Sensorcaine (BioDeep_00000681350)
代谢物信息卡片
Bupivacaine hydrochloride
化学式: C18H31ClN2O2 (342.2074)
中文名称: 盐酸布比卡因
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C.O.Cl
InChI: 1H
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C245 - Anesthetic Agent
同义名列表
2 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:77449
- ChEBI: CHEBI:60789
- KEGGdrug: D01450
- PubChem: 5282419
- MeSH: Bupivacaine
- CAS: 73360-54-0
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Tao Kang, Jiwei Tao, Xuetao Wang, Yu Liu, Dan Jin. Epidural ropivacaine versus bupivacaine for cesarean sections: a system review and meta-analysis.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.
2024 Dec; 37(1):2313356. doi:
10.1080/14767058.2024.2313356. [PMID: 38342577] - Soo Hee Lee, Sunmin Kim, Ju-Tae Sohn. Lipid emulsion treatment for local anesthetic systemic toxicity in pediatric patients: A systematic review.
Medicine.
2024 Mar; 103(11):e37534. doi:
10.1097/md.0000000000037534. [PMID: 38489714] - Susanne K Wiedmer, Ju-Tae Sohn. Lipophilicity of drugs, including local anesthetics, and its association with lipid emulsion resuscitation.
Korean journal of anesthesiology.
2024 Feb; 77(1):170-172. doi:
10.4097/kja.23825. [PMID: 38029794] - Xia Li, Jun Zhao, Qiaoqiao Lv, Yuan Tian, Li Zhang, Tong Liu. Electroacupuncture alleviates multifidus muscle injury by modulating mitochondrial function and Ca2+ uptake.
Anatomical record (Hoboken, N.J. : 2007).
2023 12; 306(12):3060-3072. doi:
10.1002/ar.24889. [PMID: 35235712] - Danting Jia, Fang Wang, Zhixia Bai, Xuexin Chen. BDNF-TrkB/proBDNF-p75NTR pathway regulation by lipid emulsion rescues bupivacaine-induced central neurotoxicity in rats.
Scientific reports.
2023 10; 13(1):18364. doi:
10.1038/s41598-023-45572-8. [PMID: 37884604] - Philipp Gerner, Kamen Vlassakov, Alexander Stone. Lipid emulsion for reversal of acute cannabinoid toxicity?.
Regional anesthesia and pain medicine.
2023 10; 48(10):532-533. doi:
10.1136/rapm-2023-104429. [PMID: 36858481] - Vladimir Smrkolj, Domen Pregeljc, Hana Kavčič, Nejc Umek, Janez Mavri. Micro-pharmacokinetics of lidocaine and bupivacaine transfer across a myelinated nerve fiber.
Computers in biology and medicine.
2023 10; 165(?):107375. doi:
10.1016/j.compbiomed.2023.107375. [PMID: 37611421] - Soraya Babaie, Mohammad Charkhpour, Maryam Kouhsoltani, Hamed Hamishehkar, Ana Cláudia Paiva-Santos. Nano-invasomes for simultaneous topical delivery of buprenorphine and bupivacaine for dermal analgesia.
Experimental dermatology.
2023 Jun; ?(?):. doi:
10.1111/exd.14850. [PMID: 37283479] - Minzhi Yu, Wenmin Yuan, Ziyun Xia, Yayuan Liu, Yan Wang, Xiaoming Xu, Jiwen Zheng, Anna Schwendeman. Characterization of exparel bupivacaine multivesicular liposomes.
International journal of pharmaceutics.
2023 May; 639(?):122952. doi:
10.1016/j.ijpharm.2023.122952. [PMID: 37054926] - Jinxin Huang, Gengzhi Wen, Qiang Huang, Bowan Huang. Anesthesia characteristic of an algorithm of bupivacaine dose based on height in caesarean section under spinal anesthesia: a retrospective cohort study.
BMC anesthesiology.
2023 May; 23(1):146. doi:
10.1186/s12871-023-02113-0. [PMID: 37131191] - Hua Jiang, Qiong Ma, Jing Dong, Xin Ye. The effect of liposomal bupivacaine for surgical wound infiltration: A meta-analysis of randomised controlled trials.
International wound journal.
2023 May; 20(5):1591-1608. doi:
10.1111/iwj.14015. [PMID: 36345868] - Soo Hee Lee, Ju-Tae Sohn. The underlying mechanism of lipid emulsion resuscitation for drug toxicity: A narrative review.
Korean journal of anesthesiology.
2023 Jan; ?(?):. doi:
10.4097/kja.23031. [PMID: 36704816] - Soo Hee Lee, Sunmin Kim, Ju-Tae Sohn. Lipid Emulsion Treatment for Drug Toxicity Caused by Nonlocal Anesthetic Drugs in Pediatric Patients: A Narrative Review.
Pediatric emergency care.
2023 Jan; 39(1):53-59. doi:
10.1097/pec.0000000000002828. [PMID: 35981328] - Qiao-Qiao Lü, Li Zhang, Xia Li, Yuan Tian, Jing Xu, Li Chen, Ze-Jun Huo. [Effect of electroacupuncture of "Weizhong" (BL40) on iron metabolism disorder in rats with lumbar multifidus muscle injury].
