Dexpramipexole (BioDeep_00000681427)
代谢物信息卡片
Dexpramipexole
化学式: C10H17N3S (211.1143122)
中文名称: (R)-普拉克索
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCNC1CCC2=C(C1)SC(=N2)N
InChI: InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)/t7-/m1/s1
描述信息
D002491 - Central Nervous System Agents > D018726 - Anti-Dyskinesia Agents > D000978 - Antiparkinson Agents
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018491 - Dopamine Agonists
C78272 - Agent Affecting Nervous System > C66884 - Dopamine Agonist
D020011 - Protective Agents > D000975 - Antioxidants
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- KEGGdrug: D09886
- PubChem: 59868
- DrugBank: DB15130
- ChEMBL: CHEMBL249420
- MeSH: Pramipexole
- CAS: 104632-28-2
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Zhengxin Wang, Saiyu Cheng. Effects of Pramipexole Combined with Nerve Growth Factor on Cognitive Impairment and Urinary AD7c-NTP Expression in Patients with Parkinson's Disease.
Computational and mathematical methods in medicine.
2022; 2022(?):3398732. doi:
10.1155/2022/3398732. [PMID: 35516456] - Yongqi Sun, Baohong Cui, Lin Ye, Yunxin Hu, Yujun Pan. Pramipexole Inhibits Neuronal Apoptosis in Rats with Parkinson's Disease.
Journal of healthcare engineering.
2022; 2022(?):7002630. doi:
10.1155/2022/7002630. [PMID: 35463692] - Mayank Singhal, César Serna, Virginia Merino, Yogeshvar N Kalia. Current profile controlled transdermal delivery of pramipexole from an iontophoretic patch system in vitro and in vivo.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2021 Sep; 166(?):175-181. doi:
10.1016/j.ejpb.2021.06.010. [PMID: 34175373] - Diego Luis-Ravelo, Felipe Fumagallo-Reading, Javier Castro-Hernandez, Pedro Barroso-Chinea, Domingo Afonso-Oramas, Alejandro Febles-Casquero, Ignacio Cruz-Muros, Josmar Salas-Hernandez, Virginia Mesa-Infante, Julia Rodriguez-Nuñez, Tomas Gonzalez-Hernandez. Prolonged dopamine D3 receptor stimulation promotes dopamine transporter ubiquitination and degradation through a PKC-dependent mechanism.
Pharmacological research.
2021 03; 165(?):105434. doi:
10.1016/j.phrs.2021.105434. [PMID: 33484816] - Concepció Marin, Mercè Bonastre, Mireya Fuentes, Joaquim Mullol. Lack of correlation between dyskinesia and pallidal serotonin transporter expression-induced by L-Dopa and Pramipexole in hemiparkinsonian rats.
Pharmacology, biochemistry, and behavior.
2020 10; 197(?):173012. doi:
10.1016/j.pbb.2020.173012. [PMID: 32750392] - Xiang You, Wanhong Wu, Jing Xu, Zheng Jiao, Meng Ke, Pinfang Huang, Cuihong Lin. Development of a Physiologically Based Pharmacokinetic Model for Prediction of Pramipexole Pharmacokinetics in Parkinson's Disease Patients With Renal Impairment.
Journal of clinical pharmacology.
2020 08; 60(8):999-1010. doi:
10.1002/jcph.1593. [PMID: 32090332] - Pedro Barroso-Chinea, Diego Luis-Ravelo, Felipe Fumagallo-Reading, Javier Castro-Hernandez, Josmar Salas-Hernandez, Julia Rodriguez-Nuñez, Alejandro Febles-Casquero, Ignacio Cruz-Muros, Domingo Afonso-Oramas, Pedro Abreu-Gonzalez, Rosario Moratalla, Mark J Millan, Tomas Gonzalez-Hernandez. DRD3 (dopamine receptor D3) but not DRD2 activates autophagy through MTORC1 inhibition preserving protein synthesis.
Autophagy.
2020 07; 16(7):1279-1295. doi:
10.1080/15548627.2019.1668606. [PMID: 31538542] - Jinzhong Huang, Wei Hong, Zhilong Yang, Jian Ding, Yi Ren. Efficacy of pramipexole combined with levodopa for Parkinson's disease treatment and their effects on QOL and serum TNF-α levels.
The Journal of international medical research.
