morphine sulfate pentahydrate (BioDeep_00000681375)
代谢物信息卡片
morphine sulfate pentahydrate
化学式: C34H50N2O15S (758.293175)
中文名称: 吗啡五水硫酸盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(C=C4)O.CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(C=C4)O.O.O.O.O.O.OS(=O)(=O)O
InChI: 1-5(2,3)4
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D009294 - Narcotics
D002492 - Central Nervous System Depressants > D009294 - Narcotics > D053610 - Opiate Alkaloids
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C67413 - Opioid Receptor Agonist
D002491 - Central Nervous System Agents > D000700 - Analgesics
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:50731
- KEGGdrug: D00842
- PubChem: 6321225
- ChEMBL: CHEMBL2103744
- MeSH: Morphine
- CAS: 6211-15-0
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Lu Liu, Jie Wu, Changlin Zhang, Tong Cao, Yongli Lu, Zhi He, Zicheng Li. Inhibition of endoplasmic reticulum stress attenuates morphine protracted abstinence-induced anxiety-like behaviors in the male mice.
Brain research.
2024 Jul; 1835(?):148930. doi:
10.1016/j.brainres.2024.148930. [PMID: 38604556] - Xiao-Lan Cheng, Yong-Lan Ruan, Jing-Ya Dai, Hai-Zhen Fan, Jin-Ying Ling, Jiao Chen, Wu-Guang Lu, Xue-Jiao Gao, Peng Cao. 8-shogaol derived from dietary ginger alleviated acute and inflammatory pain by targeting TRPV1.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jun; 128(?):155500. doi:
10.1016/j.phymed.2024.155500. [PMID: 38484627] - Shimei Li, Songjiang Tang, Lina Dai, Zhonglu Jian, Xi Li. Emodin relieves morphine-stimulated BV2 microglial activation and inflammation through the TLR4/NF-κB/NLRP3 pathway.
Neuroreport.
2024 May; 35(8):518-528. doi:
10.1097/wnr.0000000000002034. [PMID: 38597275] - Iman Khaldari, Mohammad Reza Naghavi, Elaheh Motamedi, Meisam Zargar. The effects of green and chemically-synthesized copper oxide nanoparticles on the production and gene expression of morphinan alkaloids in Oriental poppy.
Scientific reports.
2024 03; 14(1):6000. doi:
10.1038/s41598-024-56709-8. [PMID: 38472367] - Zonghui Li, Qigang Shu, Qiuping Chen, Hongwei Yang, Lu Liu, Zhi He, Hong Lin, Zicheng Li. HCN1 in the lateral habenula contributes to morphine abstinence-induced anxiety-like behaviors in male mice.
Journal of psychiatric research.
2024 Jan; 171(?):185-196. doi:
10.1016/j.jpsychires.2024.01.037. [PMID: 38301534] - Cheng Song, Dong Wang, Bin Chen. A systematic review and meta-analysis comparing the efficacy and safety of ketamine versus morphine for the treatment of acute pain.
Minerva anestesiologica.
2024 Jan; 90(1-2):77-86. doi:
10.23736/s0375-9393.23.17561-4. [PMID: 37930103] - Sara E Kern, Sarah E Voelker, Lisa M Lorenz, Rachel D Dicken, Megan E Sterling, Angie S Mohrhaus, Valerie M Toomey. Comparison of direct analysis in real-time mass spectrometry, atmospheric solids analysis probe-mass spectrometry, and ion mobility spectrometry for ensuring food safety by rapid screening of poppy seeds.
Analytical and bioanalytical chemistry.
2024 Jan; 416(3):827-837. doi:
10.1007/s00216-023-05042-6. [PMID: 37999721] - Zhengyi Lyu, Shuxin Tian, Guanai Bao, Rui Huang, Liyan Gong, Jie Zhou, Xiangming Kong, Weiping Zhang, Ran Ran, Na Nie, Yang Liu, Conghua Ji, Shan Liu, Xiaomei Shao, Guoyin Kai, Xianming Lin, Jianqiao Fang, Yi Liang. Transcutaneous electrical acupoint stimulation for cancer-related pain management in patients receiving chronic opioid therapy: a randomized clinical trial.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.
2023 Dec; 32(1):16. doi:
10.1007/s00520-023-08240-1. [PMID: 38085376] - Chan Li, Yingbo Lin, Rukun Lin, Zhijie Chen, Qichun Zhou, Chaohua Luo, Zhixian Mo. Host miR-129-5p reverses effects of ginsenoside Rg1 on morphine reward possibly mediated by changes in B. vulgatus and serotonin metabolism in hippocampus.
Gut microbes.
2023 12; 15(2):2254946. doi:
10.1080/19490976.2023.2254946. [PMID: 37698853] - Jiao Jiao, Jin Fan, Yonggang Zhang, Lingmin Chen. Efficacy and Safety of Ketamine to Treat Cancer Pain in Adult Patients: A Systematic Review.
Journal of pain and symptom management.
2023 Nov; ?(?):. doi:
10.1016/j.jpainsymman.2023.11.004. [PMID: 37972720] - Rahni Hossain, Abida Sultana, Manit Nuinoon, Kunwadee Noonong, Jitbanjong Tangpong, Kazi Helal Hossain, Md Atiar Rahman. A Critical Review of the Neuropharmacological Effects of Kratom: An Insight from the Functional Array of Identified Natural Compounds.
Molecules (Basel, Switzerland).
2023 Oct; 28(21):. doi:
10.3390/molecules28217372. [PMID: 37959790] - Shahrzad Molavinia, Mehrad Nikravesh, Marzieh Pashmforoosh, Hossein Rajabi Vardanjani, Mohammad Javad Khodayar. Zingerone Alleviates Morphine Tolerance and Dependence in Mice by Reducing Oxidative Stress-Mediated NLRP3 Inflammasome Activation.
