Avibactam (BioDeep_00000685080)
代谢物信息卡片
Avibactam
化学式: C7H11N3O6S (265.0368546)
中文名称: 阿维巴坦
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC(N2CC1N(C2=O)OS(=O)(=O)O)C(=O)N
InChI: InChI=1S/C7H11N3O6S/c8-6(11)5-2-1-4-3-9(5)7(12)10(4)16-17(13,14)15/h4-5H,1-3H2,(H2,8,11)(H,13,14,15)/t4-,5+/m1/s1
描述信息
A member of the class of azabicycloalkanes that is (2S,5R)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide in which the amino hydrogen at position 6 is replaced by a sulfooxy group. Used (in the form of its sodium salt) in combination with ceftazidime pentahydrate for the treatment of complicated urinary tract infections including pyelonephritis.
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D065093 - beta-Lactamase Inhibitors
D004791 - Enzyme Inhibitors
同义名列表
1 个代谢物同义名
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:85984
- PubChem: 9835049
- DrugBank: DB09060
- ChEMBL: CHEMBL1689063
- CAS: 1416134-69-4
- CAS: 1192500-31-4
- CAS: 396731-14-9
- CAS: 794508-22-8
- MetaboLights: MTBLC85984
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Gabriela Kroneislová, Jan Závora, Vanda Gabriela Adámková, Anna Rýdlová, Václava Adámková. In vitro activity of antibiotics potentially effective against difficult-to-treat strains of Gram-negative rods: retrospective study.
Scientific reports.
2024 04; 14(1):8310. doi:
10.1038/s41598-024-59036-0. [PMID: 38594467] - Maytham Hussein, Rafah Allobawi, Jinxin Zhao, Heidi Yu, Stephanie L Neville, Jonathan Wilksch, Labell J M Wong, Mark Baker, Christopher A McDevitt, Gauri G Rao, Jian Li, Tony Velkov. Integrated Transcriptomic and Metabolomic Mapping Reveals the Mechanism of Action of Ceftazidime/Avibactam against Pan-Drug-Resistant Klebsiella pneumoniae.
ACS infectious diseases.
2023 Oct; ?(?):. doi:
10.1021/acsinfecdis.3c00264. [PMID: 37878861] - Yixin Kang, Lu Xie, Jiyong Yang, Junchang Cui. Optimal treatment of ceftazidime-avibactam and aztreonam-avibactam against bloodstream infections or lower respiratory tract infections caused by extensively drug-resistant or pan drug-resistant (XDR/PDR) Pseudomonas aeruginosa.
Frontiers in cellular and infection microbiology.
2023; 13(?):1023948. doi:
10.3389/fcimb.2023.1023948. [PMID: 37457958] - Elkin V Lemos-Luengas, Sixta Rentería-Valoyes, Paola Cárdenas-Isaza, Jorge A Ramos-Castaneda. In vitro activity of ceftazidime/avibactam against Gram-negative strains in Colombia 2014-2018.
Journal of global antimicrobial resistance.
2022 Jun; 29(?):141-146. doi:
10.1016/j.jgar.2022.02.018. [PMID: 35257971] - Kun Feng, Nan Jia, Peijuan Zhu, Serubbabel Sy, Yanfei Liu, Dandan Dong, Shixing Zhu, Jiayuan Zhang, Yuwei Liu, Frederico S Martins, Hugh Gong, Zhihua Lv, Mingming Yu, Sherwin K B Sy, Yuanqi Zhu. Aztreonam/avibactam effect on pharmacodynamic indices for mutant selection of Escherichia coli and Klebsiella pneumoniae harbouring serine- and New Delhi metallo-β-lactamases.
The Journal of antimicrobial chemotherapy.
2021 10; 76(11):2875-2883. doi:
10.1093/jac/dkab292. [PMID: 34383928] - Véronique Goncette, Nathalie Layios, Julie Descy, Frédéric Frippiat. Continuous infusion, therapeutic drug monitoring and outpatient parenteral antimicrobial therapy with ceftazidime/avibactam: a retrospective cohort study.
Journal of global antimicrobial resistance.
2021 09; 26(?):15-19. doi:
10.1016/j.jgar.2021.04.015. [PMID: 33989847] - Punit J Shah, Thuytram Tran, Francis Emelogu, Farheen Tariq. Aztreonam, Ceftazidime/Avibactam, and Colistin Combination for the Management of Carbapenemase-Producing Klebsiella Pneumoniae Bacteremia: A Case Report.
Journal of pharmacy practice.
2021 Aug; 34(4):653-657. doi:
10.1177/0897190019882262. [PMID: 31698984] - Marianna Meschiari, Iacopo Franconi, Erica Bacca, Vincenzo Bianco, Gabriella Orlando, Gianluca Cuomo, Andrea Bedini, Cristina Mussini. Ceftazidime/avibactam and ceftolozane/tazobactam for the treatment of extensively drug-resistant Pseudomonas aeruginosa post-neurosurgical infections: three cases and a review of the literature.
