Fazarabine (BioDeep_00000682537)
代谢物信息卡片
化学式: C8H12N4O5 (244.0808)
中文名称: 法扎拉滨
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=NC(=NC(=O)N1C2C(C(C(O2)CO)O)O)N
InChI: InChI=1S/C8H12N4O5/c9-7-10-2-12(8(16)11-7)6-5(15)4(14)3(1-13)17-6/h2-6,13-15H,1H2,(H2,9,11,16)/t3-,4-,5+,6-/m1/s1
描述信息
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C272 - Antimetabolite
D000970 - Antineoplastic Agents
同义名列表
2 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- R M Goldberg, J M Reid, M M Ames, J A Sloan, J Rubin, C Erlichman, M J Kuffel, T R Fitch. Phase I and pharmacological trial of fazarabine (Ara-AC) with granulocyte colony-stimulating factor.
Clinical cancer research : an official journal of the American Association for Cancer Research.
1997 Dec; 3(12 Pt 1):2363-70. doi:
. [PMID: 9815635] - D H Ho, N Brown, J R Lin, W Covington, R A Newman, M Raber, R Amato, S Schmidt, I H Krakoff. Clinical pharmacology of 1-beta-D-arabinofuranosyl-5-azacytosine (fazarabine) following 72-hour infusion.
Drug metabolism and disposition: the biological fate of chemicals.
1991 May; 19(3):643-7. doi:
. [PMID: 1717216] - H Bailey, K D Tutsch, R Z Arzoomanian, M B Tombes, D Alberti, J Bruggink, G Wilding. Phase I clinical trial of fazarabine as a twenty-four-hour continuous infusion.
Cancer research.
1991 Feb; 51(4):1105-8. doi:
. [PMID: 1705165] - A Surbone, H Ford, J A Kelley, N Ben-Baruch, R V Thomas, R Fine, K H Cowan. Phase I and pharmacokinetic study of arabinofuranosyl-5-azacytosine (fazarabine, NSC 281272).
Cancer research.
1990 Feb; 50(4):1220-5. doi:
. [PMID: 1688736] - R L Heideman, A Gillespie, H Ford, G H Reaman, F M Balis, C Tan, J Sato, L J Ettinger, R J Packer, D G Poplack. Phase I trial and pharmacokinetic evaluation of fazarabine in children.
Cancer research.
1989 Sep; 49(18):5213-6. doi:
. [PMID: 2475244] - R L Heideman, F M Balis, C McCully, D G Poplack. Preclinical pharmacology of arabinosyl-5-azacytidine in nonhuman primates.
Cancer research.
1988 Aug; 48(15):4294-8. doi:
NULL. [PMID: 2455594] - D S Zaharko, J M Covey. Arabinosyl-5-azacytosine: plasma kinetics and therapeutic response (L1210) in vitro and in vivo in mice.
Investigational new drugs.
1985; 3(4):323-9. doi:
10.1007/bf00170753. [PMID: 2417983]