Neurochemical research.
2023 Oct; ?(?):. doi:
10.1007/s11064-023-04043-2. [PMID: 37864024] - Han Shuai, Mao Hua, Jin Tingting, Yan Rubing, Wang Ziyi, Zhang Jie, Shi Jianwen, Liang Yongxin. Inhibitory effect of berberine on morphine tolerance and hyperalgesia in mice.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2023 10; 43(5):915-924. doi:
10.19852/j.cnki.jtcm.20230802.006. [PMID: 37679979] - Asser F Bedair, Ahmed Wahid, Nesrine S El-Mezayen, Amira F El-Yazbi, Hadeel A Khalil, Nayera W Hassan, Elham A Afify. Nicorandil/ morphine crosstalk accounts for antinociception and hepatoprotection in hepatic fibrosis in rats: Distinct roles of opioid/cGMP and NO/KATP pathways.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Jun; 165(?):115068. doi:
10.1016/j.biopha.2023.115068. [PMID: 37392650] - Winfried Häuser, Patrick Welsch, Lukas Radbruch, Emma Fisher, Rae Frances Bell, R Andrew Moore. Cannabis-based medicines and medical cannabis for adults with cancer pain.
The Cochrane database of systematic reviews.
2023 06; 6(?):CD014915. doi:
10.1002/14651858.cd014915.pub2. [PMID: 37283486] - Adriana Jesus Souza, Francisco S Guimarães, Felipe V Gomes. Cannabidiol attenuates the expression of conditioned place aversion induced by naloxone-precipitated morphine withdrawal through the activation of 5-HT1A receptors.
Behavioural brain research.
2023 May; 450(?):114504. doi:
10.1016/j.bbr.2023.114504. [PMID: 37209879] - Da Shao, Donglang Jiang, Qi Huang, Shuhua Ren, Junpeng Li, Jianfei Xiao, Yihui Guan, Bin Lai, Jun Zhao, Fang Xie, Fengchun Hua. Brain glucose metabolism and dopamine transporter changes in rats with morphine-induced conditioned place preference.
Addiction biology.
2023 May; 28(5):e13277. doi:
10.1111/adb.13277. [PMID: 37186440] - Hongming Ye, Tong Cao, Qigang Shu, Yue Chen, Yongli Lu, Zhi He, Zicheng Li. Blockade of orexin receptor 1 attenuates morphine protracted abstinence-induced anxiety-like behaviors in male mice.
Psychoneuroendocrinology.
2023 May; 151(?):106080. doi:
10.1016/j.psyneuen.2023.106080. [PMID: 36931057] - Joaquim Barbosa Leite Júnior, Luiz Gustavo Soares Carvalho Crespo, Richard Ian Samuels, Norberto Cysne Coimbra, Robert J Carey, Marinete Pinheiro Carrera. Morphine and dopamine: Low dose apomorphine can prevent both the induction and expression of morphine locomotor sensitization and conditioning.
Behavioural brain research.
2023 Apr; 448(?):114434. doi:
10.1016/j.bbr.2023.114434. [PMID: 37100351] - Laura Hautrive Milanesi, Domenika Rubert Rossato, Jéssica Leandra Oliveira Rosa, Lívia Ferraz D'avila, Vinícia Garzella Metz, Camila Reck Rampelotto, Viviane Gonçalves Pereira, Scheila Rezende Schaffazick, Cristiane de Bona da Silva, Marilise E Burger. Ferulic acid-loaded nanostructure prevents morphine reinstatement: the involvement of dopamine system, NRF2, and ΔFosB in the striatum brain area of rats.
Naunyn-Schmiedeberg's archives of pharmacology.
2023 Feb; ?(?):. doi:
10.1007/s00210-023-02420-w. [PMID: 36790483] - Qian Wang, Jing Dong, Xin Ye, Yi-Feng Ren. A Meta-Analysis Showing the Quantitative Evidence Base of Preemptive Pregabalin for Postoperative Pain from Cancer-Related Surgery.
Medicina (Kaunas, Lithuania).
2023 Jan; 59(2):. doi:
10.3390/medicina59020280. [PMID: 36837482] - Guan-Yu Zhuo, Ming-Chi Chen, Tzu-Yu Lin, Shih-Ting Lin, Daniel Tzu-Li Chen, Cynthia Wei-Sheng Lee. Opioid-Modulated Receptor Localization and Erk1/2 Phosphorylation in Cells Coexpressing μ-Opioid and Nociceptin Receptors.
International journal of molecular sciences.
2023 Jan; 24(2):. doi:
10.3390/ijms24021048. [PMID: 36674576] - Chen Zhao, Roderick MacKinnon. Structural and functional analyses of a GPCR-inhibited ion channel TRPM3.
Neuron.
2023 01; 111(1):81-91.e7. doi:
10.1016/j.neuron.2022.10.002. [PMID: 36283409] - Qisheng Wang, Fenfen Qin, Yuxuan Wang, Zijing Wang, Weixin Lin, Zhonghao Li, Qingyang Liu, Xinru Mu, Hui Wang, Shang Lu, Yongwei Jiang, Shengfeng Lu, Qian Wang, Zhigang Lu. Normalization of the H3K9me2/H3K14ac-ΔFosB pathway in the nucleus accumbens underlying the reversal of morphine-induced behavioural and synaptic plasticity by Compound 511.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2023 Jan; 108(?):154467. doi:
10.1016/j.phymed.2022.154467. [PMID: 36252464] - Xin Ye, Yi-Feng Ren, Yu-Cheng Hu, Shi-Yan Tan, Hua Jiang, Long-Fei Zhang, Wei Shi, Yu-Ting Wang. Dexamethasone Does Not Provide Additional Clinical Analgesia Effect to Local Wound Infiltration: A Comprehensive Systematic Review and Meta-Analysis.
