Levocetirizine dihydrochloride (BioDeep_00000679682)
代谢物信息卡片
Levocetirizine dihydrochloride
化学式: C21H27Cl3N2O3 (460.1087162)
中文名称: 盐酸左旋西替利嗪
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CN(CCN1CCOCC(=O)O)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl.Cl.Cl
InChI: /m1../s1
描述信息
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
Levocetirizine dihydrochloride ((R)-Cetirizine dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Levocetirizine dihydrochloride is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine dihydrochloride has a higher affinity for the histamine H1-receptor than (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria[1].
同义名列表
数据库引用编号
5 个数据库交叉引用编号
- KEGGdrug: D08118
- PubChem: 9955977
- ChEMBL: CHEMBL1201190
- CAS: 130018-87-0
- medchemexpress: HY-W010841
分类词条
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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INOH(0)
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文献列表
- Bruce Chandler May, Kathleen Holly Gallivan. Levocetirizine and montelukast in the COVID-19 treatment paradigm.
International immunopharmacology.
2022 Feb; 103(?):108412. doi:
10.1016/j.intimp.2021.108412. [PMID: 34942461] - Nida Naz, Saeeda Nadir Ali, Amtul Qayoom, Sajid Iqbal, Shumaila Akram. Rapid and sensitive method for simultaneous determination of citalopram with antihistamines by liquid chromatography.
Pakistan journal of pharmaceutical sciences.
2021 May; 34(3):835-841. doi:
. [PMID: 34602404] - Dipankar Bhattacharyya. Reposition of montelukast either alone or in combination with levocetirizine against SARS-CoV-2.
Medical hypotheses.
2020 Nov; 144(?):110046. doi:
10.1016/j.mehy.2020.110046. [PMID: 33254480] - Seol Ju Moon, Kyung-Sang Yu, Jina Jung, Yong-Il Kim, Min-Gul Kim. Comparative pharmacokinetics of a montelukast/levocetirizine fixed-dose combination chewable tablet versus individual administration of montelukast and levocetirizine after a single oral administration in healthy Korean male subjects
.
International journal of clinical pharmacology and therapeutics.
2020 Jun; 58(6):354-362. doi:
10.5414/cp203709. [PMID: 32271144] - Uriel Villela-Segura, Alessandra Irais Miranda-Aguirre, Lorena Estrada-Aguilar. Crateriform plaques in a patient with end-stage renal disease. The case of an acquired reactive perforating collagenosis.
Nefrologia.
2020 May; 40(3):358-360. doi:
10.1016/j.nefro.2019.04.005. [PMID: 31351699] - Priyanka Lohar, Manish Kumar Sharma, Amit Kumar Sahu, Rajeswari Rathod, Pinaki Sengupta. Simultaneous bioanalysis and pharmacokinetic interaction study of acebrophylline, levocetirizine and pranlukast in Sprague-Dawley rats.
Biomedical chromatography : BMC.
2019 Dec; 33(12):e4672. doi:
10.1002/bmc.4672. [PMID: 31386207] - Xianqiong Huang, Zhaoyang Li, Renshan Sun. High-dose levocetirizine for the treatment of refractory chronic spontaneous urticaria and the effect on the serum inositol triphosphate level.
The Journal of international medical research.
2019 Sep; 47(9):4374-4379. doi:
10.1177/0300060519857768. [PMID: 31342821] - Ravi Raj Pal, Poonam Parashar, Indu Singh, Shubhini A Saraf. Tamanu oil potentiated novel sericin emulgel of levocetirizine: repurposing for topical delivery against DNCB-induced atopic dermatitis, QbD based development and in vivo evaluation.
Journal of microencapsulation.
2019 Aug; 36(5):432-446. doi:
10.1080/02652048.2019.1637474. [PMID: 31238752] - Yu Cheng, Bi-Juan Lin, Jin-Hua Guo, Bing-Lin Huang, Lin-Ping Fang, Wan-Cai Que, Mao-Bai Liu, Xin-Feng Chen, Hong-Qiang Qiu. The Effect Of Food On The Pharmacokinetic Properties And Bioequivalence Of Two Formulations Of Levocetirizine Dihydrochloride In Healthy Chinese Volunteers.
Drug design, development and therapy.
2019; 13(?):3625-3634. doi:
10.2147/dddt.s215316. [PMID: 31695330] - Seokuee Kim, Jae-Wook Ko, Jung-Ryul Kim. Comparison of the pharmacokinetics and tolerability of montelukast/levocetirizine administered as a fixed-dose combination and as separate tablets.
International journal of clinical pharmacology and therapeutics.
