Nomifensine (BioDeep_00000682566)

   


代谢物信息卡片


Nomifensine maleate

化学式: C20H22N2O4 (354.1579492)
中文名称: 诺米芬新马来酸盐
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN1CC(C2=C(C1)C(=CC=C2)N)C3=CC=CC=C3.C(=CC(=O)O)C(=O)O
InChI: 2-1-

描述信息

D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D018765 - Dopamine Uptake Inhibitors
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents
D049990 - Membrane Transport Modulators
Nomifensine maleate is a selective inhibitor of dopamine uptake, used in adult attention deficit disorder.

同义名列表

4 个代谢物同义名

Nomifensine maleate; Nomifensine; (±)-Nomifensine maleat; Nomifensine (maleate)



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mary K Estes, Jasric J Bland, Kenya K Ector, Melissa J Puppa, Douglas W Powell, Deranda B Lester. A high fat western diet attenuates phasic dopamine release. Neuroscience letters. 2021 06; 756(?):135952. doi: 10.1016/j.neulet.2021.135952. [PMID: 33979702]
  • Juliann D Jaumotte, Mart Saarma, Michael J Zigmond. Protection of dopamine neurons by CDNF and neurturin variant N4 against MPP+ in dissociated cultures from rat mesencephalon. PloS one. 2021; 16(2):e0245663. doi: 10.1371/journal.pone.0245663. [PMID: 33534843]
  • Alexander F Hoffman, Charles E Spivak, Carl R Lupica. Enhanced Dopamine Release by Dopamine Transport Inhibitors Described by a Restricted Diffusion Model and Fast-Scan Cyclic Voltammetry. ACS chemical neuroscience. 2016 06; 7(6):700-9. doi: 10.1021/acschemneuro.5b00277. [PMID: 27018734]
  • Marguerite Matthews, Corina Bondi, Gonzalo Torres, Bita Moghaddam. Reduced presynaptic dopamine activity in adolescent dorsal striatum. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2013 Jun; 38(7):1344-51. doi: 10.1038/npp.2013.32. [PMID: 23358239]
  • L R F Faro, I M Oliveira, R Durán, M Alfonso. In vivo neurochemical characterization of clothianidin induced striatal dopamine release. Toxicology. 2012 Dec; 302(2-3):197-202. doi: 10.1016/j.tox.2012.07.017. [PMID: 22967792]
  • Lucía Asensi-Bernardi, Yolanda Martín-Biosca, Salvador Sagrado, María J Medina-Hernández. Electrokinetic chromatographic estimation of the enantioselective binding of nomifensine to human serum albumin and total plasma proteins. Biomedical chromatography : BMC. 2012 Nov; 26(11):1357-63. doi: 10.1002/bmc.2704. [PMID: 22275209]
  • Luke S Poth, Bryan P O'Connell, Janet L McDermott, Dean E Dluzen. Nomifensine alters sex differences in striatal dopaminergic function. Synapse (New York, N.Y.). 2012 Aug; 66(8):686-93. doi: 10.1002/syn.21554. [PMID: 22389194]
  • I Mitch Taylor, Andrea Jaquins-Gerstl, Susan R Sesack, Adrian C Michael. Domain-dependent effects of DAT inhibition in the rat dorsal striatum. Journal of neurochemistry. 2012 Jul; 122(2):283-94. doi: 10.1111/j.1471-4159.2012.07774.x. [PMID: 22548305]
  • Mark J Ferris, Erin S Calipari, Yolanda Mateo, James R Melchior, David C S Roberts, Sara R Jones. Cocaine self-administration produces pharmacodynamic tolerance: differential effects on the potency of dopamine transporter blockers, releasers, and methylphenidate. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2012 Jun; 37(7):1708-16. doi: 10.1038/npp.2012.17. [PMID: 22395730]
  • Anders Borgkvist, Torun Malmlöf, Kristin Feltmann, Maria Lindskog, Björn Schilström. Dopamine in the hippocampus is cleared by the norepinephrine transporter. The international journal of neuropsychopharmacology. 2012 May; 15(4):531-40. doi: 10.1017/s1461145711000812. [PMID: 21669025]
  • Sevgi Tatar Ulu. Spectrofluorimetric determination of nomifensine in human plasma and urine by derivatization with fluorescamine. Luminescence : the journal of biological and chemical luminescence. 2012 Jan; 27(1):80-3. doi: 10.1002/bio.1329. [PMID: 21681914]
  • Melissa A Stouffer, Solav Ali, Maarten E A Reith, Jyoti C Patel, Federica Sarti, Kenneth D Carr, Margaret E Rice. SKF-83566, a D1-dopamine receptor antagonist, inhibits the dopamine transporter. Journal of neurochemistry. 2011 Sep; 118(5):714-20. doi: 10.1111/j.1471-4159.2011.07357.x. [PMID: 21689106]
  • Jeff Hewett, Peter Johanson, Nutan Sharma, David Standaert, Aygul Balcioglu. Function of dopamine transporter is compromised in DYT1 transgenic animal model in vivo. Journal of neurochemistry. 2010 Apr; 113(1):228-35. doi: 10.1111/j.1471-4159.2010.06590.x. [PMID: 20132487]