2020 Jul; 48(7):300060520922449. doi:
10.1177/0300060520922449. [PMID: 32735501] - Tian-Tian Ma, Zhikai Yang, Sainan Zhu, Jing-Hong Zhao, Yi Li, Fu-Yun Sun, Nan Zhao, Zu-Ying Xiong, Zi-Bo Xiong, Jie Dong. Pramipexole in peritoneal dialysis patients with restless legs syndrome (RLS): a protocol for a multicentre double-blind randomised controlled trial.
BMJ open.
2020 02; 10(2):e033815. doi:
10.1136/bmjopen-2019-033815. [PMID: 32075834] - Claire Kennedy, Thomas Kane, Richard Costello, Peter Conlon. Images: Identification and Effect of Periodic Limb Movements in End-Stage Renal Disease.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine.
2019 11; 15(11):1711-1713. doi:
10.5664/jcsm.8060. [PMID: 31739871] - E Hertz, L Terenius, V Vukojević, P Svenningsson. GPR37 and GPR37L1 differently interact with dopamine 2 receptors in live cells.
Neuropharmacology.
2019 07; 152(?):51-57. doi:
10.1016/j.neuropharm.2018.11.009. [PMID: 30423289] - Manuela Contin, Giovanna Lopane, Susan Mohamed, Giovanna Calandra-Buonaura, Sabina Capellari, Patrizia De Massis, Stefania Nassetti, Alessandro Perrone, Roberto Riva, Luisa Sambati, Cesa Scaglione, Pietro Cortelli. Clinical pharmacokinetics of pramipexole, ropinirole and rotigotine in patients with Parkinson's disease.
Parkinsonism & related disorders.
2019 04; 61(?):111-117. doi:
10.1016/j.parkreldis.2018.11.007. [PMID: 30446407] - Marcin Woźnica, Piotr Luliński. Design of selective molecularly imprinted sorbent for the optimized solid-phase extraction of S-pramipexole from the model multicomponent sample of human urine.
Journal of separation science.
2019 Apr; 42(7):1412-1422. doi:
10.1002/jssc.201801101. [PMID: 30681270] - Haritz Jiménez-Urbieta, Belén Gago, Ana Quiroga-Varela, Tatiana Rodríguez-Chinchilla, Leyre Merino-Galán, Amaia Oregi, Arantzazu Belloso-Iguerategui, Manuel Delgado-Alvarado, Irene Navalpotro-Gómez, Concepció Marin, Pierre-Olivier Fernagut, María C Rodríguez-Oroz. Pramipexole-induced impulsivity in mildparkinsonian rats: a model of impulse control disorders in Parkinson's disease.
Neurobiology of aging.
2019 03; 75(?):126-135. doi:
10.1016/j.neurobiolaging.2018.11.021. [PMID: 30572183] - Dalia Mohamed, Maha A Hegazy, Mona S Elshahed, Safaa S Toubar, Marwa I Helmy. Novel contribution to the simultaneous monitoring of pramipexole dihydrochloride monohydrate and levodopa as co-administered drugs in human plasma utilizing UPLC-MS/MS.
European journal of mass spectrometry (Chichester, England).
2018 Oct; 24(5):397-407. doi:
10.1177/1469066718788800. [PMID: 30012017] - Seyed Karim Hassaninejad-Darzi, Farshad Shajie. Simultaneous determination of acetaminophen, pramipexole and carbamazepine by ZSM-5 nanozeolite and TiO2 nanoparticles modified carbon paste electrode.
Materials science & engineering. C, Materials for biological applications.
2018 Oct; 91(?):64-77. doi:
10.1016/j.msec.2018.05.022. [PMID: 30033298] - Natalia Pessoa Rocha, Frankcinéia Assis, Paula Luciana Scalzo, Érica Leandro Marciano Vieira, Izabela Guimarães Barbosa, Mariana Soares de Souza, Paulo Pereira Christo, Helton José Reis, Antonio Lucio Teixeira. Reduced Activated T Lymphocytes (CD4+CD25+) and Plasma Levels of Cytokines in Parkinson's Disease.
Molecular neurobiology.
2018 02; 55(2):1488-1497. doi:
10.1007/s12035-017-0404-y. [PMID: 28176275] - Adeline Cardon-Dunbar, Tom Robertson, Michael S Roberts, Geoffrey K Isbister. Pramipexole Overdose Associated with Visual Hallucinations, Agitation and Myoclonus.
Journal of medical toxicology : official journal of the American College of Medical Toxicology.