2018 Sep; 56(9):443-450. doi:
10.5414/cp203265. [PMID: 30021691] - Saki Noguchi, Tomohiro Nishimura, Saya Mukaida, Leslie Z Benet, Emi Nakashima, Masatoshi Tomi. Cellular Uptake of Levocetirizine by Organic Anion Transporter 4.
Journal of pharmaceutical sciences.
2017 09; 106(9):2895-2898. doi:
10.1016/j.xphs.2017.03.026. [PMID: 28385546] - R Munoz-Cano, E Ainsua-Enrich, I Torres-Atencio, M Martin, J Sánchez-Lopez, J Bartra, C Picado, J Mullol, A Valero. Effects of Rupatadine on Platelet- Activating Factor-Induced Human Mast Cell Degranulation Compared With Desloratadine and Levocetirizine (The MASPAF Study).
Journal of investigational allergology & clinical immunology.
2017 ; 27(3):161-168. doi:
10.18176/jiaci.0117. [PMID: 27758758] - Hanan S Anbar, George S G Shehatou, Ghada M Suddek, Nariman M Gameil. Comparison of the effects of levocetirizine and losartan on diabetic nephropathy and vascular dysfunction in streptozotocin-induced diabetic rats.
European journal of pharmacology.
2016 Jun; 780(?):82-92. doi:
10.1016/j.ejphar.2016.03.035. [PMID: 27012991] - Han Young Eom, Myunghee Kang, Seung Woo Kang, Unyong Kim, Joon Hyuk Suh, Junghyun Kim, Hyun-Deok Cho, Yura Jung, Dong-Hyug Yang, Sang Beom Han. Rapid chiral separation of racemic cetirizine in human plasma using subcritical fluid chromatography-tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2016 Jan; 117(?):380-9. doi:
10.1016/j.jpba.2015.09.012. [PMID: 26440285] - Wisut Wichitnithad, Ponsiree Jithavech, Kingkan Sanphanya, Petploy Vicheantawatchai, Pornchai Rojsitthisak. Determination of levocetirizine in human plasma by LC-MS-MS: validation and application in a pharmacokinetic study.
Journal of chromatographic science.
2015 Nov; 53(10):1663-72. doi:
10.1093/chromsci/bmv069. [PMID: 26084706] - Se Hee Min, Anita Phung, Tae Jung Oh, Kyou-Sup Han, Man Jin Kim, Jee Min Kim, Ji Hyun Lee, Young Joo Park. Therapeutic Plasmapheresis Enabling Radioactive Iodine Treatment in a Patient with Thyrotoxicosis.
Journal of Korean medical science.
2015 Oct; 30(10):1531-4. doi:
10.3346/jkms.2015.30.10.1531. [PMID: 26425054] - Kotaro Hiraoka, Manabu Tashiro, Thomas Grobosch, Marcus Maurer, Keiichi Oda, Jun Toyohara, Kenji Ishii, Kiichi Ishiwata, Kazuhiko Yanai. Brain histamine H1 receptor occupancy measured by PET after oral administration of levocetirizine, a non-sedating antihistamine.
Expert opinion on drug safety.
2015 Feb; 14(2):199-206. doi:
10.1517/14740338.2015.989831. [PMID: 25466429] - Noha M Shawky, George S G Shehatou, Mona Abdel Rahim, Ghada M Suddek, Nariman M Gameil. Levocetirizine ameliorates high fructose diet-induced insulin resistance, vascular dysfunction and hepatic steatosis in rats.
European journal of pharmacology.
2014 Oct; 740(?):353-63. doi:
10.1016/j.ejphar.2014.07.021. [PMID: 25064340] - Nicole Schoepke, Martin K Church, Marcus Maurer. The inhibition by levocetirizine and fexofenadine of the histamine-induced wheal and flare response in healthy Caucasian and Japanese volunteers.
Acta dermato-venereologica.
2013 May; 93(3):286-93. doi:
10.2340/00015555-1490. [PMID: 23147964] - Maciej Ciebiada, Marcin Barylski, Malgorzata Gorska Ciebiada. Nasal eosinophilia and serum soluble intercellular adhesion molecule 1 in patients with allergic rhinitis treated with montelukast alone or in combination with desloratadine or levocetirizine.
American journal of rhinology & allergy.
2013 Mar; 27(2):e58-62. doi:
10.2500/ajra.2013.27.3881. [PMID: 23562192] - Ko-Haung Lue, Hai-Lun Sun, Ko-Hsiu Lu, Min-Sho Ku, Ji-Nan Sheu, Ching-Hui Chan, Yun-Hu Wang. A trial of adding Lactobacillus johnsonii EM1 to levocetirizine for treatment of perennial allergic rhinitis in children aged 7-12 years.
