Imipenem (BioDeep_00000679641)
代谢物信息卡片
Imipenem hydrate
化学式: C12H19N3O5S (317.10453640000003)
中文名称: 亚胺培南(一水物), 亚胺培南
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C1C2CC(=C(N2C1=O)C(=O)O)SCCN=CN)O.O
InChI: /m1./s1
描述信息
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D013845 - Thienamycins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
同义名列表
2 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:51799
- KEGGdrug: D00206
- PubChem: 5282372
- ChEMBL: CHEMBL43708
- MeSH: Imipenem
- CAS: 74431-23-5
- CAS: 64221-86-9
- MetaboLights: MTBLC51799
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yue Zhang, Di Wu, Qishun Sun, Zhen Luo, Yuhao Zhang, Bowei Wang, Wenting Chen. Atorvastatin combined with imipenem alleviates lung injury in sepsis by inhibiting neutrophil extracellular trap formation via the ERK/NOX2 signaling pathway.
Free radical biology & medicine.
2024 Aug; 220(?):179-191. doi:
10.1016/j.freeradbiomed.2024.05.006. [PMID: 38704053] - Mamadou Ouango, Hama Cissé, Rahim Romba, Samuel Fogné Drabo, Rasmané Semdé, Aly Savadogo, Olivier Gnankiné. Entomotherapy as an alternative treatment for diseases due to Gram-negative bacteria in Burkina Faso.
Scientific reports.
2024 01; 14(1):7. doi:
10.1038/s41598-023-50622-2. [PMID: 38167478] - Ying Liu, Rui Zhu, Xinwei Liu, Dengzhou Li, Mengyu Guo, Bing Fei, Yanying Ren, Xiaojuan You, Yongwei Li. Effect of piperine on the inhibitory potential of MexAB-OprM efflux pump and imipenem resistance in carbapenem-resistant Pseudomonas aeruginosa.
Microbial pathogenesis.
2023 Dec; 185(?):106397. doi:
10.1016/j.micpath.2023.106397. [PMID: 37852553] - Fan Wu, Ting Zhao, Yu Zhang, Yan Wang, Guoxin Liao, Baojing Zhang, Chao Wang, Xiangge Tian, Lei Feng, Bangjiang Fang, Xiaokui Huo, Xiaochi Ma. Beneficial herb-drug interaction of rhein in Jinhongtang and Imipenem/Cilastatin mediated by organic anion transporters.
Journal of ethnopharmacology.
2023 Apr; ?(?):116449. doi:
10.1016/j.jep.2023.116449. [PMID: 37023835] - Shruti Kashyap, Harsimran Sidhu, Prince Sharma, Neena Capalash. 3-indoleacetonitrile attenuates biofilm formation and enhances sensitivity to imipenem in Acinetobacter baumannii.
Pathogens and disease.
2022 08; 80(1):. doi:
10.1093/femspd/ftac029. [PMID: 35867872] - Nikhil Sadashiv Shetty, Arvind Karikal, Sharanya Menon Radhakrishnan. Melioidosis: an unusual diagnosis for deep temporal and masticatory space infection following trauma.
BMJ case reports.
2022 Jun; 15(6):. doi:
10.1136/bcr-2022-248866. [PMID: 35732363] - Nadheema Hammood Hussein, Sawsan Mohammed Kareem, Sanaa Noori Hussein Al-Kakei, Buthainah Mohammed Taha. The predominance of Klebsiella pneumoniae carbapenemase (KPC-type) gene among high-level carbapenem-resistant Klebsiella pneumoniae isolates in Baghdad, Iraq.
Molecular biology reports.
2022 Jun; 49(6):4653-4658. doi:
10.1007/s11033-022-07314-3. [PMID: 35471622] - Volodymyr Volodymyrovych Bezruk, Igor Dmytrovych Shkrobanets, Oleksii Serhiiovych Godovanets, Oleksandr Hryhorovych Buriak, Olga Ivanivna Pervozvanska, Ludmila Mykhailivna Honcharuk, Nina Ivanivna Voytkevich, Olena Victorivna Makarova, Oksana Ivanivna Yurkiv, Michael Ivanovych Sheremet, Mykhailo Mykhailovich Hresko, Mariya Ivanivna Velia, Svyatoslava Vasylivna Yurniuk, Maryna Dmytrivna Hresko, Tetiana Sergiivna Bulyk, Larysa Vasylyvna Rynzhuk. Management of antibacterial therapy of infectious and inflammatory diseases of the urinary tract in children and regional peculiarities during the COVID-19 pandemic.
Journal of medicine and life.
2022 May; 15(5):617-619. doi:
10.25122/jml-2021-0293. [PMID: 35815078] - Shahbaz Ahmad, Farooq Ali, Sadaf Anwar Qureshi, Bibi Uzma, Qismat Shakeela, Muhammad Shehryar Sabir, Sajjad Ahmad, Ijazul Haq, Atia Rasheed, Shehzad Ahmed, Muhammad Farooq. The evaluation of antibiotic susceptibility pattern and associated risk factors of UTI in tertiary care hospital of Peshawar.
Pakistan journal of pharmaceutical sciences.
2022 May; 35(3(Special)):897-903. doi:
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Drugs.
