Vinylidene chloride (BioDeep_00000677132)
代谢物信息卡片
化学式: C2H2Cl2 (95.9533552)
中文名称: 1,1-二氯乙烯标准溶液, 聚偏二氯乙烯
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C=C(Cl)Cl
InChI: InChI=1S/C2H2Cl2/c1-2(3)4/h1H2
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
1 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Amal Ibrahim, Hervé Cottet. Characterization of hydrosoluble fraction and oligomers in poly(vinylidene chloride) latexes by capillary electrophoresis using electrophoretic mobility modeling.
Journal of chromatography. A.
2019 Aug; 1598(?):223-231. doi:
10.1016/j.chroma.2019.04.016
. [PMID: 31053352] - Andreas Sjödin, Richard S Jones, Robert B Gunier, Lee-Yang Wong, Nina Holland, Brenda Eskenazi, Asa Bradman. Polybrominated Diphenyl Ethers, Polychlorinated Biphenyls, and 2,2-Bis(4-chlorophenyl)-1,1-dichloroethene in 7- and 9-Year-Old Children and Their Mothers in the Center for the Health Assessment of Mothers and Children of Salinas Cohort.
Environmental science & technology.
2018 02; 52(4):2287-2294. doi:
10.1021/acs.est.7b05460
. [PMID: 29341602] - Schantel A Hayes, Arun R Pandiri, Thai-vu T Ton, Hue-Hua L Hong, Natasha P Clayton, Keith R Shockley, Shyamal D Peddada, Kevin Gerrish, Michael Wyde, Robert C Sills, Mark J Hoenerhoff. Renal Cell Carcinomas in Vinylidene Chloride-exposed Male B6C3F1 Mice Are Characterized by Oxidative Stress and TP53 Pathway Dysregulation.
Toxicologic pathology.
2016 Jan; 44(1):71-87. doi:
10.1177/0192623315610820
. [PMID: 26682919] - John E Casida. The greening of pesticide-environment interactions: some personal observations.
Environmental health perspectives.
2012 Apr; 120(4):487-93. doi:
10.1289/ehp.1104405
. [PMID: 22472325] - Mallampati Srinivasa Reddy, Tetsuji Okuda, Satoshi Nakai, Wataru Nishijima, Mitsumasa Okada. Recovery of polypropylene and polyethylene from packaging plastic wastes without contamination of chlorinated plastic films by the combination process of wet gravity separation and ozonation.
Waste management (New York, N.Y.).
2011 Aug; 31(8):1848-51. doi:
10.1016/j.wasman.2011.03.018
. [PMID: 21530222] - Jonathan Chevrier, Kim G Harley, Asa Bradman, Myriam Gharbi, Andreas Sjödin, Brenda Eskenazi. Polybrominated diphenyl ether (PBDE) flame retardants and thyroid hormone during pregnancy.
Environmental health perspectives.
2010 Oct; 118(10):1444-9. doi:
10.1289/ehp.1001905
. [PMID: 20562054] - Britton Trabert, Anneclaire J De Roos, Stephen M Schwartz, Ulrike Peters, Delia Scholes, Dana B Barr, Victoria L Holt. Non-dioxin-like polychlorinated biphenyls and risk of endometriosis.
Environmental health perspectives.
2010 Sep; 118(9):1280-5. doi:
10.1289/ehp.0901444
. [PMID: 20423815] - J V Bruckner, C A White, S Muralidhara, C Hines, C E Dallas. Influence of exposure route and oral dosage regimen on 1, 1-dichloroethylene toxicokinetics and target organ toxicity.
The Journal of pharmacology and experimental therapeutics.
2010 May; 333(2):519-27. doi:
10.1124/jpet.109.162479
. [PMID: 20130112] - Rosana H Weldon, Monique Webster, Kim G Harley, Asa Bradman, Laura Fenster, Mark D Davis, Alan Hubbard, Dana B Barr, Nina Holland, Brenda Eskenazi. Serum persistent organic pollutants and duration of lactation among Mexican-American women.