International journal of pediatric otorhinolaryngology.
2012 Jul; 76(7):994-1001. doi:
10.1016/j.ijporl.2012.03.018. [PMID: 22513081] - Jae Kuk Ryu, Sun Dong Yoo. Simultaneous determination of levocetirizine and pseudoephedrine in dog plasma by liquid chromatography-mass spectrometry in the presence of dextrocetirizine.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.
2012; 15(4):519-27. doi:
10.18433/j39c76. [PMID: 23106955] - Rituparna Maiti, Jyothirmai Jaida, B N Raghavendra, Prakash Goud, Idris Ahmed, Anuradha Palani. Rupatadine and levocetirizine in chronic idiopathic urticaria: a comparative study of efficacy and safety.
Journal of drugs in dermatology : JDD.
2011 Dec; 10(12):1444-50. doi:
NULL. [PMID: 22134570] - Hsing-Chuan Lee, Jin-Bon Hong, Chia-Yu Chu. Chronic idiopathic urticaria in Taiwan: a clinical study of demographics, aggravating factors, laboratory findings, serum autoreactivity and treatment response.
Journal of the Formosan Medical Association = Taiwan yi zhi.
2011 Mar; 110(3):175-82. doi:
10.1016/s0929-6646(11)60028-4. [PMID: 21497281] - Seung Woo Kang, Hae Jong Jang, Victor S Moore, Ji-Young Park, Kyoung-Ah Kim, Jeong-Rok Youm, Sang Beom Han. Enantioselective determination of cetirizine in human plasma by normal-phase liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2010 Dec; 878(32):3351-7. doi:
10.1016/j.jchromb.2010.10.019. [PMID: 21081290] - M Saeed Arayne, Najma Sultana, Agha Zeeshan Mirza, Farhan Ahmed Siddiqui. Simultaneous determination of gliquidone, fexofenadine, buclizine, and levocetirizine in dosage formulation and human serum by RP-HPLC.
Journal of chromatographic science.
2010 May; 48(5):382-5. doi:
10.1093/chromsci/48.5.382. [PMID: 20515533] - Xiangping Liu, Yingxiang Du, Wen Sun, Junping Kou, Boyang Yu. Study on the interaction of levocetirizine dihydrochloride with human serum albumin by molecular spectroscopy.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2009 Dec; 74(5):1189-96. doi:
10.1016/j.saa.2009.09.033. [PMID: 19857990] - Nuggehally R Srinivas. Stereoselective renal tubular secretion of cetirizine enantiomers--initial plasma and urine data analysis may hold the key.
Fundamental & clinical pharmacology.
2009 Oct; 23(5):537; author reply 538. doi:
10.1111/j.1472-8206.2009.00766_1.x. [PMID: 19702689] - Chih-Fang Lee, Hai-Lun Sun, Ko-Hsiu Lu, Min-Sho Ku, Ko-Huang Lue. The comparison of cetirizine, levocetirizine and placebo for the treatment of childhood perennial allergic rhinitis.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.
2009 Aug; 20(5):493-9. doi:
10.1111/j.1399-3038.2008.00816.x. [PMID: 19175892] - Cai-Yun Jin, Dong-Lian Wang, Zhi-De Fang. [Effect of integrative Chinese and Western medicine in treating chronic urticaria and its impact on interleukin-10 and interleukin-8 in peripheral blood].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2008 Apr; 28(4):358-60. doi:
". [PMID: 18543494] - Nelly Frossard, Margherita Strolin-Benedetti, Ashok Purohit, Gabrielle Pauli. Inhibition of allergen-induced wheal and flare reactions by levocetirizine and desloratadine.
British journal of clinical pharmacology.
2008 Feb; 65(2):172-9. doi:
10.1111/j.1365-2125.2007.03009.x. [PMID: 17953719] - M R Morita, D Berton, R Boldin, F A P Barros, E C Meurer, A R Amarante, D R Campos, S A Calafatti, R Pereira, E Abib, J Pedrazolli. Determination of levocetirizine in human plasma by liquid chromatography-electrospray tandem mass spectrometry: application to a bioequivalence study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2008 Feb; 862(1-2):132-9. doi:
10.1016/j.jchromb.2007.11.028. [PMID: 18162446] - M Strolin Benedetti, R Whomsley, F-X Mathy, P Jacques, P Espie, M Canning. Stereoselective renal tubular secretion of levocetirizine and dextrocetirizine, the two enantiomers of the H1-antihistamine cetirizine.
Fundamental & clinical pharmacology.
