L-AP4 (BioDeep_00000679927)

   


代谢物信息卡片


(2S)-2-amino-4-phosphonobutanoic acid

化学式: C4H10NO5P (183.029658)
中文名称: L-APB
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(CP(=O)(O)O)C(C(=O)O)N
InChI: InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1

描述信息

A non-proteinogenc L-alpha-amino acid that is L-alpha-aminobutyric acid in which one of the hydrogens of the terminal methyl group has been replaced by a dihydroxy(oxido)-lambda(5)-phosphanyl group. It is a potent and selective agonist for the group III metabotropic glutamate receptors (mGluR4/6/7/8).

同义名列表

2 个代谢物同义名

(2S)-2-amino-4-phosphonobutanoic acid; L-AP4



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Tamar Vardi, Marie Fina, Lingli Zhang, Anuradha Dhingra, Noga Vardi. mGluR6 transcripts in non-neuronal tissues. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 2011 Dec; 59(12):1076-86. doi: 10.1369/0022155411425386. [PMID: 22034516]
  • Jun Hasegawa, Takehisa Obara, Kohichi Tanaka, Masao Tachibana. High-density presynaptic transporters are required for glutamate removal from the first visual synapse. Neuron. 2006 Apr; 50(1):63-74. doi: 10.1016/j.neuron.2006.02.022. [PMID: 16600856]
  • K Nakashima, H Katsukawa, K Sasamoto, Y Ninomiya. Behavioral taste similarities and differences among monosodium L-glutamate and glutamate receptor agonists in C57BL mice. Journal of nutritional science and vitaminology. 2001 Apr; 47(2):161-6. doi: 10.3177/jnsv.47.161. [PMID: 11508708]
  • M A Naples, D R Hampson. Pharmacological profiles of the metabotropic glutamate receptor ligands. Neuropharmacology. 2001; 40(2):170-7. doi: 10.1016/s0028-3908(00)00128-3. [PMID: 11114395]
  • K Matsumura, T Tsuchihashi, S Kagiyama, I Abe, M Fujishima. Subtypes of metabotropic glutamate receptors in the nucleus of the solitary tract of rats. Brain research. 1999 Sep; 842(2):461-8. doi: 10.1016/s0006-8993(99)01889-2. [PMID: 10526143]
  • P Malherbe, C Kratzeisen, K Lundstrom, J G Richards, R L Faull, V Mutel. Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8. Brain research. Molecular brain research. 1999 Apr; 67(2):201-10. doi: 10.1016/s0169-328x(99)00050-9. [PMID: 10216218]
  • G Han, D R Hampson. Ligand binding to the amino-terminal domain of the mGluR4 subtype of metabotropic glutamate receptor. The Journal of biological chemistry. 1999 Apr; 274(15):10008-13. doi: 10.1074/jbc.274.15.10008. [PMID: 10187777]
  • C Corti, S Restituito, J M Rimland, I Brabet, M Corsi, J P Pin, F Ferraguti. Cloning and characterization of alternative mRNA forms for the rat metabotropic glutamate receptors mGluR7 and mGluR8. The European journal of neuroscience. 1998 Dec; 10(12):3629-41. doi: 10.1046/j.1460-9568.1998.00371.x. [PMID: 9875342]
  • L Eriksen, C Thomsen. [3H]-L-2-amino-4-phosphonobutyrate labels a metabotropic glutamate receptor, mGluR4a. British journal of pharmacology. 1995 Dec; 116(8):3279-87. doi: 10.1111/j.1476-5381.1995.tb15136.x. [PMID: 8719808]
  • S L Crooks, M B Robinson, J F Koerner, R L Johnson. Cyclic analogues of 2-amino-4-phosphonobutanoic acid (APB) and their inhibition of hippocampal excitatory transmission and displacement of [3H]APB binding. Journal of medicinal chemistry. 1986 Oct; 29(10):1988-95. doi: 10.1021/jm00160a031. [PMID: 3020251]