B-HT 920 (BioDeep_00000684542)

   


代谢物信息卡片


Talipexole dihydrochloride

化学式: C10H17Cl2N3S (281.0520182)
中文名称: 盐酸他利克索
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C=CCN1CCC2=C(CC1)SC(=N2)N.Cl.Cl
InChI: 2*1H

描述信息

D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018491 - Dopamine Agonists
Talipexole dihydrochloride (B-HT 920 dihydrochloride) is a dopamine D2 receptor agonist, α2-adrenoceptor agonist and 5-HT3 receptor antagonist, which displays antiParkinsonian activity.

同义名列表

4 个代谢物同义名

Talipexole dihydrochloride; B-HT 920; B-HT 920 (dihydrochloride); Talipexole (dihydrochloride)



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

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Plant Reactome(0)

INOH(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • T T Zhang, M Song, T J Hang, X F Xu, A D Wen, L Yang, L Jia. Pharmacokinetic profile of talipexole in healthy volunteers is not altered when it is co-administered with Madopar (co-beneldopa). Journal of clinical pharmacy and therapeutics. 2009 Jun; 34(3):345-54. doi: 10.1111/j.1365-2710.2008.01008.x. [PMID: 19646081]
  • Minori Enomoto, Yuichi Inoue, Kazuyoshi Namba, Takashi Munezawa, Masato Matsuura. Clinical characteristics of restless legs syndrome in end-stage renal failure and idiopathic RLS patients. Movement disorders : official journal of the Movement Disorder Society. 2008 Apr; 23(6):811-6; quiz 926. doi: 10.1002/mds.21882. [PMID: 18074382]
  • Beatriz Civantos, Amaya Aleixandre. Blood pressure and alpha-vascular reactivity in hypertensive rats treated with amlodipine and dietary Ca. European journal of pharmacology. 2004 Apr; 489(1-2):101-10. doi: 10.1016/j.ejphar.2004.02.032. [PMID: 15063161]
  • Yoshitoki Takagawa, Morris E Berger, Michael L Tuck, Michael S Golub. Impaired endothelial alpha-2 adrenergic receptor-mediated vascular relaxation in the fructose-fed rat. Hypertension research : official journal of the Japanese Society of Hypertension. 2002 Mar; 25(2):197-202. doi: 10.1291/hypres.25.197. [PMID: 12047035]
  • K Orito, M Kishi, T Imaizumi, T Nakazawa, A Hashimoto, T Mori, T Kambe. alpha(2)-adrenoceptor antagonist properties of OPC-28326, a novel selective peripheral vasodilator. British journal of pharmacology. 2001 Oct; 134(4):763-70. doi: 10.1038/sj.bjp.0704309. [PMID: 11606316]
  • E Osumi, T Imai. [Increase in serum creatine phosphokinase following administration of talipexole hydrochloride]. Rinsho shinkeigaku = Clinical neurology. 2000 Oct; 40(10):1041-3. doi: NULL. [PMID: 11296371]
  • B Civantos, V López-Miranda, A Ortega, M A Aleixandre de Artiñano. Alpha-adrenoceptor-mediated pressor responses in pithed rats fed diets with different calcium contents. European journal of pharmacology. 1999 Oct; 382(2):91-101. doi: 10.1016/s0014-2999(99)00556-7. [PMID: 10528143]
  • B George, S K Kulkarni. Dopaminergic modulation of lithium/pilocarpine-induced status epilepticus in rats. Methods and findings in experimental and clinical pharmacology. 1997 Sep; 19(7):481-8. doi: ". [PMID: 9413831]
  • Y Y Lau, J M Selenka, G D Hanson, R Talaat, N Ichhpurani. Determination of pramipexole (U-98,528) in human plasma by high-performance liquid chromatography with atmospheric pressure chemical ionization tandem mass spectrometry. Journal of chromatography. B, Biomedical applications. 1996 Aug; 683(2):209-16. doi: 10.1016/0378-4347(96)00124-7. [PMID: 8891917]