Journal of environmental and public health.
2010; 2010(?):861757. doi:
10.1155/2010/861757
. [PMID: 20671963] - Kennan Kellaris Salinero, Keith Keller, William S Feil, Helene Feil, Stephan Trong, Genevieve Di Bartolo, Alla Lapidus. Metabolic analysis of the soil microbe Dechloromonas aromatica str. RCB: indications of a surprisingly complex life-style and cryptic anaerobic pathways for aromatic degradation.
BMC genomics.
2009 Aug; 10(?):351. doi:
10.1186/1471-2164-10-351
. [PMID: 19650930] - Ilisa Tawney, Jennifer G Becker, Andrew H Baldwin. A novel dual-compartment, continuous-flow wetland microcosm to assess cis-dichloroethene removal from the rhizosphere.
International journal of phytoremediation.
2008 Sep; 10(5):455-71. doi:
10.1080/15226510802100655
. [PMID: 19260226] - Emuri Abe, Charlotte Duverneuil, Geoffroy de la Grandmaison, Jean-Claude Alvarez. A fatal dichlorvos poisoning: concentrations in biological specimens.
Journal of forensic sciences.
2008 Jul; 53(4):997-1000. doi:
10.1111/j.1556-4029.2008.00774.x
. [PMID: 18547356] - Sharon K Sagiv, J Kevin Nugent, T Berry Brazelton, Anna L Choi, Paige E Tolbert, Larisa M Altshul, Susan A Korrick. Prenatal organochlorine exposure and measures of behavior in infancy using the Neonatal Behavioral Assessment Scale (NBAS).
Environmental health perspectives.
2008 May; 116(5):666-73. doi:
10.1289/ehp.10553
. [PMID: 18470320] - Edward F Fitzgerald, Erin E Belanger, Marta I Gomez, Michael Cayo, Robert J McCaffrey, Richard F Seegal, Robert L Jansing, Syni-an Hwang, Heraline E Hicks. Polychlorinated biphenyl exposure and neuropsychological status among older residents of upper Hudson River communities.
Environmental health perspectives.
2008 Feb; 116(2):209-15. doi:
10.1289/ehp.10432
. [PMID: 18288320] - Robert Pełech, Eugeniusz Milchert, Rafał Wróbel. Adsorption dynamics of chlorinated hydrocarbons from multi-component aqueous solution onto activated carbon.
Journal of hazardous materials.
2006 Oct; 137(3):1479-87. doi:
10.1016/j.jhazmat.2006.04.023
. [PMID: 16730892] - Pamela R D Williams, Jacqueline Patterson, Daniel W Briggs. VCCEP pilot: progress on evaluating children's risks and data needs.
Risk analysis : an official publication of the Society for Risk Analysis.
2006 Jun; 26(3):781-801. doi:
10.1111/j.1539-6924.2006.00766.x
. [PMID: 16834634] - Wilfried Karmaus, Susan Davis, Christopher Fussman, Kevin Brooks. Maternal concentration of dichlorodiphenyl dichloroethylene (DDE) and initiation and duration of breast feeding.
Paediatric and perinatal epidemiology.
2005 Sep; 19(5):388-98. doi:
10.1111/j.1365-3016.2005.00658.x
. [PMID: 16115291] - Erik J Martin, Poh-Gek Forkert. Evidence that 1,1-dichloroethylene induces apoptotic cell death in murine liver.
The Journal of pharmacology and experimental therapeutics.
2004 Jul; 310(1):33-42. doi:
10.1124/jpet.104.066019
. [PMID: 15028783] - Núria Ribas-Fitó, Esther Cardo, Maria Sala, M Eulàlia de Muga, Carlos Mazón, Antoni Verdú, Manolis Kogevinas, Joan O Grimalt, Jordi Sunyer. Breastfeeding, exposure to organochlorine compounds, and neurodevelopment in infants.
Pediatrics.