Infection.
2021 Jun; 49(3):549-553. doi:
10.1007/s15010-020-01539-9. [PMID: 33074365] - Zhengwu Shen, Wei Xu, Jingfeng Yu, Lixia Chen, Jinghua Zhang, Sihan Sheng, Xun Dong, Hongzhu Bian. Synthesis and in vitro antibacterial activity of new aminothiazole-oximepiperidone cephalosporins.
Bioorganic & medicinal chemistry letters.
2021 05; 40(?):127928. doi:
10.1016/j.bmcl.2021.127928. [PMID: 33705899] - Francesco Perrotta, Marco Paolo Perrini. Successful Treatment of Klebsiella pneumoniae NDM Sepsis and Intestinal Decolonization with Ceftazidime/Avibactam Plus Aztreonam Combination in a Patient with TTP Complicated by SARSCoV-2 Nosocomial Infection.
Medicina (Kaunas, Lithuania).
2021 Apr; 57(5):. doi:
10.3390/medicina57050424. [PMID: 33924769] - Tommaso Giani, Alberto Antonelli, Samanta Sennati, Vincenzo Di Pilato, Adriana Chiarelli, Antonio Cannatelli, Christopher Gatsch, Francesco Luzzaro, Teresa Spanu, Stefania Stefani, Gian Maria Rossolini. Results of the Italian infection-Carbapenem Resistance Evaluation Surveillance Trial (iCREST-IT): activity of ceftazidime/avibactam against Enterobacterales isolated from urine.
The Journal of antimicrobial chemotherapy.
2020 04; 75(4):979-983. doi:
10.1093/jac/dkz547. [PMID: 31958125] - Valentina Viaggi, Beatrice Pini, Silvia Tonolo, Francesco Luzzaro, Luigi Principe. In vitro activity of ceftazidime/avibactam against clinical isolates of ESBL-producing Enterobacteriaceae in Italy.
Journal of chemotherapy (Florence, Italy).
2019 Jul; 31(4):195-201. doi:
10.1080/1120009x.2019.1620406. [PMID: 31130090] - Poonam Giri, Harilal Patel, Nuggehally R Srinivas. Review of Clinical Pharmacokinetics of Avibactam, A Newly Approved non-β lactam β-lactamase Inhibitor Drug, In Combination Use With Ceftazidime.
Drug research.
2019 May; 69(5):245-255. doi:
10.1055/a-0748-5548. [PMID: 30296806] - Richard Dimelow, James G Wright, Merran MacPherson, Paul Newell, Shampa Das. Population Pharmacokinetic Modelling of Ceftazidime and Avibactam in the Plasma and Epithelial Lining Fluid of Healthy Volunteers.
Drugs in R&D.
2018 Sep; 18(3):221-230. doi:
10.1007/s40268-018-0241-0. [PMID: 30054895] - Eric Wenzler, Kristen L Bunnell, Susan C Bleasdale, Scott Benken, Larry H Danziger, Keith A Rodvold. Pharmacokinetics and Dialytic Clearance of Ceftazidime-Avibactam in a Critically Ill Patient on Continuous Venovenous Hemofiltration.
Antimicrobial agents and chemotherapy.
2017 07; 61(7):. doi:
10.1128/aac.00464-17. [PMID: 28416553] - Henri Merdjan, Antoine Tarral, Shampa Das, Jianguo Li. Phase 1 Study Assessing the Pharmacokinetic Profile and Safety of Avibactam in Patients With Renal Impairment.
Journal of clinical pharmacology.
2017 02; 57(2):211-218. doi:
10.1002/jcph.793. [PMID: 27402250] - Marie-Eve Beaudoin, Eric T Gangl. Bioanalytical method validation for the simultaneous determination of ceftazidime and avibactam in rat plasma.
Bioanalysis.
2016; 8(2):111-22. doi:
10.4155/bio.15.233. [PMID: 26652586] - David P Nicolau, Leonard Siew, Jon Armstrong, James Li, Timi Edeki, Maria Learoyd, Shampa Das. Phase 1 study assessing the steady-state concentration of ceftazidime and avibactam in plasma and epithelial lining fluid following two dosing regimens.
The Journal of antimicrobial chemotherapy.
2015 Oct; 70(10):2862-9. doi:
10.1093/jac/dkv170. [PMID: 26133566] - Shampa Das, Jianguo Li, Jon Armstrong, Maria Learoyd, Timi Edeki. Randomized pharmacokinetic and drug-drug interaction studies of ceftazidime, avibactam, and metronidazole in healthy subjects.
Pharmacology research & perspectives.