2022 Apr; 82(5):533-557. doi:
10.1007/s40265-022-01688-1. [PMID: 35294769] - Yannan Pan, Bing Liu, Junmeng Liu, Wei Zhuang, Qing He, Ming Lan. Clopidogrel-induced neutropenia in an 80-year-old patient with chronic kidney disease who underwent percutaneous coronary intervention: a case report and literature review.
BMC cardiovascular disorders.
2022 02; 22(1):40. doi:
10.1186/s12872-022-02490-3. [PMID: 35148681] - Fahima Bekka-Hadji, Isabelle Bombarda, Ferhat Djoudi, Sofiane Bakour, Abdelaziz Touati. Chemical Composition and Synergistic Potential of Mentha pulegium L. and Artemisia herba alba Asso. Essential Oils and Antibiotic against Multi-Drug Resistant Bacteria.
Molecules (Basel, Switzerland).
2022 Feb; 27(3):. doi:
10.3390/molecules27031095. [PMID: 35164360] - Kim Dao, Aline Fuchs, Pascal André, Eric Giannoni, Laurent A Decosterd, Oscar Marchetti, Sandra A Asner, Marc Pfister, Nicolas Widmer, Thierry Buclin, Chantal Csajka, Monia Guidi. Dosing strategies of imipenem in neonates based on pharmacometric modelling and simulation.
The Journal of antimicrobial chemotherapy.
2022 02; 77(2):457-465. doi:
10.1093/jac/dkab394. [PMID: 34791295] - Zhezhe Lin, Jianhua Yu, Shourong Liu, Mingli Zhu. Prevalence and antibiotic resistance of Klebsiella pneumoniae in a tertiary hospital in Hangzhou, China, 2006-2020.
The Journal of international medical research.
2022 Feb; 50(2):3000605221079761. doi:
10.1177/03000605221079761. [PMID: 35216543] - Robert Włodarski, Karolina Żuchowska, Wojciech Filipiak. Quantitative Determination of Unbound Piperacillin and Imipenem in Biological Material from Critically Ill Using Thin-Film Microextraction-Liquid Chromatography-Mass Spectrometry.
Molecules (Basel, Switzerland).
2022 Jan; 27(3):. doi:
10.3390/molecules27030926. [PMID: 35164191] - Tian Wei, Chengyun Zou, Jie Qin, Jianmin Tao, Li Yan, Jiangjun Wang, Hong Du, Fang Shen, Yanqin Zhao, Haiying Wang. Emergence of Hypervirulent ST11-K64 Klebsiella pneumoniae Poses a Serious Clinical Threat in Older Patients.
Frontiers in public health.
2022; 10(?):765624. doi:
10.3389/fpubh.2022.765624. [PMID: 35309213] - Li Peng, Xinyu Wang, Hongwan Dang. Simultaneous determination of meropenem and imipenem in rat plasma by LC-MS/MS and its application to a pharmacokinetic study.
Biomedical chromatography : BMC.
2021 Nov; 35(11):e5185. doi:
10.1002/bmc.5185. [PMID: 34060114] - Elaine D Por, Kevin S Akers, Kevin K Chung, Jeffrey R Livezey, Daniel J Selig. Population Pharmacokinetic Modeling and Simulations of Imipenem in Burn Patients With and Without Continuous Venovenous Hemofiltration in the Military Health System.
Journal of clinical pharmacology.
2021 09; 61(9):1182-1194. doi:
10.1002/jcph.1865. [PMID: 33811332] - Sutep Jaruratanasirikul, Apinya Boonpeng, Monchana Nawakitrangsan, Maseetoh Samaeng. NONMEM population pharmacokinetics and Monte Carlo dosing simulations of imipenem in critically ill patients with life-threatening severe infections during support with or without extracorporeal membrane oxygenation in an intensive care unit.
Pharmacotherapy.
2021 07; 41(7):572-597. doi:
10.1002/phar.2597. [PMID: 34080708] - Junying Ding, Xiang Gao, Hong Gui, Xuefei Ding, Youran Lu, Shidong An, Qingquan Liu. Proteomic Analysis of Proteins Associated with Inhibition of Pseudomonas aeruginosa Resistance to Imipenem Mediated by the Chinese Herbal Medicine Qi Gui Yin.
Microbial drug resistance (Larchmont, N.Y.).
2021 Apr; 27(4):462-470. doi:
10.1089/mdr.2020.0110. [PMID: 32924788] - Arezou Khosrojerdi, Sara Soudi, Ahmad Zavaran Hosseini, Sahar Ghaffari Khaligh, Seyed Mahmoud Hashemi. Imipenem alters systemic and liver inflammatory responses in CLP- induced sepsis mice in a dose-dependent manner.
International immunopharmacology.
2021 Apr; 93(?):107421. doi:
10.1016/j.intimp.2021.107421. [PMID: 33548581] - Ci Han, Nana Guo, Yue Bu, Yahui Peng, Xueting Li, Xiaohui Ma, Mengyuan Yang, Xiaonan Jia, Jin Zhang, Xiaowei Liu, Kaijiang Yu, Changsong Wang. Intestinal microbiota and antibiotic-associated acute gastrointestinal injury in sepsis mice.
Aging.
