AZD8055 (BioDeep_00000683599)

   


代谢物信息卡片


[5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol

化学式: C25H31N5O4 (465.2375926)
中文名称: AZD-8055
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1COCCN1C2=NC(=NC3=C2C=CC(=N3)C4=CC(=C(C=C4)OC)CO)N5CCOCC5C
InChI: InChI=1S/C25H31N5O4/c1-16-14-33-10-8-29(16)24-20-5-6-21(18-4-7-22(32-3)19(12-18)13-31)26-23(20)27-25(28-24)30-9-11-34-15-17(30)2/h4-7,12,16-17,31H,8-11,13-15H2,1-3H3/t16-,17-/m0/s1

描述信息

C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C61074 - Serine/Threonine Kinase Inhibitor
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C2201 - mTOR Inhibitor
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor
AZD-8055 is a potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM. AZD-8055 inhibits both mTORC1 and mTORC2[1].
AZD-8055 is a potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM. AZD-8055 inhibits both mTORC1 and mTORC2[1].

同义名列表

2 个代谢物同义名

[5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol; AZD8055



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jeong Hun Kim, Hyera Jung, Ye Eun Choi, Taijoon Chung. Autophagy inducers lead to transient accumulation of autophagosomes in Arabidopsis roots. Plant cell reports. 2022 Feb; 41(2):463-471. doi: 10.1007/s00299-021-02821-2. [PMID: 34977975]
  • Ana Latorre, Alfonso Latorre, Milagros Castellanos, Nuria Lafuente-Gómez, Ciro Rodriguez Diaz, Alejandra Crespo-Barreda, Mercedes Lecea, Marco Cordani, Pilar Martín-Duque, Álvaro Somoza. Albumin-based nanostructures for uveal melanoma treatment. Nanomedicine : nanotechnology, biology, and medicine. 2021 07; 35(?):102391. doi: 10.1016/j.nano.2021.102391. [PMID: 33794371]
  • Mark Dittmar, Jae Seung Lee, Kanupriya Whig, Elisha Segrist, Minghua Li, Brinda Kamalia, Lauren Castellana, Kasirajan Ayyanathan, Fabian L Cardenas-Diaz, Edward E Morrisey, Rachel Truitt, Wenli Yang, Kellie Jurado, Kirandeep Samby, Holly Ramage, David C Schultz, Sara Cherry. Drug repurposing screens reveal cell-type-specific entry pathways and FDA-approved drugs active against SARS-Cov-2. Cell reports. 2021 04; 35(1):108959. doi: 10.1016/j.celrep.2021.108959. [PMID: 33811811]
  • Jianling Xie, Kaikai Shen, Ashley T Jones, Jian Yang, Andrew R Tee, Ming Hong Shen, Mengyuan Yu, Swati Irani, Derick Wong, James E Merrett, Roman V Lenchine, Stuart De Poi, Kirk B Jensen, Paul J Trim, Marten F Snel, Makoto Kamei, Sally Kim Martin, Stephen Fitter, Shuye Tian, Xuemin Wang, Lisa M Butler, Andrew C W Zannettino, Christopher G Proud. Reciprocal signaling between mTORC1 and MNK2 controls cell growth and oncogenesis. Cellular and molecular life sciences : CMLS. 2021 Jan; 78(1):249-270. doi: 10.1007/s00018-020-03491-1. [PMID: 32170339]
  • Laura Prioretti, Frédéric Carriere, Ben Field, Luisana Avilan, Marie-Hélène Montané, Benoît Menand, Brigitte Gontero. Targeting TOR signaling for enhanced lipid productivity in algae. Biochimie. 2020 Feb; 169(?):12-17. doi: 10.1016/j.biochi.2019.06.016. [PMID: 31265860]
  • Adrian N Dauphinee, Catarina Cardoso, Kerstin Dalman, Jonas A Ohlsson, Stina Berglund Fick, Stéphanie Robert, Glenn R Hicks, Peter V Bozhkov, Elena A Minina. Chemical Screening Pipeline for Identification of Specific Plant Autophagy Modulators. Plant physiology. 2019 11; 181(3):855-866. doi: 10.1104/pp.19.00647. [PMID: 31488572]