2003 May; 111(5 Pt 1):e580-5. doi:
10.1542/peds.111.5.e580
. [PMID: 12728113] - Erik J Martin, William J Racz, Poh-Gek Forkert. Mitochondrial dysfunction is an early manifestation of 1,1-dichloroethylene-induced hepatotoxicity in mice.
The Journal of pharmacology and experimental therapeutics.
2003 Jan; 304(1):121-9. doi:
10.1124/jpet.102.041392
. [PMID: 12490582] - Stephen M Roberts, Kristen E Jordan, D Alan Warren, Janice K Britt, Robert C James. Evaluation of the carcinogenicity of 1,1-dichloroethylene (vinylidene chloride).
Regulatory toxicology and pharmacology : RTP.
2002 Feb; 35(1):44-55. doi:
10.1006/rtph.2001.1518
. [PMID: 11846635] - Fun-In Wang, Min-Liang Kuo, Chia-Tung Shun, Yee-Chung Ma, Jung-Der Wang, Tzuu-Huei Ueng. Chronic toxicity of a mixture of chlorinated alkanes and alkenes in ICR mice.
Journal of toxicology and environmental health. Part A.
2002 Feb; 65(3-4):279-91. doi:
10.1080/15287390252800864
. [PMID: 11911491] - S Muralidhara, R Ramanathan, S M Mehta, L H Lash, D Acosta, J V Bruckner. Acute, subacute, and subchronic oral toxicity studies of 1,1-dichloroethane in rats: application to risk evaluation.
Toxicological sciences : an official journal of the Society of Toxicology.
2001 Nov; 64(1):135-45. doi:
10.1093/toxsci/64.1.135
. [PMID: 11606809] - R Boopathy, R Peters. Enhanced biotransformation of trichloroethylene under mixed electron acceptor conditions.
Current microbiology.
2001 Feb; 42(2):134-8. doi:
10.1007/s002843348
. [PMID: 11136136] - R S Wang, T Nakajima, T Honma. Different change patterns of the isozymes of cytochrome P450 and glutathione S-transferases in chemically induced liver damage in rat.
Industrial health.
1999 Oct; 37(4):440-8. doi:
10.2486/indhealth.37.440
. [PMID: 10547960] - P G Forkert. 1,1-Dichloroethylene-induced Clara cell damage is associated with in situ formation of the reactive epoxide. Immunohistochemical detection of its glutathione conjugate.
American journal of respiratory cell and molecular biology.
1999 Jun; 20(6):1310-8. doi:
10.1165/ajrcmb.20.6.3525
. [PMID: 10340951] - M Ban, D Hettich, M Goutet, S Binet. Serum-borne factor(s) of 1,1-dichloroethylene and 1,2-dichlorobenzene-treated mice inhibited in vitro antibody forming cell response and natural killer cell activity.
Toxicology letters.
1998 Jan; 94(2):93-101. doi:
10.1016/s0378-4274(97)00109-4
. [PMID: 9574806] - P G Forkert, K S Collins, T F Dowsley, G M Ross. Immunochemical assay for recognition of 2-S-glutathionyl acetate, a glutathione conjugate derived from 1,1-dichloroethylene-epoxide.
The Journal of pharmacology and experimental therapeutics.
1997 Jun; 281(3):1422-30. doi:
. [PMID: 9190879]
- N Hanioka, H Jinno, T Nishimura, M Ando. Changes in cytochrome P450 enzymes by 1,1-dichloroethylene in rat liver and kidney.
Archives of toxicology.
1997; 72(1):9-16. doi:
10.1007/s002040050462
. [PMID: 9458185] - B Cossec, L Cavelier, N Moitessier-Bergé, G Morel, J de Ceaurriz. Formation of GSH-derivatives as a pathway for inactive intermediates in vinylidene chloride-treated rats.
Toxicology letters.
1996 Dec; 89(3):223-9. doi:
10.1016/s0378-4274(96)03819-2
. [PMID: 9001591] - H A el-Masri, A A Constan, H S Ramsdell, R S Yang. Physiologically based pharmacodynamic modeling of an interaction threshold between trichloroethylene and 1,1-dichloroethylene in Fischer 344 rats.