2017 Dec; 13(4):343-346. doi:
10.1007/s13181-017-0615-7. [PMID: 28547577] - Yuan-Yang Lai, Yu-Hsuan Cheng, Kung-Chiao Hsieh, Darian Nguyen, Keng-Tee Chew, Lalini Ramanathan, Jerome M Siegel. Motor hyperactivity of the iron-deficient rat - an animal model of restless legs syndrome.
Movement disorders : official journal of the Movement Disorder Society.
2017 Dec; 32(12):1687-1693. doi:
10.1002/mds.27133. [PMID: 28843017] - Matthias Rath, G Christoph Korenke, Juliane Najm, Georg F Hoffmann, Angela Hagendorff, Tim M Strom, Ute Felbor. Exome sequencing results in identification and treatment of brain dopamine-serotonin vesicular transport disease.
Journal of the neurological sciences.
2017 08; 379(?):296-297. doi:
10.1016/j.jns.2017.06.034. [PMID: 28716265] - Marco Michi, Massimo Breda, Justin Keane Belardi, Steven Dworetzky, Lara Solazzo. Development and validation of a highly sensitive gradient chiral separation of pramipexole in human plasma by LC-MS/MS.
Bioanalysis.
2017 May; 9(9):683-692. doi:
10.4155/bio-2016-0265. [PMID: 28520466] - Heibatollah Sadeghi, Mohammad Parishani, Mehdi Akbartabar Touri, Mehdi Ghavamzadeh, Mehrzad Jafari Barmak, Vahid Zarezade, Hamdollah Delaviz, Hossein Sadeghi. Pramipexole reduces inflammation in the experimental animal models of inflammation.
Immunopharmacology and immunotoxicology.
2017 Apr; 39(2):80-86. doi:
10.1080/08923973.2017.1284230. [PMID: 28162057] - ÉIlis J O'Reilly, Dawei Liu, Donald R Johns, Merit E Cudkowicz, Sabrina Paganoni, Michael A Schwarzschild, Melanie Leitner, Alberto Ascherio. Serum urate at trial entry and ALS progression in EMPOWER.
Amyotrophic lateral sclerosis & frontotemporal degeneration.
2017 02; 18(1-2):120-125. doi:
10.1080/21678421.2016.1214733. [PMID: 27677562] - Zeyad T Sahli, Jae Jo, Shaker A Mousa, Frank I Tarazi. Clinical management of restless legs syndrome in end-stage renal disease patients.
CNS spectrums.
2017 Feb; 22(1):14-21. doi:
10.1017/s109285291600064x. [PMID: 27702420] - Armin Fashi, Fatemeh Khanban, Mohammad Reza Yaftian, Abbasali Zamani. The cooperative effect of reduced graphene oxide and Triton X-114 on the electromembrane microextraction efficiency of Pramipexole as a model analyte in urine samples.
Talanta.
2017 Jan; 162(?):210-217. doi:
10.1016/j.talanta.2016.09.067. [PMID: 27837820] - P N McCormick, P J Fletcher, V S Wilson, G J Remington. The adrenergic α2 antagonist atipamezole alters the behavioural effects of pramipexole and increases pramipexole concentration in blood plasma.
Life sciences.
2016 Apr; 151(?):300-304. doi:
10.1016/j.lfs.2016.03.017. [PMID: 26976325] - Susan Mohamed, Roberto Riva, Manuela Contin. Validated UHPLC-MS/MS method for the simultaneous determination of pramipexole and ropinirole in plasma of patients with Parkinson's disease.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Apr; 1017-1018(?):114-119. doi:
10.1016/j.jchromb.2016.02.041. [PMID: 26970845] - K Berghauzen-Maciejewska, J Wardas, B Kosmowska, H Domin, M Śmiałowska, U Głowacka, K Ossowska. Adaptive down-regulation of the serotonin transporter in the 6-hydroxydopamine-induced rat model of preclinical stages of Parkinson's disease and after chronic pramipexole treatment.
Neuroscience.
2016 Feb; 314(?):22-34. doi:
10.1016/j.neuroscience.2015.11.049. [PMID: 26628402] - HongNa Yang, Jing Wang, Feng Wang, XiaoDun Liu, Heng Chen, WeiMing Duan, TingYu Qu. Dopaminergic Neuronal Differentiation from the Forebrain-Derived Human Neural Stem Cells Induced in Cultures by Using a Combination of BMP-7 and Pramipexole with Growth Factors.
Frontiers in neural circuits.
