4-hydroxy-tempo (BioDeep_00000684573)
代谢物信息卡片
4-Piperidinol, 1-hydroxy-2,2,6,6-tetramethyl-
化学式: C9H19NO2 (173.1415714)
中文名称: 4-羟基-2,2,6,6-四甲基哌啶氧
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1(CC(CC(N1O)(C)C)O)C
InChI: InChI=1S/C9H19NO2/c1-8(2)5-7(11)6-9(3,4)10(8)12/h7,11-12H,5-6H2,1-4H3
描述信息
D020011 - Protective Agents > D011837 - Radiation-Protective Agents
D020011 - Protective Agents > D000975 - Antioxidants
同义名列表
相关代谢途径
Reactome(0)
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PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Sophie Maiocchi, Jacqueline Ku, Tom Hawtrey, Irene De Silvestro, Ernst Malle, Martin Rees, Shane R Thomas, Jonathan C Morris. Polyamine-Conjugated Nitroxides Are Efficacious Inhibitors of Oxidative Reactions Catalyzed by Endothelial-Localized Myeloperoxidase.
Chemical research in toxicology.
2021 06; 34(6):1681-1692. doi:
10.1021/acs.chemrestox.1c00094. [PMID: 34085520] - Bodong Li, Haibo Xie, Xian Wang, Xiaodong Yang, Ling Yang, Jiaxiang Zhang, Feng Wang, Tong Shen, Qixing Zhu. Oxidative stress mediates renal endothelial cell damage in trichloroethylene-sensitized mice.
The Journal of toxicological sciences.
2019; 44(5):317-326. doi:
10.2131/jts.44.317. [PMID: 31068537] - Andrea Baschieri, Luca Valgimigli, Simone Gabbanini, Gino A DiLabio, Eduardo Romero-Montalvo, Riccardo Amorati. Extremely Fast Hydrogen Atom Transfer between Nitroxides and HOO· Radicals and Implication for Catalytic Coantioxidant Systems.
Journal of the American Chemical Society.
2018 08; 140(32):10354-10362. doi:
10.1021/jacs.8b06336. [PMID: 30022659] - Jie Xiong, Yongjie Yang, Guanfu Fu, Longxing Tao. Novel roles of hydrogen peroxide (H₂O₂) in regulating pectin synthesis and demethylesterification in the cell wall of rice (Oryza sativa) root tips.
The New phytologist.
2015 Apr; 206(1):118-126. doi:
10.1111/nph.13285. [PMID: 25615266] - Rajat Sandhir, Namita Mahajan, Arpit Mehrotra, Aanchal Aggarwal, Aditya Sunkaria. 4-hydroxy tempo improves mitochondrial and neurobehavioral deficits in experimental model of Huntington's disease.
Synapse (New York, N.Y.).
2015 Mar; 69(3):128-38. doi:
10.1002/syn.21793. [PMID: 25482019] - Jan T Kielstein, Hans-Gert Bernstein. The reversible part of cognitive impairment in chronic kidney disease: can mice help men break the TEMPOLimit?.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2014 Mar; 29(3):476-8. doi:
10.1093/ndt/gft403. [PMID: 24142368] - Alice Ding, Priyadharshani Kalaignanasundaram, Sharon D Ricardo, Amany Abdelkader, Paul K Witting, Brad R S Broughton, Hyun B Kim, Benjamin F Wyse, Jacqueline K Phillips, Roger G Evans. Chronic treatment with tempol does not significantly ameliorate renal tissue hypoxia or disease progression in a rodent model of polycystic kidney disease.
Clinical and experimental pharmacology & physiology.
2012 Nov; 39(11):917-29. doi:
10.1111/1440-1681.12013. [PMID: 23006058] - Hiroo Kawarazaki, Katsuyuki Ando, Shigeru Shibata, Kazuhiko Muraoka, Megumi Fujita, Chiaki Kawarasaki, Toshiro Fujita. Mineralocorticoid receptor--Rac1 activation and oxidative stress play major roles in salt-induced hypertension and kidney injury in prepubertal rats.
Journal of hypertension.
2012 Oct; 30(10):1977-85. doi:
10.1097/hjh.0b013e3283576904. [PMID: 22914542] - M Mata-Campuzano, M Alvarez-Rodríguez, E del Olmo, M R Fernández-Santos, J J Garde, F Martínez-Pastor. Quality, oxidative markers and DNA damage (DNA) fragmentation of red deer thawed spermatozoa after incubation at 37 °C in presence of several antioxidants.
Theriogenology.
2012 Sep; 78(5):1005-19. doi:
10.1016/j.theriogenology.2011.12.018. [PMID: 22818091] - Kay L H Wu, Samuel H H Chan, Julie Y H Chan. Neuroinflammation and oxidative stress in rostral ventrolateral medulla contribute to neurogenic hypertension induced by systemic inflammation.
Journal of neuroinflammation.
2012 Sep; 9(?):212. doi:
10.1186/1742-2094-9-212. [PMID: 22958438] - Yoonjung Park, Frank W Booth, Sewon Lee, Mathew J Laye, Cuihua Zhang. Physical activity opposes coronary vascular dysfunction induced during high fat feeding in mice.
The Journal of physiology.
2012 Sep; 590(17):4255-68. doi:
10.1113/jphysiol.2012.234856. [PMID: 22674721] - Takuya Kishi, Yoshitaka Hirooka, Kenji Sunagawa. Sympathoinhibition caused by orally administered telmisartan through inhibition of the AT₁ receptor in the rostral ventrolateral medulla of hypertensive rats.