  • Megan M Ford, Amanda L Smythers, Evan W McConnell, Sarah C Lowery, Derrick R J Kolling, Leslie M Hicks. Inhibition of TOR in Chlamydomonas reinhardtii Leads to Rapid Cysteine Oxidation Reflecting Sustained Physiological Changes. Cells. 2019 09; 8(10):. doi: 10.3390/cells8101171. [PMID: 31569396]
  • Eric C Kauffman, Martin Lang, Soroush Rais-Bahrami, Gopal N Gupta, Darmood Wei, Youfeng Yang, Carole Sourbier, Ramaprasad Srinivasan. Preclinical efficacy of dual mTORC1/2 inhibitor AZD8055 in renal cell carcinoma harboring a TFE3 gene fusion. BMC cancer. 2019 Sep; 19(1):917. doi: 10.1186/s12885-019-6096-0. [PMID: 31519159]
  • Adam Barrada, Meriem Djendli, Thierry Desnos, Raphael Mercier, Christophe Robaglia, Marie-Hélène Montané, Benoît Menand. A TOR-YAK1 signaling axis controls cell cycle, meristem activity and plant growth in Arabidopsis. Development (Cambridge, England). 2019 02; 146(3):. doi: 10.1242/dev.171298. [PMID: 30705074]
  • Mohamed A Salem, Patrick Giavalisco. Mutation in the Arabidopsis regulatory-associated protein TOR 1B (RAPTOR1B) leads to decreased jasmonates levels in leaf tissue. Plant signaling & behavior. 2019; 14(10):e1649567. doi: 10.1080/15592324.2019.1649567. [PMID: 31382813]
  • Zhixin Guo, Keyu Zhao, Xue Feng, Dandan Yan, Ruiyuan Yao, Yuhao Chen, Lili Bao, Zhigang Wang. mTORC2 Regulates Lipogenic Gene Expression through PPARγ to Control Lipid Synthesis in Bovine Mammary Epithelial Cells. BioMed research international. 2019; 2019(?):5196028. doi: 10.1155/2019/5196028. [PMID: 31223619]
  • Emily G Werth, Evan W McConnell, Inmaculada Couso Lianez, Zoee Perrine, Jose L Crespo, James G Umen, Leslie M Hicks. Investigating the effect of target of rapamycin kinase inhibition on the Chlamydomonas reinhardtii phosphoproteome: from known homologs to new targets. The New phytologist. 2019 01; 221(1):247-260. doi: 10.1111/nph.15339. [PMID: 30040123]
  • Jun-Ichi Inaba, Peter D Nagy. Tombusvirus RNA replication depends on the TOR pathway in yeast and plants. Virology. 2018 06; 519(?):207-222. doi: 10.1016/j.virol.2018.04.010. [PMID: 29734044]
  • Md Mamunur Rashid, Hyun-A Oh, Hyunbeom Lee, Byung Hwa Jung. Metabolite identification of AZD8055 in Sprague-Dawley rats after a single oral administration using ultra-performance liquid chromatography and mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2017 Oct; 145(?):473-481. doi: 10.1016/j.jpba.2017.06.059. [PMID: 28743078]
  • Adriana Santos Soprano, Priscila Oliveira de Giuseppe, Hugo Massayoshi Shimo, Tatiani Brenelli Lima, Fernanda Aparecida Heleno Batista, Germanna Lima Righetto, José Geraldo de Carvalho Pereira, Daniela Campos Granato, Andrey Fabricio Ziem Nascimento, Fabio Cesar Gozzo, Paulo Sérgio Lopes de Oliveira, Ana Carolina Migliorini Figueira, Juliana Helena Costa Smetana, Adriana Franco Paes Leme, Mario Tyago Murakami, Celso Eduardo Benedetti. Crystal Structure and Regulation of the Citrus Pol III Repressor MAF1 by Auxin and Phosphorylation. Structure (London, England : 1993). 2017 09; 25(9):1360-1370.e4. doi: 10.1016/j.str.2017.07.004. [PMID: 28781084]
  • Yun Song, Ge Zhao, Xueyan Zhang, Linxuan Li, Fangjie Xiong, Fengping Zhuo, Chaojun Zhang, Zuoren Yang, Raju Datla, Maozhi Ren, Fuguang Li. The crosstalk between Target of Rapamycin (TOR) and Jasmonic Acid (JA) signaling existing in Arabidopsis and cotton. Scientific reports. 2017 04; 7(?):45830. doi: 10.1038/srep45830. [PMID: 28374843]