2016; 10(?):29. doi:
10.3389/fncir.2016.00029. [PMID: 27147976] - James Bennett, Jeffrey Burns, Paul Welch, Rebecca Bothwell. Safety and Tolerability of R(+) Pramipexole in Mild-to-Moderate Alzheimer's Disease.
Journal of Alzheimer's disease : JAD.
2016; 49(4):1179-87. doi:
10.3233/jad-150788. [PMID: 26682692] - Angela Deutschländer, Christian la Fougère, Kai Boetzel, Nathalie L Albert, Franz-Josef Gildehaus, Peter Bartenstein, Guoming Xiong, Paul Cumming. Occupancy of pramipexole (Sifrol) at cerebral dopamine D2/3 receptors in Parkinson's disease patients.
NeuroImage. Clinical.
2016; 12(?):41-6. doi:
10.1016/j.nicl.2016.06.007. [PMID: 27408789] - Jana Knop, Eva Hoier, Thomas Ebner, Martin F Fromm, Fabian Müller. Renal tubular secretion of pramipexole.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2015 Nov; 79(?):73-8. doi:
10.1016/j.ejps.2015.09.004. [PMID: 26360835] - R Garrett Morgan, Jeffrey T Gibbs, Erica J Melief, Nadia O Postupna, Emily E Sherfield, Angela Wilson, C Dirk Keene, Thomas J Montine, Richard D Palmiter, Martin Darvas. Relative contributions of severe dopaminergic neuron ablation and dopamine depletion to cognitive impairment.
Experimental neurology.
2015 Sep; 271(?):205-14. doi:
10.1016/j.expneurol.2015.06.013. [PMID: 26079646] - Weilin Guo, Gao Li, Yanxia Yang, Conglian Yang, Luqin Si, Jiangeng Huang. LC-MS/MS analysis of pramipexole in mouse plasma and tissues: elimination of lipid matrix effects using weak cation exchange mode based solid-phase extraction.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2015 Apr; 988(?):157-65. doi:
10.1016/j.jchromb.2015.02.032. [PMID: 25777479] - Javier Castro-Hernández, Domingo Afonso-Oramas, Ignacio Cruz-Muros, Josmar Salas-Hernández, Pedro Barroso-Chinea, Rosario Moratalla, Mark J Millan, Tomás González-Hernández. Prolonged treatment with pramipexole promotes physical interaction of striatal dopamine D3 autoreceptors with dopamine transporters to reduce dopamine uptake.
Neurobiology of disease.
2015 Feb; 74(?):325-35. doi:
10.1016/j.nbd.2014.12.007. [PMID: 25511804] - Soutarou Taguchi, Jun-ichi Niwa, Tohru Ibi, Manabu Doyu. [Dyskinesia-hyperpyrexia syndrome in a patient with Parkinson's disease: a case report].
Rinsho shinkeigaku = Clinical neurology.
2015; 55(3):182-4. doi:
10.5692/clinicalneurol.55.182. [PMID: 25786757] - Ping He, Doug Kerr, Thomas Marbury, Daniel Ries, Wildon Farwell, Scott Stecher, Yingwen Dong, Dong Wei, Mark Rogge. Pharmacokinetics of renally excreted drug dexpramipexole in subjects with impaired renal function.
Journal of clinical pharmacology.
2014 Dec; 54(12):1383-90. doi:
10.1002/jcph.353. [PMID: 24965504] - Dong Wei, Chichih Wu, Ping He, Doug Kerr, Scott Stecher, Liyu Yang. Chiral liquid chromatography-tandem mass spectrometry assay to determine that dexpramipexole is not converted to pramipexole in vivo after administered in humans.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2014 Nov; 971(?):133-40. doi:
10.1016/j.jchromb.2014.09.029. [PMID: 25289790] - Dhaval R Kalaria, Pratikkumar Patel, Virginia Merino, Vandana B Patravale, Yogeshvar N Kalia. Controlled iontophoretic delivery of pramipexole: electrotransport kinetics in vitro and in vivo.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2014 Sep; 88(1):56-63. doi:
10.1016/j.ejpb.2014.02.002. [PMID: 24525072] - Ensieh Ghasemi, Salim Kheradmand, Orkideh Ghorban Dadrass. Solvent bar microextraction combined with high-performance liquid chromatography for preconcentration and determination of pramipexole in biological samples.
Biomedical chromatography : BMC.