Hypertension research : official journal of the Japanese Society of Hypertension.
2012 Sep; 35(9):940-6. doi:
10.1038/hr.2012.63. [PMID: 22573203] - Lijun Li, R Mayuri Garikepati, Susanna Tsukerman, S Tiwari, Carolyn M Ecelbarger. Salt sensitivity of nitric oxide generation and blood pressure in mice with targeted knockout of the insulin receptor from the renal tubule.
American journal of physiology. Regulatory, integrative and comparative physiology.
2012 Sep; 303(5):R505-12. doi:
10.1152/ajpregu.00033.2012. [PMID: 22814664] - Pushpinder Dhillion, Kedra Wallace, Florian Herse, Jeremy Scott, Gerd Wallukat, Judith Heath, Janae Mosely, James N Martin, Ralf Dechend, Babbette LaMarca. IL-17-mediated oxidative stress is an important stimulator of AT1-AA and hypertension during pregnancy.
American journal of physiology. Regulatory, integrative and comparative physiology.
2012 Aug; 303(4):R353-8. doi:
10.1152/ajpregu.00051.2012. [PMID: 22718806] - Paul W Buehler, Jin Hyen Baek, Christina Lisk, Ian Connor, Tim Sullivan, Douglas Kominsky, Susan Majka, Kurt R Stenmark, Eva Nozik-Grayck, Joe Bonaventura, David C Irwin. Free hemoglobin induction of pulmonary vascular disease: evidence for an inflammatory mechanism.
American journal of physiology. Lung cellular and molecular physiology.
2012 Aug; 303(4):L312-26. doi:
10.1152/ajplung.00074.2012. [PMID: 22728465] - Silvia Kelsen, Xiaochen He, Alejandro R Chade. Early superoxide scavenging accelerates renal microvascular rarefaction and damage in the stenotic kidney.
American journal of physiology. Renal physiology.
2012 Aug; 303(4):F576-83. doi:
10.1152/ajprenal.00154.2012. [PMID: 22622460] - Gerson J Rodrigues, Amanda C Pereira, Juliana A Vercesi, Renata G Lima, Roberto S Silva, Lusiane M Bendhack. Long-lasting hypotensive effect in renal hypertensive rats induced by nitric oxide released from a ruthenium complex.
Journal of cardiovascular pharmacology.
2012 Aug; 60(2):193-8. doi:
10.1097/fjc.0b013e31825bacc4. [PMID: 22635073] - Yilin Ren, Martin A D'Ambrosio, Hong Wang, Edward L Peterson, Jeffrey L Garvin, Oscar A Carretero. Mechanisms of angiotensin II-enhanced connecting tubule glomerular feedback.
American journal of physiology. Renal physiology.
2012 Jul; 303(2):F259-65. doi:
10.1152/ajprenal.00689.2011. [PMID: 22461303] - En Yin Lai, Zaiming Luo, Maristela L Onozato, Earl H Rudolph, Glenn Solis, Pedro A Jose, Anton Wellstein, Shakil Aslam, Mark T Quinn, Kathy Griendling, Thu Le, Ping Li, Fredrik Palm, William J Welch, Christopher S Wilcox. Effects of the antioxidant drug tempol on renal oxygenation in mice with reduced renal mass.
American journal of physiology. Renal physiology.
2012 Jul; 303(1):F64-74. doi:
10.1152/ajprenal.00005.2012. [PMID: 22492941] - Norma B Ojeda, Bettye Sue Hennington, Danielle T Williamson, Melanie L Hill, Nicole E E Betson, Julio C Sartori-Valinotti, Jane F Reckelhoff, Thomas P Royals, Barbara T Alexander. Oxidative stress contributes to sex differences in blood pressure in adult growth-restricted offspring.
Hypertension (Dallas, Tex. : 1979).
2012 Jul; 60(1):114-22. doi:
10.1161/hypertensionaha.112.192955. [PMID: 22585945] - Yoshihisa Ogawa, Masashi Mukoyama, Hideki Yokoi, Masato Kasahara, Kiyoshi Mori, Yukiko Kato, Takashige Kuwabara, Hirotaka Imamaki, Tomoko Kawanishi, Kenichi Koga, Akira Ishii, Takeshi Tokudome, Ichiro Kishimoto, Akira Sugawara, Kazuwa Nakao. Natriuretic peptide receptor guanylyl cyclase-A protects podocytes from aldosterone-induced glomerular injury.
Journal of the American Society of Nephrology : JASN.
2012 Jul; 23(7):1198-209. doi:
10.1681/asn.2011100985. [PMID: 22652704] - M Rashid, A Kotwani, M Fahim. Long-acting phosphodiesterase 5 inhibitor, tadalafil, and superoxide dismutase mimetic, tempol, protect against acute hypoxia-induced pulmonary hypertension in rats.
Human & experimental toxicology.
2012 Jun; 31(6):626-36. doi:
10.1177/0960327111429138. [PMID: 22144729] - Hyun Wha Chung, Ji Hee Lim, Min Young Kim, Seok Joon Shin, Sungjin Chung, Bum Soon Choi, Hyung Wook Kim, Yong-Soo Kim, Cheol Whee Park, Yoon Sik Chang. High-fat diet-induced renal cell apoptosis and oxidative stress in spontaneously hypertensive rat are ameliorated by fenofibrate through the PPARα-FoxO3a-PGC-1α pathway.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2012 Jun; 27(6):2213-25. doi:
10.1093/ndt/gfr613. [PMID: 22076434] - Gabriela A Eppel, Geoffrey A Head, Kate M Denton, Roger G Evans. Effects of tempol and candesartan on neural control of the kidney.