Toxicology and applied pharmacology.
1996 Nov; 141(1):124-32. doi:
10.1006/taap.1996.0268
. [PMID: 8917684] - J B Wueweera, A J Gandolfi, D A Badger, I G Sipes, K Brendel. Vitamin A potentiation of vinylidene chloride hepatotoxicity in rats and precision-cut rat liver slices.
Fundamental and applied toxicology : official journal of the Society of Toxicology.
1996 Nov; 34(1):73-83. doi:
NULL
. [PMID: 8937894] - L Cavelier, P Bonnet, G Morel, J de Ceaurriz. Role of cysteine conjugation in vinylidene chloride-induced nephrotoxicity and hepatotoxicity in fasted rats.
Journal of applied toxicology : JAT.
1996 Mar; 16(2):109-13. doi:
10.1002/(sici)1099-1263(199603)16:2<109::aid-jat308>3.0.co;2-9
. [PMID: 8935783] - W Dekant. Biotransformation and renal processing of nephrotoxic agents.
Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement.
1996; 18(?):163-72. doi:
10.1007/978-3-642-61105-6_17
. [PMID: 8678792] - M Ban, D Hettich, N Huguet, L Cavelier. Nephrotoxicity mechanism of 1,1-dichloroethylene in mice.
Toxicology letters.
1995 Jul; 78(2):87-92. doi:
10.1016/0378-4274(94)03237-2
. [PMID: 7618182] - P Speerschneider, W Dekant. Renal tumorigenicity of 1,1-dichloroethene in mice: the role of male-specific expression of cytochrome P450 2E1 in the renal bioactivation of 1,1-dichloroethene.
Toxicology and applied pharmacology.
1995 Jan; 130(1):48-56. doi:
10.1006/taap.1995.1007
. [PMID: 7839370] - D Turnbull, R J Machado, R E Boberg. Safety assessment of HCFC-141b: use as a blowing agent for insulation in building construction and refrigeration.
Regulatory toxicology and pharmacology : RTP.
1994 Jun; 19(3):282-96. doi:
10.1006/rtph.1994.1024
. [PMID: 8090952] - M F Kanz, L Kaphalia, S Mohsin, Z Taj, M T Moslen. Hyperthyroidism increases covalent binding and biliary excretion of 1,1-dichloroethylene in rats.
Journal of toxicology and environmental health.
1994 Feb; 41(2):187-206. doi:
10.1080/15287399409531836
. [PMID: 8301698] - E B Brittebo, P O Darnerud, C Eriksson, I Brandt. Nephrotoxicity and covalent binding of 1,1-dichloroethylene in buthionine sulphoximine-treated mice.
Archives of toxicology.
1993; 67(9):605-12. doi:
10.1007/bf01974067
. [PMID: 8311687] - T J Maziasz, J Liu, C Madhu, C D Klaassen. The differential effects of hepatotoxicants on the sulfation pathway in rats.
Toxicology and applied pharmacology.
1991 Sep; 110(3):365-73. doi:
10.1016/0041-008x(91)90039-h
. [PMID: 1949007] - P B Wright, L Moore. Potentiation of the toxicity of model hepatotoxicants by acetaminophen.
Toxicology and applied pharmacology.
1991 Jun; 109(2):327-35. doi:
10.1016/0041-008x(91)90179-i
. [PMID: 2068730] - M F Kanz, Z Taj, M T Moslen. 1,1-Dichloroethylene hepatotoxicity: hypothyroidism decreases metabolism and covalent binding but not injury in the rat.
Toxicology.
1991; 70(2):213-29. doi:
10.1016/0300-483x(91)90048-6
. [PMID: 1763416] - L Dahlström-King, J Couture, C Lamoureux, T Vaillancourt, G L Plaa. Dose-dependent cytotoxicity of chlorinated hydrocarbons in isolated rat hepatocytes.
Fundamental and applied toxicology : official journal of the Society of Toxicology.