Advances in wound care.
2023 01; 12(1):1-14. doi:
10.1089/wound.2021.0163. [PMID: 35081741] - Bingxu Ren, Jiannan Zhang, Xiaohu Yang, Dapeng Sun, Duanyang Sheng, Qiang Fang, Zhonghua Ji. Co-Administration of nalbuphine to improve morphine tolerance in mice with bone cancer pain.
Molecular pain.
2023 Jan; 19(?):17448069231178741. doi:
10.1177/17448069231178741. [PMID: 37226458] - Somayeh Shahidani, Zahra Jokar, Hojjatallah Alaei, Parham Reisi. Effects of treadmill exercise and chronic stress on anxiety-like behavior, neuronal activity, and oxidative stress in basolateral amygdala in morphine-treated rats.
Synapse (New York, N.Y.).
2023 01; 77(1):e22256. doi:
10.1002/syn.22256. [PMID: 36200789] - Zhonghao Li, Qinmei Sun, Qingyang Liu, Xinru Mu, Hui Wang, Han Zhang, Fenfen Qin, Qisheng Wang, Dengyun Nie, Anlong Liu, Qian Li, Jianjian Ji, Yongwei Jiang, Shengfeng Lu, Qian Wang, Zhigang Lu. Compound 511 ameliorates MRSA-induced lung injury by attenuating morphine-induced immunosuppression in mice via PI3K/AKT/mTOR pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2023 Jan; 108(?):154475. doi:
10.1016/j.phymed.2022.154475. [PMID: 36252465] - Rima Atria Japarin, Norsyifa Harun, Zurina Hassan, Mohammed Shoaib. Mitragynine, a primary constituent of kratom reinstates morphine-seeking behaviour in rats.
Behavioural pharmacology.
2022 Dec; ?(?):. doi:
10.1097/fbp.0000000000000715. [PMID: 36752325] - Xuecheng Zhang, Qi Wang, Yujiang Dong, Yuqi Jia, Zhihui Hou, Wenqi Deng, Menghe Zhang, Qiurun Mu, Hongling Jia. Acupuncture-assisted anaesthesia for catheter ablation of atrial fibrillation to reduce the consumption of morphine hydrochloride and postoperative nausea and vomiting (PONV): study protocol for a randomised controlled trial.
BMJ open.
2022 12; 12(12):e068318. doi:
10.1136/bmjopen-2022-068318. [PMID: 36521882] - Andrés Angel Calderon-Garcia, Maria Perez-Fernandez, Daniel Curto-Aguilera, Ivan Rodriguez-Martin, Mercedes Sánchez-Barba, Veronica Gonzalez-Nunez. Exposure to Morphine and Cocaine Modify the Transcriptomic Landscape in Zebrafish Embryos.
Neuroscience.
2022 12; 507(?):14-27. doi:
10.1016/j.neuroscience.2022.10.017. [PMID: 36404518] - Mirmohammadali Mirramezani Alizamini, Yonghui Li, Jian-Jun Zhang, Jing Liang, Abbas Haghparast. Endocannabinoids and addiction memory: Relevance to methamphetamine/morphine abuse.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.
2022 12; 23(10):743-763. doi:
10.1080/15622975.2022.2039408. [PMID: 35137652] - Natali Ozber, Samuel C Carr, Jeremy S Morris, Siyu Liang, Jacinta L Watkins, Kristian M Caldo, Jillian M Hagel, Kenneth K S Ng, Peter J Facchini. Alkaloid binding to opium poppy major latex proteins triggers structural modification and functional aggregation.
Nature communications.
2022 11; 13(1):6768. doi:
10.1038/s41467-022-34313-6. [PMID: 36351903] - Derya Cansız, Unsal Veli Ustundag, Ismail Unal, A Ata Alturfan, Ebru Emekli-Alturfan. Morphine attenuates neurotoxic effects of MPTP in zebrafish embryos by regulating oxidant/antioxidant balance and acetylcholinesterase activity.
Drug and chemical toxicology.
2022 Nov; 45(6):2439-2447. doi:
10.1080/01480545.2021.1957558. [PMID: 34340603] - Mohammad Ali Ahmadianmoghadam, Mohammad Hadi Nematollahi, Mitra Mehrabani, Iman Fatemi, Farzaneh Rostamzadeh, Mario Dell'Agli, Mehrnaz Mehrabani, Moslem Abolhassani, Mehrzad Mehrbani. Effect of an herbal formulation containing Peganum harmala L. and Fraxinus excelsior L. on oxidative stress, memory impairment and withdrawal syndrome induced by morphine.
The International journal of neuroscience.
2022 Oct; ?(?):1-14. doi:
10.1080/00207454.2022.2130293. [PMID: 36168934] - Jonathan Birabaharan, Raymond E West, Thomas D Nolin, Chani Traube, Michael J Bell, Philip E Empey. Simultaneous detection of a panel of nine sedatives and metabolites in plasma from critically ill pediatric patients via UPLC-MS/MS.
Journal of pharmaceutical and biomedical analysis.
2022 Sep; 218(?):114853. doi:
10.1016/j.jpba.2022.114853. [PMID: 35659658] - Yingfu Jiao, Fugui Li, Mo Chen, Zhijian He, Zhangxiang Huang, Weifeng Yu, Kangjie Xie. Pre-treatment with morphine prevents lipopolysaccharide-induced acute respiratory distress syndrome in rats via activation of opioid receptors.
Experimental cell research.
2022 09; 418(1):113224. doi:
10.1016/j.yexcr.2022.113224. [PMID: 35643178] - Briana D Hamamoto-Hardman, Eugene P Steffey, Kelsey Seminoff, Daniel S McKemie, Philip Kass, Heather K Knych. Preliminary study of the pharmacokinetics, tissue distribution, and behavioral and select physiological effects of morphine 6-glucuronide (M6G) following intravenous administration to horses.