Autonomic neuroscience : basic & clinical.
2012 May; 168(1-2):48-57. doi:
10.1016/j.autneu.2012.01.007. [PMID: 22336580] - Slaven Crnkovic, Monika Riederer, Margarete Lechleitner, Seth Hallström, Roland Malli, Wolfgang F Graier, Jörg Lindenmann, Helmut Popper, Horst Olschewski, Andrea Olschewski, Saša Frank. Docosahexaenoic acid-induced unfolded protein response, cell cycle arrest, and apoptosis in vascular smooth muscle cells are triggered by Ca²⁺-dependent induction of oxidative stress.
Free radical biology & medicine.
2012 May; 52(9):1786-95. doi:
10.1016/j.freeradbiomed.2012.02.036. [PMID: 22391221] - Sarah F Knight, Kousik Kundu, Giji Joseph, Sergey Dikalov, Daiana Weiss, Niren Murthy, W Robert Taylor. Folate receptor-targeted antioxidant therapy ameliorates renal ischemia-reperfusion injury.
Journal of the American Society of Nephrology : JASN.
2012 May; 23(5):793-800. doi:
10.1681/asn.2011070711. [PMID: 22282594] - Hui Lin, Bao-yuan Chen, Qiu-fang Jiang, Cheng-ying Kong, Jing Zhang, Li-wen Zheng. [Influence of chronic intermittent hypoxia on sympathetic nerve activity in rats and effect of the antioxidant Tempol].
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases.
2012 May; 35(5):345-8. doi:
NULL. [PMID: 22883993] - Gaurav Chugh, Mustafa F Lokhandwala, Mohammad Asghar. Altered functioning of both renal dopamine D1 and angiotensin II type 1 receptors causes hypertension in old rats.
Hypertension (Dallas, Tex. : 1979).
2012 May; 59(5):1029-36. doi:
10.1161/hypertensionaha.112.192302. [PMID: 22411927] - Carmen M Troncoso Brindeiro, Pascale H Lane, Pamela K Carmines. Tempol prevents altered K(+) channel regulation of afferent arteriolar tone in diabetic rat kidney.
Hypertension (Dallas, Tex. : 1979).
2012 Mar; 59(3):657-64. doi:
10.1161/hypertensionaha.111.184218. [PMID: 22252401] - Keisa W Mathis, Marcia Venegas-Pont, C Warren Masterson, Nicholas J Stewart, Katie L Wasson, Michael J Ryan. Oxidative stress promotes hypertension and albuminuria during the autoimmune disease systemic lupus erythematosus.
Hypertension (Dallas, Tex. : 1979).
2012 Mar; 59(3):673-9. doi:
10.1161/hypertensionaha.111.190009. [PMID: 22291449] - A F Ahmeda, E J Johns. The regulation of blood perfusion in the renal cortex and medulla by reactive oxygen species and nitric oxide in the anaesthetised rat.
Acta physiologica (Oxford, England).
2012 Mar; 204(3):443-50. doi:
10.1111/j.1748-1716.2011.02346.x. [PMID: 21827636] - Xiao Yu Tian, Wing Tak Wong, Fung Ping Leung, Yang Zhang, Yi-Xiang Wang, Hung Kay Lee, Chi Fai Ng, Zhen Yu Chen, Xiaoqiang Yao, Chak Leung Au, Chi Wai Lau, Paul M Vanhoutte, John P Cooke, Yu Huang. Oxidative stress-dependent cyclooxygenase-2-derived prostaglandin f(2α) impairs endothelial function in renovascular hypertensive rats.
Antioxidants & redox signaling.
2012 Feb; 16(4):363-73. doi:
10.1089/ars.2010.3874. [PMID: 21951274] - Christopher S Wilcox. Asymmetric dimethylarginine and reactive oxygen species: unwelcome twin visitors to the cardiovascular and kidney disease tables.
Hypertension (Dallas, Tex. : 1979).
2012 Feb; 59(2):375-81. doi:
10.1161/hypertensionaha.111.187310. [PMID: 22215715] - Shunsuke Yamada, Masatomo Taniguchi, Masanori Tokumoto, Jiro Toyonaga, Kiichiro Fujisaki, Takaichi Suehiro, Hideko Noguchi, Mitsuo Iida, Kazuhiko Tsuruya, Takanari Kitazono. The antioxidant tempol ameliorates arterial medial calcification in uremic rats: important role of oxidative stress in the pathogenesis of vascular calcification in chronic kidney disease.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
2012 Feb; 27(2):474-85. doi:
10.1002/jbmr.539. [PMID: 21987400] - Angela Martín, José V Pérez-Girón, Raquel Hernanz, Roberto Palacios, Ana M Briones, Ana Fortuño, Guillermo Zalba, Mercedes Salaices, María J Alonso. Peroxisome proliferator-activated receptor-γ activation reduces cyclooxygenase-2 expression in vascular smooth muscle cells from hypertensive rats by interfering with oxidative stress.
Journal of hypertension.