1990 May; 14(4):833-41. doi:
. [PMID: 2361581]
- M T Moslen, H A Dunsford, C Karnasuta, P Chieco, M F Kanz. Histochemical and immunocytochemical evidence of early, selective bile canaliculi injury after 1,1-dichloroethylene in rats.
The American journal of pathology.
1989 May; 134(5):1099-112. doi:
NULL
. [PMID: 2541611] - M T Moslen, R F Whitehead, A E Ferguson, M F Kanz. Protection by L-2-oxothiazolidine-4-carboxylate, a cysteine prodrug, against 1,1-dichloroethylene hepatotoxicity in rats is associated with decreases in toxin metabolism and cytochrome P-450.
The Journal of pharmacology and experimental therapeutics.
1989 Jan; 248(1):157-63. doi:
NULL
. [PMID: 2913268] - Z Gregus, C White, S Howell, C D Klaassen. Effect of glutathione depletion on sulfate activation and sulfate ester formation in rats.
Biochemical pharmacology.
1988 Nov; 37(22):4307-12. doi:
10.1016/0006-2952(88)90611-9
. [PMID: 3196355] - M F Kanz, R F Whitehead, A E Ferguson, M T Moslen. Potentiation of 1,1-dichloroethylene hepatotoxicity: comparative effects of hyperthyroidism and fasting.
Toxicology and applied pharmacology.
1988 Aug; 95(1):93-103. doi:
10.1016/s0041-008x(88)80011-5
. [PMID: 3413796] - M E Andersen, M L Gargas, H J Clewell, K M Severyn. Quantitative evaluation of the metabolic interactions between trichloroethylene and 1,1-dichloroethylene in vivo using gas uptake methods.
Toxicology and applied pharmacology.
1987 Jun; 89(2):149-57. doi:
10.1016/0041-008x(87)90035-4
. [PMID: 3603553] - R M Long, L Moore. Cytosolic calcium after carbon tetrachloride, 1,1-dichloroethylene, and phenylephrine exposure. Studies in rat hepatocytes with phosphorylase a and quin2.
Biochemical pharmacology.
1987 Apr; 36(8):1215-21. doi:
10.1016/0006-2952(87)90073-6
. [PMID: 3593411] - L K Okine, T E Gram. In vitro studies on the metabolism and covalent binding of [14C]1,1-dichloroethylene by mouse liver, kidney and lung.
Biochemical pharmacology.
1986 Aug; 35(16):2789-95. doi:
10.1016/0006-2952(86)90191-7
. [PMID: 3741469] - M F Kanz, E S Reynolds. Early effects of 1,1-dichloroethylene on canalicular and plasma membranes: ultrastructure and stereology.
Experimental and molecular pathology.
1986 Feb; 44(1):93-110. doi:
10.1016/0014-4800(86)90037-7
. [PMID: 3948981] - L K Okine, T E Gram. Tissue distribution and covalent binding of [14C]1,1-dichloroethylene in mice: in vivo and in vitro studies.
Advances in experimental medicine and biology.
1986; 197(?):903-10. doi:
10.1007/978-1-4684-5134-4_86
. [PMID: 3766300] - N M Jackson, R B Conolly. Acute nephrotoxicity of 1,1-dichloroethylene in the rat after inhalation exposure.
Toxicology letters.
1985 Dec; 29(2-3):191-9. doi:
10.1016/0378-4274(85)90041-4
. [PMID: 3937299] - L K Okine, J M Goochee, T E Gram. Studies on the distribution and covalent binding of 1,1-dichloroethylene in the mouse. Effect of various pretreatments on covalent binding in vivo.
Biochemical pharmacology.
1985 Nov; 34(22):4051-7. doi:
10.1016/0006-2952(85)90386-7
. [PMID: 4062975] - M T Moslen, L R Poisson, E S Reynolds. Cholestasis and increased biliary excretion of inulin in rats given 1,1-dichloroethylene.
Toxicology.