Zhen ci yan jiu = Acupuncture research.
2022 Dec; 47(12):1073-9. doi:
10.13702/j.1000-0607.20211277. [PMID: 36571222] - Wentao Deng, Yu Yan, Peipei Zhuang, Xiaoxu Liu, Ke Tian, Wenfang Huang, Cai Li. Synthesis of nanocapsules blended polymeric hydrogel loaded with bupivacaine drug delivery system for local anesthetics and pain management.
Drug delivery.
2022 Dec; 29(1):399-412. doi:
10.1080/10717544.2021.2023702. [PMID: 35098821] - C Philip Larson, Kevin Youssefzadeh, Jane S Moon. The Bupivacaine Story: A Tribute to George A. Albright, MD (1931-2020).
Anesthesia and analgesia.
2022 11; 135(5):1115-1119. doi:
10.1213/ane.0000000000006161. [PMID: 35924832] - Meng-Si Luo, Guan-Jiang Huang. The efficacy of peritonsillar injection of bupivacaine vs intravenous acetaminophen on post-tonsillectomy pain in children.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery.
2022 11; 279(11):5459-5461. doi:
10.1007/s00405-021-07146-0. [PMID: 34671857] - Chenran Wang, Shen Sun, Jing Jiao, Xinhua Yu, Shaoqiang Huang. Effects of nalbuphine on the cardiotoxicity of ropivacaine in rats.
Fundamental & clinical pharmacology.
2022 Oct; 36(5):811-817. doi:
10.1111/fcp.12778. [PMID: 35373856] - Susan Wojtalewicz, Jonathon Vizmeg, Sierra Erickson, Caleb Lade, Jill Shea, Himanshu Sant, Jules Magda, Bruce Gale, Jayant Agarwal, Brett Davis. Evaluating the influence of particle morphology and density on the viscosity and injectability of a novel long-acting local anesthetic suspension.
Journal of biomaterials applications.
2022 10; 37(4):724-736. doi:
10.1177/08853282221106486. [PMID: 35649287] - Yujia Li, Zhien Shen, Hongmei Wang, Tonghui Feng, Yanfei Xia. Efficacy of liposomal bupivacaine for pain control in shoulder surgery: a systematic review and meta-analysis.
Journal of shoulder and elbow surgery.
2022 Sep; 31(9):1957-1968. doi:
10.1016/j.jse.2022.02.037. [PMID: 35430368] - Ju-Tae Sohn. Lipid emulsion dosage used for resuscitation after drug toxicity.
The American journal of emergency medicine.
2022 09; 59(?):168-169. doi:
10.1016/j.ajem.2022.07.026. [PMID: 35868991] - Matilde Zaballos, Ignacio Fernández, Lucia Rodríguez, Sergio García, Olalla Varela, Oscar Quintela, María-José Anadón, Jesús Almendral. Effects of intravenous lipid emulsions on the reversal of pacing-induced ventricular arrhythmias and electrophysiological alterations in an animal model of ropivacaine toxicity.
Clinical toxicology (Philadelphia, Pa.).
2022 08; 60(8):902-911. doi:
10.1080/15563650.2022.2080075. [PMID: 35658706] - Chenran Wang, Shen Sun, Jing Jiao, Xinhua Yu, Shaoqiang Huang. Effects of delta-opioid receptor agonist pretreatment on the cardiotoxicity of bupivacaine in rats.
BMC anesthesiology.
2022 01; 22(1):19. doi:
10.1186/s12871-022-01568-x. [PMID: 35021986] - Wangcheng Zhao, Yan Du, Shameen Ashfaq, Shafaqat Ali, Amer M Alanazi, Moreno Santi. Evaluation of the Efficacy, Biocompatibility, and Permeation of Bupivacaine-Loaded Poly(epsilon-caprolactone) Nano-Capsules as an Anesthetic.
Journal of biomedical nanotechnology.
2022 Jan; 18(1):268-276. doi:
10.1166/jbn.2022.3223. [PMID: 35180921] - Seong-Ho Ok, Dawon Kang, Soo Hee Lee, Hyun-Jin Kim, Seung Hyun Ahn, Ju-Tae Sohn. Lipid emulsions attenuate the inhibition of carnitine acylcarnitine translocase induced by toxic doses of local anesthetics in rat cardiomyoblasts.
Human & experimental toxicology.
2022 Jan; 41(?):9603271211065978. doi:
10.1177/09603271211065978. [PMID: 35135371] - Victoria M Lim, Taylor Barney, Arun L Jayaraman. Multiple myeloma and malignant lesions: a potential risk factor for local anesthetic systemic toxicity.
Regional anesthesia and pain medicine.
2021 12; 46(12):1103-1106. doi:
10.1136/rapm-2021-102845. [PMID: 34535547] - D Viderman, B Ben-David, A Sarria-Santamera. Analysis of bupivacaine and ropivacaine-related cardiac arrests in regional anesthesia: A systematic review of case reports.