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire.
2022 Jul; 86(3):172-180. doi:
. [PMID: 35794968] - Christina Abdel Shaheed, Justin Beardsley, Richard O Day, Andrew J McLachlan. Immunomodulatory effects of pharmaceutical opioids and antipyretic analgesics: Mechanisms and relevance to infection.
British journal of clinical pharmacology.
2022 07; 88(7):3114-3131. doi:
10.1111/bcp.15281. [PMID: 35229890] - Claudenise Caldas da Silva Dantas Viegas, Alexandre Sérgio Silva, Renan Marinho Braga, Humberto Hugo Nunes de Andrade, Aline Kely Felício de Sousa Santos, Maria Denise Leite Ferreira, Mateus Duarte Ribeiro, Luiz Henrique Agra Cavalcante Silva, Loiane Alves de Lima, Reinaldo Nobrega de Almeida, Maria de Fátima Vanderlei de Souza, Temilce Simões de Assis Cantalice. Antinociceptive, anti-inflammatory and antioxidant activities of the crude ethanolic extract and alkaloid fraction of Waltheria viscosissima A. St. - Hil. (Malvaceae).
Journal of ethnopharmacology.
2022 Jun; 292(?):115173. doi:
10.1016/j.jep.2022.115173. [PMID: 35314418] - Leila Mohammadzadeh, Amir Mohammad Alizadeh, Mohammad Sadegh Feiz, Shole Jamali, Mohaddeseh Abedi, Hamid Latifi, Abbas Haghparast. Acute morphine administration, morphine dependence, and naloxone-induced withdrawal syndrome affect the resting-state functional connectivity and Local Field Potentials of the rat prefrontal cortex.
Behavioural brain research.
2022 06; 427(?):113859. doi:
10.1016/j.bbr.2022.113859. [PMID: 35337941] - Ava A Brozovich, Stephen J Incavo, Bradley S Lambert, Thomas C Sullivan, Austin E Wininger, Terry A Clyburn, Francesca Taraballi, Kwan J Park. Intraosseous Morphine Decreases Postoperative Pain and Pain Medication Use in Total Knee Arthroplasty: A Double-Blind, Randomized Controlled Trial.
The Journal of arthroplasty.
2022 06; 37(6S):S139-S146. doi:
10.1016/j.arth.2021.10.009. [PMID: 35272897] - Xueqin Yan, Zheng Gong, Rui Pan, Huili Wang, Haijie Tang, Hanyang He, Saixian Wen, Yongmei Fu, Jun Dong. Synergistic Effect and Mechanism of Apoptosis Induction by Morphine and the HIV-1gp120V3 Loop in Hippocampal Neurons.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology.
2022 06; 17(1-2):165-180. doi:
10.1007/s11481-021-09989-0. [PMID: 33791922] - Zhijie Chen, Yingbo Lin, Qichun Zhou, Shilin Xiao, Chan Li, Rukun Lin, Jing Li, Yifei Chen, Chaohua Luo, Zhixian Mo. Ginsenoside Rg1 mitigates morphine dependence via regulation of gut microbiota, tryptophan metabolism, and serotonergic system function.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Jun; 150(?):112935. doi:
10.1016/j.biopha.2022.112935. [PMID: 35447543] - Chayanin Kiratipaiboon, Peththa Wadu Dasuni Wasana, Hasriadi, Suchada Sukrong, Nijsiri Ruangrungsri, Pasarapa Towiwat. Herbal root extracts in Ben-Cha-Moon-Yai remedy attenuated pain-like behaviors and inflammation through the opioid and prostaglandin systems.
Journal of ethnopharmacology.
2022 May; 290(?):115088. doi:
10.1016/j.jep.2022.115088. [PMID: 35149131] - Mohammad Mehdi Habibi, Jahan B Ghasemi, Alireza Badiei, Parviz Norouzi. Simultaneous electrochemical determination of morphine and methadone by using CMK-5 mesoporous carbon and multivariate calibration.
Scientific reports.
2022 05; 12(1):8270. doi:
10.1038/s41598-022-12506-9. [PMID: 35585173] - Raka Jain, Siddharth Sarkar, Nizamuddin Saifi, Shayani Ghosh. Urinalysis based assessment of compliance and drug use patterns in patients prescribed tramadol: A cross-sectional study from a tertiary care centre.
Asian journal of psychiatry.
2022 May; 71(?):103080. doi:
10.1016/j.ajp.2022.103080. [PMID: 35305452] - Gianluca Bini, Eli B Cohen, Ludovica Chiavaccini, Kristen M Messenger, Kate M Bailey. Intravenous dexmedetomidine, morphine, or a combination can result in gallbladder wall thickening; with no significant association with plasma histamine concentrations.
Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association.
2022 May; 63(3):319-327. doi:
10.1111/vru.13056. [PMID: 35006624] - Christa K Raak, Wolfram Scharbrodt, Bettina Berger, Arndt Büssing, Anna Schönenberg-Tu, David D Martin, Sibylle Robens, Thomas Ostermann. Hypericum perforatum to Improve Postoperative Pain Outcome After Monosegmental Spinal Sequestrectomy (HYPOS): Results of a Randomized, Double-Blind, Placebo-Controlled Trial.
Journal of integrative and complementary medicine.
2022 May; 28(5):407-417. doi:
10.1089/jicm.2021.0389. [PMID: 35171041] - Hadi Mahmoudi-Moghaddam, Mahnaz Amiri, Hamid Akbari Javar, Qahtan A Yousif, Masoud Salavati-Niasari. A facile green synthesis of a perovskite-type nanocomposite using Crataegus and walnut leaf for electrochemical determination of morphine.