  • Y Y Lau, G D Hanson, N Ichhpurani. Determination of pramipexole (U-98,528) in human plasma and urine by high-performance liquid chromatography with electrochemical and ultraviolet detection. Journal of chromatography. B, Biomedical applications. 1996 Aug; 683(2):217-23. doi: 10.1016/0378-4347(96)00123-5. [PMID: 8891918]
  • T Inoue, M Domae, K Yamada, T Furukawa. Effects of the novel antipsychotic agent 7-(4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butyloxy)-3,4-dihydro -2(1H)-quinolinone (OPC-14597) on prolactin release from the rat anterior pituitary gland. The Journal of pharmacology and experimental therapeutics. 1996 Apr; 277(1):137-43. doi: NULL. [PMID: 8613910]
  • J W Oliver, L K Abney, J R Strickland, R D Linnabary. Vasoconstriction in bovine vasculature induced by the tall fescue alkaloid lysergamide. Journal of animal science. 1993 Oct; 71(10):2708-13. doi: 10.2527/1993.71102708x. [PMID: 7901191]
  • T Ohmori, T Koyama, T Inoue, S Matsubara, I Yamashita. B-HT 920, a dopamine D2 agonist, in the treatment of negative symptoms of chronic schizophrenia. Biological psychiatry. 1993 May; 33(10):687-93. doi: 10.1016/0006-3223(93)90117-v. [PMID: 8102551]
  • M Memo, M Pizzi, M Belloni, M Benarese, P Spano. Activation of dopamine D2 receptors linked to voltage-sensitive potassium channels reduces forskolin-induced cyclic AMP formation in rat pituitary cells. Journal of neurochemistry. 1992 Nov; 59(5):1829-35. doi: 10.1111/j.1471-4159.1992.tb11016.x. [PMID: 1357100]
  • Z Y Du, O L Woodman. The effect of hypercholesterolaemia and atherosclerosis on alpha-adrenoceptor-mediated vasoconstriction in conscious rabbits and rabbit aorta. European journal of pharmacology. 1992 Feb; 211(2):149-56. doi: 10.1016/0014-2999(92)90522-6. [PMID: 1351845]
  • P Onali, M C Olianas. B-HT 920 activates dopamine D2 receptors coupled to inhibition of adenylate cyclase activity. Journal of neural transmission. General section. 1992; 88(2):95-104. doi: 10.1007/bf01244815. [PMID: 1352980]
  • H Weiss, F Friedrich, M Paulmichl, E Wöll, F Lang. Effect of BHT 920 on calcium-activated K+ channels in renal epithelioid MDCK cells. Biochimica et biophysica acta. 1991 Nov; 1069(2):165-70. doi: 10.1016/0005-2736(91)90119-s. [PMID: 1681905]
  • C Y Kwan, V Gaspar, A G Shi, Z L Wang, M C Chen, A Ohta, E J Cragoe, E E Daniel. Vascular effects of tetramethylpyrazine: direct interaction with smooth muscle alpha-adrenoceptors. European journal of pharmacology. 1991 May; 198(1):15-21. doi: 10.1016/0014-2999(91)90556-6. [PMID: 1680713]
  • P Navarra, W Eechaute, P Preziosi, E Lacroix. Alpha 2-adrenoceptor-mediated inhibition of prolactin release in suckling- or fenfluramine-induced hyperprolactinemia. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 1991 May; 23(5):213-7. doi: 10.1055/s-2007-1003656. [PMID: 1678730]
  • J M Guillon, E Etiemble, P Roubert, M Auguet, P E Chabrier, P Braquet. Cross-desensitization between angiotensin II and endothelin-1 in the pithed rat. Journal of cardiovascular pharmacology. 1991; 17 Suppl 7(?):S366-9. doi: 10.1097/00005344-199100177-00104. [PMID: 1725382]
  • M Domae, K Yamada, Y Hanabusa, S Matsumoto, T Furukawa. Decrease of prolactin secretion via stimulation of pituitary dopamine D-2 receptors after application of talipexole and SND 919. European journal of pharmacology. 1990 Apr; 179(1-2):75-82. doi: 10.1016/0014-2999(90)90403-s. [PMID: 2142088]
  • K Wiedemann, O Benkert, F Holsboer. B-HT 920--a novel dopamine autoreceptor agonist in the treatment of patients with schizophrenia. Pharmacopsychiatry. 1990 Jan; 23(1):50-5. doi: 10.1055/s-2007-1014482. [PMID: 1969167]