Revista espanola de anestesiologia y reanimacion.
2021 Oct; 68(8):472-483. doi:
10.1016/j.redare.2020.10.005. [PMID: 34538765] - Fernando Freitas de Lima, Bianca Brandão da Silva, Juliana Damasceno Oliveira, Ludmilla David de Moura, Gustavo Henrique Rodrigues da Silva, Priscila Cordeiro Lima Fernandes, Roosevelt Isaias Carvalho Souza, Ariany Carvalho Dos Santos, Eneida de Paula. Prolonged anesthesia and decreased toxicity of enantiomeric-excess bupivacaine loaded in ionic gradient liposomes.
International journal of pharmaceutics.
2021 Sep; 606(?):120944. doi:
10.1016/j.ijpharm.2021.120944. [PMID: 34324985] - Matthew McDaniel, Kevin B Flores, Belinda S Akpa. Predicting Inter-individual Variability During Lipid Resuscitation of Bupivacaine Cardiotoxicity in Rats: A Virtual Population Modeling Study.
Drugs in R&D.
2021 Sep; 21(3):305-320. doi:
10.1007/s40268-021-00353-4. [PMID: 34279844] - Shuang-Hua Dai, Ya-Wen Li, Qing-Xiong Hong, Tao Su, Shi-Yuan Xu. Exaggerated activities of TRPM7 underlie bupivacaine-induced neurotoxicity in the SH-SY5Y cells preconditioned with high glucose.
Journal of biochemical and molecular toxicology.
2021 Aug; 35(8):e22826. doi:
10.1002/jbt.22826. [PMID: 34060177] - Yi Han, Xiaoyuan Chen, Panpan Mi, Yunzhao Ji, Xiangan Meng, Pengbo Han, Jingyi Zhang. Different Concentrations of Ropivacaine under Ultrasound Guidance on Quadratus Lumbar Muscle Nerve Block in Elderly Patients with Hip Replacement.
BioMed research international.
2021; 2021(?):9911352. doi:
10.1155/2021/9911352. [PMID: 34977251] - Brett Davis, Sierra Erickson, Susan Wojtalewicz, Andrew Simpson, Cameron Metcalf, Himanshu Sant, Jill Shea, Bruce Gale, Jayant Agarwal. Entrapping bupivacaine-loaded emulsions in a crosslinked-hydrogel increases anesthetic effect and duration in a rat sciatic nerve block model.
International journal of pharmaceutics.
2020 Oct; 588(?):119703. doi:
10.1016/j.ijpharm.2020.119703. [PMID: 32739385] - Hyun Joo Kim, Hyun Soo Kim, Ja Rang Jung, Ha Yan Kim, Carl Lynch, Wyun Kon Park. Lipid Emulsion Restoration of Myocardial Contractions After Bupivacaine-Induced Asystole In Vitro: A Benefit of Long- and Medium-Chain Triglyceride Over Long-Chain Triglyceride.
Anesthesia and analgesia.
2020 09; 131(3):917-927. doi:
10.1213/ane.0000000000004637. [PMID: 32011393] - Chunai Wang, Xi Liang, Yan Yu, Yulan Li, Xiaohui Wen, Min Liu. Electroacupuncture pretreatment alleviates myocardial injury through regulating mitochondrial function.
European journal of medical research.
2020 Aug; 25(1):29. doi:
10.1186/s40001-020-00431-4. [PMID: 32738910] - Hao Nie, Zhixia Bai, Zhenzhou Li, Li Yan, Xue-Xin Chen. Intravenous lipid emulsion modifies synaptic transmission in hippocampal CA1 pyramidal neurons after bupivacaine-induced central nervous system toxicity.
Journal of neurochemistry.
2020 07; 154(2):144-157. doi:
10.1111/jnc.14924. [PMID: 31758799] - Alexander M Sidlak, Joseph H Yanta, Michael J Lynch. Intrathecal bupivacaine and morphine toxicity leading to transient hypotension and delayed status epilepticus.
The American journal of emergency medicine.
2020 05; 38(5):1046.e5-1046.e7. doi:
10.1016/j.ajem.2019.12.055. [PMID: 31952869] - Gustavo H Rodrigues da Silva, Gabriela Geronimo, Lígia N M Ribeiro, Viviane A Guilherme, Ludmilla David de Moura, André L Bombeiro, Juliana Damasceno Oliveira, Márcia C Breitkreitz, Eneida de Paula. Injectable in situ forming nanogel: A hybrid Alginate-NLC formulation extends bupivacaine anesthetic effect.
Materials science & engineering. C, Materials for biological applications.
2020 Apr; 109(?):110608. doi:
10.1016/j.msec.2019.110608. [PMID: 32228992] - C De Diego, M Zaballos, O Quintela, R Sevilla, D Callejo, J González-Panizo, Ma J Anadón, J Almendral. Bupivacaine Toxicity Increases Transmural Dispersion of Repolarization, Developing of a Brugada-like Pattern and Ventricular Arrhythmias, Which is Reversed by Lipid Emulsion Administration. Study in an Experimental Porcine Model.