2021 03; 13(7):10099-10111. doi:
10.18632/aging.202768. [PMID: 33818419] - Matilde Zaballos, Mercedes Power, María Iluminada Canal-Alonso, María Ángeles González-Nicolás, Wenceslao Vasquez-Jimenez, Pablo Lozano-Lominchar, Pilar Cabrerizo-Torrente, Natividad Palencia-García, Susana Gago-Quiroga, María Dolores Ginel-Feito, Consuelo Jiménez, Alberto Lázaro, Luis González-Bayón. Effect of Cilastatin on Cisplatin-Induced Nephrotoxicity in Patients Undergoing Hyperthermic Intraperitoneal Chemotherapy.
International journal of molecular sciences.
2021 Jan; 22(3):. doi:
10.3390/ijms22031239. [PMID: 33513824] - Sutep Jaruratanasirikul, Veerapong Vattanavanit, Wibul Wongpoowarak, Monchana Nawakitrangsan, Maseetoh Samaeng. Pharmacokinetics and Monte Carlo Dosing Simulations of Imipenem in Critically Ill Patients with Life-Threatening Severe Infections During Support with Extracorporeal Membrane Oxygenation.
European journal of drug metabolism and pharmacokinetics.
2020 Dec; 45(6):735-747. doi:
10.1007/s13318-020-00643-3. [PMID: 32886347] - Iris H Chen, David P Nicolau, Joseph L Kuti. Imipenem/Cilastatin/Relebactam Alone and in Combination against Pseudomonas aeruginosa in the In Vitro Pharmacodynamic Model.
Antimicrobial agents and chemotherapy.
2020 11; 64(12):. doi:
10.1128/aac.01764-20. [PMID: 33139283] - Li Su, Ye Tu, De-Pei Kong, Da-Gui Chen, Chen-Xi Zhang, Wan-Nian Zhang, Chun-Lin Zhuang, Zhi-Bin Wang. Drug repurposing of anti-infective clinical drugs: Discovery of two potential anti-cytokine storm agents.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Nov; 131(?):110643. doi:
10.1016/j.biopha.2020.110643. [PMID: 32846329] - Weishuai Bian, Wei Chen, Xuyun Gu, Suozhu Wang, Yang Liu, Guomin Zhao, Yujun Qin. [Analysis of related factors of carbapenem resistant Klebsiella pneumoniae infection in patients with artificial airway].
Zhonghua wei zhong bing ji jiu yi xue.
2020 Nov; 32(11):1324-1330. doi:
10.3760/cma.j.cn121430-20200601-00431. [PMID: 33463491] - Xiaokui Huo, Qiang Meng, Changyuan Wang, Jingjing Wu, Yanna Zhu, Pengyuan Sun, Xiaodong Ma, Huijun Sun, Kexin Liu. Targeting renal OATs to develop renal protective agent from traditional Chinese medicines: Protective effect of Apigenin against Imipenem-induced nephrotoxicity.
Phytotherapy research : PTR.
2020 Nov; 34(11):2998-3010. doi:
10.1002/ptr.6727. [PMID: 32468621] - Taisuke Kuroda, Shun-Ichi Nagata, Norihisa Tamura, Yuta Kinoshita, Hidekazu Niwa, Hiroshi Mita, Takuto Minami, Kentaro Fukuda, Seiji Hobo, Atsutoshi Kuwano. Single-dose pharmacokinetics of orally administered metronidazole and intravenously administered imipenem in healthy horses and computer-based simulation of pleural fluid concentrations with multiple dosing.
American journal of veterinary research.
2020 Oct; 81(10):783-789. doi:
10.2460/ajvr.81.10.783. [PMID: 32969731] - Narges Fatemi, Mohammad Reza Sharifmoghadam, Masoumeh Bahreini, Bahman Khameneh, Hanieh Shadifar. Antibacterial and Synergistic Effects of Herbal Extracts in Combination with Amikacin and Imipenem Against Multidrug-Resistant Isolates of Acinetobacter.
Current microbiology.
2020 Sep; 77(9):1959-1967. doi:
10.1007/s00284-020-02105-0. [PMID: 32623484] - Zhi Rao, Zi-Long Dang, Bin Li, Lei Zhu, Hong-Yan Qin, Xin-An Wu, Yu-Hui Wei. Determination of Total and Unbound Meropenem, Imipenem/Cilastatin, and Cefoperazone/Sulbactam in Human Plasma: Application for Therapeutic Drug Monitoring in Critically Ill Patients.
Therapeutic drug monitoring.
2020 08; 42(4):578-587. doi:
10.1097/ftd.0000000000000736. [PMID: 32049891] - Zhe Li, Jing Bai, Aiping Wen, Su Shen, Meili Duan, Xingang Li. Pharmacokinetic and Pharmacodynamic Analysis of Critically Ill Patients Undergoing Continuous Renal Replacement Therapy With Imipenem.
Clinical therapeutics.
2020 08; 42(8):1564-1577.e8. doi:
10.1016/j.clinthera.2020.06.010. [PMID: 32741646] - Sophia Rehm, Katharina M Rentsch. HILIC LC-MS/MS method for the quantification of cefepime, imipenem and meropenem.
Journal of pharmaceutical and biomedical analysis.