  • Jian Yu, Donald E Mathisen, Doug Burdette, Dean G Brown, Christopher Becker, David Aharony. Identification of multiple glutathione conjugates of 8-amino- 2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline maleate (nomifensine) in liver microsomes and hepatocyte preparations: evidence of the bioactivation of nomifensine. Drug metabolism and disposition: the biological fate of chemicals. 2010 Jan; 38(1):46-60. doi: 10.1124/dmd.109.028803. [PMID: 19812352]
  • John A Gruner, Val R Marcy, Yin-Guo Lin, Donna Bozyczko-Coyne, Michael J Marino, Maciej Gasior. The roles of dopamine transport inhibition and dopamine release facilitation in wake enhancement and rebound hypersomnolence induced by dopaminergic agents. Sleep. 2009 Nov; 32(11):1425-38. doi: 10.1093/sleep/32.11.1425. [PMID: 19928382]
  • M B Santana, K J A Rodrigues, R Durán, M Alfonso, L Vidal, F Campos, I M De Oliveira, L R F Faro. Evaluation of the effects and mechanisms of action of flutriafol, a triazole fungicide, on striatal dopamine release by using in vivo microdialysis in freely moving rats. Ecotoxicology and environmental safety. 2009 Jul; 72(5):1565-71. doi: 10.1016/j.ecoenv.2009.01.004. [PMID: 19232726]
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  • Dieter Scheller, Nick Dürmüller, Paul Moser, Roger D Porsolt. Continuous stimulation of dopaminergic receptors by rotigotine does not interfere with the sleep-wake cycle in the rat. European journal of pharmacology. 2008 Apr; 584(1):111-7. doi: 10.1016/j.ejphar.2008.01.038. [PMID: 18304531]
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  • Jing Jiang, Lina Geng, Feng Qu, Aiqin Luo, Hong Li, Yulin Deng. Application of protein-liposome conjugate as a pseudo-stationary phase in capillary electrophoresis. Journal of chromatographic science. 2007 Oct; 45(9):587-92. doi: 10.1093/chromsci/45.9.587. [PMID: 17988446]
  • Paulo H C Diniz, Janice H Silva, Marcus V Gomez, Cristina Guatimosim, Renato S Gomez. Halothane increases non-vesicular [(3)H]dopamine release from brain cortical slices. Cellular and molecular neurobiology. 2007 Sep; 27(6):757-70. doi: 10.1007/s10571-007-9162-0. [PMID: 17680357]
  • F Campos, R Durán, L Vidal, L R F Faro, M Alfonso. In vivo neurochemical characterization of anatoxin-a evoked dopamine release from striatum. Journal of neural transmission (Vienna, Austria : 1996). 2007 Feb; 114(2):173-84. doi: 10.1007/s00702-006-0542-2. [PMID: 16897603]
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  • Tatyana D Sotnikova, Jean-Martin Beaulieu, Larry S Barak, William C Wetsel, Marc G Caron, Raul R Gainetdinov. Dopamine-independent locomotor actions of amphetamines in a novel acute mouse model of Parkinson disease. PLoS biology. 2005 Aug; 3(8):e271. doi: 10.1371/journal.pbio.0030271. [PMID: 16050778]
  • Cyrille Orset, Sandrine Parrot, Valérie Sauvinet, Jean-Marie Cottet-Emard, Anne Bérod, Jean-Marc Pequignot, Luc Denoroy. Dopamine transporters are involved in the onset of hypoxia-induced dopamine efflux in striatum as revealed by in vivo microdialysis. Neurochemistry international. 2005 Jun; 46(8):623-33. doi: 10.1016/j.neuint.2005.02.005. [PMID: 15863240]
  • Irmgard Paris, Pedro Martinez-Alvarado, Carolina Perez-Pastene, Marcelo N N Vieira, Claudio Olea-Azar, Rita Raisman-Vozari, Sergio Cardenas, Rebeca Graumann, Pablo Caviedes, Juan Segura-Aguilar. Monoamine transporter inhibitors and norepinephrine reduce dopamine-dependent iron toxicity in cells derived from the substantia nigra. Journal of neurochemistry. 2005 Mar; 92(5):1021-32. doi: 10.1111/j.1471-4159.2004.02931.x. [PMID: 15715653]
  • Michael Neal, Joanna Cunningham, Isobel Lever, Sophie Pezet, Marzia Malcangio. Mechanism by which brain-derived neurotrophic factor increases dopamine release from the rabbit retina. Investigative ophthalmology & visual science. 2003 Feb; 44(2):791-8. doi: 10.1167/iovs.02-0557. [PMID: 12556415]
  • P A Garris, E A Budygin, P E M Phillips, B J Venton, D L Robinson, B P Bergstrom, G V Rebec, R M Wightman. A role for presynaptic mechanisms in the actions of nomifensine and haloperidol. Neuroscience. 2003; 118(3):819-29. doi: 10.1016/s0306-4522(03)00005-8. [PMID: 12710989]
  • Dong-Yih Kuo, Juei-Tang Cheng. Role of cerebral dopamine but not plasma insulin, leptin and glucocorticoid in the development of tolerance to the anorectic effect of amphetamine. Neuroscience research. 2002 Sep; 44(1):63-9. doi: 10.1016/s0168-0102(02)00086-x. [PMID: 12204294]
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