Cardiovascular toxicology.
2019 10; 19(5):432-440. doi:
10.1007/s12012-019-09515-y. [PMID: 30945064] - Mahmud Arif Pavel, Hae-Won Chung, E Nicholas Petersen, Scott B Hansen. Polymodal Mechanism for TWIK-Related K+ Channel Inhibition by Local Anesthetic.
Anesthesia and analgesia.
2019 10; 129(4):973-982. doi:
10.1213/ane.0000000000004216. [PMID: 31124840] - Rama Prajapati, Susan Weng Larsen, Anan Yaghmur. Citrem-phosphatidylcholine nano-self-assemblies: solubilization of bupivacaine and its role in triggering a colloidal transition from vesicles to cubosomes and hexosomes.
Physical chemistry chemical physics : PCCP.
2019 Jul; 21(27):15142-15150. doi:
10.1039/c9cp01878f. [PMID: 31243413] - Matilde Zaballos, David Callejo, Raul Sevilla, Oscar Quintela, Ramiro López-Menchaca, Arturo Melone, Olalla Varela, Mª José Anadón Baselga, Jesús Almendral. Comparative Effects of Sodium Bicarbonate and Intravenous Lipid Emulsions on Reversing Bupivacaine-Induced Electrophysiological Toxicity in a Porcine Experimental Model.
Anesthesia and analgesia.
2019 07; 129(1):63-72. doi:
10.1213/ane.0000000000003875. [PMID: 31210652] - Guy L Weinberg, Peter Bedocs, Michael R Fettiplace. Pigs and Paradigms: Stop Using Swine to Study Lipid Resuscitation.
Anesthesia and analgesia.
2019 07; 129(1):4-7. doi:
10.1213/ane.0000000000004101. [PMID: 31206444] - Mahmoud Reza Moradkhani, Arash Karimi. Effect of Artemisia Aucheri.L and Bupivacaine Encapsulated Nanoparticles on Nociceptive Pain.
Drug research.
2019 Jul; 69(7):401-405. doi:
10.1055/a-0825-6487. [PMID: 30616248] - Jun Ho Yang, Adrian S Siregar, Eun-Jin Kim, Marie Merci Nyiramana, Eui-Jung Shin, Jaehee Han, Ju-Tae Sohn, Jong Woo Kim, Dawon Kang. Involvement of TREK-1 Channel in Cell Viability of H9c2 Rat Cardiomyoblasts Affected by Bupivacaine and Lipid Emulsion.
Cells.
2019 05; 8(5):. doi:
10.3390/cells8050454. [PMID: 31091801] - Bryant W Tran, Spencer T Liebman, Trevor W Reichman, Michael J Scott. Hemodynamic Instability and Lipid Emulsion Resuscitation After Subcutaneous Injection of a Liposomal Bupivacaine Admixture: A Case Report.
A&A practice.
2019 Apr; 12(7):223-225. doi:
10.1213/xaa.0000000000000889. [PMID: 30199400] - D H Lim, J-T Sohn. Bupivacaine-induced cardiotoxicity and lipid emulsion.
Human & experimental toxicology.
2019 04; 38(4):494-495. doi:
10.1177/0960327118819042. [PMID: 30556419] - José Luis Zeballos, Gary R Strichartz. Tuning Up the Life Saver: An Experimental Approach to Optimizing the Delivery of Intravenous Lipid Emulsions.
Anesthesia and analgesia.
2019 02; 128(2):199-201. doi:
10.1213/ane.0000000000003863. [PMID: 30649040] - Le Liu, Zhousheng Jin, Xixi Cai, Yun Xia, Meiling Zhang, Thomas J Papadimos, Xuzhong Xu, Kejian Shi. Comparative Regimens of Lipid Rescue From Bupivacaine-Induced Asystole in a Rat Model.
Anesthesia and analgesia.
2019 02; 128(2):256-263. doi:
10.1213/ane.0000000000003711. [PMID: 30113398] - Soumyarwit Manna, Yong Wu, Yan Wang, Bonhye Koo, Lynn Chen, Peter Petrochenko, Yixuan Dong, Stephanie Choi, Darby Kozak, Berk Oktem, Xiaoming Xu, Jiwen Zheng. Probing the mechanism of bupivacaine drug release from multivesicular liposomes.
Journal of controlled release : official journal of the Controlled Release Society.
2019 01; 294(?):279-287. doi:
10.1016/j.jconrel.2018.12.029. [PMID: 30576748] - Hongfei Chen, Fangfang Xia, Zhousheng Jin, Kejian Shi, Yun Xia, Le Liu, Thomas J Papadimos, Xuzhong Xu, Limei Chen. Levosimendan is superior to epinephrine on coronary flow for lipid-base resuscitation of bupivacaine-induced asystole in the isolated rat heart.
BMC anesthesiology.