2020 Jul; 186(?):113289. doi:
10.1016/j.jpba.2020.113289. [PMID: 32428767] - Femke de Velde, Brenda C M de Winter, Michael N Neely, Walter M Yamada, Birgit C P Koch, Stephan Harbarth, Elodie von Dach, Teun van Gelder, Angela Huttner, Johan W Mouton. Population Pharmacokinetics of Imipenem in Critically Ill Patients: A Parametric and Nonparametric Model Converge on CKD-EPI Estimated Glomerular Filtration Rate as an Impactful Covariate.
Clinical pharmacokinetics.
2020 07; 59(7):885-898. doi:
10.1007/s40262-020-00859-1. [PMID: 31956969] - Deepjyoti Paul, Debadatta Dhar Chanda, Atanu Chakravarty, Amitabha Bhattacharjee. An insight into analysis and elimination of plasmids encoding metallo-β-lactamases in Pseudomonas aeruginosa.
Journal of global antimicrobial resistance.
2020 06; 21(?):3-7. doi:
10.1016/j.jgar.2019.09.002. [PMID: 31518725] - Ling Song, Zhiheng Yu, Yifan Xu, Xiaobei Li, Xuanlin Liu, Dongyang Liu, Tianyan Zhou. Preliminary physiologically based pharmacokinetic modeling of renally cleared drugs in Chinese pregnant women.
Biopharmaceutics & drug disposition.
2020 Jun; 41(6):248-267. doi:
10.1002/bdd.2243. [PMID: 32520400] - Sharon Akinpelu, Abraham Ajayi, Stella I Smith, Adeyemi I Adeleye. Efflux pump activity, biofilm formation and antibiotic resistance profile of Klebsiella spp. isolated from clinical samples at Lagos University Teaching Hospital.
BMC research notes.
2020 May; 13(1):258. doi:
10.1186/s13104-020-05105-2. [PMID: 32456668] - Yingzi Huang, Kang Xu, Ying Zhan, Xian Zha, Songqiao Liu, Jianfeng Xie, Lin Liu, Qing Li, Hua Shao, Yi Yang. Comparable Effect of Two-Step Versus Extended Infusions on the Pharmacokinetics of Imipenem in Patients with Sepsis and Septic Shock.
Advances in therapy.
2020 05; 37(5):2246-2255. doi:
10.1007/s12325-020-01339-5. [PMID: 32277344] - Pratik Bhagunde, Francheska Colon-Gonzalez, Yang Liu, Jin Wu, Shiyao Sherrie Xu, Graigory Garrett, Patricia Jumes, Kenneth Lasseter, Thomas Marbury, Matthew L Rizk, Mallika Lala, Elizabeth G Rhee, Joan R Butterton, Keith Boundy. Impact of renal impairment and human organic anion transporter inhibition on pharmacokinetics, safety and tolerability of relebactam combined with imipenem and cilastatin.
British journal of clinical pharmacology.
2020 05; 86(5):944-957. doi:
10.1111/bcp.14204. [PMID: 31856304] - Keith S Kaye, Helen W Boucher, Michelle L Brown, Angela Aggrey, Ireen Khan, Hee-Koung Joeng, Robert W Tipping, Jiejun Du, Katherine Young, Joan R Butterton, Amanda Paschke. Comparison of Treatment Outcomes between Analysis Populations in the RESTORE-IMI 1 Phase 3 Trial of Imipenem-Cilastatin-Relebactam versus Colistin plus Imipenem-Cilastatin in Patients with Imipenem-Nonsusceptible Bacterial Infections.
Antimicrobial agents and chemotherapy.
2020 04; 64(5):. doi:
10.1128/aac.02203-19. [PMID: 32094127] - Rasha M M Khairy, Mahmoud Shokry Mahmoud, Raghda Raouf Shady, Mona Abdel Monem Esmail. Multidrug-resistant Klebsiella pneumoniae in hospital-acquired infections: Concomitant analysis of antimicrobial resistant strains.
International journal of clinical practice.
2020 Apr; 74(4):e13463. doi:
10.1111/ijcp.13463. [PMID: 31830351] - Kai-Chih Chang, Ya-Yun Cheng, Meng-Jiun Lai, Anren Hu. Identification of carbonylated proteins in a bactericidal process induced by curcumin with blue light irradiation on imipenem-resistant Acinetobacter baumannii.
Rapid communications in mass spectrometry : RCM.
2020 Apr; 34 Suppl 1(?):e8548. doi:
10.1002/rcm.8548. [PMID: 31397940] - Yingzi Huang, Jie Yang, Jianfeng Xie, Ling Liu, Songqiao Liu, Fengmei Guo, Haibo Qiu, Yi Yang. Association Between Pathophysiology and Volume of Distribution Among Patients With Sepsis or Septic Shock Treated With Imipenem: A Prospective Cohort Study.
The Journal of infectious diseases.
2020 03; 221(Suppl 2):S272-S278. doi:
10.1093/infdis/jiz651. [PMID: 32176787] - Baochao Ji, Guoqing Li, Xiaogang Zhang, Yang Wang, Wenbo Mu, Li Cao. Effective treatment of single-stage revision using intra-articular antibiotic infusion for culture-negative prosthetic joint infection.
The bone & joint journal.
2020 Mar; 102-B(3):336-344. doi:
10.1302/0301-620x.102b3.bjj-2019-0820.r1. [PMID: 32114816] - Wenxia Zhang, Yan Guo, Yang Yang, Dong Dong, Yonggui Zheng, Demei Zhu, Fupin Hu. Study of In Vitro Synergistic Bactericidal Activity of Dual β-Lactam Antibiotics Against KPC-2-Producing Klebsiella pneumoniae.