2012 Feb; 30(2):315-26. doi:
10.1097/hjh.0b013e32834f043b. [PMID: 22179086] - Paul J Fadel, Martin Farias Iii, Kevin M Gallagher, Zhongyun Wang, Gail D Thomas. Oxidative stress and enhanced sympathetic vasoconstriction in contracting muscles of nitrate-tolerant rats and humans.
The Journal of physiology.
2012 Jan; 590(2):395-407. doi:
10.1113/jphysiol.2011.218917. [PMID: 22106180] - Takuya Kishi, Yoshitaka Hirooka, Masato Katsuki, Kiyohiro Ogawa, Keisuke Shinohara, Kengo Isegawa, Kenji Sunagawa. Exercise training causes sympathoinhibition through antioxidant effect in the rostral ventrolateral medulla of hypertensive rats.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2012; 34(4):278-83. doi:
10.3109/10641963.2012.681084. [PMID: 22578069] - Megumi Fujita, Katsuyuki Ando, Hiroo Kawarazaki, Chiaki Kawarasaki, Kazuhiko Muraoka, Hiroshi Ohtsu, Hideki Shimizu, Toshiro Fujita. Sympathoexcitation by brain oxidative stress mediates arterial pressure elevation in salt-induced chronic kidney disease.
Hypertension (Dallas, Tex. : 1979).
2012 Jan; 59(1):105-12. doi:
10.1161/hypertensionaha.111.182923. [PMID: 22083162] - Jorge Rojas-Rivera, Alberto Ortiz, Jesus Egido. Antioxidants in kidney diseases: the impact of bardoxolone methyl.
International journal of nephrology.
2012; 2012(?):321714. doi:
10.1155/2012/321714. [PMID: 22701794] - Hideo Nakamura, Satoaki Matoba, Eri Iwai-Kanai, Masaki Kimata, Atsushi Hoshino, Mikihiko Nakaoka, Maki Katamura, Yoshifumi Okawa, Makoto Ariyoshi, Yuichiro Mita, Koji Ikeda, Mitsuhiko Okigaki, Souichi Adachi, Hideo Tanaka, Tetsuro Takamatsu, Hiroaki Matsubara. p53 promotes cardiac dysfunction in diabetic mellitus caused by excessive mitochondrial respiration-mediated reactive oxygen species generation and lipid accumulation.
Circulation. Heart failure.
2012 Jan; 5(1):106-15. doi:
10.1161/circheartfailure.111.961565. [PMID: 22075967] - Kento Kitada, Daisuke Nakano, Ya Liu, Yoshihide Fujisawa, Hirofumi Hitomi, Yuki Shibayama, Hirotaka Shibata, Yukiko Nagai, Hirohito Mori, Tsutomu Masaki, Hiroyuki Kobori, Akira Nishiyama. Oxidative stress-induced glomerular mineralocorticoid receptor activation limits the benefit of salt reduction in Dahl salt-sensitive rats.
PloS one.
2012; 7(7):e41896. doi:
10.1371/journal.pone.0041896. [PMID: 22911865] - Mohammad Sharif Talebianpoor, Hossein Mirkhani. The effect of tempol administration on the aortic contractile responses in rat preeclampsia model.
ISRN pharmacology.
2012; 2012(?):187208. doi:
10.5402/2012/187208. [PMID: 22988523] - Beatriz Cannizzo, Agustín Luján, Natalia Estrella, Carina Lembo, Montserrat Cruzado, Claudia Castro. Insulin resistance promotes early atherosclerosis via increased proinflammatory proteins and oxidative stress in fructose-fed ApoE-KO mice.
Experimental diabetes research.
2012; 2012(?):941304. doi:
10.1155/2012/941304. [PMID: 22474431] - Ai-Dong Chen, Xiao-Qing Xiong, Xian-Bing Gan, Feng Zhang, Ye-Bo Zhou, Xing-Ya Gao, Ying Han. Endothelin-1 in paraventricular nucleus modulates cardiac sympathetic afferent reflex and sympathetic activity in rats.
PloS one.
2012; 7(7):e40748. doi:
10.1371/journal.pone.0040748. [PMID: 22815806] - Jiajie Luan, Weiping Li, Jia Han, Wen Zhang, Huiling Gong, Rong Ma. Renal protection of in vivo administration of tempol in streptozotocin-induced diabetic rats.
Journal of pharmacological sciences.
2012; 119(2):167-76. doi:
10.1254/jphs.12002fp. [PMID: 22673147] - Arjan van der Tol, Wim Van Biesen, Steven Van Laecke, Kris Bogaerts, Koen De Lombaert, Hans Warrinnier, Raymond Vanholder. Statin use and the presence of microalbuminuria. Results from the ERICABEL trial: a non-interventional epidemiological cohort study.
PloS one.
2012; 7(2):e31639. doi:
10.1371/journal.pone.0031639. [PMID: 22359611] - Elisa B M I Peixoto, Alexandros Papadimitriou, Jacqueline M Lopes de Faria, Jose B Lopes de Faria. Tempol reduces podocyte apoptosis via PARP signaling pathway in experimental diabetes mellitus.
Nephron. Experimental nephrology.
2012; 120(2):e81-90. doi:
10.1159/000337364. [PMID: 22555049] - Emin Ozbek. Induction of oxidative stress in kidney.
International journal of nephrology.