2018 11; 18(1):174. doi:
10.1186/s12871-018-0627-0. [PMID: 30458723] - Soo Hee Lee, Dawon Kang, Seong-Ho Ok, Seong-Chun Kwon, Hyun-Jin Kim, Eun-Jin Kim, Jeong-Min Hong, Ji-Yoon Kim, Sung Il Bae, Seungmin An, Ju-Tae Sohn. Linoleic Acid Attenuates the Toxic Dose of Bupivacaine-Mediated Reduction of Vasodilation Evoked by the Activation of Adenosine Triphosphate-Sensitive Potassium Channels.
International journal of molecular sciences.
2018 Jun; 19(7):. doi:
10.3390/ijms19071876. [PMID: 29949899] - Ö Pişkin, B G Aydın. Effects of insulin+glucose pretreatment on bupivacaine cardiotoxicity in rats.
Human & experimental toxicology.
2018 May; 37(5):451-457. doi:
10.1177/0960327117712384. [PMID: 28565972] - Zhan-Xia Yu, Zhao-Zhi Yang, Lu-Lan Yao. Effectiveness of liposome bupivacaine for postoperative pain control in total knee arthroplasty: A PRISMA-compliant meta-analysis of randomized controlled trials.
Medicine.
2018 Mar; 97(13):e0171. doi:
10.1097/md.0000000000010171. [PMID: 29595645] - Yaocun Yue, Dandan Zhao, Qiuwen Yin. Hyaluronic acid modified nanostructured lipid carriers for transdermal bupivacaine delivery: In vitro and in vivo anesthesia evaluation.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Feb; 98(?):813-820. doi:
10.1016/j.biopha.2017.12.103. [PMID: 29571251] - Özcan Pişkin, Hilal Ayoğlu. Effects of Remifentanil Pretreatment on Bupivacaine Cardiotoxicity in Rats.
Cardiovascular toxicology.
2018 02; 18(1):56-62. doi:
10.1007/s12012-017-9413-3. [PMID: 28540470] - Gustavo Henrique Rodrigues Da Silva, Ligia Nunes de Morais Ribeiro, Viviane Aparecida Guilherme, Simone Ramos de Castro, Marcia Cristina Breitkreitz, Eneida de Paula. Bupivacaine (S75:R25) Loaded in Nanostructured Lipid Carriers: Factorial Design, HPLC Quantification Method and Physicochemical Stability Study.
Current drug delivery.
2018; 15(3):388-396. doi:
10.2174/1567201814666170726101113. [PMID: 28745230] - Seong-Ho Ok, Jeong-Min Hong, Soo Hee Lee, Ju-Tae Sohn. Lipid Emulsion for Treating Local Anesthetic Systemic Toxicity.
International journal of medical sciences.
2018; 15(7):713-722. doi:
10.7150/ijms.22643. [PMID: 29910676] - Hironori Tsuchiya, Maki Mizogami. Discrimination of Stereoisomers by Their Enantioselective Interactions with Chiral Cholesterol-Containing Membranes.
Molecules (Basel, Switzerland).
2017 Dec; 23(1):. doi:
10.3390/molecules23010049. [PMID: 29295605] - Masashi Yoshimoto, Takashi Horiguchi, Tetsu Kimura, Toshiaki Nishikawa. Recovery From Ropivacaine-Induced or Levobupivacaine-Induced Cardiac Arrest in Rats: Comparison of Lipid Emulsion Effects.
Anesthesia and analgesia.
2017 11; 125(5):1496-1502. doi:
10.1213/ane.0000000000002435. [PMID: 28877036] - Zhe Chen, Zhousheng Jin, Yun Xia, Shishi Zhao, Xuzhong Xu, Thomas J Papadimos, Quanguang Wang. The protective effect of lipid emulsion in preventing bupivacaine-induced mitochondrial injury and apoptosis of H9C2 cardiomyocytes.
Drug delivery.
2017 Nov; 24(1):430-436. doi:
10.1080/10717544.2016.1261379. [PMID: 28165812] - Fubei Nan, Xixi Cai, Yingchao Ye, Xuzhong Xu, Zhengqian Li, Min Li, Limei Chen. Levosimendan combined with epinephrine improves rescue outcomes in a rat model of lipid-based resuscitation from bupivacaine-induced cardiac arrest.
BMC anesthesiology.
2017 Sep; 17(1):128. doi:
10.1186/s12871-017-0414-3. [PMID: 28915792] - Gustavo H Rodrigues da Silva, Lígia N M Ribeiro, Hery Mitsutake, Viviane A Guilherme, Simone R Castro, Ronei J Poppi, Márcia C Breitkreitz, Eneida de Paula. Optimised NLC: a nanotechnological approach to improve the anaesthetic effect of bupivacaine.
International journal of pharmaceutics.
2017 Aug; 529(1-2):253-263. doi:
10.1016/j.ijpharm.2017.06.066. [PMID: 28655546] - Michael R Fettiplace, Daniel J McCabe. Lipid emulsion improves survival in animal models of local anesthetic toxicity: a meta-analysis.
Clinical toxicology (Philadelphia, Pa.).