Microbial drug resistance (Larchmont, N.Y.).
2020 Mar; 26(3):204-210. doi:
10.1089/mdr.2019.0126. [PMID: 31553260] - Wafaa Jamal, Fatima Bibi Khodakhast, Ameerah AlAzmi, Jόzsef Sόki, Ghayda AlHashem, Vincent O Rotimi. Prevalence and antimicrobial susceptibility of enterotoxigenic extra-intestinal Bacteroides fragilis among 13-year collection of isolates in Kuwait.
BMC microbiology.
2020 01; 20(1):14. doi:
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Annals of clinical microbiology and antimicrobials.
2019 Dec; 18(1):41. doi:
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Water research.
2019 Dec; 166(?):115037. doi:
10.1016/j.watres.2019.115037. [PMID: 31494490] - Niloofar Hassannejad, Abbas Bahador, Nasim Hayati Rudbari, Mohammad Hossein Modarressi, Kazem Parivar. In vivo antibacterial activity of Zataria multiflora Boiss extract and its components, carvacrol, and thymol, against colistin-resistant Acinetobacter baumannii in a pneumonic BALB/c mouse model.
Journal of cellular biochemistry.
2019 11; 120(11):18640-18649. doi:
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Xenobiotica; the fate of foreign compounds in biological systems.
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CPT: pharmacometrics & systems pharmacology.
2019 10; 8(10):748-758. doi:
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International journal of molecular sciences.
2019 Jul; 20(14):. doi:
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Journal of pharmaceutical and biomedical analysis.
2019 May; 169(?):142-150. doi:
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Proceedings of the National Academy of Sciences of the United States of America.
2019 03; 116(13):6226-6231. doi:
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Toxicology.
2019 03; 416(?):44-53. doi:
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Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.
2019 Mar; 25(3):383.e1-383.e4. doi:
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International journal of antimicrobial agents.
2019 Feb; 53(2):190-194. doi:
10.1016/j.ijantimicag.2018.10.024. [PMID: 30391645] - Sanwang Li, Feifan Xie. Population pharmacokinetics and simulations of imipenem in critically ill patients undergoing continuous renal replacement therapy.
International journal of antimicrobial agents.
2019 Jan; 53(1):98-105. doi:
10.1016/j.ijantimicag.2018.10.006. [PMID: 30626495] - Ying Jiang, Jun Li, Yingrui Zhang, Xinlan Hu, Xiaoguang Zhang, Xiuling Shang, Shurong Gong, Rongguo Yu. Clinical Situations of Bacteriology and Prognosis in Patients with Urosepsis.
BioMed research international.
2019; 2019(?):3080827. doi:
10.1155/2019/3080827. [PMID: 30881985] - Rania Ben Helal, Raoudha Dziri, Meriem Chedly, Naouel Klibi, Farouk Barguellil, Mohamed Selim El Asli, Mohamed Ben Moussa. Occurrence and Characterization of Carbapenemase-Producing Enterobacteriaceae in a Tunisian Hospital.
Microbial drug resistance (Larchmont, N.Y.).
2018 Nov; 24(9):1361-1367. doi:
10.1089/mdr.2018.0013. [PMID: 29596032] - Varsha Rani Gajamer, Amitabha Bhattacharjee, Deepjyoti Paul, Chandrayee Deshamukhya, Ashish Kr Singh, Nilu Pradhan, Hare Krishna Tiwari. Escherichia coli encoding blaNDM-5 associated with community-acquired urinary tract infections with unusual MIC creep-like phenomenon against imipenem.
Journal of global antimicrobial resistance.
2018 09; 14(?):228-232. doi:
10.1016/j.jgar.2018.05.004. [PMID: 29775789] - Antonio Morales, Manuel Campos, Jose M Juarez, Bernardo Canovas-Segura, Francisco Palacios, Roque Marin. A decision support system for antibiotic prescription based on local cumulative antibiograms.
Journal of biomedical informatics.
2018 08; 84(?):114-122. doi:
10.1016/j.jbi.2018.07.003. [PMID: 29981885] - Amit Vikram, John W Schmidt. Functional blaKPC-2 Sequences Are Present in U.S. Beef Cattle Feces Regardless of Antibiotic Use.
Foodborne pathogens and disease.
2018 07; 15(7):444-448. doi:
10.1089/fpd.2017.2406. [PMID: 29672169] - Junting Yang, Shunwen Zhang, Jiangdong Wu, Jie Zhang, Jiangtao Dong, Peng Guo, Suyu Tang, Wanjiang Zhang, Fang Wu. Imipenem and normal saline with cyclophosphamide have positive effects on the intestinal barrier in rats with sepsis.
Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia.
2018 Jun; 162(2):90-98. doi:
10.5507/bp.2018.032. [PMID: 29935492] - Hao-Yuan Lee, Shih-Yun Hsu, Jen-Fu Hsu, Chyi-Liang Chen, Yi-Hsin Wang, Cheng-Hsun Chiu. Risk factors and molecular epidemiology of Acinetobacter baumannii bacteremia in neonates.
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi.