Analytica chimica acta.
2022 Apr; 1203(?):339691. doi:
10.1016/j.aca.2022.339691. [PMID: 35361418] - Ainur Kagarmanova, Mark Donald Mwesiga, Matthew L Sisk, Cynthia Kabagambe, Sheba Nyakaisiki, Tom Marentette, Lacey N Ahern. Palliative care in Uganda: quantitative descriptive study of key palliative care indicators 2018-2020.
BMC palliative care.
2022 Apr; 21(1):55. doi:
10.1186/s12904-022-00930-7. [PMID: 35459171] - Vlad Radoi, Gerd Jakobsson, Vinko Palada, Andrej Nikosjkov, Henrik Druid, Lars Terenius, Eva Kosek, Vladana Vukojević. Non-Peptide Opioids Differ in Effects on Mu-Opioid (MOP) and Serotonin 1A (5-HT1A) Receptors Heterodimerization and Cellular Effectors (Ca2+, ERK1/2 and p38) Activation.
Molecules (Basel, Switzerland).
2022 Apr; 27(7):. doi:
10.3390/molecules27072350. [PMID: 35408749] - Songlin Li, Xiangshuai Zhang, Mingxing Liu, Qunshan Lu, Yang Yu, Zhuang Miao, Desu Luo, Kaifei Han, Lei Li, Wenwei Qian, Peilai Liu. Not using a tourniquet is superior to tourniquet use for high tibial osteotomy: a prospective, randomised controlled trial.
International orthopaedics.
2022 04; 46(4):823-829. doi:
10.1007/s00264-021-05246-4. [PMID: 34677629] - Manuel Á Gómez-Ríos, Pastora Codesido-Barreiro, Carmen Seco-Vilariño, Marta Calvín-Lamas, Federico Curt-Nuño, Laura Nieto-Serradilla, María T Rabuñal-Álvarez, Fernando Fernández-Rodríguez, Javier Peteiro-Cartelle, Ramón Pensado-Boo, Germán Bou, Alberto Pensado-Castiñeiras, Rubén Casans-Francés. Wound Infusion of 0.35\% Levobupivacaine Reduces Mechanical Secondary Hyperalgesia and Opioid Consumption After Cesarean Delivery: A Prospective, Randomized, Triple-Blind, Placebo-Controlled Trial.
Anesthesia and analgesia.
2022 04; 134(4):791-801. doi:
10.1213/ane.0000000000005917. [PMID: 35086112] - Manuel Suter, Bernardo Bollen Pinto, Alessandro Belletti, Alessandro Putzu. Efficacy and safety of perioperative vitamin C in patients undergoing noncardiac surgery: a systematic review and meta-analysis of randomised trials.
British journal of anaesthesia.
2022 Apr; 128(4):664-678. doi:
10.1016/j.bja.2021.11.039. [PMID: 35090721] - Jing Dong, Yi-Feng Ren, Meng-Ling Wei, Xin Ye, Xiao-Yun Peng, Long-Fei Zhang, Fang Li, Wei Shi. Re-evaluating the clinical efficacy of intrathecal nalbuphine: Based on minimal clinically important difference and statistical threshold correction.
Pain practice : the official journal of World Institute of Pain.
2022 04; 22(4):497-499. doi:
10.1111/papr.13104. [PMID: 35178877] - Nayere Askari, Ali Mousavi, Mohammad Reza Vaez-Mahdavi. Maternal deprivation effect on morphine-induced CPP is related to changes in opioid receptors in selected rat brain regions (hippocampus, prefrontal cortex, and nucleus accumbens).
Behavioural processes.
2022 Apr; 197(?):104607. doi:
10.1016/j.beproc.2022.104607. [PMID: 35218881] - Yusuke Mizobuchi, Kanako Miyano, Sei Manabe, Eiko Uezono, Akane Komatsu, Yui Kuroda, Miki Nonaka, Yoshikazu Matsuoka, Tetsufumi Sato, Yasuhito Uezono, Hiroshi Morimatsu. Ketamine Improves Desensitization of µ-Opioid Receptors Induced by Repeated Treatment with Fentanyl but Not with Morphine.
Biomolecules.
2022 03; 12(3):. doi:
10.3390/biom12030426. [PMID: 35327617] - Luiz Gustavo Soares Carvalho Crespo, Joaquim Barbosa Leite Júnior, João Marcos de Mello Bastos, Richard Ian Samuels, Norberto Cysne Coimbra, Robert J Carey, Marinete Pinheiro Carrera. Context evoked morphine conditioned effects can be equivalent to morphine induced drug effects in terms of behavioral response and ERK activation in reward associated subcortical brain structures.
Pharmacology, biochemistry, and behavior.
2022 03; 214(?):173356. doi:
10.1016/j.pbb.2022.173356. [PMID: 35181379] - Rasoul Moradi, Nazila Pour Khalili, Ni Luh Wulan Septiani, Chia-Hung Liu, Esmail Doustkhah, Yusuke Yamauchi, Slava V Rotkin. Nanoarchitectonics for Abused-Drug Biosensors.
Small (Weinheim an der Bergstrasse, Germany).
2022 03; 18(10):e2104847. doi:
10.1002/smll.202104847. [PMID: 34882957] - Riccardo Maccioni, Marcello Serra, Jacopo Marongiu, Filippo Cottiglia, Elias Maccioni, Valentina Bassareo, Micaela Morelli, Sanjay B Kasture, Elio Acquas. Effects of docosanyl ferulate, a constituent of Withania somnifera, on ethanol- and morphine-elicited conditioned place preference and ERK phosphorylation in the accumbens shell of CD1 mice.
Psychopharmacology.
2022 Mar; 239(3):795-806. doi:
10.1007/s00213-022-06069-w. [PMID: 35088095] - Kinomi Yomiya. [For the Clinical Use-Clinical Guidelines for Pharmacological Management of Cancer Pain 2020].
