2-Deoxy-5-fluorcytidine (BioDeep_00000679893)

   


代谢物信息卡片


5-Fluoro-2-deoxycytidine

化学式: C9H12FN3O4 (245.0811804)
中文名称: 5-氟脱氧胞苷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C(C(OC1N2C=C(C(=NC2=O)N)F)CO)O
InChI: InChI=1S/C9H12FN3O4/c10-4-2-13(9(16)12-8(4)11)7-1-5(15)6(3-14)17-7/h2,5-7,14-15H,1,3H2,(H2,11,12,16)/t5-,6+,7+/m0/s1

描述信息

C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C272 - Antimetabolite
5-Fluoro-2'-deoxycytidine, a fluoropyrimidine nucleoside analogue, is a DNA methyltransferase (DNMT) inhibitor. 5-Fluoro-2'-deoxycytidine is a tumor-selective proagent of the potent thymidylate synthase inhibitor 5-fluoro-2′-dUMP[1][2].

同义名列表

3 个代谢物同义名

5-Fluoro-2-deoxycytidine; 2-Deoxy-5-fluorcytidine; 5-Fluoro-2'-deoxycytidine



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Hung-Man Yu, Ching-Hung Chiu, Wei-Ting Chen, Chi-Han Wu, Pei-Yao Lin, Ya-Yao Huang, Jyun-Hong Chen, Kai-Yuan Tzen, Chyng-Yann Shiue, Wuu-Jyh Lin. Evaluation of 5-[18F]fluoro-2'-deoxycytidine as a tumor imaging agent: A comparison of [18F]FdUrd, [18F]FLT and [18F]FDG. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. 2019 Jun; 148(?):152-159. doi: 10.1016/j.apradiso.2019.03.034. [PMID: 30959352]
  • Julianne L Holleran, Jan H Beumer, David L McCormick, William D Johnson, Edward M Newman, James H Doroshow, Shivaani Kummar, Joseph M Covey, Myrtle Davis, Julie L Eiseman. Oral and intravenous pharmacokinetics of 5-fluoro-2'-deoxycytidine and THU in cynomolgus monkeys and humans. Cancer chemotherapy and pharmacology. 2015 Oct; 76(4):803-11. doi: 10.1007/s00280-015-2857-x. [PMID: 26321472]
  • Edward M Newman, Robert J Morgan, Shivaani Kummar, Jan H Beumer, M Suzette Blanchard, Christopher Ruel, Anthony B El-Khoueiry, Mary I Carroll, Jessie M Hou, Chun Li, Heinz J Lenz, Julie L Eiseman, James H Doroshow. A phase I, pharmacokinetic, and pharmacodynamic evaluation of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine, administered with tetrahydrouridine. Cancer chemotherapy and pharmacology. 2015 Mar; 75(3):537-46. doi: 10.1007/s00280-014-2674-7. [PMID: 25567350]
  • Jan H Beumer, Robert A Parise, Edward M Newman, James H Doroshow, Timothy W Synold, Heinz-Josef Lenz, Merrill J Egorin. Concentrations of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine (FdCyd) and its cytotoxic metabolites in plasma of patients treated with FdCyd and tetrahydrouridine (THU). Cancer chemotherapy and pharmacology. 2008 Jul; 62(2):363-8. doi: 10.1007/s00280-007-0603-8. [PMID: 17899082]
  • Jan H Beumer, Julie L Eiseman, Robert A Parise, Erin Joseph, Julianne L Holleran, Joseph M Covey, Merrill J Egorin. Pharmacokinetics, metabolism, and oral bioavailability of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine in mice. Clinical cancer research : an official journal of the American Association for Cancer Research. 2006 Dec; 12(24):7483-91. doi: 10.1158/1078-0432.ccr-06-1250. [PMID: 17138702]
  • D A Boothman, T V Briggle, S Greer. Tumor-selective metabolism of 5-fluoro-2'-deoxycytidine coadministered with tetrahydrouridine compared to 5-fluorouracil in mice bearing Lewis lung carcinoma. Cancer research. 1987 May; 47(9):2354-62. doi: . [PMID: 2952263]
  • D A Boothman, T V Briggle, S Greer. Protective, tumor-selective dual pathway activation of 5-fluoro-2'-deoxycytidine provided by tetrahydrouridine in mice bearing mammary adenocarcinoma-755. Cancer research. 1987 May; 47(9):2344-53. doi: . [PMID: 2436761]
  • M Iigo, Z Yamaizumi, S Nishimura, A Hoshi. Elevation of plasma levels of fluorinated pyrimidines by guanosine 5'-monophosphate. Cancer chemotherapy and pharmacology. 1987; 20(1):1-4. doi: 10.1007/bf00252949. [PMID: 3040286]