2018 Jun; 51(3):367-376. doi:
10.1016/j.jmii.2017.07.013. [PMID: 28830746] - Saeed Shams, Ali Hashemi, Mohammad Esmkhani, Somaye Kermani, Elham Shams, Alessandra Piccirillo. Imipenem resistance in clinical Escherichia coli from Qom, Iran.
BMC research notes.
2018 May; 11(1):314. doi:
10.1186/s13104-018-3406-6. [PMID: 29776449] - Talles Prosperi de Paula, Patrícia Campi Santos, Raquel Duque do Nascimento Arifa, Angélica T Vieira, Ludmila de Matos Baltazar, Thiago Vinícius Ávila, Caio Tavares Fagundes, Zélia Menezes Garcia, Renata Lacerda Lima, Mauro Martins Teixeira, Danielle G Souza. Treatment with Atorvastatin Provides Additional Benefits to Imipenem in a Model of Gram-Negative Pneumonia Induced by Klebsiella pneumoniae in Mice.
Antimicrobial agents and chemotherapy.
2018 05; 62(5):. doi:
10.1128/aac.00764-17. [PMID: 29463546] - Weihong Shi, Mingyang Duan, Ligang Jie, Weifeng Sun. A successful treatment of severe systemic lupus erythematosus caused by occult pulmonary infection-associated with hemophagocytic syndrome: A case report.
Medicine.
2018 May; 97(19):e0595. doi:
10.1097/md.0000000000010595. [PMID: 29742693] - Hiromu Takemura, Shigemi Terakubo, Ninyo Okamura, Hideki Nakashima. The reduction of l-cystine to l-cysteine in the supernatant of A549 cell culture causes imipenem inactivation.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2018 May; 24(5):341-346. doi:
10.1016/j.jiac.2017.10.020. [PMID: 29496335] - Manal Mohamed Elhassan Taha, Hisham Elraih Homeida, Omer Mohammed Elhassan Dafalla, Siddig Ibrahim Abdelwahab. Multidrug resistance, prevalence and phylogenetic analysis of genes encoding class II and III integrons in clinically isolated Escherichia coli.
Cellular and molecular biology (Noisy-le-Grand, France).
2018 Apr; 64(5):122-126. doi:
10.14715/cmb/2018.64.5.21. [PMID: 29729705] - Matthew L Rizk, Elizabeth G Rhee, Patricia A Jumes, Mark H Gotfried, Tian Zhao, Eric Mangin, Sheng Bi, Cynthia M Chavez-Eng, Zufei Zhang, Joan R Butterton. Intrapulmonary Pharmacokinetics of Relebactam, a Novel β-Lactamase Inhibitor, Dosed in Combination with Imipenem-Cilastatin in Healthy Subjects.
Antimicrobial agents and chemotherapy.
2018 03; 62(3):. doi:
10.1128/aac.01411-17. [PMID: 29311084] - Takaya Segawa, Tsuyoshi Sekizuka, Satowa Suzuki, Keigo Shibayama, Mari Matsui, Makoto Kuroda. The plasmid-encoded transcription factor ArdK contributes to the repression of the IMP-6 metallo-β-lactamase gene blaIMP-6, leading to a carbapenem-susceptible phenotype in the blaIMP-6-positive Escherichia coli strain A56-1S.
PloS one.
2018; 13(12):e0208976. doi:
10.1371/journal.pone.0208976. [PMID: 30533034] - Roya Ghanavati, Elnaz Ohadi, Hossein Kazemian, Fateme Yazdani, Alireza Torki, Behrooz S Kalani, Gholamreza Irajian. Evaluation of Fosfomycin Activity Against Extended Spectrum Beta Lactamase (ESBL) Producing Enterobacteriaceae Isolated from Three Centers of Tehran, Iran.
Recent patents on anti-infective drug discovery.
2018; 13(2):180-186. doi:
10.2174/1574891x13666180517075803. [PMID: 29769010] - Alejandro Cabrera Reina, Ana B Martínez-Piernas, Yannis Bertakis, Christina Brebou, Nikolaos P Xekoukoulotakis, Ana Agüera, José Antonio Sánchez Pérez. Photochemical degradation of the carbapenem antibiotics imipenem and meropenem in aqueous solutions under solar radiation.
Water research.
2018 01; 128(?):61-70. doi:
10.1016/j.watres.2017.10.047. [PMID: 29091805] - Abeer M Rababa’h, Tamara B Hijjawi, Karem H Alzoubi, Saddam Al Demour, Mera A Ababneh. The Nephroprotective Effect of N-Acetyl-L-Cysteine and Atorvastatin against Imipenem induced Nephrotoxicity.
Current molecular pharmacology.
2018; 11(2):155-161. doi:
10.2174/1874467210666170731115928. [PMID: 28762308] - Gabriel Hundeshagen, David N Herndon, Karel D Capek, Ludwik K Branski, Charles D Voigt, Elizabeth A Killion, Janos Cambiaso-Daniel, Michaela Sljivich, Andrew De Crescenzo, Ronald P Mlcak, Michael P Kinsky, Celeste C Finnerty, William B Norbury. Co-administration of vancomycin and piperacillin-tazobactam is associated with increased renal dysfunction in adult and pediatric burn patients.
Critical care (London, England).