Gan to kagaku ryoho. Cancer & chemotherapy.
2022 Feb; 49(2):119-124. doi:
NULL. [PMID: 35249042] - Kim Juhani Blomqvist, Katarzyna Anna Dudek, Hanna Viisanen, Kert Mätlik, Fredrik Harry Gustav Ahlström, Jouko Laitila, Eija Anneli Kalso, Pekka Veli Rauhala, Tuomas Olavi Lilius. Antagonism of peripheral opioid receptors by methylnaltrexone does not prevent morphine tolerance in rats.
Journal of neuroscience research.
2022 01; 100(1):329-338. doi:
10.1002/jnr.24638. [PMID: 32459013] - Eva Mercado, Nancy Paniagua, Eva M Sánchez-Robles, Rocío Girón, Diego Alvarez de la Rosa, Teresa Giraldez, Carlos Goicoechea. SGK1.1 isoform is involved in nociceptive modulation, offering a protective effect against noxious cold stimulus in a sexually dimorphic manner.
Pharmacology, biochemistry, and behavior.
2022 01; 212(?):173302. doi:
10.1016/j.pbb.2021.173302. [PMID: 34838531] - S R Karna, P Chambers, P Singh, N Lopez-Villalobos, K Kongara. Evaluation of analgesic interaction between morphine, maropitant and dexmedetomidine in dogs undergoing ovariohysterectomy.
New Zealand veterinary journal.
2022 Jan; 70(1):10-21. doi:
10.1080/00480169.2021.1927231. [PMID: 33950785] - Yoshito Kumagai. Biotransformation of Morphinone and Its Glutathione Adduct Derived from Morphine by Anaerobic Gut Microbes in Guinea Pigs.
Biological & pharmaceutical bulletin.
2022; 45(7):968-971. doi:
10.1248/bpb.b22-00240. [PMID: 35786605] - Mozhdeh Taheri-Amlashi, Shahin Hassanpour, Bita Vazir. Effects of the prenatal exposure to crocin in the expression of withdrawal syndrome on reflexive motor behaviors in mice offspring's.
Neuroscience letters.
2022 01; 766(?):136352. doi:
10.1016/j.neulet.2021.136352. [PMID: 34788677] - Hiroki Yamaura, Hirotoshi Ishikawa, Kenichiro Otsuka, Noriaki Kasayuki. Reverse Takotsubo Cardiomyopathy as a Cause of Acute Chest Pain in a Young Woman Following COVID-19 Vaccination.
Circulation. Cardiovascular imaging.
2022 01; 15(1):e013661. doi:
10.1161/circimaging.121.013661. [PMID: 34961327] - Juan F Iglesias, Marco Valgimigli, Federico Carbone, Nathalie Lauriers, Pier-Giorgio Masci, Sophie Degrauwe. Comparative effects of fentanyl versus morphine on platelet inhibition induced by ticagrelor in patients with ST-segment elevation myocardial infarction: Full results of the PERSEUS randomized trial.
Cardiology journal.
2022; 29(4):591-600. doi:
10.5603/cj.a2022.0049. [PMID: 35762079] - Louben Dorval, Brian I Knapp, Olufolake A Majekodunmi, Sophia Eliseeva, Jean M Bidlack. Mice with high FGF21 serum levels had a reduced preference for morphine and an attenuated development of acute antinociceptive tolerance and physical dependence.
Neuropharmacology.
2022 01; 202(?):108858. doi:
10.1016/j.neuropharm.2021.108858. [PMID: 34715121] - Piotr Niezgoda, Malwina A Barańska, Joanna Sikora, Przemysław Sobczak, Katarzyna Buszko, Adam Sikora, Michał P Marszałł, Eliano P Navarese, Bernd Jilma, Jacek Kubica. Oral NAloxone to overcome the moRphine effect in acute COronary syndrome patients treated with TICagrelor - NARCOTIC trial.
Cardiology journal.
2022; 29(3):432-440. doi:
10.5603/cj.a2020.0040. [PMID: 32207836] - Nazanin Mozafari, Jalal Hassanshahi, Hamid Ostadebrahimi, Ali Shamsizadeh, Fatemeh Ayoobi, Elham Hakimizadeh, Mohammad Pak-Hashemi, Ayat Kaeidi. Neuroprotective effect of Achillea millefolium aqueous extract against oxidative stress and apoptosis induced by chronic morphine in rat hippocampal CA1 neurons.
Acta neurobiologiae experimentalis.
2022; 82(2):179-186. doi:
10.55782/ane-2022-016. [PMID: 35833817] - Thomas Duflot, Tony Pereira, Marie-Pierre Tavolacci, Robinson Joannidès, Frédéric Aubrun, Fabien Lamoureux, Virginie Eve Lvovschi. Pharmacokinetic modeling of morphine and its glucuronides: Comparison of nebulization versus intravenous route in healthy volunteers.
CPT: pharmacometrics & systems pharmacology.
2022 01; 11(1):82-93. doi:
10.1002/psp4.12735. [PMID: 34842366] - Emma Gordon, Levent Dirikolu, Chin-Chi Liu, Alexander V Ulanov, Zhong Li, Matt Welborn, Chance Armstrong, Danielle Vallotton, Sarah Keeton, Sarah Camlic, Clare M Scully. Pharmacokinetic profiles of three dose rates of morphine sulfate following single intravenous, intramuscular, and subcutaneous administration in the goat.
Journal of veterinary pharmacology and therapeutics.
2022 Jan; 45(1):107-116. doi:
10.1111/jvp.13011. [PMID: 34494277] - Grzegorz Kowalski, Bogumił Olczak, Wojciech Leppert, Agnieszka Bienert, Artur Teżyk, Danuta Szkutnik-Fiedler, Michał Adamski, Katarzyna Wieczorowska-Tobis. Analgesic Efficacy and Safety of Spinal Oxycodone in Total Hip Arthroplasty: A Preliminary Study.