2008 Feb; 22(1):19-23. doi:
10.1111/j.1472-8206.2007.00543.x. [PMID: 18005357] - Chen Chen. Physicochemical, pharmacological and pharmacokinetic properties of the zwitterionic antihistamines cetirizine and levocetirizine.
Current medicinal chemistry.
2008; 15(21):2173-91. doi:
10.2174/092986708785747625. [PMID: 18781943] - Réginald Hulhoven, Dominique Rosillon, Michel Letiexhe, Marie-Anne Meeus, Agnès Daoust, Armel Stockis. Levocetirizine does not prolong the QT/QTc interval in healthy subjects: results from a thorough QT study.
European journal of clinical pharmacology.
2007 Nov; 63(11):1011-7. doi:
10.1007/s00228-007-0366-5. [PMID: 17891537] - Hannele Hasala, Mirkka Janka-Junttila, Eeva Moilanen, Hannu Kankaanranta. Levocetirizine and cytokine production and apoptosis of human eosinophils.
Allergy and asthma proceedings.
2007 Sep; 28(5):582-91. doi:
10.2500/aap2007.28.3045. [PMID: 18034979] - A Gupta, M Gillard, B Christophe, P Chatelain, R Massingham, M Hammarlund-Udenaes. Peripheral and central H1 histamine receptor occupancy by levocetirizine, a non-sedating antihistamine; a time course study in the guinea pig.
British journal of pharmacology.
2007 Aug; 151(7):1129-36. doi:
10.1038/sj.bjp.0707318. [PMID: 17558437] - M Caproni, W Volpi, B Giomi, D Torchia, E Del Bianco, P Fabbri. Cellular adhesion molecules in chronic urticaria: modulation of serum levels occurs during levocetirizine treatment.
The British journal of dermatology.
2006 Dec; 155(6):1270-4. doi:
10.1111/j.1365-2133.2006.07548.x. [PMID: 17107400] - M Gillard, M Strolin Benedetti, P Chatelain, E Baltes. Histamine H1 receptor occupancy and pharmacodynamics of second generation H1-antihistamines.
Inflammation research : official journal of the European Histamine Research Society ... [et al.].
2005 Sep; 54(9):367-9. doi:
10.1007/s00011-005-1368-3. [PMID: 16273334] - Giovanni Passalacqua, Giorgio Walter Canonica. A review of the evidence from comparative studies of levocetirizine and desloratadine for the symptoms of allergic rhinitis.
Clinical therapeutics.
2005 Jul; 27(7):979-92. doi:
10.1016/j.clinthera.2005.07.011. [PMID: 16154477] - Stephen Holgate, Richard Powell, Maureen Jenkins, Omar Ali. A treatment for allergic rhinitis: a view on the role of levocetirizine.
Current medical research and opinion.
2005 Jul; 21(7):1099-106. doi:
10.1185/030079905x53298. [PMID: 16004679] - N Cranswick, J Turzíkova, M Fuchs, R Hulhoven. Levocetirizine in 1-2 year old children: pharmacokinetic and pharmacodynamic profile.
International journal of clinical pharmacology and therapeutics.
2005 Apr; 43(4):172-7. doi:
10.5414/cpp43172. [PMID: 15966463] - F Estelle R Simons. Population pharmacokinetics of levocetirizine in very young children: the pediatricians' perspective.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.
2005 Mar; 16(2):97-103. doi:
10.1111/j.1399-3038.2005.00240.x. [PMID: 15787865] - Ziad Hussein, Maria Pitsiu, Oneeb Majid, Leon Aarons, Marc de Longueville, Armel Stockis. Retrospective population pharmacokinetics of levocetirizine in atopic children receiving cetirizine: the ETAC study.
British journal of clinical pharmacology.
2005 Jan; 59(1):28-37. doi:
10.1111/j.1365-2125.2005.02242.x. [PMID: 15606437] - M Molimard, B Diquet, M Strolin Benedetti. Comparison of pharmacokinetics and metabolism of desloratadine, fexofenadine, levocetirizine and mizolastine in humans.
Fundamental & clinical pharmacology.
2004 Aug; 18(4):399-411. doi:
10.1111/j.1472-8206.2004.00254.x. [PMID: 15312146] - Françoise Bree, Laetitia Thiault, Gwenaelle Gautiers, Margherita Strolin Benedetti, Eugène Baltes, Jean-Pierre Rihoux, Jean-Paul Tillement. Blood distribution of levocetirizine, a new non-sedating histamine H1-receptor antagonist, in humans.
Fundamental & clinical pharmacology.
2002 Dec; 16(6):471-8. doi:
10.1046/j.1472-8206.2002.00111.x. [PMID: 12685505]