2012; 2012(?):465897. doi:
10.1155/2012/465897. [PMID: 22577546] - Fabien J Cousin, Sandrine Jouan-Lanhouet, Marie-Thérèse Dimanche-Boitrel, Laurent Corcos, Gwénaël Jan. Milk fermented by Propionibacterium freudenreichii induces apoptosis of HGT-1 human gastric cancer cells.
PloS one.
2012; 7(3):e31892. doi:
10.1371/journal.pone.0031892. [PMID: 22442660] - Qing Li, Xiujuan Peng, Hyekyung Yang, Hongbing Wang, Yan Shu. Deficiency of multidrug and toxin extrusion 1 enhances renal accumulation of paraquat and deteriorates kidney injury in mice.
Molecular pharmaceutics.
2011 Dec; 8(6):2476-83. doi:
10.1021/mp200395f. [PMID: 21991918] - Xiang Gao, Andreas Patzak, Mauricio Sendeski, Peter G Scheffer, Tom Teerlink, Johan Sällström, Bertil B Fredholm, A Erik G Persson, Mattias Carlström. Adenosine A₁-receptor deficiency diminishes afferent arteriolar and blood pressure responses during nitric oxide inhibition and angiotensin II treatment.
American journal of physiology. Regulatory, integrative and comparative physiology.
2011 Dec; 301(6):R1669-81. doi:
10.1152/ajpregu.00268.2011. [PMID: 21975649] - Min-Shan Tsai, Chien-Hua Huang, Chia-Ying Tsai, Huei-Wen Chen, Hsin-Chen Lee, Hsaio-Ju Cheng, Chiung-Yuan Hsu, Tzung-Dau Wang, Wei-Tien Chang, Wen-Jone Chen. Ascorbic acid mitigates the myocardial injury after cardiac arrest and electrical shock.
Intensive care medicine.
2011 Dec; 37(12):2033-40. doi:
10.1007/s00134-011-2362-6. [PMID: 21953354] - María T Grande, Gloria Pascual, Adela S Riolobos, Milagros Clemente-Lorenzo, Beatriz Bardaji, Luz Barreiro, Olga Tornavaca, Anna Meseguer, Jose M López-Novoa. Increased oxidative stress, the renin-angiotensin system, and sympathetic overactivation induce hypertension in kidney androgen-regulated protein transgenic mice.
Free radical biology & medicine.
2011 Nov; 51(10):1831-41. doi:
10.1016/j.freeradbiomed.2011.08.014. [PMID: 21906672] - Catalina Carrasco-Pozo, Martin Gotteland, Hernán Speisky. Apple peel polyphenol extract protects against indomethacin-induced damage in Caco-2 cells by preventing mitochondrial complex I inhibition.
Journal of agricultural and food chemistry.
2011 Nov; 59(21):11501-8. doi:
10.1021/jf202621d. [PMID: 21954913] - Francisca Rodriguez, Bernardo Lopez, Cayetano Perez, Francisco J Fenoy, Isabel Hernandez, David E Stec, Giovanni Li Volti, Miguel G Salom. Chronic tempol treatment attenuates the renal hemodynamic effects induced by a heme oxygenase inhibitor in streptozotocin diabetic rats.
American journal of physiology. Regulatory, integrative and comparative physiology.
2011 Nov; 301(5):R1540-8. doi:
10.1152/ajpregu.00847.2010. [PMID: 21849637] - Hisato Deguchi, Keiji Yasukawa, Toshihide Yamasaki, Fumiya Mito, Yuichi Kinoshita, Tatsuya Naganuma, Suguru Sato, Mayumi Yamato, Kazuhiro Ichikawa, Kiyoshi Sakai, Hideo Utsumi, Ken-ichi Yamada. Nitroxides prevent exacerbation of indomethacin-induced gastric damage in adjuvant arthritis rats.
Free radical biology & medicine.
2011 Nov; 51(9):1799-805. doi:
10.1016/j.freeradbiomed.2011.08.010. [PMID: 21906674] - Aaishwarya B Deshmukh, Jayvadan K Patel. Aqueous extract of Annona squamosa (L.) ameliorates renal failure induced by 5/6 nephrectomy in rat.
Indian journal of pharmacology.
2011 Nov; 43(6):718-21. doi:
10.4103/0253-7613.89834. [PMID: 22144782] - Daniel E Francés, María T Ronco, Paola I Ingaramo, Juan A Monti, Gerardo B Pisani, Juan P Parody, José M Pellegrino, María C Carrillo, Paloma Martín-Sanz, Cristina E Carnovale. Role of reactive oxygen species in the early stages of liver regeneration in streptozotocin-induced diabetic rats.
Free radical research.
2011 Oct; 45(10):1143-53. doi:
10.3109/10715762.2011.602345. [PMID: 21740310] - En Yin Lai, Anton Wellstein, William J Welch, Christopher S Wilcox. Superoxide modulates myogenic contractions of mouse afferent arterioles.
Hypertension (Dallas, Tex. : 1979).
2011 Oct; 58(4):650-6. doi:
10.1161/hypertensionaha.111.170472. [PMID: 21859962] - Elisabetta Aldieri, Chiara Riganti, Francesca Silvagno, Sara Orecchia, Pier Giacomo Betta, Sophie Doublier, Elena Gazzano, Manuela Polimeni, Amalia Bosia, Dario Ghigo. Antioxidants prevent the RhoA inhibition evoked by crocidolite asbestos in human mesothelial and mesothelioma cells.
American journal of respiratory cell and molecular biology.