  • S Regunathan, K Missala, T L Sourkes. Central regulation of adrenal tyrosine hydroxylase: effect of induction on catecholamine levels in the adrenal medulla and plasma. Journal of neurochemistry. 1989 Dec; 53(6):1706-10. doi: 10.1111/j.1471-4159.1989.tb09234.x. [PMID: 2572679]
  • A G Shi, S Ahmad, C Y Kwan, E E Daniel. Characterization of alpha-adrenoceptor subtypes by [3H]prazosin and [3H]rauwolscine binding to canine venous smooth muscle membranes. Canadian journal of physiology and pharmacology. 1989 Sep; 67(9):1067-73. doi: 10.1139/y89-169. [PMID: 2557148]
  • S A Douglas, C J Bowmer, M S Yates. Vascular smooth muscle function in rats with acute renal failure. The Journal of pharmacy and pharmacology. 1989 Aug; 41(8):541-4. doi: 10.1111/j.2042-7158.1989.tb06522.x. [PMID: 2477522]
  • K Szemeredi, Z Zukowska-Grojec, G Bagdy, M I Fekete, I J Kopin. Opposite effects of chronic cortisol treatment on pre- and postsynaptic actions of clonidine in pithed rats. Journal of autonomic pharmacology. 1989 Feb; 9(1):35-43. doi: 10.1111/j.1474-8673.1989.tb00194.x. [PMID: 2566614]
  • K A King, C C Pang. Differential cardiovascular effects of central clonidine and B-HT 920 in conscious rats. Canadian journal of physiology and pharmacology. 1988 Nov; 66(11):1455-60. doi: 10.1139/y88-237. [PMID: 3242780]
  • I Zebrowska-Lupina, M Stelmasiak, A Porowska, T Pietrasiewicz. Immobilization stress modifies locomotor response to catecholamine receptor agonists in rats. Polish journal of pharmacology and pharmacy. 1988 Sep; 40(5):441-50. doi: NULL. [PMID: 3253715]
  • M Kyozuka, D J Crankshaw, J Crankshaw, I Berezin, C Y Kwan, E E Daniel. Alpha-2 adrenoceptors on nerves and muscles of rat uterus. The Journal of pharmacology and experimental therapeutics. 1988 Mar; 244(3):1128-38. doi: NULL. [PMID: 2855241]
  • J T Daugirdas, Z M Nawab. Acetate relaxation of isolated vascular smooth muscle. Kidney international. 1987 Jul; 32(1):39-46. doi: 10.1038/ki.1987.169. [PMID: 3626298]
  • D W Wolff, F A Gesek, J W Strandhoy. In vivo assessment of rat renal alpha adrenoceptors. The Journal of pharmacology and experimental therapeutics. 1987 May; 241(2):472-6. doi: NULL. [PMID: 2883300]
  • M Schmidt, J P Krieger, E Giesen-Crouse, J L Imbs. Characterisation of the alpha-adrenoceptors of the rat renal vascular bed. Fundamental & clinical pharmacology. 1987; 1(1):7-22. doi: 10.1111/j.1472-8206.1987.tb00541.x. [PMID: 2822558]
  • K Svensson, M Carlsson, A Carlsson, S Hjorth, A M Johansson, E Eriksson. The putatively selective dopamine autoreceptor antagonists (+)-AJ 76 and (+)-UH 232 stimulate prolactin release in rats. European journal of pharmacology. 1986 Nov; 130(3):237-42. doi: 10.1016/0014-2999(86)90273-6. [PMID: 3792447]
  • A Pettersson, J Hedner, T Hedner. The diuretic effect of atrial natriuretic peptide (ANP) is dependent on dopaminergic activation. Acta physiologica Scandinavica. 1986 Apr; 126(4):619-21. doi: 10.1111/j.1748-1716.1986.tb07865.x. [PMID: 2940811]
  • E Eriksson, K Svensson, D Clark. The putative dopamine autoreceptor agonist B-HT 920 decreases nigral dopamine cell firing rate and prolactin release in rat. Life sciences. 1985 May; 36(19):1819-27. doi: 10.1016/0024-3205(85)90154-7. [PMID: 3990512]
  • R Hammer, W Kobinger, L Pichler. Binding of an imidazolidine (clonidine), an oxazoloazepin (B-HT 933) and a thiazoloazepin (B-HT 920) to rat brain alpha-adrenoceptors and relation to cardiovascular effects. European journal of pharmacology. 1980 Apr; 62(4):277-85. doi: 10.1016/0014-2999(80)90095-3. [PMID: 6245898]