1985 Mar; 34(3):201-9. doi:
10.1016/0300-483x(85)90171-4
. [PMID: 3975918] - C P Siegers, W Horn, M Younes. Effect of hypoxia on the metabolism and hepatotoxicity of carbon tetrachloride and vinylidene chloride in rats.
Acta pharmacologica et toxicologica.
1985 Feb; 56(2):81-6. doi:
10.1111/j.1600-0773.1985.tb01257.x
. [PMID: 3993389] - M T Moslen, E S Reynolds. Rapid, substrate-specific, and dose-dependent deactivation of liver cytosolic glutathione S-transferases in vivo by 1,1-dichloroethylene.
Research communications in chemical pathology and pharmacology.
1985 Jan; 47(1):59-72. doi:
. [PMID: 3983471]
- D C Liebler, M J Meredith, F P Guengerich. Formation of glutathione conjugates by reactive metabolites of vinylidene chloride in microsomes and isolated hepatocytes.
Cancer research.
1985 Jan; 45(1):186-93. doi:
. [PMID: 3965130]
- E S Reynolds, M F Kanz, P Chieco, M T Moslen. 1,1-Dichloroethylene: an apoptotic hepatotoxin?.
Environmental health perspectives.
1984 Aug; 57(?):313-20. doi:
10.1289/ehp.8457313
. [PMID: 6499813] - K R Krijgsheld, M C Lowe, E G Mimnaugh, M A Trush, E Ginsburg, T E Gram. Selective damage to nonciliated bronchiolar epithelial cells in relation to impairment of pulmonary monooxygenase activities by 1,1-dichloroethylene in mice.
Toxicology and applied pharmacology.
1984 Jun; 74(2):201-13. doi:
10.1016/0041-008x(84)90144-3
. [PMID: 6740671] - K R Krijgsheld, T E Gram. Selective induction of renal microsomal cytochrome P-450-linked monooxygenases by 1,1-dichloroethylene in mice.
Biochemical pharmacology.
1984 Jun; 33(12):1951-6. doi:
10.1016/0006-2952(84)90554-9
. [PMID: 6610421] - F Oesch, M Protić-Sabljić, T Friedberg, H J Klimisch, H R Glatt. Vinylidene chloride: changes in drug-metabolizing enzymes, mutagenicity and relation to its targets for carcinogenesis.
Carcinogenesis.
1983 Aug; 4(8):1031-8. doi:
10.1093/carcin/4.8.1031
. [PMID: 6347425] - W R Hewitt, G L Plaa. Dose-dependent modification of 1,1-dichloroethylene toxicity by acetone.
Toxicology letters.
1983 Apr; 16(1-2):145-52. doi:
10.1016/0378-4274(83)90023-1
. [PMID: 6836608] - K R Krijgsheld, M C Lowe, E G Mimnaugh, M A Trush, E Ginsburg, T E Gram. Lung-selective impairment of cytochrome P-450-dependent monooxygenases and cellular injury by 1,1-dichloroethylene in mice.
Biochemical and biophysical research communications.
1983 Jan; 110(2):675-81. doi:
10.1016/0006-291x(83)91202-0
. [PMID: 6838545] - P G Forkert, E M Custer, A J Alpert, G A Ansari, E S Reynolds. Lactate dehydrogenase activity in mouse lung following 1,1-dichloroethylene: index of airway injury.
Experimental lung research.
1982 Dec; 4(1):67-77. doi:
10.3109/01902148209039250
. [PMID: 7169062] - C P Siegers, W Hübscher, M Younes. Glutathione-S-transferase and GSH-peroxidase activities during the state of GSH-depletion leading to lipid peroxidation in rat liver.
Research communications in chemical pathology and pharmacology.
1982 Aug; 37(2):163-9. doi:
"
. [PMID: 7134625] - S N Lin, F W Fu, J V Bruckner. Quantitation of 1,1- and 1,2-dichloroethylene in body tissues by purge-and-trap gas chromatography.
Journal of chromatography.
1982 Jul; 244(2):311-20. doi:
10.1016/s0021-9673(00)85695-2
. [PMID: 7119076]