2011 Sep; 45(3):625-31. doi:
10.1165/rcmb.2010-0089oc. [PMID: 21257924] - Peter Vavrinec, Richard Pe van Dokkum, Maaike Goris, Hendrik Buikema, Robert H Henning. Losartan protects mesenteric arteries from ROS-associated decrease in myogenic constriction following 5/6 nephrectomy.
Journal of the renin-angiotensin-aldosterone system : JRAAS.
2011 Sep; 12(3):184-94. doi:
10.1177/1470320310391328. [PMID: 21393360] - Anees Ahmad Banday, Mustafa F Lokhandwala. Angiotensin II-mediated biphasic regulation of proximal tubular Na+/H+ exchanger 3 is impaired during oxidative stress.
American journal of physiology. Renal physiology.
2011 Aug; 301(2):F364-70. doi:
10.1152/ajprenal.00121.2011. [PMID: 21593187] - Norma B Ojeda. Low birth weight increases susceptibility to renal injury in a rat model of mild ischemia-reperfusion.
American journal of physiology. Renal physiology.
2011 Aug; 301(2):F420-6. doi:
10.1152/ajprenal.00045.2011. [PMID: 21613420] - Mariëtte H W Kappers, Frank M M Smedts, Thomas Horn, Joep H M van Esch, Stefan Sleijfer, Frank Leijten, Sebastiaan Wesseling, Helena Strevens, A H Jan Danser, Anton H van den Meiracker. The vascular endothelial growth factor receptor inhibitor sunitinib causes a preeclampsia-like syndrome with activation of the endothelin system.
Hypertension (Dallas, Tex. : 1979).
2011 Aug; 58(2):295-302. doi:
10.1161/hypertensionaha.111.173559. [PMID: 21670421] - Nesrine S El-Sayed, Laila G Mahran, Mahmoud M Khattab. Tempol, a membrane-permeable radical scavenger, ameliorates lipopolysaccharide-induced acute lung injury in mice: a key role for superoxide anion.
European journal of pharmacology.
2011 Aug; 663(1-3):68-73. doi:
10.1016/j.ejphar.2011.04.054. [PMID: 21554869] - Yong Zhang, Xia Yang, Hongyang Shi, Lei Dong, Jian Bai. Effect of α-linolenic acid on endoplasmic reticulum stress-mediated apoptosis of palmitic acid lipotoxicity in primary rat hepatocytes.
Lipids in health and disease.
2011 Jul; 10(?):122. doi:
10.1186/1476-511x-10-122. [PMID: 21787405] - Mushfiquddin Khan, Harutoshi Sakakima, Tajinder S Dhammu, Anandakumar Shunmugavel, Yeong-Bin Im, Anne G Gilg, Avtar K Singh, Inderjit Singh. S-nitrosoglutathione reduces oxidative injury and promotes mechanisms of neurorepair following traumatic brain injury in rats.
Journal of neuroinflammation.
2011 Jul; 8(?):78. doi:
10.1186/1742-2094-8-78. [PMID: 21733162] - J Stegbauer, S A Potthoff, I Quack, E Mergia, T Clasen, S Friedrich, O Vonend, M Woznowski, E Königshausen, L Sellin, L C Rump. Chronic treatment with angiotensin-(1-7) improves renal endothelial dysfunction in apolipoproteinE-deficient mice.
British journal of pharmacology.
2011 Jul; 163(5):974-83. doi:
10.1111/j.1476-5381.2011.01295.x. [PMID: 21371005] - Pengyu Cao, Osamu Ito, Qi Guo, Daisuke Ito, Yoshikazu Muroya, Rong Rong, Takefumi Mori, Sadayoshi Ito, Masahiro Kohzuki. Endogenous hydrogen peroxide up-regulates the expression of nitric oxide synthase in the kidney of SHR.
Journal of hypertension.
2011 Jun; 29(6):1167-74. doi:
10.1097/hjh.0b013e3283468367. [PMID: 21505355] - Maarten P Koeners, Branko Braam, Jaap A Joles. Perinatal inhibition of NF-kappaB has long-term antihypertensive effects in spontaneously hypertensive rats.
Journal of hypertension.
2011 Jun; 29(6):1160-6. doi:
10.1097/hjh.0b013e3283468344. [PMID: 21505356] - Hiroo Kawarazaki, Katsuyuki Ando, Megumi Fujita, Hiromitsu Matsui, Ai Nagae, Kazuhiko Muraoka, Chiaki Kawarasaki, Toshiro Fujita. Mineralocorticoid receptor activation: a major contributor to salt-induced renal injury and hypertension in young rats.
American journal of physiology. Renal physiology.
2011 Jun; 300(6):F1402-9. doi:
10.1152/ajprenal.00691.2010. [PMID: 21478481] - Amy L Sindler, Bradley S Fleenor, John W Calvert, Kurt D Marshall, Melanie L Zigler, David J Lefer, Douglas R Seals. Nitrite supplementation reverses vascular endothelial dysfunction and large elastic artery stiffness with aging.
Aging cell.
2011 Jun; 10(3):429-37. doi:
10.1111/j.1474-9726.2011.00679.x. [PMID: 21276184] - Yong Zhang, Lei Dong, Xia Yang, Hongyang Shi, Li Zhang. α-Linolenic acid prevents endoplasmic reticulum stress-mediated apoptosis of stearic acid lipotoxicity on primary rat hepatocytes.
