27-8
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Makoto Isono, Akinori Sato, Takako Asano, Kazuki Okubo, Tomohiko Asano. Delanzomib Interacts with Ritonavir Synergistically to Cause Endoplasmic Reticulum Stress in Renal Cancer Cells.
Anticancer research.
2018 Jun; 38(6):3493-3500. doi:
10.21873/anticanres.12620. [PMID: 29848702] - Theodoros Eleftheriadis, Georgios Pissas, Georgia Antoniadi, Vassilios Liakopoulos, Ioannis Stefanidis. A comparative analysis between proteasome and immunoproteasome inhibition in cellular and humoral alloimmunity.
International immunopharmacology.
2017 Sep; 50(?):48-54. doi:
10.1016/j.intimp.2017.06.009. [PMID: 28628770] - Theodoros Eleftheriadis, Georgios Pissas, Georgia Antoniadi, Vassilios Liakopoulos, Ioannis Stefanidis. Proteasome or immunoproteasome inhibitors cause apoptosis in human renal tubular epithelial cells under normoxic and hypoxic conditions.
International urology and nephrology.
2016 Jun; 48(6):907-15. doi:
10.1007/s11255-016-1247-6. [PMID: 26920131] - Falk Hiepe, Andreas Radbruch. Plasma cells as an innovative target in autoimmune disease with renal manifestations.
Nature reviews. Nephrology.
2016 Apr; 12(4):232-40. doi:
10.1038/nrneph.2016.20. [PMID: 26923204] - Elisa Gallerani, Massimo Zucchetti, Dario Brunelli, Elena Marangon, Cristina Noberasco, Dagmar Hess, Angelo Delmonte, Giovanni Martinelli, Steffen Böhm, Christopher Driessen, Filippo De Braud, Silvia Marsoni, Roberta Cereda, Federica Sala, Maurizio D'Incalci, Cristiana Sessa. A first in human phase I study of the proteasome inhibitor CEP-18770 in patients with advanced solid tumours and multiple myeloma.
European journal of cancer (Oxford, England : 1990).
2013 Jan; 49(2):290-6. doi:
10.1016/j.ejca.2012.09.009. [PMID: 23058787] - Matthew M Seavey, Lily D Lu, Kristine L Stump, Nate H Wallace, Bruce A Ruggeri. Novel, orally active, proteasome inhibitor, delanzomib (CEP-18770), ameliorates disease symptoms and glomerulonephritis in two preclinical mouse models of SLE.
International immunopharmacology.
2012 Jan; 12(1):257-70. doi:
10.1016/j.intimp.2011.11.019. [PMID: 22178195] - Nerea Gallastegui, Michael Groll. Analysing properties of proteasome inhibitors using kinetic and X-ray crystallographic studies.
Methods in molecular biology (Clifton, N.J.).
2012; 832(?):373-90. doi:
10.1007/978-1-61779-474-2_26. [PMID: 22350899] - Federica Sala, Elena Marangon, Renzo Bagnati, Valeria Livi, Roberta Cereda, Maurizio D'Incalci, Massimo Zucchetti. Development and validation of a high-performance liquid chromatography-tandem mass spectrometry method for the determination of the novel proteasome inhibitor CEP-18770 in human plasma and its application in a clinical pharmacokinetic study.
Journal of mass spectrometry : JMS.
2010 Nov; 45(11):1299-305. doi:
10.1002/jms.1842. [PMID: 20872901]