2017 12; 21(1):318. doi:
10.1186/s13054-017-1899-3. [PMID: 29262848] - C Melexopoulou, I D Pavlopoulou, A Zormpala, G L Daikos, J N Boletis, S Marinaki. Syndrome of Inappropriate Antidiuretic Hormone Secretion Complicating Systemic Nocardiosis in a Renal Transplant Recipient: A Case Report.
Transplantation proceedings.
2017 Dec; 49(10):2368-2371. doi:
10.1016/j.transproceed.2017.09.015. [PMID: 29198680] - Amal Tahri, Kamilia Ksouda, Rim Kallel, Salima Daoud, Tahia Boudawara, Khaled Mounir Zeghal, Zouheir Sahnoun. A carbapenem antibiotic imipenem/cilastatin induces an oxidative stress-status and gonadotoxic effects in « wistar » rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 Nov; 95(?):308-316. doi:
10.1016/j.biopha.2017.08.039. [PMID: 28858728] - Shi-Wei Liu, Xiao-Yang Xu, Jie Xu, Jiu-Yun Yuan, Wei-Kang Wu, Ning Zhang, Ze-Liang Chen. Multi-drug resistant uropathogenic Escherichia coli and its treatment by Chinese medicine.
Chinese journal of integrative medicine.
2017 Oct; 23(10):763-769. doi:
10.1007/s11655-016-2738-0. [PMID: 28028717] - Krishus Nepal, Narayan Dutt Pant, Bibhusan Neupane, Ankit Belbase, Rikesh Baidhya, Ram Krishna Shrestha, Binod Lekhak, Dwij Raj Bhatta, Bharat Jha. Extended spectrum beta-lactamase and metallo beta-lactamase production among Escherichia coli and Klebsiella pneumoniae isolated from different clinical samples in a tertiary care hospital in Kathmandu, Nepal.
Annals of clinical microbiology and antimicrobials.
2017 Sep; 16(1):62. doi:
10.1186/s12941-017-0236-7. [PMID: 28927454] - Anna Silva Machado, Maura S Oliveira, Cristina Sanches, Carlindo Vieira da Silva Junior, David S Gomez, Rolf Gemperli, Silvia Regina Cavani Jorge Santos, Anna S Levin. Clinical Outcome and Antimicrobial Therapeutic Drug Monitoring for the Treatment of Infections in Acute Burn Patients.
Clinical therapeutics.
2017 Aug; 39(8):1649-1657.e3. doi:
10.1016/j.clinthera.2017.06.008. [PMID: 28705450] - Imran Ali, Muhammad Shabbir. Antibiotics susceptibility patterns of uropathogenic E. coli with special reference to fluoroquinolones in different age and gender groups.
JPMA. The Journal of the Pakistan Medical Association.
2017 Aug; 67(8):1161-1165. doi:
NULL. [PMID: 28839298] - So Yeon Kim, Sang Yop Shin, Ji-Young Rhee, Kwan Soo Ko. Imipenem-resistant Gram-negative bacterial isolates carried by persons upon medical examination in Korea.
Journal of microbiology (Seoul, Korea).
2017 Aug; 55(8):612-618. doi:
10.1007/s12275-017-6555-8. [PMID: 28721477] - N Grall, V Lazarevic, N Gaïa, C Couffignal, C Laouénan, E Ilic-Habensus, I Wieder, P Plesiat, C Angebault, M E Bougnoux, L Armand-Lefevre, A Andremont, X Duval, J Schrenzel. Unexpected persistence of extended-spectrum β-lactamase-producing Enterobacteriaceae in the faecal microbiota of hospitalised patients treated with imipenem.
International journal of antimicrobial agents.
2017 Jul; 50(1):81-87. doi:
10.1016/j.ijantimicag.2017.02.018. [PMID: 28499958] - Gowrishankar Soundararajan, Satya Prathyusha Bhamidimarri, Mathias Winterhalter. Understanding Carbapenem Translocation through OccD3 (OpdP) of Pseudomonas aeruginosa.
ACS chemical biology.
2017 06; 12(6):1656-1664. doi:
10.1021/acschembio.6b01150. [PMID: 28440622] - Marina Oviaño, Cecilia de la Luna Ramírez, Luis Pedro Barbeyto, Germán Bou. Rapid direct detection of carbapenemase-producing Enterobacteriaceae in clinical urine samples by MALDI-TOF MS analysis.
The Journal of antimicrobial chemotherapy.
2017 05; 72(5):1350-1354. doi:
10.1093/jac/dkw579. [PMID: 28119478] - Rumyana Markovska, Temenuga Stoeva, Lyudmila Boyanova, Petya Stankova, Daniela Pencheva, Radka Kaneva, Vanyo Mitev, Ivan Mitov. Isolation of Escherichia coli ST131 producing KPC-2 in Bulgaria.
Infectious diseases (London, England).
2017 May; 49(5):429-431. doi:
10.1080/23744235.2016.1270464. [PMID: 28049378] - Z Zhu, G W Cao, J J Bao, Z H Hu, Z Shen, H Tao, B Cao, F Xu. [Effects of application of vancomycin in the early stage of patients with extremely severe burn].
Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns.