Lipids in health and disease.
2011 May; 10(?):81. doi:
10.1186/1476-511x-10-81. [PMID: 21592363] - Katie A Wilkins, James Bancroft, Maurice Bosch, Jennifer Ings, Nicholas Smirnoff, Vernonica E Franklin-Tong. Reactive oxygen species and nitric oxide mediate actin reorganization and programmed cell death in the self-incompatibility response of papaver.
Plant physiology.
2011 May; 156(1):404-16. doi:
10.1104/pp.110.167510. [PMID: 21386034] - Aiki Marushima, Kensuke Suzuki, Yukio Nagasaki, Toru Yoshitomi, Kazuko Toh, Hideo Tsurushima, Aki Hirayama, Akira Matsumura. Newly synthesized radical-containing nanoparticles enhance neuroprotection after cerebral ischemia-reperfusion injury.
Neurosurgery.
2011 May; 68(5):1418-25; discussion 1425. doi:
10.1227/neu.0b013e31820c02d9. [PMID: 21273921] - Gregory N Adams, Gretchen A LaRusch, Evi Stavrou, Yihua Zhou, Marvin T Nieman, Gretta H Jacobs, Yingjie Cui, Yuan Lu, Mukesh K Jain, Fakhri Mahdi, Zia Shariat-Madar, Yoshio Okada, Louis G D'Alecy, Alvin H Schmaier. Murine prolylcarboxypeptidase depletion induces vascular dysfunction with hypertension and faster arterial thrombosis.
Blood.
2011 Apr; 117(14):3929-37. doi:
10.1182/blood-2010-11-318527. [PMID: 21297000] - Miwa Morita, Shozo Yano, Toru Yamaguchi, Mika Yamauchi, Toshitsugu Sugimoto. Phenylacetic acid stimulates reactive oxygen species generation and tumor necrosis factor-α secretion in vascular endothelial cells.
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy.
2011 Apr; 15(2):147-50. doi:
10.1111/j.1744-9987.2010.00887.x. [PMID: 21426506] - Hong Wang, Jeffrey L Garvin, Martin A D'Ambrosio, John R Falck, Pablo Leung, Ruisheng Liu, YiLin Ren, Oscar A Carretero. Heme oxygenase metabolites inhibit tubuloglomerular feedback in vivo.
American journal of physiology. Heart and circulatory physiology.
2011 Apr; 300(4):H1320-6. doi:
10.1152/ajpheart.01118.2010. [PMID: 21239629] - Jian Wang, Kostas Pantopoulos. Regulation of cellular iron metabolism.
The Biochemical journal.
2011 Mar; 434(3):365-81. doi:
10.1042/bj20101825. [PMID: 21348856] - Ying Han, Zhi-Dan Fan, Ning Yuan, Gui-Qin Xie, Juan Gao, Wei De, Xing-Ya Gao, Guo-Qing Zhu. Superoxide anions in the paraventricular nucleus mediate the enhanced cardiac sympathetic afferent reflex and sympathetic activity in renovascular hypertensive rats.
Journal of applied physiology (Bethesda, Md. : 1985).
2011 Mar; 110(3):646-52. doi:
10.1152/japplphysiol.00908.2010. [PMID: 21164151] - Carmen De Miguel, Chuanling Guo, Hayley Lund, Di Feng, David L Mattson. Infiltrating T lymphocytes in the kidney increase oxidative stress and participate in the development of hypertension and renal disease.
American journal of physiology. Renal physiology.
2011 Mar; 300(3):F734-42. doi:
10.1152/ajprenal.00454.2010. [PMID: 21159736] - Arti Dhar, Indu Dhar, Bo Jiang, Kaushik M Desai, Lingyun Wu. Chronic methylglyoxal infusion by minipump causes pancreatic beta-cell dysfunction and induces type 2 diabetes in Sprague-Dawley rats.
Diabetes.
2011 Mar; 60(3):899-908. doi:
10.2337/db10-0627. [PMID: 21300844] - Anees A Banday, Mustafa F Lokhandwala. Oxidative stress causes renal angiotensin II type 1 receptor upregulation, Na+/H+ exchanger 3 overstimulation, and hypertension.
Hypertension (Dallas, Tex. : 1979).
2011 Mar; 57(3):452-9. doi:
10.1161/hypertensionaha.110.162339. [PMID: 21282559] - Yu-Jung Chen, Margarita Santos, John Quilley. Treatment of diabetic rats with a peroxynitrite decomposition catalyst prevents induction of renal COX-2.
American journal of physiology. Heart and circulatory physiology.
2011 Mar; 300(3):H1125-32. doi:
10.1152/ajpheart.00768.2010. [PMID: 21239635] - Sabina Tabaczar, Marcin Talar, Krzysztof Gwoździński. [Nitroxides as antioxidants - possibilities of their application in chemoprevention and radioprotection].
Postepy higieny i medycyny doswiadczalnej (Online).
2011 Feb; 65(?):46-54. doi:
10.5604/17322693.932256. [PMID: 21357994] - Aurélie Edwards, Chunhua Cao, Thomas L Pallone. Cellular mechanisms underlying nitric oxide-induced vasodilation of descending vasa recta.
American journal of physiology. Renal physiology.
2011 Feb; 300(2):F441-56. doi:
10.1152/ajprenal.00499.2010. [PMID: 21084408] - Ruy R Campos, Elizabeth B Oliveira-Sales, Erika E Nishi, Mirian A Boim, Miriam S Dolnikoff, Cássia T Bergamaschi. The role of oxidative stress in renovascular hypertension.