Current medicinal chemistry.
2022; 29(21):3806-3814. doi:
10.2174/0929867329666220126125256. [PMID: 35081884] - Bo Fu, Jun-Qi Yao, Chang Lu, Bin Wang, Zeqi Li, Ming Huang, Tian Tian, Hui Peng, Shao-Jun Liu. Dorsal Raphe Nucleus Serotoninergic Neurons Mediate Morphine Rewarding Effect and Conditioned Place Preference.
Neuroscience.
2022 01; 480(?):108-116. doi:
10.1016/j.neuroscience.2021.10.031. [PMID: 34762982] - Nurul H M Yusoff, Zurina Hassan, Vikneswaran Murugaiyah, Christian P Müller. The effect of mitragynine on extracellular activity of brain dopamine and its metabolites.
Brain research bulletin.
2022 01; 178(?):1-8. doi:
10.1016/j.brainresbull.2021.11.002. [PMID: 34774992] - Heather Leduc-Pessah, Cynthia Xu, Churmy Y Fan, Rebecca Dalgarno, Yuta Kohro, Sydney Sparanese, Nikita N Burke, Kenneth A Jacobson, Christophe Altier, Daniela Salvemini, Tuan Trang. Spinal A3 adenosine receptor activation acutely restores morphine antinociception in opioid tolerant male rats.
Journal of neuroscience research.
2022 01; 100(1):251-264. doi:
10.1002/jnr.24869. [PMID: 34075613] - Cathy R Lammers, Amy J Schwinghammer, Brent Hall, Robert Scott Kriss, Debbie A Aizenberg, Jamie L Funamura, Craig W Senders, Vinay Nittur, Richard L Applegate. Comparison of Oral Loading Dose to Intravenous Acetaminophen in Children for Analgesia After Tonsillectomy and Adenoidectomy: A Randomized Clinical Trial.
Anesthesia and analgesia.
2021 12; 133(6):1568-1576. doi:
10.1213/ane.0000000000005678. [PMID: 34304234] - Taylor L Curley, Douglas H Thamm, Sam W Johnson, Pedro Boscan. Effects of morphine on histamine release from two cell lines of canine mast cell tumor and on plasma histamine concentrations in dogs with cutaneous mast cell tumor.
American journal of veterinary research.
2021 Nov; 82(12):1013-1018. doi:
10.2460/ajvr.20.08.0137. [PMID: 34714766] - Jamie Lewis, Karlee De Monnin, Jonathan Smith, Evan Lewis, Marian Wilson. Interpreting Urine Drug Test Results in the Context of Chronic Opioid Analgesic Therapy and Poppy Seed Consumption.
Pain medicine (Malden, Mass.).
2021 11; 22(11):2776-2778. doi:
10.1093/pm/pnab082. [PMID: 33710300] - Myoung Hwa Kim, Jeong-Rim Lee, Ki-Joon Kim, Ji Hae Jun, Hye Jeong Hwang, Wootaek Lee, Seung Hyun Nam, Ju Eun Oh, Young Chul Yoo. Identification for antitumor effects of tramadol in a xenograft mouse model using orthotopic breast cancer cells.
Scientific reports.
2021 11; 11(1):22113. doi:
10.1038/s41598-021-01701-9. [PMID: 34764420] - Gui-Ying Zan, Yu-Jun Wang, Xue-Ping Li, Jun-Fan Fang, Song-Yu Yao, Jun-Ying Du, Qian Wang, Xiang Sun, Rui Liu, Xiao-Mei Shao, Jian-Dong Long, Jing-Rui Chai, Ying-Zhi Deng, Ye-Qing Chen, Qing-Lin Li, Jian-Qiao Fang, Zhi-Qiang Liu, Jing-Gen Liu. Amygdalar κ-opioid receptor-dependent upregulating glutamate transporter 1 mediates depressive-like behaviors of opioid abstinence.
Cell reports.
2021 11; 37(5):109913. doi:
10.1016/j.celrep.2021.109913. [PMID: 34731618] - Juan Morgaz, David F Latorre, Juan M Serrano-Rodríguez, María M Granados, Juan M Domínguez, J Andrés Fernández-Sarmiento, Setefilla Quiros-Carmona, Rocío Navarrete-Calvo. Preperitoneal ropivacaine infusion versus epidural ropivacaine-morphine for postoperative analgesia in dogs undergoing ovariohysterectomy: a randomized clinical trial.
Veterinary anaesthesia and analgesia.
2021 Nov; 48(6):935-942. doi:
10.1016/j.vaa.2021.04.009. [PMID: 34561181] - Joachim Nagler, Sonja C Schriever, Artem Romanov, Daniela Vogt-Weisenhorn, Wolfgang Wurst, Paul T Pfluger, Karl-Werner Schramm. Determination of morphine and norlaudanosoline in murine brain regions by dispersive liquid-liquid micro-extraction and liquid chromatograpy-electrochemical detection.
Neurochemistry international.
2021 11; 150(?):105174. doi:
10.1016/j.neuint.2021.105174. [PMID: 34474098] - Ida Kuhlmann, Amanda Nøddebo Nyrup, Tore Bjerregaard Stage, Mette Marie Hougaard Christensen, Troels Korshøj Bergmann, Per Damkier, Flemming Nielsen, Kurt Højlund, Kim Brøsen. Oral and intravenous pharmacokinetics of metformin with and without oral codeine intake in healthy subjects: A cross-over study.
Clinical and translational science.