2015 Oct; 3(5):e00172. doi:
10.1002/prp2.172. [PMID: 26516584] - Mamun-Ur Rashid, Staffan Rosenborg, Georgios Panagiotidis, Karin Söderberg-Löfdal, Andrej Weintraub, Carl Erik Nord. Ecological Effect of Ceftaroline-Avibactam on the Normal Human Intestinal Microbiota.
Antimicrobial agents and chemotherapy.
2015 Aug; 59(8):4504-9. doi:
10.1128/aac.00530-15. [PMID: 25987638] - Nobumitsu Tominaga, Timi Edeki, James Li, Maria Learoyd, M René Bouw, Shampa Das. Phase I study assessing the safety, tolerability, and pharmacokinetics of avibactam and ceftazidime-avibactam in healthy Japanese volunteers.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2015 Aug; 21(8):551-8. doi:
10.1016/j.jiac.2015.04.006. [PMID: 26076867] - Henri Merdjan, Manickam Rangaraju, Antoine Tarral. Safety and pharmacokinetics of single and multiple ascending doses of avibactam alone and in combination with ceftazidime in healthy male volunteers: results of two randomized, placebo-controlled studies.
Clinical drug investigation.
2015 May; 35(5):307-17. doi:
10.1007/s40261-015-0283-9. [PMID: 25813217] - Johanna Berkhout, Maria J Melchers, Anita C van Mil, Seyedmojtaba Seyedmousavi, Claudia M Lagarde, Wright W Nichols, Johan W Mouton. Pharmacokinetics and penetration of ceftazidime and avibactam into epithelial lining fluid in thigh- and lung-infected mice.
Antimicrobial agents and chemotherapy.
2015 Apr; 59(4):2299-304. doi:
10.1128/aac.04627-14. [PMID: 25645843] - Antoine Tarral, Henri Merdjan. Effect of age and sex on the pharmacokinetics and safety of avibactam in healthy volunteers.
Clinical therapeutics.
2015 Apr; 37(4):877-86. doi:
10.1016/j.clinthera.2015.01.009. [PMID: 25769615] - Henrik Sillén, Richard Mitchell, Rebecca Sleigh, Guy Mainwaring, Katherine Catton, Richard Houghton, Karen Glendining. Determination of avibactam and ceftazidime in human plasma samples by LC-MS.
Bioanalysis.
2015; 7(12):1423-34. doi:
10.4155/bio.15.76. [PMID: 26168250] - Fernando Caravaca-Fontán, Sara Jiménez-Álvaro, Roberto Marcén-Letosa, Ana Fernández-Rodríguez, Carlos Quereda Rodríguez-Navarro. Ceftazidime-avibactam in urinary tract infections due to carbapenemase-producing Klebsiella in kidney transplantation.
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia.
2015; 35(4):412-3. doi:
10.1016/j.nefro.2015.01.001. [PMID: 26306955] - Karthick Vishwanathan, Stuart Mair, Anshul Gupta, James Atherton, Jacqueline Clarkson-Jones, Timi Edeki, Shampa Das. Assessment of the mass balance recovery and metabolite profile of avibactam in humans and in vitro drug-drug interaction potential.
Drug metabolism and disposition: the biological fate of chemicals.
2014 May; 42(5):932-42. doi:
10.1124/dmd.113.055335. [PMID: 24616266] - Shampa Das, Jon Armstrong, David Mathews, Jianguo Li, Timi Edeki. Randomized, placebo-controlled study to assess the impact on QT/QTc interval of supratherapeutic doses of ceftazidime-avibactam or ceftaroline fosamil-avibactam.
Journal of clinical pharmacology.
2014 Mar; 54(3):331-40. doi:
10.1002/jcph.199. [PMID: 24150927] - Seth T Housman, Jared L Crandon, Wright W Nichols, David P Nicolau. Efficacies of ceftazidime-avibactam and ceftazidime against Pseudomonas aeruginosa in a murine lung infection model.
Antimicrobial agents and chemotherapy.
2014; 58(3):1365-71. doi:
10.1128/aac.02161-13. [PMID: 24342641] - Todd A Riccobene, Sheng Fang Su, Douglas Rank. Single- and multiple-dose study to determine the safety, tolerability, and pharmacokinetics of ceftaroline fosamil in combination with avibactam in healthy subjects.
Antimicrobial agents and chemotherapy.
2013 Mar; 57(3):1496-504. doi:
10.1128/aac.02134-12. [PMID: 23295928] - George G Zhanel, Christopher D Lawson, Heather Adam, Frank Schweizer, Sheryl Zelenitsky, Philippe R S Lagacé-Wiens, Andrew Denisuik, Ethan Rubinstein, Alfred S Gin, Daryl J Hoban, Joseph P Lynch, James A Karlowsky. Ceftazidime-avibactam: a novel cephalosporin/β-lactamase inhibitor combination.
Drugs.
2013 Feb; 73(2):159-77. doi:
10.1007/s40265-013-0013-7. [PMID: 23371303]