Clinical and experimental pharmacology & physiology.
2011 Feb; 38(2):144-52. doi:
10.1111/j.1440-1681.2010.05437.x. [PMID: 20678153] - Elizabeth A Mazzio, Fran Close, Karam F A Soliman. The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease.
International journal of molecular sciences.
2011 Jan; 12(1):506-69. doi:
10.3390/ijms12010506. [PMID: 21340000] - Caroline Fréguin-Bouilland, Michel Godin, Jeremy Bellien, Vincent Richard, Isabelle Remy-Jouet, Brigitte Dautreaux, Jean-Paul Henry, Patricia Compagnon, Christian Thuillez, Didier Plissonnier, Robinson Joannidès. Protective effect of mycophenolate mofetil on endothelial function in an aortic allograft model.
Transplantation.
2011 Jan; 91(1):35-41. doi:
10.1097/tp.0b013e3181fe12d6. [PMID: 21441851] - Katarzyna Winiarska, Michal Grabowski, Maciej K Rogacki. Inhibition of renal gluconeogenesis contributes to hypoglycaemic action of NADPH oxidase inhibitor, apocynin.
Chemico-biological interactions.
2011 Jan; 189(1-2):119-26. doi:
10.1016/j.cbi.2010.09.033. [PMID: 20934416] - Xian-Bing Gan, Yang-Can Duan, Xiao-Qing Xiong, Peng Li, Bai-Ping Cui, Xing-Ya Gao, Guo-Qing Zhu. Inhibition of cardiac sympathetic afferent reflex and sympathetic activity by baroreceptor and vagal afferent inputs in chronic heart failure.
PloS one.
2011; 6(10):e25784. doi:
10.1371/journal.pone.0025784. [PMID: 21991351] - María Inés Rosón, Silvana Lorena Della Penna, Gabriel Cao, Susana Gorzalczany, Marcela Pandolfo, Carolina Cerrudo, Belisario E Fernández, Jorge E Toblli. High-sodium diet promotes a profibrogenic reaction in normal rat kidneys: effects of Tempol administration.
Journal of nephrology.
2011 Jan; 24(1):119-27. doi:
10.5301/jn.2010.5824. [PMID: 20954139] - Takuya Kishi, Yoshitaka Hirooka, Kiyohiro Ogawa, Satomi Konno, Kenji Sunagawa. Calorie restriction inhibits sympathetic nerve activity via anti-oxidant effect in the rostral ventrolateral medulla of obesity-induced hypertensive rats.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2011; 33(4):240-5. doi:
10.3109/10641963.2011.583969. [PMID: 21699450] - Sílvia Helena Cestari, Jairo Kennup Bastos, Luiz Claudio Di Stasi. Intestinal Anti-Inflammatory Activity of Baccharis dracunculifolia in the Trinitrobenzenesulphonic Acid Model of Rat Colitis.
Evidence-based complementary and alternative medicine : eCAM.
2011; 2011(?):524349. doi:
10.1093/ecam/nep081. [PMID: 19592480] - Xiaoyan Zhou, Martin F Crook, Wanda Sharif-Rodriguez, Yonghua Zhu, Zadok Ruben, Yi Pan, Olga Urosevic-Price, Li Wang, Amy M Flattery, Gail Forrest, Daphne Szeto, Huawei Zhao, Sophie Roy, Michael J Forrest. Chronic antagonism of the mineralocorticoid receptor ameliorates hypertension and end organ damage in a rodent model of salt-sensitive hypertension.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2011; 33(8):538-47. doi:
10.3109/10641963.2011.566956. [PMID: 21950654] - Melpomeni Peppa, Maria Krania, Sotirios A Raptis. Hypertension and other morbidities with Cushing's syndrome associated with corticosteroids: a review.
Integrated blood pressure control.
2011; 4(?):7-16. doi:
10.2147/ibpc.s9486. [PMID: 21949634] - J Tatebe, T Morita. Enhancement of TNF-α expression and inhibition of glucose uptake by nicotine in the presence of a free fatty acid in C2C12 skeletal myocytes.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2011 Jan; 43(1):11-6. doi:
10.1055/s-0030-1267996. [PMID: 21080305] - Omotayo O Erejuwa, Siti A Sulaiman, Mohd Suhaimi Ab Wahab, Kuttulebbai N S Sirajudeen, Md Salzihan Md Salleh, Sunil Gurtu. Differential responses to blood pressure and oxidative stress in streptozotocin-induced diabetic Wistar-Kyoto rats and spontaneously hypertensive rats: effects of antioxidant (honey) treatment.
International journal of molecular sciences.
2011; 12(3):1888-907. doi:
10.3390/ijms12031888. [PMID: 21673929] - Atsuko Matsumoto, Ken-ichiro Matsumoto, Shingo Matsumoto, Fuminori Hyodo, Anastasia L Sowers, Janusz W Koscielniak, Nallathamby Devasahayam, Sankaran Subramanian, James B Mitchell, Murali C Krishna. Intracellular hypoxia of tumor tissue estimated by noninvasive electron paramagnetic resonance oximetry technique using paramagnetic probes.
Biological & pharmaceutical bulletin.
2011; 34(1):142-5. doi:
10.1248/bpb.34.142. [PMID: 21212532]