2021 11; 14(6):2408-2419. doi:
10.1111/cts.13107. [PMID: 34268884] - Iftikhar Ali, Muhammad Ali, Huma Shareef, Sadaf Naeem, Adeeba Khadim, Meher Ali, Faiza Amber, Hidayat Hussain, Muhammad Ismail, Syed Tasadaque A Shah, Ali Noor, Daijie Wang. Phytochemical analysis and biological activities of 'Cherchoomoro' (Nepeta adenophyta Hedge).
Journal of ethnopharmacology.
2021 Oct; 279(?):114402. doi:
10.1016/j.jep.2021.114402. [PMID: 34245832] - Tao Feng, Si Zeng, Jie Ding, Gong Chen, Bin Wang, Daguo Wang, Xueli Li, Kunfeng Wang. Comparative analysis of the effects of opioids in angiogenesis.
BMC anesthesiology.
2021 10; 21(1):257. doi:
10.1186/s12871-021-01475-7. [PMID: 34702181] - Linghai Li, Jinghui Wang, Ding Li, Huina Zhang. Morphine increases myocardial triacylglycerol through regulating adipose triglyceride lipase S406 phosphorylation.
Life sciences.
2021 Oct; 283(?):119866. doi:
10.1016/j.lfs.2021.119866. [PMID: 34352257] - Mauro Congiu, Laura Micheli, Michele Santoni, Claudia Sagheddu, Anna Lisa Muntoni, Alexandros Makriyannis, Michael S Malamas, Carla Ghelardini, Lorenzo Di Cesare Mannelli, Marco Pistis. N-Acylethanolamine Acid Amidase Inhibition Potentiates Morphine Analgesia and Delays the Development of Tolerance.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics.
2021 10; 18(4):2722-2736. doi:
10.1007/s13311-021-01116-4. [PMID: 34553321] - Fabiolla Patusco Dias, Luiz Gustavo Soares Carvalho Crespo, Joaquim Barbosa Leite Junior, Richard Ian Samuels, Norberto Cysne Coimbra, Robert J Carey, Marinete Pinheiro Carrera. Morphine reward effects and morphine behavioral sensitization: The adventitious association of morphine activation of brain reward effects with ongoing spontaneous activity.
Pharmacology, biochemistry, and behavior.
2021 10; 209(?):173244. doi:
10.1016/j.pbb.2021.173244. [PMID: 34363828] - Swagata Tripathy, P Bhaskar Rao. Epidural morphine in COVID ARDS patients with high respiratory drive: a structured summary of a study protocol for a randomised controlled trial.
Trials.
2021 Sep; 22(1):632. doi:
10.1186/s13063-021-05570-5. [PMID: 34530881] - Xue-Ming Hu, Wei Yang, Meng-Ting Zhang, Li-Xia Du, Jia-He Tian, Jian-Yu Zhu, Yu Chen, Feng Hai, Shen-Bin Liu, Qi-Liang Mao-Ying, Yu-Xia Chu, Hong Zhou, Yan-Qing Wang, Wen-Li Mi. Glial IL-33 signaling through an ST2-to-CXCL12 pathway in the spinal cord contributes to morphine-induced hyperalgesia and tolerance.
Science signaling.
2021 Sep; 14(699):eabe3773. doi:
10.1126/scisignal.abe3773. [PMID: 34516755] - Yingbo Lin, Hancheng Li, Ju Peng, Chan Li, Chen Zhu, Yuting Zhou, Zhijie Chen, Jing Li, Chaohua Luo, Zhixian Mo. Decrease of morphine-CPP by sinomenine via mediation of tyrosine hydroxylase, NMDA receptor subunit 2B and opioid receptor in the zebrafish brain.
Pakistan journal of pharmaceutical sciences.
2021 Sep; 34(5):1659-1665. doi:
. [PMID: 34802999] - Edel M Hughes, Patricia Calcagno, Connie Sanchez, Karen Smith, John P Kelly, David P Finn, Michelle Roche. Mu-opioid receptor agonism differentially alters social behaviour and immediate early gene expression in male adolescent rats prenatally exposed to valproic acid versus controls.
Brain research bulletin.
2021 09; 174(?):260-267. doi:
10.1016/j.brainresbull.2021.06.018. [PMID: 34197938] - Fatemeh Asgharzadeh, Shiva Roshan-Milani, Amin Abdollahzade Fard, Kimia Ahmadi, Ehsan Saboory, Masoumeh Pourjabali, Leila Chodari, Mohammad Amini. The protective effect of zinc on morphine-induced testicular toxicity via p53 and Akt pathways: An in vitro and in vivo approach.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS).
2021 Sep; 67(?):126776. doi:
10.1016/j.jtemb.2021.126776. [PMID: 33984544] - Jai Shankar K Yadlapalli, Zaineb A F Albayati, Philip J Breen, Maxim Dobretsov, Narsimha R Penthala, Howard P Hendrickson, Peter A Crooks. A pharmacokinetic study of morphine-6-O-sulfate in rat plasma and brain.
Drug development research.
2021 09; 82(6):802-814. doi:
10.1002/ddr.21785. [PMID: 33427316] - Magali Chartier, Michael Desgagné, Marc Sousbie, Charles Rumsby, Lucie Chevillard, Léa Théroux, Lounès Haroune, Jérôme Côté, Jean-Michel Longpré, Pierre-Luc Boudreault, Éric Marsault, Philippe Sarret. Pharmacodynamic and pharmacokinetic profiles of a neurotensin receptor type 2 (NTS2) analgesic macrocyclic analog.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Sep; 141(?):111861. doi:
10.1016/j.biopha.2021.111861. [PMID: 34229249] - Peter Steffen, Frieder Keller. [Analgesic Drug Therapy in Kidney Patients].
Deutsche medizinische Wochenschrift (1946).
2021 08; 146(15):1009-1015. doi:
10.1055/a-1388-9889. [PMID: 34344039]