Emricasan (BioDeep_00000683682)
代谢物信息卡片
化学式: C26H27F4N3O7 (569.178504)
中文名称: 恩利卡生
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C(=O)NC(CC(=O)O)C(=O)COC1=C(C(=CC(=C1F)F)F)F)NC(=O)C(=O)NC2=CC=CC=C2C(C)(C)C
InChI: InChI=1S/C26H27F4N3O7/c1-12(31-24(38)25(39)32-16-8-6-5-7-13(16)26(2,3)4)23(37)33-17(10-19(35)36)18(34)11-40-22-20(29)14(27)9-15(28)21(22)30/h5-9,12,17H,10-11H2,1-4H3,(H,31,38)(H,32,39)(H,33,37)(H,35,36)/t12-,17-/m0/s1
描述信息
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C471 - Enzyme Inhibitor
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- KEGGdrug: D10004
- PubChem: 12000240
- DrugBank: DB05408
- ChEMBL: CHEMBL197672
- CAS: 254750-02-2
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Stephen A Harrison, Zachary Goodman, Abdul Jabbar, Ravi Vemulapalli, Ziad H Younes, Bradley Freilich, Muhammad Y Sheikh, Jörn M Schattenberg, Zeid Kayali, Adam Zivony, Aasim Sheikh, Javier Garcia-Samaniego, Sanjaya K Satapathy, George Therapondos, Edward Mena, Detlef Schuppan, James Robinson, Jean L Chan, David T Hagerty, Arun J Sanyal. A randomized, placebo-controlled trial of emricasan in patients with NASH and F1-F3 fibrosis.
Journal of hepatology.
2020 05; 72(5):816-827. doi:
10.1016/j.jhep.2019.11.024
. [PMID: 31887369] - Catherine T Frenette, Giuseppe Morelli, Mitchell L Shiffman, R Todd Frederick, Raymond A Rubin, Michael B Fallon, Jason T Cheng, Matt Cave, Saira A Khaderi, Omar Massoud, Nikolaos Pyrsopoulos, James S Park, James M Robinson, Mason Yamashita, Alfred P Spada, Jean L Chan, David T Hagerty. Emricasan Improves Liver Function in Patients With Cirrhosis and High Model for End-Stage Liver Disease Scores Compared With Placebo.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.
2019 03; 17(4):774-783.e4. doi:
10.1016/j.cgh.2018.06.012
. [PMID: 29913280] - Mitchell Shiffman, Bradley Freilich, Raj Vuppalanchi, Kymberly Watt, Jean L Chan, Al Spada, David T Hagerty, Eugene Schiff. Randomised clinical trial: emricasan versus placebo significantly decreases ALT and caspase 3/7 activation in subjects with non-alcoholic fatty liver disease.
Alimentary pharmacology & therapeutics.
2019 01; 49(1):64-73. doi:
10.1111/apt.15030
. [PMID: 30430605] - M L Shiffman, P Pockros, J G McHutchison, E R Schiff, M Morris, G Burgess. Clinical trial: the efficacy and safety of oral PF-03491390, a pancaspase inhibitor - a randomized placebo-controlled study in patients with chronic hepatitis C.
Alimentary pharmacology & therapeutics.
2010 May; 31(9):969-78. doi:
10.1111/j.1365-2036.2010.04264.x
. [PMID: 20163376] - Yoshinobu Ueno, Takashi Ohmi, Mitsuko Yamamoto, Naoto Kato, Yukiko Moriguchi, Midori Kojima, Rieko Shimozono, Sachiko Suzuki, Tomomi Matsuura, Hiroyuki Eda. Orally-administered caspase inhibitor PF-03491390 is retained in the liver for prolonged periods with low systemic exposure, exerting a hepatoprotective effect against alpha-fas-induced liver injury in a mouse model.
Journal of pharmacological sciences.
2007 Oct; 105(2):201-5. doi:
10.1254/jphs.sc0070207
. [PMID: 17928737] - E S Baskin-Bey, K Washburn, S Feng, T Oltersdorf, D Shapiro, Mira Huyghe, L Burgart, M Garrity-Park, F G I van Vilsteren, L K Oliver, C B Rosen, G J Gores. Clinical Trial of the Pan-Caspase Inhibitor, IDN-6556, in Human Liver Preservation Injury.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
2007 Jan; 7(1):218-25. doi:
10.1111/j.1600-6143.2006.01595.x
. [PMID: 17227570]