  • Anna E Martin, Douglas A Schober, Alexander Nikolayev, Vladimir V Tolstikov, Wesley H Anderson, Richard E Higgs, Ming-Shang Kuo, Anastasia Laksmanan, John T Catlow, Xia Li, Christian C Felder, Jeffrey M Witkin. Further Evaluation of Mechanisms Associated with the Antidepressantlike Signature of Scopolamine in Mice. CNS & neurological disorders drug targets. 2017; 16(4):492-500. doi: 10.2174/1871527316666170309142646. [PMID: 28294051]
  • Hui Wang, Yujian Zhang, Yongning Lu, Jiajia Song, Min Huang, Jin Zhang, Yiran Huang. The role of stearoyl-coenzyme A desaturase 1 in clear cell renal cell carcinoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 2016 Jan; 37(1):479-89. doi: 10.1007/s13277-015-3451-x. [PMID: 26224474]
  • Sousuke Imamura, Yasuko Kawase, Ikki Kobayashi, Mie Shimojima, Hiroyuki Ohta, Kan Tanaka. TOR (target of rapamycin) is a key regulator of triacylglycerol accumulation in microalgae. Plant signaling & behavior. 2016; 11(3):e1149285. doi: 10.1080/15592324.2016.1149285. [PMID: 26855321]
  • Yanmei Zhang, Feng Li, Mingxia Li, Jingwu Kang. Screening of mammalian target of rapamycin inhibitors in natural product extracts by capillary electrophoresis in combination with high performance liquid chromatography-tandem mass spectrometry. Journal of chromatography. A. 2015 Apr; 1388(?):267-73. doi: 10.1016/j.chroma.2015.02.033. [PMID: 25725958]
  • Marie-Hélène Montané, Benoît Menand. ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change. Journal of experimental botany. 2013 Nov; 64(14):4361-74. doi: 10.1093/jxb/ert242. [PMID: 23963679]
  • Maria Serova, Armand de Gramont, Annemilaï Tijeras-Raballand, Célia Dos Santos, Maria Eugenia Riveiro, Khemaies Slimane, Sandrine Faivre, Eric Raymond. Benchmarking effects of mTOR, PI3K, and dual PI3K/mTOR inhibitors in hepatocellular and renal cell carcinoma models developing resistance to sunitinib and sorafenib. Cancer chemotherapy and pharmacology. 2013 May; 71(5):1297-307. doi: 10.1007/s00280-013-2129-6. [PMID: 23479136]
  • Paul A Dickinson, Ragheb Abu Rmaileh, Lee Ashworth, Richard A Barker, Wendy M Burke, Claire M Patterson, Nick Stainforth, Mohammed Yasin. An investigation into the utility of a multi-compartmental, dynamic, system of the upper gastrointestinal tract to support formulation development and establish bioequivalence of poorly soluble drugs. The AAPS journal. 2012 Jun; 14(2):196-205. doi: 10.1208/s12248-012-9333-x. [PMID: 22374384]
  • Qingsong Liu, Jinhua Wang, Seong A Kang, Carson C Thoreen, Wooyoung Hur, Tausif Ahmed, David M Sabatini, Nathanael S Gray. Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer. Journal of medicinal chemistry. 2011 Mar; 54(5):1473-80. doi: 10.1021/jm101520v. [PMID: 21322566]
  • Christine M Chresta, Barry R Davies, Ian Hickson, Tom Harding, Sabina Cosulich, Susan E Critchlow, John P Vincent, Rebecca Ellston, Darren Jones, Patrizia Sini, Dominic James, Zoe Howard, Phillippa Dudley, Gareth Hughes, Lisa Smith, Sharon Maguire, Marc Hummersone, Karine Malagu, Keith Menear, Richard Jenkins, Matt Jacobsen, Graeme C M Smith, Sylvie Guichard, Martin Pass. AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity. Cancer research. 2010 Jan; 70(1):288-98. doi: 10.1158/0008-5472.can-09-1751. [PMID: 20028854]