2014 Apr; 28(4):486-91. doi:
10.1002/bmc.3058. [PMID: 24122839] - Rajesh Verma, Vivek Junewar, Bhanu Pratap Singh Rathaur. An atypical case of neuroleptic malignant syndrome precipitated by valproate.
BMJ case reports.
2014 Mar; 2014(?):. doi:
10.1136/bcr-2013-202578. [PMID: 24604797] - C S Lee, S D Lee, S-H Kang, H Y Park, I-Y Yoon. Comparison of the efficacies of oral iron and pramipexole for the treatment of restless legs syndrome patients with low serum ferritin.
European journal of neurology.
2014 Feb; 21(2):260-6. doi:
10.1111/ene.12286. [PMID: 24267148] - Candan Depboylu, Lukas Maurer, Andreas Matusch, Guido Hermanns, Andrea Windolph, Martin Béhé, Wolfgang H Oertel, Günter U Höglinger. Effect of long-term treatment with pramipexole or levodopa on presynaptic markers assessed by longitudinal [123I]FP-CIT SPECT and histochemistry.
NeuroImage.
2013 Oct; 79(?):191-200. doi:
10.1016/j.neuroimage.2013.04.076. [PMID: 23631981] - Debora Aricò, Alberto Raggi, Maddalena Siragusa, Marco Zucconi, Raffaele Ferri. Restless legs syndrome as the presenting symptom of multiple myeloma.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine.
2013 Apr; 9(4):383-5. doi:
10.5664/jcsm.2596. [PMID: 23585755] - Jennifer J Rilstone, Reem A Alkhater, Berge A Minassian. Brain dopamine-serotonin vesicular transport disease and its treatment.
The New England journal of medicine.
2013 Feb; 368(6):543-50. doi:
10.1056/nejmoa1207281. [PMID: 23363473] - Masayuki Ueda, Nobuhito Nakajima, Hiroshi Nagayama, Yasuhiro Nishiyama, Kenji Ishii, Yasuo Katayama. Therapeutic response to pramipexole in a patient with multiple system atrophy with predominant parkinsonism: positron emission tomography and pharmacokinetic assessments.
Internal medicine (Tokyo, Japan).
2013; 52(15):1731-5. doi:
10.2169/internalmedicine.52.9442. [PMID: 23903508] - Stefano de Biase, Giovanni Merlino, Simone Lorenzut, Mariarosaria Valente, Gian Luigi Gigli. ADMET considerations for restless leg syndrome drug treatments.
Expert opinion on drug metabolism & toxicology.
2012 Oct; 8(10):1247-61. doi:
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Clinical neuropharmacology.
2012 Jul; 35(4):174-81. doi:
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European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2012 Jun; 22(6):415-8. doi:
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Molecular genetics and metabolism.
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Neurobiology of disease.
2012 Mar; 45(3):1031-41. doi:
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Mutagenesis.
2012 Jan; 27(1):41-8. doi:
10.1093/mutage/ger054. [PMID: 21825114] - Eva-Maria Hametner, Klaus Seppi, Werner Poewe. Role and clinical utility of pramipexole extended release in the treatment of early Parkinson's disease.
Clinical interventions in aging.
2012; 7(?):83-8. doi:
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European journal of neurology.
2011 Nov; 18(11):1299-303. doi:
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Expert opinion on drug metabolism & toxicology.
2011 Oct; 7(10):1307-14. doi:
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Expert review of neurotherapeutics.
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Journal of clinical pharmacology.
2011 Aug; 51(8):1177-85. doi:
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Biomedical chromatography : BMC.
2011 Apr; 25(4):524-30. doi:
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Neuro endocrinology letters.
2011; 32(1):39-43. doi:
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Pharmacological reports : PR.
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Parkinson's disease.
2010 Dec; 2010(?):612619. doi:
10.4061/2010/612619. [PMID: 21209705] - Manish Yadav, Rajasekhar Rao, Hemal Kurani, Jaysukh Rathod, Rakesh Patel, Puran Singhal, Pranav S Shrivastav. Validated ultra-performance liquid chromatography tandem mass spectrometry method for the determination of pramipexole in human plasma.
Journal of chromatographic science.
2010 Nov; 48(10):811-8. doi:
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Toxicology.
2010 Oct; 276(3):164-71. doi:
10.1016/j.tox.2010.08.002. [PMID: 20705114] - Lei Diao, Yan Shu, James E Polli. Uptake of pramipexole by human organic cation transporters.
Molecular pharmaceutics.
2010 Aug; 7(4):1342-7. doi:
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