2017 Apr; 33(4):206-210. doi:
10.3760/cma.j.issn.1009-2587.2017.04.004. [PMID: 28427133] - Marcelo V Radisic, Laura Linares, Javier Afeltra, Natalia Pujato, Roxana G Vitale, Martin Bravo, Ana C Dotta, Domingo H Casadei. Acute pulmonary involvement by paracoccidiodomycosis disease immediately after kidney transplantation: Case report and literature review.
Transplant infectious disease : an official journal of the Transplantation Society.
2017 Apr; 19(2):. doi:
10.1111/tid.12655. [PMID: 28039947] - Hana Suchánková, Michal Lipš, Karel Urbánek, Michael N Neely, Jan Strojil. Is continuous infusion of imipenem always the best choice?.
International journal of antimicrobial agents.
2017 Mar; 49(3):348-354. doi:
10.1016/j.ijantimicag.2016.12.005. [PMID: 28189734] - Esther Ríos, María Carmen López, Iciar Rodríguez-Avial, Esther Culebras, Juan José Picazo. Detection of Escherichia coli ST131 clonal complex (ST705) and Klebsiella pneumoniae ST15 among faecal carriage of extended-spectrum β-lactamase- and carbapenemase-producing Enterobacteriaceae.
Journal of medical microbiology.
2017 Feb; 66(2):169-174. doi:
10.1099/jmm.0.000399. [PMID: 27902381] - Mario Martínez-Florensa, Marta Consuegra-Fernández, Fernando Aranda, Noelia Armiger-Borràs, Marianna Di Scala, Esther Carrasco, Jerónimo Pachón, Jordi Vila, Gloria González-Aseguinolaza, Francisco Lozano. Protective Effects of Human and Mouse Soluble Scavenger-Like CD6 Lymphocyte Receptor in a Lethal Model of Polymicrobial Sepsis.
Antimicrobial agents and chemotherapy.
2017 01; 61(1):. doi:
10.1128/aac.01391-16. [PMID: 27895015] - James A Karlowsky, Daryl J Hoban, Meredith A Hackel, Sibylle H Lob, Daniel F Sahm. Antimicrobial susceptibility of Gram-negative ESKAPE pathogens isolated from hospitalized patients with intra-abdominal and urinary tract infections in Asia-Pacific countries: SMART 2013-2015.
Journal of medical microbiology.
2017 Jan; 66(1):61-69. doi:
10.1099/jmm.0.000421. [PMID: 28051952] - Fabrice Compain, Benjamin Rossi, Clémence Richaud, Emmanuel Guerot, Hidayeth Rostane, Sophie Jarraud, Isabelle Podglajen. Photo Quiz: A 44-Year-Old Kidney Transplant Patient with Pneumonia.
Journal of clinical microbiology.
2017 01; 55(1):1-2. doi:
10.1128/jcm.masthead.55-1. [PMID: 28031443] - Bradley A Boucher, Joanna Q Hudson, David M Hill, Joseph M Swanson, G Christopher Wood, S Casey Laizure, Angela Arnold-Ross, Zhe-Yi Hu, William L Hickerson. Pharmacokinetics of Imipenem/Cilastatin Burn Intensive Care Unit Patients Undergoing High-Dose Continuous Venovenous Hemofiltration.
Pharmacotherapy.
2016 12; 36(12):1229-1237. doi:
10.1002/phar.1866. [PMID: 27862103] - Aryann R Ganjo, Delshad M Maghdid, Isam Y Mansoor, Dik J Kok, Juliette A Severin, Henri A Verbrugh, Deborah Kreft, M H Fatah, A A Alnakshabandi, Asad Dlnya, Anette M Hammerum, Kim Ng, Wil Goessens. OXA-Carbapenemases Present in Clinical Acinetobacter baumannii-calcoaceticus Complex Isolates from Patients in Kurdistan Region, Iraq.
Microbial drug resistance (Larchmont, N.Y.).
2016 Dec; 22(8):627-637. doi:
10.1089/mdr.2015.0060. [PMID: 27003287] - Chien-Chih Wu, Tsung-Yu Pai, Fei-Yuan Hsiao, Li-Jiuan Shen, Fe-Lin Lin Wu. The Effect of Different Carbapenem Antibiotics (Ertapenem, Imipenem/Cilastatin, and Meropenem) on Serum Valproic Acid Concentrations.
Therapeutic drug monitoring.
2016 10; 38(5):587-92. doi:
10.1097/ftd.0000000000000316. [PMID: 27322166] - L Y Deng, Z C Yang, Y L Gong, G T Huang, S P Yin, B Jiang, Y Z Peng. [Therapeutic effect of phages on extensively drug-resistant Acinetobacter baumannii-induced sepsis in mice].
Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns.
2016 Sep; 32(9):523-8. doi:
10.3760/cma.j.issn.1009-2587.2016.09.003. [PMID: 27647067] - Naoki Kuroshima, Takayuki Tanaka, Tamotsu Kuroki, Amane Kitasato, Tomohiko Adachi, Shinichiro Ono, Hajime Matsushima, Takanori Hirayama, Akihiko Soyama, Masaaki Hidaka, Mitsuhisa Takatsuki, Susumu Eguchi. Triple-drug therapy to prevent pancreatic fistula after pancreatectomy in a rat model.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].
2016 Sep; 16(5):917-21. doi:
10.1016/j.pan.2016.06.011. [PMID: 27396917]