Pretazettine (BioDeep_00000006838)

 

Secondary id: BioDeep_00001869830

human metabolite Volatile Flavor Compounds natural product


代谢物信息卡片


(1S,11R,13R,16S,18S)-18-methoxy-15-methyl-5,7,12-trioxa-15-azapentacyclo[11.7.0.0¹,¹⁶.0²,¹⁰.0⁴,⁸]icosa-2,4(8),9,19-tetraen-11-ol

化学式: C18H21NO5 (331.1419656)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN1CC2C3(C1CC(C=C3)OC)C4=CC5=C(C=C4C(O2)O)OCO5
InChI: InChI=1S/C18H21NO5/c1-19-8-16-18(4-3-10(21-2)5-15(18)19)12-7-14-13(22-9-23-14)6-11(12)17(20)24-16/h3-4,6-7,10,15-17,20H,5,8-9H2,1-2H3/t10-,15+,16+,17-,18+/m1/s1

描述信息

Pretazettine, also known as pretazettine hydrochloride, (6abeta,8beta)-isomer, is a member of the class of compounds known as tazettine-type amaryllidaceae alkaloids. Tazettine-type amaryllidaceae alkaloids are amaryllidaceae alkaloids derived from the haemanthamine-type alkaloids, which are characterized as a linkage between C6 and C11 by an oxygen atom to form a [3,4-g]benzopyran framework. Pretazettine is slightly soluble (in water) and a very weakly acidic compound (based on its pKa). Pretazettine can be found in lovage, which makes pretazettine a potential biomarker for the consumption of this food product.

同义名列表

4 个代谢物同义名

(1S,11R,13R,16S,18S)-18-methoxy-15-methyl-5,7,12-trioxa-15-azapentacyclo[11.7.0.0¹,¹⁶.0²,¹⁰.0⁴,⁸]icosa-2,4(8),9,19-tetraen-11-ol; CHEMBL2010422; Pretazettine; Pretazettine



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

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Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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PharmGKB(0)

55 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Daniel Zaragoza-Puchol, Javier E Ortiz, Alejandro A Orden, Marianela Sanchez, Jorge Palermo, Alejandro Tapia, Jaume Bastida, Gabriela E Feresin. Alkaloids Analysis of Habranthus cardenasianus (Amaryllidaceae), Anti-Cholinesterase Activity and Biomass Production by Propagation Strategies. Molecules (Basel, Switzerland). 2021 Jan; 26(1):. doi: 10.3390/molecules26010192. [PMID: 33401696]
  • Jerald J Nair, Johannes van Staden. Antiprotozoal alkaloid principles of the plant family Amaryllidaceae. Bioorganic & medicinal chemistry letters. 2019 10; 29(20):126642. doi: 10.1016/j.bmcl.2019.126642. [PMID: 31515186]
  • Stefania Vergura, Ernesto Santoro, Marco Masi, Antonio Evidente, Patrizia Scafato, Stefano Superchi, Giuseppe Mazzeo, Giovanna Longhi, Sergio Abbate. Absolute configuration assignment to anticancer Amaryllidaceae alkaloid jonquailine. Fitoterapia. 2018 Sep; 129(?):78-84. doi: 10.1016/j.fitote.2018.06.013. [PMID: 29928968]
  • István Zupkó, Borbála Réthy, Judit Hohmann, Joseph Molnár, Imre Ocsovszki, George Falkay. Antitumor activity of alkaloids derived from Amaryllidaceae species. In vivo (Athens, Greece). 2009 Jan; 23(1):41-8. doi: . [PMID: 19368123]
  • Susana López, Jaume Bastida, Francesc Viladomat, Carles Codina. Solid-phase extraction and reversed-phase high-performance liquid chromatography of the five major alkaloids in Narcissus confusus. Phytochemical analysis : PCA. 2002 Nov; 13(6):311-5. doi: 10.1002/pca.660. [PMID: 12494748]
  • Judit Hohmann, Peter Forgo, Joseph Molnár, Krisztina Wolfard, Annamária Molnár, Theresia Thalhammer, Imre Máthé, Derek Sharples. Antiproliferative amaryllidaceae alkaloids isolated from the bulbs of Sprekelia formosissima and Hymenocallis x festalis. Planta medica. 2002 May; 68(5):454-7. doi: 10.1055/s-2002-32068. [PMID: 12058326]
  • S W Baldwin, J S Debenham. Total syntheses of (-)-haemanthidine, (+)-pretazettine, and (+)-tazettine. Organic letters. 2000 Jan; 2(2):99-102. doi: 10.1021/ol9911472. [PMID: 10814256]
  • E Furusawa, S Furusawa. Effect of pretazettine and viva-natural, a dietary seaweed extract, on spontaneous AKR leukemia in comparison with standard drugs. Oncology. 1988; 45(3):180-6. doi: 10.1159/000226558. [PMID: 3368194]