2017 Aug; 55(7):617-623. doi:
10.1080/15563650.2017.1288911. [PMID: 28346007] - Lotte C G Hoegberg, Sophie Gosselin. Lipid resuscitation in acute poisoning: after a decade of publications, what have we really learned?.
Current opinion in anaesthesiology.
2017 Aug; 30(4):474-479. doi:
10.1097/aco.0000000000000484. [PMID: 28562387] - Zhong-Hua Ji, Zhong-Jie Liu, Zi-Ting Liu, Wei Zhao, Brian A Williams, Hong-Fei Zhang, Le Li, Shi-Yuan Xu. Diphenyleneiodonium Mitigates Bupivacaine-Induced Sciatic Nerve Damage in a Diabetic Neuropathy Rat Model by Attenuating Oxidative Stress.
Anesthesia and analgesia.
2017 08; 125(2):653-661. doi:
10.1213/ane.0000000000002186. [PMID: 28682956] - Zongwen Gao, Feng Cui, Xuemei Cao, Dejun Wang, Xiao Li, Tianzuo Li. Local infiltration of the surgical wounds with levobupivacaine, dexibuprofen, and norepinephrine to reduce postoperative pain: A randomized, vehicle-controlled, and preclinical study.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 Aug; 92(?):459-467. doi:
10.1016/j.biopha.2017.05.038. [PMID: 28570980] - Wyun Kon Park, Hyun Soo Kim, Soo Hwan Kim, Ja Rang Jung, Carl Lynch, Nar Hyun Min. Intralipid Restoration of Myocardial Contractions Following Bupivacaine-Induced Asystole: Concentration- and Time-Dependence In Vitro.
Anesthesia and analgesia.
2017 07; 125(1):91-100. doi:
10.1213/ane.0000000000002124. [PMID: 28537978] - Pengju Ma, Ting Li, Huaixin Xing, Suzhen Wang, Yingui Sun, Xiugui Sheng, Kaiguo Wang. Local anesthetic effects of bupivacaine loaded lipid-polymer hybrid nanoparticles: In vitro and in vivo evaluation.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 May; 89(?):689-695. doi:
10.1016/j.biopha.2017.01.175. [PMID: 28267672] - J A Heinonen, A A Schramko, M B Skrifvars, E Litonius, J T Backman, E Mervaala, P H Rosenberg. The effects of intravenous lipid emulsion on hemodynamic recovery and myocardial cell mitochondrial function after bupivacaine toxicity in anesthetized pigs.
Human & experimental toxicology.
2017 Apr; 36(4):365-375. doi:
10.1177/0960327116650010. [PMID: 27222493] - Xu-Jiao Yu, Wei Zhao, Yu-Jie Li, Feng-Xian Li, Zhong-Jie Liu, Hua-Li Xu, Lu-Ying Lai, Rui Xu, Shi-Yuan Xu. Neurotoxicity Comparison of Two Types of Local Anaesthetics: Amide-Bupivacaine versus Ester-Procaine.
Scientific reports.
2017 03; 7(?):45316. doi:
10.1038/srep45316. [PMID: 28338089] - Gail K Wong, Carolyne Pehora, Mark W Crawford. L-carnitine reduces susceptibility to bupivacaine-induced cardiotoxicity: an experimental study in rats.
Canadian journal of anaesthesia = Journal canadien d'anesthesie.
2017 Mar; 64(3):270-279. doi:
10.1007/s12630-016-0797-5. [PMID: 28032304] - Seong-Ho Ok, Soo Hee Lee, Seong-Chun Kwon, Mun Hwan Choi, Il-Woo Shin, Sebin Kang, Miyeong Park, Jeong-Min Hong, Ju-Tae Sohn. A Lipid Emulsion Reverses Toxic-Dose Bupivacaine-Induced Vasodilation during Tyrosine Phosphorylation-Evoked Contraction in Isolated Rat Aortae.
International journal of molecular sciences.
2017 Feb; 18(2):. doi:
10.3390/ijms18020394. [PMID: 28208809] - Thomas W Hamilton, Vassilis Athanassoglou, Stephen Mellon, Louise H Strickland, Marialena Trivella, David Murray, Hemant G Pandit. Liposomal bupivacaine infiltration at the surgical site for the management of postoperative pain.
The Cochrane database of systematic reviews.
2017 02; 2(?):CD011419. doi:
10.1002/14651858.cd011419.pub2. [PMID: 28146271] - Negar Motayagheni, Sheshanna Phan, Ala Nozari, Anthony Atala. Lipid Emulsion, More Than Reversing Bupivacaine Cardiotoxicity: Potential Organ Protection.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.
2017; 20(1):329-331. doi:
10.18433/j30d2v. [PMID: 29145932] - Wan Tang, Quanguang Wang, Kejian Shi, Jiaojiao Dong, Shengxian Lin, Shishi Zhao, Cong Wu, Yun Xia, Thomas J Papadimos, Xuzhong Xu. The Effect of Lipid Emulsion on Pharmacokinetics of Bupivacaine in Rats: Long-Chain Triglyceride Versus Long- and Medium-Chain Triglyceride.
Anesthesia and analgesia.
2016 11; 123(5):1116-1122. doi:
10.1213/ane.0000000000001410. [PMID: 27224931] - S-H Ok, J Yu, Y Lee, H Cho, I-W Shin, J-T Sohn. Lipid emulsion attenuates apoptosis induced by a toxic dose of bupivacaine in H9c2 rat cardiomyoblast cells.
Human & experimental toxicology.
2016 Sep; 35(9):929-37. doi:
10.1177/0960327115608930. [PMID: 26437793] - Pauline Dureau, Beny Charbit, Nathalie Nicolas, Dan Benhamou, Jean-Xavier Mazoit. Effect of Intralipid® on the Dose of Ropivacaine or Levobupivacaine Tolerated by Volunteers: A Clinical and Pharmacokinetic Study.
Anesthesiology.
2016 09; 125(3):474-83. doi:
10.1097/aln.0000000000001230. [PMID: 27404223] - Thomas W Hamilton, Vassilis Athanassoglou, Marialena Trivella, Louise H Strickland, Stephen Mellon, David Murray, Hemant G Pandit. Liposomal bupivacaine peripheral nerve block for the management of postoperative pain.
The Cochrane database of systematic reviews.
2016 Aug; ?(8):CD011476. doi:
10.1002/14651858.cd011476.pub2. [PMID: 27558150] - Ramón Eizaga Rebollar, María V García Palacios, Javier Morales Guerrero, Luis M Torres Morera. Lipid rescue in children: The prompt decision.
Journal of clinical anesthesia.
2016 Aug; 32(?):248-52. doi:
10.1016/j.jclinane.2016.03.018. [PMID: 27290983] - Matthew Musielak, John McCall. Lipid Rescue in a Pediatric Burn Patient.
Journal of burn care & research : official publication of the American Burn Association.
2016 Jul; 37(4):e380-2. doi:
10.1097/bcr.0000000000000263. [PMID: 26035145] - Mengxu Luo, Xia Yun, Chaoxing Chen, Nana Bao, Xiaona Feng, Linmin Pan, Zhousheng Jin, Cong Wu, Xianqin Wang, Thomas J Papadimos, Xuzhong Xu. Giving Priority to Lipid Administration Can Reduce Lung Injury Caused by Epinephrine in Bupivacaine-Induced Cardiac Depression.
Regional anesthesia and pain medicine.
2016 Jul; 41(4):469-76. doi:
10.1097/aap.0000000000000424. [PMID: 27281728] - J A Heinonen, M B Skrifvars, J Haasio, J T Backman, P H Rosenberg, E Litonius. Intravenous lipid emulsion for levobupivacaine intoxication in acidotic and hypoxaemic pigs.
Anaesthesia and intensive care.
2016 Mar; 44(2):270-7. doi:
10.1177/0310057x1604400214. [PMID: 27029660] - Danni Lv, Zhixia Bai, Libin Yang, Xiaohui Li, Xuexin Chen. Lipid emulsion reverses bupivacaine-induced apoptosis of h9c2 cardiomyocytes: PI3K/Akt/GSK-3β signaling pathway.
Environmental toxicology and pharmacology.
2016 Mar; 42(?):85-91. doi:
10.1016/j.etap.2016.01.004. [PMID: 26809062] - Michael R Fettiplace, Katarzyna Kowal, Richard Ripper, Alexandria Young, Kinga Lis, Israel Rubinstein, Marcelo Bonini, Richard Minshall, Guy Weinberg. Insulin Signaling in Bupivacaine-induced Cardiac Toxicity: Sensitization during Recovery and Potentiation by Lipid Emulsion.
Anesthesiology.
2016 Feb; 124(2):428-42. doi:
10.1097/aln.0000000000000974. [PMID: 26646023] - M Zaballos, R Sevilla, J González, D Callejo, C de Diego, J Almendral, O Quintela, M J Anadón. Analysis of the temporal regression of the QRS widening induced by bupivacaine after Intralipid administration. Study in an experimental porcine model.
Revista espanola de anestesiologia y reanimacion.
2016 Jan; 63(1):13-21. doi:
10.1016/j.redar.2015.02.002. [PMID: 25799289] - Seong-Ho Ok, Won Ho Kim, Jongsun Yu, Youngju Lee, Mun-Jeoung Choi, Dong Hoon Lim, Yeran Hwang, Yeon A Kim, Ju-Tae Sohn. Effects of Acidification and Alkalinization on the Lipid Emulsion-Mediated Reversal of Toxic Dose Levobupivacaine-Induced Vasodilation in the Isolated Rat Aorta.
International journal of medical sciences.
2016; 13(1):68-76. doi:
10.7150/ijms.13016. [PMID: 26917987] - Z Sarikus, N Bedirli, G Yilmaz, U Bagriacik, F Bozkirli. The effects of epidural bupivacaine on ischemia/reperfusion-induced liver injury.
Bratislavske lekarske listy.
2016; 117(1):41-6. doi:
10.4149/bll_2016_009. [PMID: 26810169] - Juhong Ran, Yanping Wang, Fangkun Li, Wei Zhang, Minyu Ma. Pharmacodynamics and Pharmacokinetics of Levobupivacaine Used for Epidural Anesthesia in Patients with Liver Dysfunction.
Cell biochemistry and biophysics.
2015 Dec; 73(3):717-21. doi:
10.1007/s12013-015-0677-6. [PMID: 27259315] - K Hori, T Matsuura, S Tsujikawa, T Mori, M Kuno, K Nishikawa. The significant contribution of the partitioning effect in lipid resuscitation for bupivacaine-induced cardiotoxicity: evaluation using centrifuged solution in vivo and in isolated hearts.
British journal of anaesthesia.
2015 Dec; 115(6):935-7. doi:
10.1093/bja/aev386. [PMID: 26582857] - Zahida Mamou, Jacques Descotes, Philippe Chevalier, Bernard Bui-Xuan, Caroline Romestaing, Quadiri Timour. Electrophysiological, haemodynamic, and mitochondrial alterations induced by levobupivacaine during myocardial ischemia in a pig model: protection by lipid emulsions?.
Fundamental & clinical pharmacology.
2015 Oct; 29(5):439-49. doi:
10.1111/fcp.12131. [PMID: 26118736] - Libin Yang, Zhixia Bai, Danni Lv, Haibo Liu, Xiaohui Li, Xuexin Chen. Rescue effect of lipid emulsion on bupivacaine-induced cardiac toxicity in cardiomyocytes.
Molecular medicine reports.
2015 Sep; 12(3):3739-3747. doi:
10.3892/mmr.2015.3852. [PMID: 26018942] - Hao Guo, He-fei Zhang, Wen-qi Xu, Qian Du, Jing Zhao, Lei-ming Ren. Differential effects of short- and long-term bupivacaine treatment on α1-adrenoceptor-mediated contraction of isolated rat aorta rings and the reversal effect of lipid emulsion.
Acta pharmacologica Sinica.
2015 Aug; 36(8):976-86. doi:
10.1038/aps.2015.40. [PMID: 26073324] - Parisa Partownavid, Salil Sharma, Jignyuan Li, Soban Umar, Siamak Rahman, Mansoureh Eghbali. Involvement of Opioid Receptors in the Lipid Rescue of Bupivacaine-Induced Cardiotoxicity.
Anesthesia and analgesia.
2015 Aug; 121(2):340-7. doi:
10.1213/ane.0000000000000788. [PMID: 25993392] - Zhousheng Jin, Yun Xia, Fangfang Xia, Cong Wu, Zhe Chen, Fubei Nan, Bingjing Wu, Li Wan, Xianqin Wang, Thomas J Papadimos, Xuzhong Xu. Epinephrine administration in lipid-based resuscitation in a rat model of bupivacaine-induced cardiac arrest: optimal timing.
Regional anesthesia and pain medicine.
2015 May; 40(3):223-31. doi:
10.1097/aap.0000000000000220. [PMID: 25675288] - Michael R Fettiplace, Adrian Pichurko, Richard Ripper, Bocheng Lin, Katarzyna Kowal, Kinga Lis, David Schwartz, Douglas L Feinstein, Israel Rubinstein, Guy Weinberg. Cardiac depression induced by cocaine or cocaethylene is alleviated by lipid emulsion more effectively than by sulfobutylether-β-cyclodextrin.
Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.
2015 May; 22(5):508-17. doi:
10.1111/acem.12657. [PMID: 25908403] - Artur Udelsmann, Marcos De Simone Melo. Hemodynamic changes with two lipid emulsions for treatment of bupivacaine toxicity in swines.
Acta cirurgica brasileira.
2015 Feb; 30(2):87-93. doi:
10.1590/s0102-86502015002000001. [PMID: 25714686] - Seong-Ho Ok, Hyo-Jin Byon, Seong-Chun Kwon, Jungchul Park, Youngju Lee, Yeran Hwang, Jiseok Baik, Mun-Jeoung Choi, Ju-Tae Sohn. Lipid Emulsion Inhibits Vasodilation Induced by a Toxic Dose of Bupivacaine via Attenuated Dephosphorylation of Myosin Phosphatase Target Subunit 1 in Isolated Rat Aorta.
International journal of medical sciences.
2015; 12(12):958-67. doi:
10.7150/ijms.13299. [PMID: 26664257] - Philipp Lirk, Susanne Picardi, Markus W Hollmann. Local anaesthetics: 10 essentials.
European journal of anaesthesiology.
2014 Nov; 31(11):575-85. doi:
10.1097/eja.0000000000000137. [PMID: 25192265] - Sandrine Lemoine, René Rouet, Alain Manrique, Jean-Luc Hanouz. Effect of long-chain triglyceride lipid emulsion on bupivacaine-induced changes in electrophysiological parameters of rabbit Purkinje cells.
Fundamental & clinical pharmacology.
2014 Oct; 28(5):481-8. doi:
10.1111/fcp.12058. [PMID: 24279803]
